EXPERIMENT ID PUBMED ID SPECIES EXPERIMENT DESCRIPTION SAMPLE SAMPLE SOURCE SAMPLE NAME IDENTIFICATIONS METHODS YEAR ISOLATION METHOD VESICLE TYPE 1 6307529 Ovis aries Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Reticulocytes ts Reticulocytes Protein Antibody based methods 1983 - Exosomes 2 3597417 Ovis aries Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). Reticulocytes ts Reticulocytes Protein Enzyme assay|Antibody based methods 1987 Differential centrifugation Exosomes 3 10545503 Mus musculus Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. Dendritic cells cl D1 Protein Mass spectrometry [MALDI TOF]|Western blotting 1999 Differential centrifugation|Sucrose density gradient Exosomes 4 11487543 Homo sapiens Intestinal epithelial cells secrete exosome-like vesicles. Intestinal epithelial cells cl HT29-19A|T84-DRB1*0401/CIITA Protein Mass spectrometry [MALDI TOF]|Western blotting 2001 Differential centrifugation|Sucrose density gradient Exosomes 5 11145662 Mus musculus Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. Mast cells cl P815|MC9|Bone marrow-derived mast cells Protein Mass spectrometry [MALDI TOF]|ELISA 2001 Differential centrifugation Exosomes 6 11306949 Mus musculus Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes. Mast cells ts Bone marrow-derived mast cells Protein Western blotting 2001 - Exosomes 7 12626558 Mus musculus Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. Mast cells ts Bone marrow-derived mast cells Protein Western blotting 2003 Differential centrifugation Exosomes 8 12626558 Mus musculus Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. B cells ts B Cells Protein Western blotting 2003 Differential centrifugation Exosomes 9 12626558 Mus musculus Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. Macrophages ts Macrophages Protein Western blotting 2003 Differential centrifugation Exosomes 10 11390481 Mus musculus Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. Dendritic cells cl D1 Protein Mass spectrometry [MALDI TOF]|Mass spectrometry [QTOF]|Western blotting 2001 Differential centrifugation|Sucrose density gradient Exosomes 11 12519789 Homo sapiens Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. B cells cl RN (HLA-DR15+) Protein|Lipids Mass spectrometry [MALDI TOF]|Mass spectrometry [QTOF]|Western blotting|Thin layer chromatography|HPLC 2003 Differential centrifugation|Sucrose density gradient Exosomes 12 15478216 Homo sapiens Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Melanoma cells cl MeWo|SK-MEL-28 Protein Mass spectrometry [4700 Proteomics Analyzer]|Western blotting 2004 Filtration|Ultracentrifugation|Sucrose density gradient Exosomes 13 15326289 Homo sapiens Identification and proteomic profiling of exosomes in human urine. Urine ts Urine - Normal Protein Mass spectrometry [LCQ DECA XP]|Western blotting 2004 Ultracentrifugation Exosomes 14 16081791 Mus musculus Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. Microglia cl N9 Protein Mass spectrometry [LCQ DECA XP]|Western blotting 2005 Differential centrifugation|Sucrose density gradient Exosomes 15 17486113 Mus musculus|Homo sapiens Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Mast cells cl|ts MC9|Bone marrow-derived mast cells|HMC-1 Protein|mRNA|miRNA Mass spectrometry [MALDI TOF]|Western blotting|Microarray|miRCURY LNA Array 2007 Filtration|Ultracentrifugation|Sucrose density gradient Exosomes 16 9685355 Homo sapiens Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. B cells cl RN (HLA-DR15+) Protein Western blotting|Immunoelectron Microscopy 1998 Differential centrifugation|Sucrose density gradient Exosomes 17 11907077 Homo sapiens TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. T cells cl Jurkat|T cell blasts|E+ cells|MART-1+ T cell Protein Western blotting|Immunoelectron Microscopy 2002 Filtration|Ultracentrifugation Exosomes 18 11907077 Homo sapiens TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. T cells cl Jurkat|T cell blasts Protein FACS 2002 Filtration|Ultracentrifugation Exosomes 19 16302729 Homo sapiens Purification, characterization and biological significance of tumor-derived exosomes. Breast cancer cells cl BT-474|MDA-MB-231 Protein Western blotting|FACS 2005 Differential centrifugation|Sucrose density gradient|Filtration|Immunobeads(HER2) Exosomes 20 17956143 Homo sapiens Proteomic analysis of microvesicles derived from human colorectal cancer cells. Colorectal cancer cells cl HT29 Protein Mass spectrometry [LTQ]|Western blotting 2007 Differential centrifugation|Sucrose density gradient|Diafiltration Exosomes 21 19837982 Homo sapiens Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215. Colorectal cancer cells cl LIM1215 Protein Mass spectrometry [Orbitrap]|Western blotting 2009 Filtration|Ultracentrifugation|Sucrose density gradient Exosomes 22 15940614 Homo sapiens Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Colorectal cancer cells cl SW403|1869col|CRC28462 Protein Western blotting|Immunoelectron Microscopy|FACS 2005 Differential centrifugation Exosomes 23 11231627 Mus musculus Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Mammary adenocarcinoma cl TS/A (H-2d)|P815 mastocytoma cells (H-2d) Protein Western blotting|Immunoelectron Microscopy 2001 Differential centrifugation|Sucrose density gradient Exosomes 24 11231627 Homo sapiens Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Melanoma cells cl Fon|Mel-888 Protein Western blotting 2001 Differential centrifugation|Sucrose density gradient Exosomes 25 15111327 Homo sapiens Proteomic analysis of exosomes secreted by human mesothelioma cells. Mesothelioma cells cl PMR-MM7|PMR-MM8 Protein Mass spectrometry [MALDI TOF]|Western blotting 2004 Differential centrifugation Exosomes 26 19109410 Mus musculus Proteomic and immunologic analyses of brain tumor exosomes. Brain tumor cl SMA560vIII Protein Mass spectrometry [MALDI TOF/TOF]|Western blotting 2008 Differential centrifugation|Sucrose density gradient Exosomes 27 19109410 Homo sapiens Proteomic and immunologic analyses of brain tumor exosomes. Medulloblastoma cl D283MED Protein Western blotting 2008 Differential centrifugation|Sucrose density gradient Exosomes 28 19109410 Homo sapiens Proteomic and immunologic analyses of brain tumor exosomes. Glioma cells cl X43,T|D456MG|H2159MG|D54MG|D247MG Protein Western blotting 2008 Differential centrifugation|Sucrose density gradient Exosomes 29 19109410 Homo sapiens Proteomic and immunologic analyses of brain tumor exosomes. Serum ts Serum - Brain tumor Protein Western blotting 2008 Differential centrifugation|Sucrose density gradient Exosomes 30 16446100 Rattus norvegicus Exosomes are released by cultured cortical neurones. Cortical neurones ts Neurones Protein Mass spectrometry [QTOF]|Western blotting 2006 Differential centrifugation|Sucrose density gradient Exosomes 31 10572093 Homo sapiens Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Platelets ts Platelets Protein Western blotting|FACS|Immunoelectron Microscopy 1999 Differential centrifugation|Sucrose density gradient Exosomes 32 18452139 Homo sapiens Primary human keratinocytes externalize stratifin protein via exosomes. Keratinocytes ts Keratinocytes Protein Western blotting 2008 Differential centrifugation|Sucrose density gradient|Diafiltration Exosomes 33 0 Mus musculus Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons? Oligodendrocytes ts Oligodendrocytes|Oli-neu Protein Mass spectrometry [QTOF]|Western blotting|Immunoelectron Microscopy 2007 Differential centrifugation|Sucrose density gradient Exosomes 34 19190083 Homo sapiens Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Tracheobronchial cells ts Tracheobronchial epithelial cells Protein|mRNA Mass spectrometry [QTOF]|Western blotting|Immunoelectron Microscopy|FACS 2009 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 35 19367702 Rattus norvegicus Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes. Hepatocytes ts Hepatocytes Protein Mass spectrometry [QTOF]|Western blotting 2008 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 36 19367702 Mus musculus Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes. Hepatocytes cl MLP-29 Protein Western blotting 2008 Differential centrifugation|Filtration Exosomes 37 10878338 Homo sapiens Direct immunosuppressive effects of EBV-encoded latent membrane protein 1. B cells cl JY|B95-8 Protein Western blotting 2000 Differential centrifugation Exosomes 38 15210972 Oryctolagus cuniculus Cells release prions in association with exosomes. Rov epithelial cells cl RK13 Protein Western blotting|Immunoelectron Microscopy 2004 Differential centrifugation|Sucrose density gradient Exosomes 39 15210972 Mus musculus Cells release prions in association with exosomes. Mov neuroglial cell cl Mov neuroglial cell Protein Mass spectrometry [QSTAR]|Western blotting|Immunoelectron Microscopy 2004 Differential centrifugation|Sucrose density gradient Exosomes 40 15908444 Homo sapiens Exosomal-like vesicles are present in human blood plasma. Plasma ts Plasma - Normal Protein Western blotting|FACS|Immunoelectron Microscopy 2005 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 41 15908444 Homo sapiens Exosomal-like vesicles are present in human blood plasma. Mast cells cl HMC-1 Protein Western blotting|FACS|Immunoelectron Microscopy 2005 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 42 15908444 Homo sapiens Exosomal-like vesicles are present in human blood plasma. Bone marrow cells cl PBMC Protein Western blotting 2005 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 43 17076679 Homo sapiens Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences. Plasma ts Plasma - Pregnant and not-pregnant women Protein Western blotting 2006 Size exclusion|Ultracentrifugation|Immunobeads (CD3, CD19, CD56, CD83, PLAP) Exosomes 44 19028452 Homo sapiens Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. Plasma ts Plasma Protein Mass spectrometry [LTQ]|Western blotting|Immunoelectron Microscopy 2009 Filtration|Size exclusion|Sucrose density gradient Exosomes 45 18589210 Homo sapiens MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Serum ts Serum - Papillary adenocarcinoma of ovary Protein|miRNA Western blotting|467microRNA Array 2008 Ultracentrifugation|Immunobeads (EpCAM) Exosomes 46 17641064 Homo sapiens Exosomes with immune modulatory features are present in human breast milk. Breast milk ts Breast milk - colostrum Protein Mass spectrometry [QSTAR]|Western blotting|Immunoelectron Microscopy|FACS 2007 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 47 17641064 Homo sapiens Exosomes with immune modulatory features are present in human breast milk. B cells cl B cells Protein FACS 2007 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 48 17641064 Homo sapiens Exosomes with immune modulatory features are present in human breast milk. Breast milk ts Breast milk - mature milk Protein Mass spectrometry [QSTAR]|Western blotting|Immunoelectron Microscopy|FACS 2007 Differential centrifugation|Filtration|Sucrose density gradient Exosomes 49 14582906 Homo sapiens Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Bronchoalveolar lavage fluid ts Bronchoalveolar lavage fluid Protein FACS|Immunoelectron Microscopy 2003 Differential centrifugation|Immunobeads (EpCAM) Exosomes 50 14582906 Homo sapiens Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Dendritic cells ts Monocyte-derived dendritic cells Protein FACS|Immunoelectron Microscopy 2003 Differential centrifugation|Immunobeads (EpCAM) Exosomes 51 14975938 Homo sapiens Proteomic analysis of exosomes isolated from human malignant pleural effusions. Malignant pleural effusions ts Pleural Fluid - Breast cancer Protein Mass spectrometry [MALDI TOF]|Western blotting 2004 Differential centrifugation|Sucrose density gradient Exosomes 52 14975938 Homo sapiens Proteomic analysis of exosomes isolated from human malignant pleural effusions. Malignant pleural effusions ts Pleural Fluid - Lung cancer Protein Mass spectrometry [MALDI TOF]|Western blotting 2004 Differential centrifugation|Sucrose density gradient Exosomes 53 14975938 Homo sapiens Proteomic analysis of exosomes isolated from human malignant pleural effusions. Malignant pleural effusions ts Pleural Fluid - Mesothelioma Protein Mass spectrometry [MALDI TOF]|Western blotting 2004 Differential centrifugation|Sucrose density gradient Exosomes 54 14975938 Homo sapiens Proteomic analysis of exosomes isolated from human malignant pleural effusions. Malignant pleural effusions ts Pleural Fluid - Ovarian adenocarcioma Protein Western blotting 2004 Differential centrifugation|Sucrose density gradient Exosomes 55 12147373 Homo sapiens Malignant effusions and immunogenic tumour-derived exosomes. Malignant pleural effusions ts Malignant pleural effusions Protein Western blotting 2002 Differential centrifugation|Sucrose density gradient Exosomes 56 12147373 Homo sapiens Malignant effusions and immunogenic tumour-derived exosomes. Malignant ascites ts Malignant ascites Protein Western blotting 2002 Differential centrifugation|Sucrose density gradient Exosomes 57 17700640 Homo sapiens CD24 is a marker of exosomes secreted into urine and amniotic fluid. Urine ts Urine - Normal Protein Western blotting|FACS 2007 Differential centrifugation|Sucrose density gradient Exosomes 58 17700640 Homo sapiens CD24 is a marker of exosomes secreted into urine and amniotic fluid. Amniotic fluid ts Amniotic fluid Protein Western blotting 2007 Differential centrifugation|Sucrose density gradient Exosomes 59 17700640 Mus musculus CD24 is a marker of exosomes secreted into urine and amniotic fluid. Amniotic fluid ts Amniotic fluid Protein Western blotting 2007 Differential centrifugation|Sucrose density gradient Exosomes 60 17700640 Mus musculus CD24 is a marker of exosomes secreted into urine and amniotic fluid. Urine ts Urine - Normal Protein Western blotting 2007 Differential centrifugation|Sucrose density gradient Exosomes 61 17133577 Mus musculus Association of citrullinated proteins with synovial exosomes. Synovial fluid ts Synovial fluid - osteoarthritis and reactive arthritis Protein Immunoelectron Microscopy|Mass spectrometry [MALDI TOF]|Western blotting 2006 Differential centrifugation|Sucrose density gradient Exosomes 62 17133577 Mus musculus Association of citrullinated proteins with synovial exosomes. Synovial fluid ts Synovial fluid - rheumatoid arthritis Protein Immunoelectron Microscopy|Mass spectrometry [MALDI TOF]|Western blotting 2006 Differential centrifugation|Sucrose density gradient Exosomes 63 19056867 Homo sapiens Large-scale proteomics and phosphoproteomics of urinary exosomes. Urine ts Urine - Normal Protein Mass spectrometry [LTQ]|Western blotting 2009 Differential centrifugation Exosomes 64 18520029 Homo sapiens Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. Saliva ts Saliva Protein Western blotting|Immunoelectron Microscopy|N-terminal animo acid sequencing 2008 Filtration|Diafiltration|Gel filtration Exosomes 65 19415654 Homo sapiens Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7. Breast cancer cells cl MCF-7 Protein Mass spectrometry [MALDI TOF]|Western blotting 2009 Differential centrifugation|Sucrose density gradient Exosomes 66 19199708 Homo sapiens Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Saliva ts Saliva Protein Mass spectrometry [LTQ]|Western blotting|Immunoelectron Microscopy 2009 Differential centrifugation Exosomes 67 19619303 Homo sapiens Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer. Ovarian cancer cells cl BG-1 Protein Western blotting|Immunoelectron Microscopy 2009 Differential centrifugation|Sucrose density gradient Exosomes 68 19619303 Homo sapiens Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer. Plasma ts Plasma - Ovarian cancer Protein Western blotting 2009 Differential centrifugation Exosomes 69 19812188 Rattus norvegicus Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII. Dendritic cells cl Bone marrow-derived immature dendritic cells Protein Western blotting 2009 Differential centrifugation|Sucrose density gradient Exosomes 70 19812188 Rattus norvegicus Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII. Dendritic cells cl Bone marrow-derived mature dendritic cells Protein Western blotting 2009 Differential centrifugation Exosomes 71 19801663 Homo sapiens Microenvironmental pH is a key factor for exosome traffic in tumor cells. Melanoma cells cl Mel1 Protein|Lipids Western blotting|Thin layer chromatography 2009 Differential centrifugation|Sucrose density gradient Exosomes 72 19801663 Homo sapiens Microenvironmental pH is a key factor for exosome traffic in tumor cells. Melanoma cells cl Me665/1 Protein|Lipids Western blotting|Thin layer chromatography 2009 Differential centrifugation Exosomes 73 18494037 Mus musculus Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes. Embryonic fibroblast cells cl NIH3T3 Protein Mass spectrometry [LCQ DECA]|Western blotting 2008 Differential centrifugation Exosomes 74 19381331 Homo sapiens High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. Melanoma cells cl Me501 Protein Western blotting|ELISA|FACS 2009 Differential centrifugation Exosomes 75 19381331 Homo sapiens High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. Plasma ts Plasma - melanoma Protein Western blotting|ELISA|FACS 2009 Differential centrifugation Exosomes 76 20224111 Homo sapiens Proteomics analysis of bladder cancer exosomes. Bladder cancer cells cl HT1376 Protein Mass spectrometry [MALDI TOF/TOF]|Western blotting|FACS 2010 Differential centrifugation|Sucrose density gradient Exosomes 77 20224111 Homo sapiens Proteomics analysis of bladder cancer exosomes. Urine ts Urine - Normal Protein FACS 2010 Differential centrifugation|Sucrose density gradient Exosomes 78 20224111 Homo sapiens Proteomics analysis of bladder cancer exosomes. Urine ts Urine - Prostate cancer Protein FACS 2010 Differential centrifugation|Sucrose density gradient Exosomes 79 20458337 Homo sapiens MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1 B cells cl RN (HLA-DR15) Protein Mass spectrometry [FT-ICR]|Western blotting 2010 Differential centrifugation|Sucrose density gradient|Immunobeads (MHC Class II) Exosomes 80 20458337 Homo sapiens MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2 B cells cl RN (HLA-DR15) Protein Mass spectrometry [FT-ICR]|Western blotting 2010 Differential centrifugation|Sucrose density gradient|Immunobeads (MHC Class II) Exosomes 81 20458337 Homo sapiens MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3 B cells cl RN (HLA-DR15) Protein Mass spectrometry [FT-ICR]|Western blotting 2010 Differential centrifugation|Sucrose density gradient|Immunobeads (MHC Class II) Exosomes 82 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Stomach cancer cells cl AZ-521 Protein|miRNA Western blotting|RT-PCR|Human miRNA Microarray Kit 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 83 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Lung cancer cells cl SBC-3 Protein|miRNA Western blotting|RT-PCR|Human miRNA Microarray Kit 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 84 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Lung cancer cells cl DMS-53 miRNA Human miRNA Microarray Kit|RT-PCR 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 85 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Lung cancer cells cl NCI-H69 miRNA Human miRNA Microarray Kit|RT-PCR 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 86 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Colorectal cancer cells cl SW480 miRNA Human miRNA Microarray Kit|RT-PCR 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 87 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Colorectal cancer cells cl SW620 miRNA RT-PCR 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 88 20949044 Homo sapiens Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line Stomach cancer cells cl AZ-P7a Protein|miRNA Immunoelectron Microscopy|Western blotting|RT-PCR|Human miRNA Microarray Kit 2010 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 89 20424270 Rattus norvegicus Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. Basophilic leukemia cells cl RBL-2H3 Protein|Lipids Western blotting|Gas chromatography|Thin layer chromatography|Mass spectrometry [Qstar XL]|FACS 2010 Differential centrifugation|Sucrose density gradient Exosomes 90 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D2 Rep 1 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 91 21252909 Homo sapiens Diacylglycerol kinase a regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes T cells cl J-HM1-2.2 Protein|Lipids Western blotting|FACS|Immunofluorescence 2011 Differential centrifugation|Ultracentrifugation Exosomes 92 20124479 Rattus norvegicus Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Pancreatic adenocarcinoma cells cl AS Protein|mRNA RT-PCR|Western blotting|RatRef-12 Microarray|FACS|Mass spectrometry [MALDI TOF] 2010 Differential centrifugation|Sucrose density gradient Exosomes 93 20124479 Rattus norvegicus Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Pancreatic adenocarcinoma cells cl AS-Tspan8 Protein|mRNA RT-PCR|Western blotting 2010 Differential centrifugation|Sucrose density gradient Exosomes 94 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D4 Rep 1 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 95 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D7 Rep 1 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 96 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D2 Rep 2 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 97 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D4 Rep 2 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 98 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D7 Rep 2 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 99 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D2 Rep 3 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 100 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D4 Rep 3 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 101 21828046 Rattus norvegicus The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Reticulocytes ts Reticulocytes - D7 Rep 3 Protein|Lipids Mass spectrometry [QSTAR]|Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 102 21082674 Homo sapiens Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Urine ts Urine - Normal Protein Mass spectrometry|Western blotting|Immunoelectron Microscopy 2010 Differential centrifugation|Ultracentrifugation Exosomes 103 21763319 Homo sapiens Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Pancreatic adenocarcinoma cells cl Panc1 Protein Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracentrifugation Exosomes 104 21763319 Homo sapiens Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Pancreatic adenocarcinoma cells cl BxPC3 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracentrifugation Exosomes 105 21763319 Homo sapiens Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Pancreatic adenocarcinoma cells cl Paca44 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracentrifugation Exosomes 106 21763319 Homo sapiens Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Pancreatic adenocarcinoma cells cl MiaPaca2 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracentrifugation Exosomes 107 21763319 Homo sapiens Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Pancreatic adenocarcinoma cells cl A818-4 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracentrifugation Exosomes 108 21601258 Homo sapiens Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. Malignant ascites ts Malignant ascites - ovarian cancer Protein|miRNA Western blotting|Immunoelctron microscopy 2011 Differential centrifugation|Sucrose density gradient|Immunobeads (EPCAM, CD24) Exosomes 109 21601258 Homo sapiens Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. Pleural effusions ts Pleural effusions - breast cancer Protein|miRNA Western blotting 2011 Differential centrifugation|Sucrose density gradient|Immunobeads (EPCAM) Exosomes 110 21601258 Homo sapiens Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. Ascites ts Ascites - liver cirrhosis Protein|miRNA Western blotting|Immunoelctron microscopy 2011 Differential centrifugation|Sucrose density gradient Exosomes 111 21601258 Homo sapiens Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. Serum ts Serum - breast cancer Protein|miRNA Western blotting 2011 Differential centrifugation|Sucrose density gradient|Immunobeads (CD24) Exosomes 112 21601258 Homo sapiens Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. Serum ts Serum - Normal Protein|miRNA Western blotting 2011 Differential centrifugation|Sucrose density gradient Exosomes 113 21557262 Homo sapiens Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. Urine ts Urine - Normal Protein Mass spectrometry|Western blotting 2011 Differential centrifugation|Ultracentrifugation Exosomes 114 21557262 Homo sapiens Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. Urine ts Urine - Lung cancer Protein Mass spectrometry|Western blotting 2011 Differential centrifugation|Ultracentrifugation Exosomes 115 21505438 Homo sapiens Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. T cells cl J77 Protein|miRNA Mass spectrometry|Microarray 2011 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 116 21505438 Homo sapiens Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. B cells cl Raji Protein|miRNA Mass spectrometry|Microarray 2011 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 117 21505438 Homo sapiens Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Dendritic cells ts Dendritic cells Protein|miRNA Mass spectrometry|Microarray 2011 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 118 21362503 Homo sapiens Protein profile of exosomes from trabecular meshwork cells. Tabecular meshwork cells ts Tabecular meshwork cells Protein Mass spectrometry [LTQ]|Western blotting 2011 Differential centrifugation|Sucrose density gradient Exosomes 119 21362503 Homo sapiens Protein profile of exosomes from trabecular meshwork cells. Urine ts Urine - Normal Protein Mass spectrometry [LTQ]|Western blotting 2011 Differential centrifugation|Sucrose density gradient Exosomes 120 21362503 Homo sapiens Protein profile of exosomes from trabecular meshwork cells. Aqueous humor ts Aqueous humor - Normal Protein Western blotting 2011 Differential centrifugation|Sucrose density gradient Exosomes 121 21276792 Homo sapiens Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells. Trophoblast cells cl Sw71 Protein Mass spectrometry [Orbitrap]|Western blotting 2011 Differential centrifugation|Ultrafiltration|Ultracentrifugation|Sucrose density gradient Exosomes 122 21235781 Homo sapiens Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. Saliva ts Saliva - Normal Protein FACS|Immunoelectron Microscopy|Western blotting 2011 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 123 21235781 Homo sapiens Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. Plasma ts Plasma - Normal Protein FACS|Immunoelectron Microscopy|Western blotting 2011 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 124 21235781 Homo sapiens Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. Breast milk ts Breast milk - Normal Protein FACS|Immunoelectron Microscopy|Western blotting 2011 Differential centrifugation|Filtration|Ultracentrifugation Exosomes 125 21059916 Homo sapiens Human tumor virus utilizes exosomes for intercellular communication. Nasopharyngeal carcinoma cells cl C666 Protein Western blotting 2010 Differential centrifugation Exosomes 126 0 Homo sapiens Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy? Mesenchymal stem cells cl huES9.E1 Protein Western blotting|Antobody array|Mass spectrometry 2011 HPLC Exosomes 127 21828046 Rattus norvegicus Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation Reticulocytes ts Reticulocytes Protein|Lipids Gas-liquid chromatography|High performance thin layer chromatography 2011 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Exosomes 128 14965343 Homo sapiens Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization Dendritic cells ts Bone marrow - Dendritic cells Lipids HPLC|Gas chromatography 2004 Differential centrifugation|Ultracentrifugation Exosomes 129 14965343 Rattus norvegicus Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization Tumoral mast cells cl RBL-2H3 Lipids HPLC|Gas chromatography 2004 Differential centrifugation|Ultracentrifugation Exosomes 130 18309083 Mus musculus Ceramide triggers budding of exosome vesicles into multivesicular endosomes Oligodendrocytes cl Oli-neu cells Protein|Lipids Western blotting|Mass spectrometry [QTOF] 2008 Differential centrifugation|Sucrose density gradient Exosomes 131 19188015 Homo sapiens Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes Malignant ascites ts Malignant ascites - Ovarian cancer Protein|Lipids Cytofluorographic analysis|Annexin-V-FITC|Western blotting|FACS 2009 Differential centrifugation|Sucrose density gradient Exosomes 132 19188015 Homo sapiens Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes Ovarian cancer cells cl OVMz Protein|Lipids Cytofluorographic analysis|Annexin-V-FITC|FACS 2009 Differential centrifugation|Sucrose density gradient Exosomes 133 19188015 Homo sapiens Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes Ovarian cancer cells cl SKOV3ip Protein|Lipids Cytofluorographic analysis|Annexin-V-FITC|FACS 2009 Differential centrifugation|Sucrose density gradient Exosomes 134 15304316 Rattus norvegicus PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes Basophilic leukemia cells cl RBL-2H3 Protein|Lipids Western blotting|FACS 2004 Differential centrifugation Exosomes 135 2777884 Cavia porcellus Asymmetric Distribution of Phospholipids in the Membrane of Vesicles Released During In Vitro Maturation of Guinea Pig Reticulocytes: Evidence Precluding a Role for "Aminophospholipid Translocase Reticulocytes ts Reticulocytes - Normal Proteins|Lipids Immunoelectron microscopy|Thin layer chromatography|Western blotting 1989 Differential centrifugation|Ultracentrifugation Exosomes 136 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl PC3 - Rep 2 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 137 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl PC3 - Rep 3 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 138 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl DU145 - Rep 2 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 139 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl DU145 - Rep 3 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 140 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl VCaP - Rep 2 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 141 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl VCaP - Rep 3 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 142 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl LNCaP - Rep 2 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 143 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl LNCaP - Rep 3 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 144 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl C4-2 - Rep 2 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 145 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl C4-2 - Rep 3 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 146 0 Homo sapiens Prostate cancer cell derived exosomes Prostate cancer cells cl RWPE - Rep 2 Protein Mass spectrometry [QTOF] 2012 Sucrose density gradient Exosomes 151 22075275 Homo sapiens Methodology for isolation, identification and characterization of microvesicles in peripheral blood Plasma ts Plasma - Normal Protein FACS 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 152 22064971 Homo sapiens Oxidized low-density lipoprotein-dependent platelet-derived microvesicles trigger procoagulant effects and amplify oxidative stress Platelets ts Platelets Protein FACS|ELISA 2011 Differential centrifugation Microvesicles 153 22022598 Homo sapiens Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity Placenta ts Placenta Protein FACS 2011 Differential centrifugation Microvesicles 154 21966536 Mus musculus Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide Plasma ts Plasma - Normal Protein FACS 2011 Differential centrifugation|Filtration Microvesicles 155 21939504 Homo sapiens Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells Macrophages ts Macrophages - Unactivated miRNA RT-PCR 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 156 21939504 Homo sapiens Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells Macrophages ts Macrophages - IL-4 activated miRNA RT-PCR 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 157 21630462 Homo sapiens Proteomic analysis of microvesicles derived from human colorectal cancer ascites Malignant ascites ts Malignant ascites - Colorectal cancer patient 1 Protein Mass spectrometry [LTQ] 2011 Differential centrifugation|Sucrose density gradient|OptiPrep density gradient Microvesicles 158 21630462 Homo sapiens Proteomic analysis of microvesicles derived from human colorectal cancer ascites Malignant ascites ts Malignant ascites - Colorectal cancer patient 2 Protein Mass spectrometry [LTQ] 2011 Differential centrifugation|Sucrose density gradient|OptiPrep density gradient Microvesicles 159 21630462 Homo sapiens Proteomic analysis of microvesicles derived from human colorectal cancer ascites Malignant ascites ts Malignant ascites - Colorectal cancer patient 3 Protein Mass spectrometry [LTQ] 2011 Differential centrifugation|Sucrose density gradient|OptiPrep density gradient Microvesicles 160 21630462 Homo sapiens Proteomic analysis of microvesicles derived from human colorectal cancer ascites Malignant ascites ts Malignant ascites - Colorectal cancer Protein Western blotting 2011 Differential centrifugation|Sucrose density gradient|OptiPrep density gradient Microvesicles 161 21901833 Drosophila melanogaster Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells Hematocytes cl Kc167 Protein|PTM Ubiquitination Western blotting|Mass spectrometry [HCT ETD II iontrap] 2011 Differential centrifugation|Sucrose density gradient|Ultracenrifugation Microvesicles 162 21901833 Drosophila melanogaster Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells Hematocytes cl S2 Protein|PTM Ubiquitination Western blotting|Mass spectrometry [HCT ETD II iontrap] 2011 Differential centrifugation|Sucrose density gradient|Ultracenrifugation Microvesicles 163 21901833 Drosophila melanogaster Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells Hematocytes cl S2-tub-wg Protein Western blotting|Immunoelectron Microscopy 2011 Differential centrifugation|Sucrose density gradient|Ultracenrifugation Microvesicles 164 21864488 Homo sapiens Marrow cell genetic phenotype change induced by human lung cancer cells Lung cancer cells ts Lung cancer cells - patient 1 mRNA RT-PCR 2011 Differential centrifugation|Ultracenrifugation Microvesicles 165 21864488 Homo sapiens Marrow cell genetic phenotype change induced by human lung cancer cells Lung cancer cells ts Lung cancer cells - patient 2 mRNA RT-PCR 2011 Differential centrifugation|Ultracenrifugation Microvesicles 166 21864488 Homo sapiens Marrow cell genetic phenotype change induced by human lung cancer cells Lung cancer cells ts Lung cancer cells - patient 3 mRNA RT-PCR 2011 Differential centrifugation|Ultracenrifugation Microvesicles 167 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles T cells cl Jurkat Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 168 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles T cells cl SupT1 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 169 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles T cells cl H9 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 170 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles Colorectal cancer cells cl HCT-15 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 171 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles Colorectal cancer cells cl HT-29 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 172 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles Skin cancer cells cl SkMel-5 Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 173 21859146 Homo sapiens Identification of a conserved glycan signature for microvesicles Breast milk ts Breast milk - normal Protein Western blotting 2011 Differential centrifugation|Filtration|Ultracenrifugation Microvesicles 174 21842121 Mus musculus Oligodendroglioma cells shed microvesicles which contain TRAIL as well as molecular chaperones and induce cell death in astrocytes Oligodendrocytes cl G26/24 Protein Western blotting 2011 Differential centrifugation Microvesicles 175 19002258 Homo sapiens Detection of microRNA Expression in Human Peripheral Blood Microvesicles Plasma ts Plasma - Normal miRNA RT-PCR 2008 Differential centrifugation Microvesicles 176 21788507 Homo sapiens Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells Glioblastoma cells cl U87-MG Protein Immunoelectron Microscopy|Western blotting 2011 Differential centrifugation Microvesicles 177 19567368 Homo sapiens Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells Retinal epithelial cells cl ARPE-19 Protein Western blotting|Mass spectrometry [LTQ-FT Ultra] 2009 Differential centrifugation Membrane blebs 178 20686450 Homo sapiens Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome Urine ts Urine - NM UF Protein Western blotting|Mass spectrometry [MALDI TOF] 2010 Differential centrifugation|Ultrafiltration Microvesicles 179 20686450 Homo sapiens Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome Urine ts Urine - UC Protein Western blotting|Mass spectrometry [MALDI TOF] 2010 Differential centrifugation|Ultracenrifugation Microvesicles 180 20686450 Homo sapiens Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome Urine ts Urine - SEC Protein Western blotting|Mass spectrometry [MALDI TOF] 2010 Differential centrifugation|Ultracenrifugation|Size exclusion chromatography|Filtration Microvesicles 181 20668554 Homo sapiens Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs Mesenchymal stem cells ts Mesenchymal stem cells - Normal Protein|miRNA Western blotting|RT-PCR|Immunogold|Immunoelectron Microscopy 2010 Differential centrifugation|Ultracenrifugation Microvesicles 182 20668554 Homo sapiens Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs Liver stem cells ts Liver stem cells - Normal miRNA Western blotting|RT-PCR|Immunogold|Immunoelectron Microscopy 2010 Differential centrifugation|Ultracenrifugation Microvesicles 183 21741384 Homo sapiens A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma Plasma ts Plasma - Normal Protein FACS|ELISA 2011 Differential centrifugation|Filtration Microvesicles 184 21672581 Rattus norvegicus Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier Astrocytes ts Astrocytes - Normal Protein Immunoelectron Microscopy 2011 Differential centrifugation Microvesicles 185 22116803 Equus caballus Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle Follicular fluid ts Follicular fluid - Ovarian - Young mare Protein|miRNA Western blotting|RT-PCR|Mass spectrometry [LTQ] 2011 Differential centrifugation|Exoquick Exosomes 186 22116803 Equus caballus Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle Follicular fluid ts Follicular fluid - Ovarian Protein|miRNA RT-PCR|FACS 2011 Differential centrifugation|Ultracentrifugation Microvesicles 187 22116803 Equus caballus Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle Serum ts Serum - Normal Protein FACS 2011 Differential centrifugation|Exoquick Exosomes 189 21741384 Homo sapiens A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma Plasma ts Plasma - Normal Protein FACS|ELISA 2011 Differential centrifugation|Filtration Exosomes 190 22116803 Equus caballus Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle Follicular fluid ts Follicular fluid - Ovarian - Old mare miRNA RT-PCR 2011 Differential centrifugation|Exoquick Exosomes 191 21635979 Mus musculus Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice Thymocytes ts Thymocytes - Normal Protein Western blotting|FACS|Mass spectrometry [Q-TOF] 2011 Differential centrifugation|Filtration Microvesicles 192 21635979 Mus musculus Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice Thymocytes ts Thymocytes - Normal Protein Western blotting|FACS|Mass spectrometry [Q-TOF] 2011 Differential centrifugation|Filtration Apoptotic bodies 193 21575145 Homo sapiens Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants Placenta ts Placenta - Normal Protein Western blotting 2011 Differential centrifugation|Ultracenrifugation Microvesicles 195 21668449 Mus musculus SV31 is a Zn2+-binding synaptic vesicle protein PC12 cells ts PC12 cells Protein Western blotting 2011 Differential centrifugation|Sucrose density gradient Large dense core vesicle 196 21668449 Mus musculus SV31 is a Zn2+-binding synaptic vesicle protein PC12 cells ts PC12 cells - Transfected Protein Western blotting 2011 Differential centrifugation|Sucrose density gradient Large dense core vesicle 197 21616097 Homo sapiens Release of podocalyxin into the extracellular space. Role of metalloproteinases Testicular cancer cells cl Tera-1 Protein Western blotting 2011 Differential centrifugation Microvesicles 198 21555566 Homo sapiens Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer Plasma ts Plasma - Prostate cancer Protein Proximity ligation assay 2011 Differential centrifugation|Ultracenrifugation|Gel chromatography Microvesicles 199 21609964 Homo sapiens Characterization of extracellular circulating microRNA Plasma ts Plasma - Normal Protein Western blotting 2011 Differential centrifugation|Filtration Exosomes 200 21606166 Homo sapiens Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1 Serum ts Serum - Normal Protein Western blotting|FACS 2011 Exclusion chromatography|Ultracenrifugation Microvesicles 201 21606166 Homo sapiens Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta2 Serum ts Serum - Acute myeloid leukemia Protein Western blotting|FACS 2011 Exclusion chromatography|Ultracenrifugation Microvesicles 202 21601655 Homo sapiens Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis Placenta ts Placenta - Normal Protein FACS|Immunoelectron microscopy 2011 Differential centrifugation|Ultracenrifugation Microvesicles 203 19011622 Homo sapiens Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Glioblastoma cells ts Glioblastoma cells Protein|miRNA|mRNA RT-PCR|Antibody array|Microarray 2008 Differential centrifugation|Ultracenrifugation|Filtration Microvesicles 204 19011622 Homo sapiens Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Serum ts Serum - Normal mRNA|miRNA RT-PCR 2008 Differential centrifugation|Ultracenrifugation|Filtration Microvesicles 205 19011622 Homo sapiens Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Serum ts Serum - Glioblastoma mRNA|miRNA RT-PCR 2008 Differential centrifugation|Ultracenrifugation|Filtration Microvesicles 206 21435393 Rattus norvegicus Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis Adipocytes ts Adipocytes - Large mRNA|miRNA RT-PCR 2011 Differential centrifugation|Immunobeads (Gce1/CD73) Microvesicles 207 21435393 Rattus norvegicus Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis Adipocytes ts Stromal vascular cells - Differentiated adipocytes mRNA|miRNA RT-PCR 2011 Differential centrifugation|Sucrose density gradient|Size-exclusion chromatography Microvesicles 208 21435393 Rattus norvegicus Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis Serum ts Serum - Normal mRNA|miRNA RT-PCR 2011 Differential centrifugation|Sucrose density gradient|Immunobeads (Gce1/CD73) Microvesicles 209 21435393 Rattus norvegicus Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis Adipocytes ts Adipocytes - Small mRNA|miRNA RT-PCR 2011 Differential centrifugation|Immunobeads (Gce1/CD73) Microvesicles 210 21368175 Homo sapiens Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells Breast cancer cells cl MDAMB231 Protein Western blotting|Immunofluorescent microscopy|Scanning electron microscopy|Mass spectrometry [4000 Q Trap] 2011 Differential centrifugation|Filtration Microvesicles 211 21368175 Homo sapiens Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells Glioma cells cl U87 Protein Western blotting|Mass spectrometry [4000 Q Trap] 2011 Differential centrifugation|Filtration Microvesicles 212 21372807 Rattus norvegicus Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes Adipocytes ts Adipocytes - Large Protein Western blotting 2011 Differential centrifugation Microvesicles 213 21372807 Rattus norvegicus Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes Adipocytes ts Adipocytes - Small Protein Western blotting 2011 Differential centrifugation Microvesicles 214 21364924 Homo sapiens Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells T cells cl Jurkat Protein Western blotting|Immunoelectron microscopy|FACS 2011 Differential centrifugation|Ultracenrifugation|Filtration|Sucrose density gradient|FACS Exosomes 215 21364924 Homo sapiens Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells B cells cl Raji Protein Western blotting|Immunoelectron microscopy|FACS 2011 Differential centrifugation|Ultracenrifugation|Filtration|Sucrose density gradient|FACS Exosomes 216 21293856 Homo sapiens Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC Breast cancer cells cl BT474 Protein Western blotting|Immunoelectron microscopy|FACS|Dot blot 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracenrifugation|Sucrose density gradient Exosomes 217 21293856 Homo sapiens Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC Serum ts Serum - Breast cancer Protein ELISA|Dot blot 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracenrifugation|Sucrose density gradient Exosomes 218 10694520 Homo sapiens Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes Plasma ts Plasma - Stable angina Protein Immunoaffinity 2000 Immunoaffinity [Annexin V] Microparticles 219 10694520 Homo sapiens Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes Plasma ts Plasma - Acute coronary syndromes Protein Immunoaffinity 2000 Immunoaffinity [Annexin V] Microparticles 220 10694520 Homo sapiens Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes Plasma ts Plasma - Noncoronary heart disease Protein Immunoaffinity 2000 Immunoaffinity [Annexin V] Microparticles 221 9918520 Homo sapiens Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity Atherosclerotic plaques ts Atherosclerotic plaques Protein|Lipids Immunohistochemistry|Immunoaffinity 1999 Differential centrifugation|Immunoaffinity [Annexin V] Apoptotic bodies 222 12514112 Homo sapiens Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets Plasma ts Plasma - Normal Protein Immunoelectron microscopy|FACS|Western blotting 2003 Differential centrifugation|FACS Microvesicles 223 10393703 Homo sapiens In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant Endothelial cells cl HUVECS Protein FACS|Confocal microscopy|Western blotting 1999 Differential centrifugation|Ultracentrifugation Microparticles 224 10393703 Homo sapiens In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant Plasma ts Plasma - Normal Protein Confocal microscopy|FACS 1999 Differential centrifugation Microparticles 225 10393703 Homo sapiens In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant Plasma ts Plasma - Lupus anticoagulant Protein FACS 1999 Differential centrifugation Microparticles 226 12514112 Homo sapiens Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets Platelets ts Platelets Protein Western blotting 2003 Differential centrifugation Microvesicles 227 2942561 Homo sapiens Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery Plasma ts Plasma - Normal Protein Antibody based methods 1986 Differential centrifugation Microparticles 228 2942561 Homo sapiens Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery Serum ts Serum - Normal Protein Antibody based methods 1986 Differential centrifugation Microparticles 229 2942561 Homo sapiens Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery Plasma ts Plasma - Adult respiratory distress syndrome Protein Antibody based methods 1986 Differential centrifugation Microparticles 230 2294986 Homo sapiens Direct detection of activated platelets and platelet-derived microparticles in humans Plasma ts Plasma - Cardiopulmonary bypass Protein FACS 1990 FACS Microparticles 231 2294986 Homo sapiens Direct detection of activated platelets and platelet-derived microparticles in humans Plasma ts Plasma - Standardized bleeding time Protein FACS 1990 FACS Microparticles 232 7697722 Homo sapiens Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells Erythrocyte ts Erythrocyte Lipids Thin layer chromatography|Cytofluorographic analysis 1995 Differential centrifugation Microvesicles 233 7697722 Homo sapiens Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells Inflammatory fluids ts Inflammatory fluids - Arthritis Lipids Thin layer chromatography|Cytofluorographic analysis 1995 Differential centrifugation Microvesicles 234 10648405 Homo sapiens Cellular origin and procoagulant properties of microparticles in meningococcal sepsis Plasma ts Plasma - Meningococcal sepsis - Survived Protein FACS 2000 Differential centrifugation|FACS Microparticles 235 10648405 Homo sapiens Cellular origin and procoagulant properties of microparticles in meningococcal sepsis Plasma ts Plasma - Normal Protein FACS 2000 Differential centrifugation|FACS Microparticles 236 10648405 Homo sapiens Cellular origin and procoagulant properties of microparticles in meningococcal sepsis Plasma ts Plasma - Meningococcal sepsis - Nonsurvived Protein FACS 2000 Differential centrifugation|FACS Microparticles 237 21293856 Homo sapiens Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC Melanoma cells cl Mel624.38 Protein Dot blot 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracenrifugation|Sucrose density gradient Exosomes 238 21293856 Homo sapiens Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC Malignant ascites ts Malignant ascites - Ovarian cancer Protein Dot blot 2011 Differential centrifugation|Filtration|Ultrafiltration|Ultracenrifugation|Sucrose density gradient Exosomes 240 10233897 Homo sapiens Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia Platelets ts Platelets - Paroxysmal nocturnal hemoglobinuria patients Protein|Lipids FACS 1999 Differential centrifugation|FACS Microparticles 241 16192427 Homo sapiens Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure Plasma ts Plasma - End-stage renal failure patients Protein FACS 2005 Differential centrifugation|FACS Microparticles 242 9151784 Homo sapiens Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles Platelets ts Platelets Lipids Mass spectrometry|HPLC 1997 Differential centrifugation Microparticles 243 22149170 Homo sapiens The Protein Interaction Network of Extracellular Vesicles Derived from Human Colorectal Cancer Cells Colorectal cancer cells cl HT29 Protein Mass spectrometry [LTQ]|Microarray|Western blotting|Confocal microscopy 2011 Differential centrifugation|Ultrafiltration|Ultracenrifugation|Sucrose density gradient 244 22148876 Homo sapiens Proteomic analysis of microvesicles derived from human mesenchymal stem cells Mesenchymal stem cells ts Mesenchymal stem cells - Rep 1 Protein Western blotting|Mass spectrometry[Q-TOF] 2011 Differential centrifugation|Ultrafiltration|Ultracenrifugation|Sucrose density gradient|Optiprep density gradient Microvesicles 245 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations T lymphoma cl H9 - non infected Protein|mRNA Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 246 18425114 Homo sapiens Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Glioblastoma cells cl U373vIII Protein Western blotting 2008 Differential centrifugation|Ultracentrifugation Microvesicles 247 15741221 Homo sapiens Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation Plasma ts Plasma - Normal Protein Western blotting 2005 Differential centrifugation|Immunobeads (TF) Microvesicles 248 15741221 Homo sapiens Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation Monocytic leukemia cells cl THP-1 Protein Western blotting 2005 Differential centrifugation Microvesicles 249 15741221 Homo sapiens Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation Monocytes ts Monocytes Protein Western blotting 2005 Differential centrifugation Microvesicles 250 9396452 Homo sapiens Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant Plasma ts Plasma - Systemic blood - Cardiopulmonary bypass patients Protein|Lipids FACS|Annexin V-FITC 1997 Differential centrifugation Microparticles 251 9396452 Homo sapiens Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant Plasma ts Plasma - Pericardial blood - Cardiopulmonary bypass patients Protein|Lipids FACS|Annexin V-FITC 1997 Differential centrifugation Microparticles 252 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations T lymphoma cl H9 - HIV infected Protein Radioimmunoassay|Northern blotting 1997 Differential centrifugation|Sucrose density gradient Microvesicles 253 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations T4-lymphoblastoid cells cl CEM-SS - HIV non infected Protein Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 254 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations T4-lymphoblastoid cells cl CEM-SS - HIV infected Protein Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 255 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations Burkitt's lymphoma cl DAUDI - HIV non infected Protein Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 256 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations Burkitt's lymphoma cl DAUDI - HIV infected Protein Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 257 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations Acute T lymphoblastic leukemia cl MOLT-3 - HIV non infected Protein Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 258 9126269 Homo sapiens Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations Acute T lymphoblastic leukemia cl MOLT-3 - HIV infected Protein Radioimmunoassay 1997 Differential centrifugation|Sucrose density gradient Microvesicles 259 18425114 Homo sapiens Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Glioma cells cl U373 Protein Western blotting 2008 Differential centrifugation|Ultracentrifugation Microvesicles 260 10888925 Homo sapiens Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection Mononuclear cells ts Mononuclear cells Protein Western blotting 2000 Differential centrifugation|Filtration Microparticles 261 12805058 Homo sapiens Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes Plasma ts Plasma - Sickle cell patients - Crisis Protein|Lipids FACS|Annexin V-FITC 2003 Differential centrifugation|Ultracentrifugation|FACS Microparticles 262 12805058 Homo sapiens Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes Plasma ts Plasma - Sickle cell patients - Steady state Protein|Lipids FACS|Annexin V-FITC 2003 Differential centrifugation|Ultracentrifugation|FACS Microparticles 263 12805058 Homo sapiens Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes Plasma ts Plasma - Normal Protein FACS 2003 Differential centrifugation|Ultracentrifugation|FACS Microparticles 264 18425114 Homo sapiens Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Epidermoid carcinoma cells cl A431 Protein Western blotting 2008 Differential centrifugation|Ultracentrifugation Microvesicles 265 18425114 Homo sapiens Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Endothelial cells cl HUVECs Protein Western blotting 2008 Differential centrifugation|Ultracentrifugation Microvesicles 266 18425114 Mus musculus Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Plasma ts Plasma - Tumour Protein Western blotting 2008 Differential centrifugation|Ultracentrifugation Microvesicles 267 12757771 Homo sapiens Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis Brain microvascular endothelial cells cl Brain microvascular endothelial cells - ACBRI 376 - Control|TNF alpha|GFD Protein FACS 2003 Differential centrifugation|FACS Microparticles 268 12757771 Homo sapiens Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis Glomerular microvascular endothelial cells cl Glomerular microvascular endothelial cells - ACBRI 128 - Control|TNF alpha|GFD Protein FACS 2003 Differential centrifugation|FACS Microparticles 269 12757771 Homo sapiens Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis Coronary artery endothelial cells cl Coronary artery endothelial cells - ACBRI 377 - Control|TNF alpha|GFD Protein FACS 2003 Differential centrifugation|FACS Microparticles 270 10903724 Homo sapiens Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface Dendritic cells ts Follicular dendritic cells Protein Immunoelectron microscopy 2000 - Microvesicles 271 10903724 Homo sapiens Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface B cells cl RN Protein Immunoelectron microscopy 2000 Differential centrifugation Exosomes 272 8896411 Homo sapiens High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles Platelets ts Platelets Protein|Lipids FACS|Annexin V-FITC 1996 Differential centrifugation|FACS Microparticles 273 12021310 Homo sapiens Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles T cells cl Jurkat Protein Western blotting 2002 Differential centrifugation|Ultracentrifugation Microvesicles 274 12021310 Homo sapiens Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles Melanoma cells cl Me15392 Protein Imunoelectron microscopy|Western blotting|FACS 2002 Differential centrifugation|Ultracentrifugation Microvesicles 275 12021310 Homo sapiens Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles Melanoma cells cl 501mel Protein Imunoelectron microscopy|Western blotting|FACS 2002 Differential centrifugation|Ultracentrifugation Microvesicles 276 12021310 Homo sapiens Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles Melanoma cells cl Me30966 Protein Imunoelectron microscopy|Western blotting|FACS 2002 Differential centrifugation|Ultracentrifugation Microvesicles 277 22030351 Homo sapiens Expression of PTRF in PC-3 cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways Prostate cancer cells cl PC-3 Protein Mass spectrometry [Q-TOF] 2011 Differential centrifugation Exosomes 278 10233897 Homo sapiens Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia Platelets ts Platelets - Normal Protein|Lipids FACS 1999 Differential centrifugation|FACS Microparticles 279 16192427 Homo sapiens Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure Plasma ts Plasma - Normal Protein FACS 2005 Differential centrifugation|FACS Microparticles 280 15499615 Homo sapiens Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Lung cancer cells cl A549 Protein|mRNA RT-PCR|FACS 2005 Differential centrifugation|FACS Microvesicles 281 15499615 Homo sapiens Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Lung cancer cells cl A549 mRNA RT-PCR 2005 Differential centrifugation|Ultracentrifugation Exosomes 282 19234131 Homo sapiens Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR Lung cancer cells cl A549 Protein Western blotting 2009 Differential centrifugation Microvesicles 283 19234131 Homo sapiens Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR Colorectal cancer cells cl DLD-1 Protein Western blotting 2009 Differential centrifugation Microvesicles 284 12796750 Homo sapiens High levels of circulating endothelial microparticles in patients with acute coronary syndromes Plasma ts Plasma - Stable angina Protein FACS 2003 Differential centrifugation|FACS Microparticles 285 12796750 Homo sapiens High levels of circulating endothelial microparticles in patients with acute coronary syndromes Plasma ts Plasma - Unstable angina Protein FACS 2003 Differential centrifugation|FACS Microparticles 286 12417540 Homo sapiens Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus Plasma ts Plasma - Type 2 diabetes Protein FACS 2002 Differential centrifugation|FACS Microparticles 287 12417540 Homo sapiens Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus Plasma ts Plasma - Normal Protein FACS 2002 Differential centrifugation|FACS Microparticles 288 12196479 Homo sapiens Type 1 and type 2 diabetic patients display different patterns of cellular microparticles Plasma ts Plasma - Healthy donors Protein|Lipids FACS|Annexin V-FITC 2002 Differential centrifugation|FACS Microparticles 289 12196479 Homo sapiens Type 1 and type 2 diabetic patients display different patterns of cellular microparticles Plasma ts Plasma - Type 1 diabetes Protein|Lipids FACS|Annexin V-FITC 2002 Differential centrifugation|FACS Microparticles 290 12196479 Homo sapiens Type 1 and type 2 diabetic patients display different patterns of cellular microparticles Plasma ts Plasma - Type 2 diabetes Protein|Lipids FACS|Annexin V-FITC 2002 Differential centrifugation|FACS Microparticles 291 15072974 Rattus norvegicus Endothelium-derived microparticles impair endothelial function in vitro Endothelial cells cl RMVECs Protein Western blotting 2004 Differential centrifugation|Ultracentrifugation|FACS Microparticles 292 10415024 Homo sapiens Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles T cells cl Jurkat - PHA stimulated Protein Western blotting|FACS 1999 Differential centrifugation|Ultracentrifugation|FACS Microvesicles 293 10415024 Homo sapiens Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles T cells ts T cell blasts Protein Western blotting|FACS 1999 Differential centrifugation|Ultracentrifugation|FACS Microvesicles 294 2071604 Homo sapiens Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets Platelets ts Platelets Protein Western blotting 1991 Differential centrifugation|Filtration Microvesicles 295 10233897 Homo sapiens Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia Platelets ts Platelets - Aplastic anemia patients Lipids FACS 1999 Differential centrifugation|FACS Microparticles 296 12796750 Homo sapiens High levels of circulating endothelial microparticles in patients with acute coronary syndromes Plasma ts Plasma - Normal Protein FACS 2003 Differential centrifugation|FACS Microparticles 297 12796750 Homo sapiens High levels of circulating endothelial microparticles in patients with acute coronary syndromes Plasma ts Plasma - Acute coronary syndrome Protein FACS 2003 Differential centrifugation|FACS Microparticles 298 12796750 Homo sapiens High levels of circulating endothelial microparticles in patients with acute coronary syndromes Plasma ts Plasma - Coronary artery disease Protein FACS 2003 Differential centrifugation|FACS Microparticles 299 12796750 Homo sapiens High levels of circulating endothelial microparticles in patients with acute coronary syndromes Plasma ts Plasma - Myocardial infarction Protein FACS 2003 Differential centrifugation|FACS Microparticles 300 19234131 Homo sapiens Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR Epidermoid carcinoma cells cl A431 Protein Western blotting 2009 Differential centrifugation Microvesicles 301 19234131 Homo sapiens Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR Endothelial cells cl HUVECs Protein Western blotting 2009 Differential centrifugation Microvesicles 302 1321158 Rattus norvegicus Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. Pancreatic cells cl Pancreatic cells Protein Immunoelectron microscopy 1992 Differential centrifugation Microvesicles 303 19930720 Homo sapiens Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells Colorectal cancer cells cl SW480 Protein|mRNA Western blotting|RT-PCR|Microarray [Illumina] 2009 Differential centrifugation|Ultrafiltration|Optiprep density gradient Microvesicles 304 17478559 Mus musculus Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth 8-associated microvesicles Adipocytes cl 3T3-L1 Protein Immunoelectron Microscopy|Western blotting|Mass spectrometry [LCQ-DECA XP] 2007 Differential centrifugation|Ultracentrifugation|Sucrose density gradient Microvesicles 305 17478559 Rattus norvegicus Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth 8-associated microvesicles Adipocytes ts Adipocytes Protein Western blotting 2007 Differential centrifugation Microvesicles 306 16342139 Homo sapiens Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization T cells cl CEM T cell - PHA activation Protein Mass spectrometry [MALDI TOF/TOF]|Mass spectrometry [Q-TOF] 2006 Differential centrifugation Microparticles 307 16342139 Homo sapiens Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization T cells cl CEM T cell - ActD activation Protein Mass spectrometry [MALDI TOF/TOF]|Mass spectrometry [Q-TOF] 2006 Differential centrifugation Microparticles 308 16342139 Homo sapiens Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization B cells ts B cells - Chronic B cell lymphoid patient Protein Mass spectrometry [MALDI TOF/TOF]|Mass spectrometry [Q-TOF] 2006 Differential centrifugation Microparticles 309 17536014 Homo sapiens Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of Mrna Endothelial cells ts Endothelial cells - Healthy donors Protein|mRNA FACS|RT-PCR|Microarray [Illumina] 2007 Differential centrifugation|Ultracentrifugation|FACS Microvesicles 310 22148876 Homo sapiens Proteomic analysis of microvesicles derived from human mesenchymal stem cells Mesenchymal stem cells ts Mesenchymal stem cells - Rep 2 Protein Western blotting|Mass spectrometry[Q-TOF] 2011 Differential centrifugation|Ultrafiltration|Ultracenrifugation|Sucrose density gradient|Optiprep density gradient Microvesicles 311 22148876 Homo sapiens Proteomic analysis of microvesicles derived from human mesenchymal stem cells Mesenchymal stem cells ts Mesenchymal stem cells - Rep 3 Protein Western blotting|Mass spectrometry[Q-TOF] 2011 Differential centrifugation|Ultrafiltration|Ultracenrifugation|Sucrose density gradient|Optiprep density gradient Microvesicles 312 15499615 Homo sapiens Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Lung cancer cells cl CRL 2062 Protein FACS 2005 Differential centrifugation|FACS Microvesicles 313 15499615 Homo sapiens Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Lung cancer cells cl CRL 2066 Protein FACS 2005 Differential centrifugation|FACS Microvesicles 314 15499615 Homo sapiens Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Lung cancer cells cl HTB 177 Protein FACS 2005 Differential centrifugation|FACS Microvesicles 315 15499615 Homo sapiens Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Lung cancer cells cl HTB 183 Protein FACS 2005 Differential centrifugation|FACS Microvesicles 316 18472965 Homo sapiens Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles Ovarian cancer cells cl CABA I Protein Westen blotting|Zymography 2008 Differential centrifugation Microvesicles 317 19266099 Homo sapiens Transfer of microRNAs by embryonic stem cell microvesicles Embryonic stem cells ts Embryonic stem cells mRNA|miRNA|snRNA RT-PCR 2009 Differential centrifugation Microvesicles 318 19483673 Homo sapiens Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen Monocytes ts Monocytes Protein Western blotting 2009 Differential centrifugation|Filtration Microvesicles 319 20615901 Homo sapiens Export of microRNAs and microRNA-protective protein by mammalian cells Lung cancer cells cl HepG2 miRNA RT-PCR 2010 Differential centrifugation Microvesicles 320 20615901 Homo sapiens Export of microRNAs and microRNA-protective protein by mammalian cells Epithelial cells cl A549 miRNA RT-PCR 2010 Differential centrifugation Microvesicles 321 19951903 Homo sapiens MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome Plasma ts Plasma - Normal miRNA Microarray [ArrayExpress]|RT-PCR 2010 Differential centrifugation|Filtration Microvesicles 322 19951903 Homo sapiens MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome Plasma ts Plasma - Iritable bowel syndrome patients miRNA Microarray [ArrayExpress]|RT-PCR 2010 Differential centrifugation|Filtration Microvesicles 323 20304794 Homo sapiens Functional delivery of viral miRNAs via exosomes B cells ts B cells - Transformed with Epstein–Barr virus Protein Western blotting 2010 Differential centrifugation Exosomes 324 20079801 Mus musculus Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription Lung cells ts Lung cells Protein|miRNA FACS|RT-PCR 2010 Differential centrifugation|FACS Microvesicles 325 19289371 Homo sapiens Exosomal microRNA: a diagnostic marker for lung cancer Plasma ts Plasma - Lung adenocarcinoma patients miRNA Microarray 2009 Size exclusion chromatography|Immunobeads (EpCAM) Exosomes 326 20428099 Homo sapiens Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease Urine ts Urine - Normal mRNA RT-PCR 2010 Differential centrifugation|Ultracentrifugation Microvesicles 327 20428099 Homo sapiens Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease Urine ts Urine - Normal mRNA RT-PCR 2010 Differential centrifugation|Ultracentrifugation Exosomes 328 20428099 Rattus norvegicus Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease Urine ts Urine - Renal acidosis mRNA RT-PCR 2010 Differential centrifugation|Ultracentrifugation Microvesicles 329 20304794 Homo sapiens Functional delivery of viral miRNAs via exosomes B cells cl B95-8 miRNA RT-PCR 2010 Differential centrifugation Exosomes 330 20304794 Homo sapiens Functional delivery of viral miRNAs via exosomes B cells cl X50-7 miRNA RT-PCR 2010 Differential centrifugation Exosomes 331 19627513 Homo sapiens Exosomes from human saliva as a source of microRNA biomarkers Saliva ts Saliva - Normal Protein|miRNA Western blotting|RT-PCR 2010 Differential centrifugation|Ultracentrifugation Exosomes 332 19627513 Homo sapiens Exosomes from human saliva as a source of microRNA biomarkers Saliva ts Saliva - Sjogren’s syndrome patients miRNA Microarray [Exiqon] 2010 Differential centrifugation|Ultracentrifugation Exosomes 333 20976003 Homo sapiens Selective release of microRNA species from normal and malignant mammary epithelial cells Breast cancer cells cl MCF7 Protein|miRNA Slot blot|RT-PCR|Microarray 2010 Differential centrifugation|Filtration Exosomes 334 20976003 Homo sapiens Selective release of microRNA species from normal and malignant mammary epithelial cells Breast cancer cells cl MDA-MB-231 Protein|miRNA Slot blot|RT-PCR 2010 Differential centrifugation|Filtration Exosomes 335 20976003 Homo sapiens Selective release of microRNA species from normal and malignant mammary epithelial cells Breast cancer cells cl BT-20 Protein|miRNA Slot blot|RT-PCR 2010 Differential centrifugation|Filtration Exosomes 336 20976003 Homo sapiens Selective release of microRNA species from normal and malignant mammary epithelial cells Breast cancer cells cl MCF 10A Protein|miRNA Slot blot|RT-PCR 2010 Differential centrifugation|Filtration Exosomes 337 20976003 Homo sapiens Selective release of microRNA species from normal and malignant mammary epithelial cells Breast cancer cells cl SK-BR-3 miRNA RT-PCR 2010 Differential centrifugation|Filtration Exosomes 338 20621060 Rattus norvegicus Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation Adipocytes cl 3T3-L1 mRNA|miRNA RT-PCR 2010 Differential centrifugation|Ultracentrifugation Microvesicles 339 20621060 Rattus norvegicus Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation Serum ts Serum mRNA RT-PCR 2010 Differential centrifugation|Ultracentrifugation Microvesicles 340 20615901 Homo sapiens Export of microRNAs and microRNA-protective protein by mammalian cells Lung cancer cells cl HepG2 miRNA RT-PCR 2010 Differential centrifugation Exosomes 341 20615901 Homo sapiens Export of microRNAs and microRNA-protective protein by mammalian cells Epithelial cells cl A549 miRNA RT-PCR 2010 Differential centrifugation Exosomes