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 | Browse results for content type: protein |
| Vesiclepedia ID | PubMed ID | Species | Experiment description | Sample | Identifications | Isolation methods | Vesicle type | MISEV | |
| 1 | Vesiclepedia_1559 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2 | Vesiclepedia_1577 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 3 | Vesiclepedia_399 | 19530224 | Homo sapiens | Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes. | Keratinocytes | Protein | - | Exosomes | EVs |
| 4 | Vesiclepedia_2725 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 5 | Vesiclepedia_184 | 21672581 | Rattus norvegicus | Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier | Astrocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 6 | Vesiclepedia_3357 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Plasma | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 7 | Vesiclepedia_3103 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 8 | Vesiclepedia_693 | 28170197 | Homo sapiens | Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21 | Bone marrow mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 9 | Vesiclepedia_795 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 10 | Vesiclepedia_1010 | 23185418 | Homo sapiens | Improved flow cytometric assessment reveals distinct microvesicle (cell-derived microparticle) signatures in joint diseases. | Synovial fluid | Protein | Filtration Ultracentrifugation |
Microvesicles | EVs |
| 11 | Vesiclepedia_227 | 2942561 | Homo sapiens | Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery | Plasma | Protein | Differential centrifugation | Microparticles | EVs |
| 12 | Vesiclepedia_2759 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Tangential flow filtration | Exosomes | Small EVs |
| 13 | Vesiclepedia_2842 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 14 | Vesiclepedia_1882 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 15 | Vesiclepedia_2694 | 35210436 | Homo sapiens | M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway | Macrophage |
Protein mRNA |
Total Exosome Isolation Reagent | Exosomes | Small EVs |
| 16 | Vesiclepedia_1745 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 17 | Vesiclepedia_3320 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 18 | Vesiclepedia_1569 | 33738083 | Homo sapiens | Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 19 | Vesiclepedia_1057 | 30035390 | Mus musculus | Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. | Mouse embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 20 | Vesiclepedia_3377 | 36581870 | Mus musculus | Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Qiagen Exosome Purification Kit |
Extracellular vesicles | EVs |
| 21 | Vesiclepedia_1113 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 22 | Vesiclepedia_1421 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 23 | Vesiclepedia_3506 | 31110292 | Mus musculus | The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency | Liver cancer cells | Protein | Differential centrifugation | Microparticles | Large EVs |
| 24 | Vesiclepedia_3505 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 25 | Vesiclepedia_3063 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Serum | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 26 | Vesiclepedia_2389 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 27 | Vesiclepedia_996 | 24392111 | Mus musculus | Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk? | Murine myoblast | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 28 | Vesiclepedia_678 | 29951053 | Mus musculus | Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. | Myeloid-derived suppressor cells | Protein | Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 29 | Vesiclepedia_2901 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Pancreatic cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 30 | Vesiclepedia_139 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 31 | Vesiclepedia_1401 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 32 | Vesiclepedia_3392 | 31827089 | Lactobacillus crispatus | Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues | Lactobacillus crispatus |
Protein Metabolite |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 33 | Vesiclepedia_2382 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 34 | Vesiclepedia_2067 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 35 | Vesiclepedia_83 | 20949044 | Homo sapiens | Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line | Lung cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 36 | Vesiclepedia_1579 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | ProteinmRNA | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 37 | Vesiclepedia_2106 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 38 | Vesiclepedia_1845 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 39 | Vesiclepedia_1896 | 36260670 | Mus musculus | Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice | Mesenchymal stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 40 | Vesiclepedia_2407 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Myoblasts | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 41 | Vesiclepedia_163 | 21901833 | Drosophila melanogaster | Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells | Hematocytes | Protein | Differential centrifugation Sucrose density gradient Ultracentrifugation |
Microvesicles | EVs |
| 42 | Vesiclepedia_471 | 23035643 | Drosophila melanogaster | Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes. | Drosophila S2 cells | Protein | - | Exosomes | EVs |
| 43 | Vesiclepedia_1628 | 34012515 | Homo sapiens | CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells | Melanoma cells |
Protein Lipid |
Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 44 | Vesiclepedia_130 | 18309083 | Mus musculus | Ceramide triggers budding of exosome vesicles into multivesicular endosomes | Oligodendrocytes |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 45 | Vesiclepedia_2014 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 46 | Vesiclepedia_2504 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 47 | Vesiclepedia_684 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 48 | Vesiclepedia_978 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 49 | Vesiclepedia_2426 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 50 | Vesiclepedia_2240 | 36648227 | Mus musculus | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 51 | Vesiclepedia_720 | 26148937 | Homo sapiens | Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression. | Cholangiocytes | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 52 | Vesiclepedia_1237 | 25421927 | Heligmosomoides polygyrus | Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. | Heligmosomoides polygyrus |
miRNA Protein |
Filtration Ultracentrifugation |
Exosomes | EVs |
| 53 | Vesiclepedia_2822 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk |
Protein mRNA miRNA tRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 54 | Vesiclepedia_39 | 15210972 | Mus musculus | Cells release prions in association with exosomes. | Mov neuroglial cell | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 55 | Vesiclepedia_669 | 29953960 | Homo sapiens | Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. | Macrophage | Protein | Microfiltration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 56 | Vesiclepedia_1032 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
exoEasy columns | Extracellular vesicles | EVs |
| 57 | Vesiclepedia_823 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 58 | Vesiclepedia_1395 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva |
Protein Lipid |
Differential centrifugation Tangential flow filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 59 | Vesiclepedia_21 | 19837982 | Homo sapiens | Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215. | Colorectal cancer cells | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 60 | Vesiclepedia_2528 | 34315885 | Mus musculus | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Kidney epithelial cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 61 | Vesiclepedia_1715 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 62 | Vesiclepedia_2803 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 63 | Vesiclepedia_1736 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 64 | Vesiclepedia_3499 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 65 | Vesiclepedia_2131 | 36515353 | Homo sapiens | Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin | Plasma |
Metabolite Protein |
ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 66 | Vesiclepedia_3310 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 67 | Vesiclepedia_1943 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 68 | Vesiclepedia_287 | 12417540 | Homo sapiens | Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 69 | Vesiclepedia_1333 | 33368224 | Homo sapiens | Colorectal cancer prompted adipose tissue browning and cancer cachexia through transferring exosomal miR-146b-5p | Intestinal epithelial cells |
Protein mRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 70 | Vesiclepedia_211 | 21368175 | Homo sapiens | Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells | Glioma cells | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 71 | Vesiclepedia_536 | 23818640 | Homo sapiens | Modulation of B-cell exosome proteins by gamma herpesvirus infection. | B cells | Protein | - | Exosomes/Microvesicles/Oncosomes/Microparticles | EVs |
| 72 | Vesiclepedia_65 | 19415654 | Homo sapiens | Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7. | Breast cancer cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 73 | Vesiclepedia_266 | 18425114 | Mus musculus | Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 74 | Vesiclepedia_2081 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 75 | Vesiclepedia_2972 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 76 | Vesiclepedia_2952 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 77 | Vesiclepedia_2104 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 78 | Vesiclepedia_1272 | 24058411 | Homo sapiens | Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 79 | Vesiclepedia_713 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 80 | Vesiclepedia_1600 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 81 | Vesiclepedia_2867 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 82 | Vesiclepedia_1762 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 83 | Vesiclepedia_1437 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 84 | Vesiclepedia_1750 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 85 | Vesiclepedia_1396 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva |
Protein Lipid |
Differential centrifugation Tangential flow filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 86 | Vesiclepedia_933 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Bladder cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 87 | Vesiclepedia_717 | 26148937 | Homo sapiens | Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression. | Cholangiocytes | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 88 | Vesiclepedia_1212 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultracentrifugation | Extracellular vesicles | EVs |
| 89 | Vesiclepedia_1131 | 23954818 | Homo sapiens | Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state. | Squamous carcinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 90 | Vesiclepedia_489 | 23260141 | Mus musculus | Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration. | Fibroblasts | Protein | - | Exosomes | EVs |
| 91 | Vesiclepedia_1626 | 34012515 | Homo sapiens | CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells | Melanoma cells | Protein | Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 92 | Vesiclepedia_3298 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 93 | Vesiclepedia_3017 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 94 | Vesiclepedia_2431 | 29320704 | Homo sapiens | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Plasma | Protein | Centrifugation | Extracellular vesicles | EVs |
| 95 | Vesiclepedia_2400 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 96 | Vesiclepedia_524 | 23658846 | Mus musculus | Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. | Macrophage | Protein | - | Exosomes | EVs |
| 97 | Vesiclepedia_240 | 10233897 | Homo sapiens | Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia | Platelets |
Protein Lipids |
Differential centrifugation FACS |
Microparticles | EVs |
| 98 | Vesiclepedia_1546 | 33767144 | Homo sapiens | Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 99 | Vesiclepedia_2487 | 34388111 | Homo sapiens | miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis | Monocytic leukemia cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 100 | Vesiclepedia_2209 | 36013250 | Escherichia coli | Proteomic Profiling of Outer Membrane Vesicles Released by Escherichia coli LPS Mutants Defective in Heptose Biosynthesis | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 101 | Vesiclepedia_1911 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 102 | Vesiclepedia_2964 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 103 | Vesiclepedia_1310 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 104 | Vesiclepedia_2648 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 105 | Vesiclepedia_252 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | T cells | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 106 | Vesiclepedia_2894 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 107 | Vesiclepedia_790 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 108 | Vesiclepedia_1041 | 27770278 | Homo sapiens | Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Extracellular vesicles | EVs |
| 109 | Vesiclepedia_2800 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 110 | Vesiclepedia_1268 | 24218614 | Homo sapiens | Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 111 | Vesiclepedia_2488 | 34388111 | Homo sapiens | miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis | Monocytic leukemia cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 112 | Vesiclepedia_2117 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 113 | Vesiclepedia_2990 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 114 | Vesiclepedia_379 | 18346024 | Homo sapiens | The proteome of red cell membranes and vesicles during storage in blood bank conditions. | Red blood cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 115 | Vesiclepedia_3151 | 34887361 | Mus musculus | Endothelial cell-derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway | Endothelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 116 | Vesiclepedia_3064 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Serum | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 117 | Vesiclepedia_1 | 6307529 | Ovis aries | Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. | Reticulocytes | Protein | - | Exosomes | EVs |
| 118 | Vesiclepedia_1667 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 119 | Vesiclepedia_796 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 120 | Vesiclepedia_470 | 23029346 | Fasciola hepatica | Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells. | Fasciola hepatica | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 121 | Vesiclepedia_2136 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 122 | Vesiclepedia_2651 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 123 | Vesiclepedia_3129 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 124 | Vesiclepedia_1972 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 125 | Vesiclepedia_1927 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 126 | Vesiclepedia_1069 | 29937354 | Homo sapiens | Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 127 | Vesiclepedia_171 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 128 | Vesiclepedia_2007 | 35979935 | Homo sapiens | Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients | Serum |
Protein Lipid |
Differential centrifugation | Extracellular vesicles | EVs |
| 129 | Vesiclepedia_1792 | 36594832 | Mus musculus | Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia | Neuroblastoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 130 | Vesiclepedia_2018 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Centrifugation | Large extracellular vesicles | Large EVs |
| 131 | Vesiclepedia_2575 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 132 | Vesiclepedia_222 | 12514112 | Homo sapiens | Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets | Plasma | Protein | Differential centrifugation FACS |
Microvesicles | EVs |
| 133 | Vesiclepedia_3196 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 134 | Vesiclepedia_3289 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 135 | Vesiclepedia_1553 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 136 | Vesiclepedia_864 | 22046311 | Mus musculus | Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections | Plasma | Protein | Differential centrifugation Filtration Sucrose density gradient Ultracentrifugation |
Exosomes | EVs |
| 137 | Vesiclepedia_2548 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 138 | Vesiclepedia_891 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 139 | Vesiclepedia_1864 | 35931686 | Homo sapiens | Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression | Chondrocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 140 | Vesiclepedia_2764 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 141 | Vesiclepedia_2056 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 142 | Vesiclepedia_1939 | 36193887 | Homo sapiens | Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 143 | Vesiclepedia_3028 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 144 | Vesiclepedia_3015 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 145 | Vesiclepedia_1218 | 27872147 | Homo sapiens | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Islets | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 146 | Vesiclepedia_2687 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 147 | Vesiclepedia_3156 | 34789738 | Homo sapiens | P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells | Melanoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 148 | Vesiclepedia_3019 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 149 | Vesiclepedia_464 | 22909304 | Pseudomonas aeruginosa | Identification of proteins associated with the Pseudomonas aeruginosa biofilm extracellular matrix. | Pseudomonas aeruginosa | Protein | - | Membrane vesicles | EVs |
| 150 | Vesiclepedia_414 | 20559436 | Saccharomyces cerevisiae | Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis. | Saccharomyces cerevisiae | Protein | - | Extracellular vesicles | EVs |
| 151 | Vesiclepedia_2255 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 152 | Vesiclepedia_2767 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 153 | Vesiclepedia_2570 | 35260554 | Homo sapiens | Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis | Gastric cancer cells | Protein | Centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 154 | Vesiclepedia_3290 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 155 | Vesiclepedia_659 | 29982104 | Mus musculus | NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo. | Macrophage | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration |
Exosomes | EVs |
| 156 | Vesiclepedia_2817 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 157 | Vesiclepedia_1387 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 158 | Vesiclepedia_2888 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 159 | Vesiclepedia_1254 | 24468161 | Homo sapiens | Molecular characterization of exosome-like vesicles from breast cancer cells. | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 160 | Vesiclepedia_248 | 15741221 | Homo sapiens | Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation | Monocytic leukemia cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 161 | Vesiclepedia_72 | 19801663 | Homo sapiens | Microenvironmental pH is a key factor for exosome traffic in tumor cells. | Melanoma cells |
Protein Lipids |
Differential centrifugation | Exosomes | EVs |
| 162 | Vesiclepedia_1273 | 24058411 | Homo sapiens | Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 163 | Vesiclepedia_1779 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 164 | Vesiclepedia_2301 | 31489147 | Homo sapiens | Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles | Blood | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 165 | Vesiclepedia_1756 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 166 | Vesiclepedia_2409 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Platelets | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 167 | Vesiclepedia_887 | 25102470 | Homo sapiens | Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 168 | Vesiclepedia_2953 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 169 | Vesiclepedia_1965 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 170 | Vesiclepedia_3197 | 34690112 | Homo sapiens | Exosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling | Plasma |
Protein lncRNA |
ExoQuick Kit | Exosomes | EVs |
| 171 | Vesiclepedia_964 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 172 | Vesiclepedia_2642 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Mammary epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 173 | Vesiclepedia_1151 | 22367951 | Acinetobacter baumannii | Acinetobacter baumannii outer membrane protein A modulates the biogenesis of outer membrane vesicles. | Acinetobacter baumannii | Protein | Differential centrifugation Ultrafiltration Ultracentrifugation |
Outer membrane vesicles | EVs |
| 174 | Vesiclepedia_35 | 19367702 | Rattus norvegicus | Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes. | Hepatocytes | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 175 | Vesiclepedia_538 | 23844026 | Homo sapiens | Characterization of human thymic exosomes. | Thymus | Protein | - | Exosomes | EVs |
| 176 | Vesiclepedia_1880 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 177 | Vesiclepedia_2151 | 36781972 | Pseudomonas aeruginosa | The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition | Pseudomonas aeruginosa | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 178 | Vesiclepedia_2430 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 179 | Vesiclepedia_491 | 23264574 | Francisella novicida | Production of Outer Membrane Vesicles and Outer Membrane Tubes by Francisella novicida. | Francisella novicida | Protein | - | Membrane vesicles | EVs |
| 180 | Vesiclepedia_444 | 22418980 | Homo sapiens | A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. | Urine | Protein | - | Exosomes | EVs |
| 181 | Vesiclepedia_1697 | 34108659 | Mus musculus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Monocyte/macrophage-like cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 182 | Vesiclepedia_3110 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 183 | Vesiclepedia_894 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 184 | Vesiclepedia_143 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 185 | Vesiclepedia_685 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 186 | Vesiclepedia_261 | 12805058 | Homo sapiens | Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes | Plasma |
Protein Lipids |
Differential centrifugation Ultracentrifugation FACS |
Microparticles | EVs |
| 187 | Vesiclepedia_92 | 20124479 | Rattus norvegicus | Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. | Pancreatic cancer cells |
Protein mRNA |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 188 | Vesiclepedia_2795 | 37309723 | Mus musculus | Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells | T-cell lymphoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 189 | Vesiclepedia_2711 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Kidney cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 190 | Vesiclepedia_2847 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 191 | Vesiclepedia_3178 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 192 | Vesiclepedia_296 | 12796750 | Homo sapiens | High levels of circulating endothelial microparticles in patients with acute coronary syndromes | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 193 | Vesiclepedia_2670 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 194 | Vesiclepedia_2961 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 195 | Vesiclepedia_3257 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 196 | Vesiclepedia_191 | 21635979 | Mus musculus | Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice | Thymus | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 197 | Vesiclepedia_1649 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 198 | Vesiclepedia_44 | 19028452 | Homo sapiens | Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. | Plasma | Protein | Filtration Size exclusion chromatography Sucrose density gradient |
Exosomes | EVs |
| 199 | Vesiclepedia_578 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Breast cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 200 | Vesiclepedia_256 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | Burkitt's lymphoma | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 201 | Vesiclepedia_301 | 19234131 | Homo sapiens | Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR | Endothelial cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 202 | Vesiclepedia_238 | 21293856 | Homo sapiens | Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC | Ascites | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 203 | Vesiclepedia_18 | 11907077 | Homo sapiens | TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. | T cells | Protein | Filtration Ultracentrifugation |
Exosomes | EVs |
| 204 | Vesiclepedia_1501 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum |
Protein miRNA |
ExoQuick Kit | Extracellular vesicles | Small EVs |
| 205 | Vesiclepedia_2 | 3597417 | Ovis aries | Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). | Reticulocytes |
Protein Lipids |
Differential centrifugation | Exosomes | EVs |
| 206 | Vesiclepedia_1568 | 33738083 | Homo sapiens | Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 207 | Vesiclepedia_1405 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 208 | Vesiclepedia_2091 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 209 | Vesiclepedia_2802 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 210 | Vesiclepedia_2379 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 211 | Vesiclepedia_1377 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 212 | Vesiclepedia_2203 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 213 | Vesiclepedia_915 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 214 | Vesiclepedia_1416 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 215 | Vesiclepedia_2988 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 216 | Vesiclepedia_1899 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 217 | Vesiclepedia_121 | 21276792 | Homo sapiens | Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells. | Trophoblast cells | Protein | Differential centrifugation Ultrafiltration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 218 | Vesiclepedia_1192 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 219 | Vesiclepedia_2974 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Iodixanol density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 220 | Vesiclepedia_2049 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 221 | Vesiclepedia_3403 | 31712780 | Homo sapiens | Non-reversible tissue fixation retains extracellular vesicles for in situ imaging | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 222 | Vesiclepedia_1439 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 223 | Vesiclepedia_1582 | 33785738 | Homo sapiens | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Osteosarcoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 224 | Vesiclepedia_192 | 21635979 | Mus musculus | Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice | Thymus | Protein | Differential centrifugation Filtration |
Apoptotic bodies | EVs |
| 225 | Vesiclepedia_3127 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 226 | Vesiclepedia_1096 | 24976626 | Homo sapiens | Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. | Renal proximal tubule cells | Protein | Differential centrifugation Ultracentrifugation Immunoaffinity |
Exosomes | EVs |
| 227 | Vesiclepedia_2149 | 35605283 | Spinacia oleracea | Phytochemical Engineered Bacterial Outer Membrane Vesicles for Photodynamic Effects Promoted Immunotherapy | Spinach | Protein | Differential centrifugation Sonication Filtration |
Nanovesicles | Small EVs |
| 228 | Vesiclepedia_1616 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 229 | Vesiclepedia_1975 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 230 | Vesiclepedia_871 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 231 | Vesiclepedia_1220 | 27872147 | Rattus norvegicus | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Insulinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 232 | Vesiclepedia_64 | 18520029 | Homo sapiens | Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. | Saliva | Protein | Filtration Diafiltration Gel filtration |
Exosomes | EVs |
| 233 | Vesiclepedia_2545 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 234 | Vesiclepedia_3348 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Breast cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 235 | Vesiclepedia_3519 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 236 | Vesiclepedia_2491 | 34370714 | Homo sapiens | MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression | Wound fluid |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 237 | Vesiclepedia_1013 | 22711894 | Homo sapiens | Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. | Macrophage |
Protein Lipids |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 238 | Vesiclepedia_2543 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 239 | Vesiclepedia_2159 | 34140472 | Dermacentor andersoni | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Dermacentor andersoni | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 240 | Vesiclepedia_1262 | 24371517 | Homo sapiens | Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 241 | Vesiclepedia_517 | 23585443 | Homo sapiens | Proteome profiling of exosomes derived from human primary and metastatic colorectal cells reveal differential expression of key metastatic factors and signal transduction components. | Colorectal cancer cells | Protein | - | Exosomes/Membrane vesicles | EVs |
| 242 | Vesiclepedia_1558 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 243 | Vesiclepedia_2449 | 34465793 | Homo sapiens | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer | Breast cancer cells |
Protein miRNA |
Centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 244 | Vesiclepedia_3493 | 31278254 | Mus musculus | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 245 | Vesiclepedia_1001 | 24079734 | Mus musculus | Immunostimulatory activity of murine keratinocyte-derived exosomes. | Keratinocytes | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 246 | Vesiclepedia_939 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 247 | Vesiclepedia_2032 | 36123372 | Homo sapiens | Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells | Glioma stem cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 248 | Vesiclepedia_3407 | 31666321 | Drosophila melanogaster | Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia | Hemolymph | Protein | Differential centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 249 | Vesiclepedia_1615 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 250 | Vesiclepedia_2808 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 251 | Vesiclepedia_1722 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 252 | Vesiclepedia_1698 | 34108659 | Mus musculus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 253 | Vesiclepedia_2404 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 254 | Vesiclepedia_3208 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 255 | Vesiclepedia_2726 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 256 | Vesiclepedia_3325 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 257 | Vesiclepedia_1343 | 33159193 | Rattus norvegicus | Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles | Serum | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 258 | Vesiclepedia_1717 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 259 | Vesiclepedia_1705 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 260 | Vesiclepedia_2836 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 261 | Vesiclepedia_2275 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 262 | Vesiclepedia_77 | 20224111 | Homo sapiens | Proteomics analysis of bladder cancer exosomes. | Urine | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 263 | Vesiclepedia_117 | 21505438 | Homo sapiens | Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. | Dendritic cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 264 | Vesiclepedia_316 | 18472965 | Homo sapiens | Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles | Ovarian cancer cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 265 | Vesiclepedia_387 | 18563738 | Homo sapiens | Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. | Endothelial cells | Protein | - | Microparticles | EVs |
| 266 | Vesiclepedia_2547 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 267 | Vesiclepedia_1083 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 268 | Vesiclepedia_1567 | 33523942 | Homo sapiens | Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models | Embryonic kidney cells | Protein | Centrifugation Filtration Size exclusion chromatography |
Exosomes | Small EVs |
| 269 | Vesiclepedia_588 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 270 | Vesiclepedia_2432 | 29320704 | Homo sapiens | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Plasma | Protein | Ultracentrifugation | Extracellular vesicles | EVs |
| 271 | Vesiclepedia_3113 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 272 | Vesiclepedia_2623 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 273 | Vesiclepedia_1036 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
Exo-spin | Extracellular vesicles | EVs |
| 274 | Vesiclepedia_1372 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 275 | Vesiclepedia_728 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 276 | Vesiclepedia_1332 | 33431899 | Mus musculus | High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 277 | Vesiclepedia_3527 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 278 | Vesiclepedia_3314 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 279 | Vesiclepedia_2119 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 280 | Vesiclepedia_710 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 281 | Vesiclepedia_1275 | 23489476 | Sus scrofa | Boar seminal plasma exosomes: effect on sperm function and protein identification by sequencing. | Seminal plasma | Protein | Differential centrifugation Gel filtration Ultracentrifugation |
Exosomes | EVs |
| 282 | Vesiclepedia_3371 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Glioblastoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 283 | Vesiclepedia_1223 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Exo-spin | Extracellular vesicles | EVs |
| 284 | Vesiclepedia_2665 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 285 | Vesiclepedia_2555 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 286 | Vesiclepedia_2009 | 35979935 | Homo sapiens | Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients | Serum |
Protein Lipid |
Differential centrifugation | Extracellular vesicles | EVs |
| 287 | Vesiclepedia_519 | 23585444 | Homo sapiens | Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions. | Malignant pleural effusions | Protein | - | Exosomes/Microvesicles/Ectosomes/Microparticles | EVs |
| 288 | Vesiclepedia_2526 | 34315885 | Mus musculus | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Embryonic kidney cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 289 | Vesiclepedia_3118 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Brain | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 290 | Vesiclepedia_2118 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 291 | Vesiclepedia_2959 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 292 | Vesiclepedia_201 | 21606166 | Homo sapiens | Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta2 | Serum | Protein | Size exclusion chromatography Ultracentrifugation |
Microvesicles | EVs |
| 293 | Vesiclepedia_1110 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 294 | Vesiclepedia_559 | 26098775 | Citrus Limon L. | Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death | Lemon juice | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 295 | Vesiclepedia_2011 | 36417867 | Homo sapiens | Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 296 | Vesiclepedia_3115 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Podocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 297 | Vesiclepedia_984 | 25287304 | Candida albicans | Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans. | Candida albicans | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 298 | Vesiclepedia_2134 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Serum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 299 | Vesiclepedia_927 | 25483805 | Homo sapiens | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 300 | Vesiclepedia_3443 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 301 | Vesiclepedia_3109 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 302 | Vesiclepedia_1485 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 303 | Vesiclepedia_1290 | 19912576 | Homo sapiens | HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. | Lymphoblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 304 | Vesiclepedia_1150 | 22807456 | Homo sapiens | Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells. | Lymphocytes | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 305 | Vesiclepedia_416 | 20687614 | Myxococcus xanthus | Profiling the outer membrane proteome during growth and development of the social bacterium Myxococcus xanthus by selective biotinylation and analyses of outer membrane vesicles. | Myxococcus xanthus | Protein | - | Membrane vesicles | EVs |
| 306 | Vesiclepedia_980 | 25471885 | Drosophila melanogaster | The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. | Drosophila wing imaginal Disc | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 307 | Vesiclepedia_1644 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 308 | Vesiclepedia_2140 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Serum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 309 | Vesiclepedia_1094 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 310 | Vesiclepedia_283 | 19234131 | Homo sapiens | Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR | Colorectal cancer cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 311 | Vesiclepedia_3119 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Kidney cells | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 312 | Vesiclepedia_611 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 313 | Vesiclepedia_1536 | 33589572 | Homo sapiens | Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis | Lung cancer cells | Protein | Centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 314 | Vesiclepedia_775 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 315 | Vesiclepedia_2043 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatocytes | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 316 | Vesiclepedia_442 | 22288420 | Paracoccidioides brasiliensis | Vesicle and vesicle-free extracellular proteome of Paracoccidioides brasiliensis: comparative analysis with other pathogenic fungi. | Paracoccidioides brasiliensis | Protein | - | Extracellular vesicles | EVs |
| 317 | Vesiclepedia_3195 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 318 | Vesiclepedia_3398 | 31054213 | Homo sapiens | Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma | Cholangiocarcinoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 319 | Vesiclepedia_2357 | 36708245 | Homo sapiens | Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases | Faeces |
Protein Lipid |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 320 | Vesiclepedia_1434 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 321 | Vesiclepedia_427 | 21408115 | Edwardsiella tarda | Outer membrane vesicles as a candidate vaccine against edwardsiellosis. | Edwardsiella tarda | Protein | - | Membrane vesicles | EVs |
| 322 | Vesiclepedia_2070 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 323 | Vesiclepedia_2676 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic duct epithelial cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 324 | Vesiclepedia_2660 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 325 | Vesiclepedia_1785 | 35927827 | Mus musculus | Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles | Dendritic cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 326 | Vesiclepedia_1702 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Urine | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 327 | Vesiclepedia_331 | 19627513 | Homo sapiens | Exosomes from human saliva as a source of microRNA biomarkers | Saliva |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 328 | Vesiclepedia_2681 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 329 | Vesiclepedia_2947 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 330 | Vesiclepedia_1607 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 331 | Vesiclepedia_853 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 332 | Vesiclepedia_1213 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultracentrifugation | Extracellular vesicles | EVs |
| 333 | Vesiclepedia_602 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Leukemia cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 334 | Vesiclepedia_2250 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 335 | Vesiclepedia_2933 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 336 | Vesiclepedia_1073 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 337 | Vesiclepedia_873 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 338 | Vesiclepedia_3 | 10545503 | Mus musculus | Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. | Dendritic cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 339 | Vesiclepedia_1720 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 340 | Vesiclepedia_1646 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Forebrain neurons |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 341 | Vesiclepedia_2864 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 342 | Vesiclepedia_2768 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Polyethylene glycol-based precipitation |
Exosomes | Small EVs |
| 343 | Vesiclepedia_2970 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 344 | Vesiclepedia_3029 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 345 | Vesiclepedia_1397 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva |
Protein Lipid |
Differential centrifugation Tangential flow filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 346 | Vesiclepedia_118 | 21362503 | Homo sapiens | Protein profile of exosomes from trabecular meshwork cells. | Tabecular meshwork cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 347 | Vesiclepedia_116 | 21505438 | Homo sapiens | Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. | B cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 348 | Vesiclepedia_1255 | 24468161 | Homo sapiens | Molecular characterization of exosome-like vesicles from breast cancer cells. | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 349 | Vesiclepedia_2884 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 350 | Vesiclepedia_2969 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 351 | Vesiclepedia_815 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 352 | Vesiclepedia_2196 | 29511463 | Bos taurus | Biocompatibility of highly purified bovine milk-derived extracellular vesicles | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 353 | Vesiclepedia_2716 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 354 | Vesiclepedia_2728 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 355 | Vesiclepedia_603 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Leukemia cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 356 | Vesiclepedia_3525 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 357 | Vesiclepedia_268 | 12757771 | Homo sapiens | Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis | Endothelial cells | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 358 | Vesiclepedia_1021 | 20332430 | Homo sapiens | Proteomic analysis of prostate cancer metastasis-derived prostasomes. | Skeletal tissue | Protein | Differential centrifugation Ultracentrifugation |
Prostasomes | EVs |
| 359 | Vesiclepedia_2408 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Adipocytes | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 360 | Vesiclepedia_1583 | 33686255 | Homo sapiens | Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy. | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 361 | Vesiclepedia_3030 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 362 | Vesiclepedia_743 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 363 | Vesiclepedia_314 | 15499615 | Homo sapiens | Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer | Lung cancer cells | Protein | Differential centrifugation FACS |
Microvesicles | EVs |
| 364 | Vesiclepedia_97 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 365 | Vesiclepedia_1384 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 366 | Vesiclepedia_2819 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 367 | Vesiclepedia_492 | 23333927 | Homo sapiens | Characterization and proteomic analysis of ovarian cancer-derived exosomes. | Ovarian cancer cells | Protein | - | Exosomes | EVs |
| 368 | Vesiclepedia_3307 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 369 | Vesiclepedia_2829 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 370 | Vesiclepedia_3317 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 371 | Vesiclepedia_2530 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 372 | Vesiclepedia_922 | 25483805 | Homo sapiens | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 373 | Vesiclepedia_2922 | 33661579 | Homo sapiens | Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size | T lymphoblast | Protein | Differential centrifugation | Apoptotic bodies | Large EVs |
| 374 | Vesiclepedia_2958 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 375 | Vesiclepedia_3008 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 376 | Vesiclepedia_1684 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 377 | Vesiclepedia_2503 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | exoEasy Maxi Kit | Extracellular vesicles | EVs |
| 378 | Vesiclepedia_694 | 28842968 | Homo sapiens | Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 379 | Vesiclepedia_2780 | 35304471 | Mus musculus | Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox | Bone | Protein | Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 380 | Vesiclepedia_1936 | 36103526 | Homo sapiens | Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases | Hepatic stellate cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 381 | Vesiclepedia_3085 | 35665306 | Mus musculus | Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles | Serum | Protein | Size exclusion chromatography Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 382 | Vesiclepedia_2966 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 383 | Vesiclepedia_676 | 29951053 | Mus musculus | Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. | Myeloid-derived suppressor cells | Protein | Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 384 | Vesiclepedia_706 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles/Apoptotic bodies | EVs |
| 385 | Vesiclepedia_2714 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 386 | Vesiclepedia_569 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (CD9 FT) |
Extracellular vesicles | EVs |
| 387 | Vesiclepedia_1656 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Glioblastoma cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 388 | Vesiclepedia_1269 | 24218614 | Homo sapiens | Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 389 | Vesiclepedia_105 | 21763319 | Homo sapiens | Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation |
Exosomes | EVs |
| 390 | Vesiclepedia_2416 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 391 | Vesiclepedia_931 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 392 | Vesiclepedia_2985 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 393 | Vesiclepedia_959 | 26196085 | Homo sapiens | Identification of prostate cancer biomarkers in urinary exosomes. | Urine | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 394 | Vesiclepedia_697 | 28842968 | Homo sapiens | Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 395 | Vesiclepedia_662 | 29956871 | Homo sapiens | Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation Filtration |
Microvesicles | EVs |
| 396 | Vesiclepedia_1657 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Foreskin fibroblasts |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 397 | Vesiclepedia_784 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 398 | Vesiclepedia_783 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 399 | Vesiclepedia_3500 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 400 | Vesiclepedia_1152 | 22057275 | Homo sapiens | Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 401 | Vesiclepedia_3509 | 31110292 | Mus musculus | The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency | Liver cancer cells | Protein | Differential centrifugation | Microparticles | Large EVs |
| 402 | Vesiclepedia_2807 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 403 | Vesiclepedia_1433 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 404 | Vesiclepedia_2538 | 34293122 | Mus musculus | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets |
Protein Lipid |
Centrifugation | Extracellular vesicles | Large EVs |
| 405 | Vesiclepedia_2442 | 34489604 | Mus musculus | Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 | Hepatocytes |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 406 | Vesiclepedia_2385 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 407 | Vesiclepedia_3046 | 34294888 | Homo sapiens | Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2 | Plasma |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 408 | Vesiclepedia_2141 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Serum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 409 | Vesiclepedia_2324 | 31807237 | Homo sapiens | Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 410 | Vesiclepedia_2155 | 30488570 | Helicobacter pylori | Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles | Helicobacter pylori | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 411 | Vesiclepedia_3207 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 412 | Vesiclepedia_3433 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 413 | Vesiclepedia_991 | 25138791 | Homo sapiens | The exocyst and regulatory GTPases in urinary exosomes. | Urine | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 414 | Vesiclepedia_418 | 21049385 | Homo sapiens | The plasma microparticle proteome. | Plasma | Protein | - | Microparticles | EVs |
| 415 | Vesiclepedia_3473 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 416 | Vesiclepedia_60 | 17700640 | Mus musculus | CD24 is a marker of exosomes secreted into urine and amniotic fluid. | Urine | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 417 | Vesiclepedia_2484 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 418 | Vesiclepedia_245 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | T cells |
Protein mRNA |
Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 419 | Vesiclepedia_1563 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 420 | Vesiclepedia_3133 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 421 | Vesiclepedia_3009 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Breast cancer cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 422 | Vesiclepedia_1121 | 24347249 | Homo sapiens | Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 423 | Vesiclepedia_2004 | 34112803 | Mus musculus | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 424 | Vesiclepedia_2927 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 425 | Vesiclepedia_607 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Leukemia cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 426 | Vesiclepedia_69 | 19812188 | Rattus norvegicus | Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII. | Dendritic cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 427 | Vesiclepedia_760 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 428 | Vesiclepedia_2103 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 429 | Vesiclepedia_2396 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 430 | Vesiclepedia_1660 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic duct epithelial cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 431 | Vesiclepedia_2391 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 432 | Vesiclepedia_411 | 20124223 | Homo sapiens | Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. | Squamous carcinoma cells | Protein | - | Exosomes | EVs |
| 433 | Vesiclepedia_3184 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 434 | Vesiclepedia_94 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 435 | Vesiclepedia_3311 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 436 | Vesiclepedia_2445 | 34489604 | Mus musculus | Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 | Hepatocytes |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 437 | Vesiclepedia_2730 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 438 | Vesiclepedia_550 | 24009881 | Homo sapiens | Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. | Colorectal cancer cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles/Ectosomes | EVs |
| 439 | Vesiclepedia_3112 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 440 | Vesiclepedia_2390 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 441 | Vesiclepedia_1364 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 442 | Vesiclepedia_1336 | 33199621 | Mus musculus | Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice | Plasma |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 443 | Vesiclepedia_754 | 29963269 | Homo sapiens | Mining of potential microRNAs with clinical correlation - regulation of syndecan-1 expression by miR-122-5p altered mobility of breast cancer cells and possible correlation with liver injury | Hepatoma cells | Protein | Total Exosome Isolation Kit Differential centrifugation |
Exosomes | EVs |
| 444 | Vesiclepedia_62 | 17133577 | Mus musculus | Association of citrullinated proteins with synovial exosomes. | Synovial fluid | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 445 | Vesiclepedia_3168 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 446 | Vesiclepedia_122 | 21235781 | Homo sapiens | Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. | Saliva | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 447 | Vesiclepedia_2973 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 448 | Vesiclepedia_1941 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 449 | Vesiclepedia_2632 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 450 | Vesiclepedia_1562 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 451 | Vesiclepedia_2241 | 36648227 | Mus musculus | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 452 | Vesiclepedia_3396 | 31792209 | Homo sapiens | Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 453 | Vesiclepedia_3203 | 34596354 | Homo sapiens | Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p | Mesenchymal stem cells | Protein | Tangential flow filtration | Extracellular vesicles | Small EVs |
| 454 | Vesiclepedia_1996 | 34112803 | Mus musculus | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 455 | Vesiclepedia_2520 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 456 | Vesiclepedia_1584 | 33692129 | Macaca fascicularis | Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates | Mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 457 | Vesiclepedia_766 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 458 | Vesiclepedia_624 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 459 | Vesiclepedia_735 | 25285581 | Mus musculus | Ubiquitinated proteins in exosomes secreted by myeloid-derived suppressor cells. | Myeloid-derived suppressor cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 460 | Vesiclepedia_3220 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 461 | Vesiclepedia_1930 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 462 | Vesiclepedia_2229 | 36648227 | Mus musculus | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 463 | Vesiclepedia_1547 | 33638284 | Canis lupus familiaris | Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial-mesenchymal transition | Kidney cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 464 | Vesiclepedia_1438 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 465 | Vesiclepedia_3425 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 466 | Vesiclepedia_3322 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 467 | Vesiclepedia_2395 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 468 | Vesiclepedia_2960 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 469 | Vesiclepedia_2329 | 32487994 | Homo sapiens | Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence | Plasma | Protein | Centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 470 | Vesiclepedia_950 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 471 | Vesiclepedia_1967 | 35915084 | Mus musculus | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 472 | Vesiclepedia_734 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 473 | Vesiclepedia_1415 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 474 | Vesiclepedia_2263 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 475 | Vesiclepedia_38 | 15210972 | Oryctolagus cuniculus | Cells release prions in association with exosomes. | Epithelial cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 476 | Vesiclepedia_2300 | 31489147 | Homo sapiens | Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles | Monocytes |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 477 | Vesiclepedia_3107 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 478 | Vesiclepedia_674 | 29953960 | Homo sapiens | Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. | Macrophage | Protein | Microfiltration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 479 | Vesiclepedia_1006 | 23463506 | Mus musculus | The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. | T cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 480 | Vesiclepedia_2536 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 481 | Vesiclepedia_615 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 482 | Vesiclepedia_2506 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 483 | Vesiclepedia_1712 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 484 | Vesiclepedia_1998 | 34112803 | Homo sapiens | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 485 | Vesiclepedia_1241 | 25329303 | Homo sapiens | Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins. | Urine | Protein | Vn96 peptide precipitation | Extracellular vesicles | EVs |
| 486 | Vesiclepedia_2085 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 487 | Vesiclepedia_568 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (CD9 PD) |
Extracellular vesicles | EVs |
| 488 | Vesiclepedia_1126 | 24295599 | Mus musculus | Exosomes from myeloid-derived suppressor cells carry biologically active proteins. | Myeloid-derived suppressor cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 489 | Vesiclepedia_1654 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Glioblastoma cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 490 | Vesiclepedia_439 | 22129587 | Bos taurus | Bovine milk exosome proteome. | Bovine milk | Protein | - | Exosomes/Membrane vesicles | EVs |
| 491 | Vesiclepedia_2832 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 492 | Vesiclepedia_3094 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 493 | Vesiclepedia_3518 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 494 | Vesiclepedia_1239 | 25329303 | Homo sapiens | Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins. | Urine | Protein | Vn96 peptide precipitation | Extracellular vesicles | EVs |
| 495 | Vesiclepedia_289 | 12196479 | Homo sapiens | Type 1 and type 2 diabetic patients display different patterns of cellular microparticles | Plasma |
Protein Lipids |
Differential centrifugation FACS |
Microparticles | EVs |
| 496 | Vesiclepedia_2050 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 497 | Vesiclepedia_395 | 19413345 | Homo sapiens | Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. | B cells | Protein | - | Microparticles | EVs |
| 498 | Vesiclepedia_137 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 499 | Vesiclepedia_3489 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Immunoaffinity capture Centrifugation |
Extracellular vesicles | Small EVs |
| 500 | Vesiclepedia_1862 | 35931686 | Homo sapiens | Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression | Chondrocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 501 | Vesiclepedia_3075 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 502 | Vesiclepedia_2114 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 503 | Vesiclepedia_22 | 15940614 | Homo sapiens | Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. | Colorectal cancer cells | Protein | Differential centrifugation | Exosomes | EVs |
| 504 | Vesiclepedia_3319 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 505 | Vesiclepedia_2288 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Natural killer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 506 | Vesiclepedia_881 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 507 | Vesiclepedia_1798 | 36594832 | Mus musculus | Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia | Neuroblastoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 508 | Vesiclepedia_1844 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 509 | Vesiclepedia_849 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 510 | Vesiclepedia_1605 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 511 | Vesiclepedia_2653 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 512 | Vesiclepedia_1581 | 33785738 | Homo sapiens | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Osteosarcoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 513 | Vesiclepedia_3284 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 514 | Vesiclepedia_3279 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 515 | Vesiclepedia_3405 | 31666321 | Drosophila melanogaster | Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia | Embryonic cells |
Protein miRNA |
Differential centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 516 | Vesiclepedia_478 | 23082778 | Homo sapiens | Comparative and Targeted Proteomic Analyses of Urinary Microparticles from Bladder Cancer and Hernia Patients. | Urine | Protein | - | Exosomes/Membrane vesicles | EVs |
| 517 | Vesiclepedia_1309 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 518 | Vesiclepedia_976 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 519 | Vesiclepedia_2233 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 520 | Vesiclepedia_824 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 521 | Vesiclepedia_2157 | 34140472 | Amblyomma americanum | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Amblyomma americanum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 522 | Vesiclepedia_1635 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 523 | Vesiclepedia_1659 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 524 | Vesiclepedia_2184 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 525 | Vesiclepedia_2905 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 526 | Vesiclepedia_1752 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 527 | Vesiclepedia_1240 | 25329303 | Homo sapiens | Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins. | Urine | Protein | Ultracentrifugation | Extracellular vesicles | EVs |
| 528 | Vesiclepedia_1687 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 529 | Vesiclepedia_567 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (Igg1 FT) |
Extracellular vesicles | EVs |
| 530 | Vesiclepedia_855 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 531 | Vesiclepedia_3134 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 532 | Vesiclepedia_2013 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation | Medium extracellular vesicles | Large EVs |
| 533 | Vesiclepedia_3329 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 534 | Vesiclepedia_2047 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Plasma | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 535 | Vesiclepedia_3034 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 536 | Vesiclepedia_2000 | 34112803 | Homo sapiens | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Plasma | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 537 | Vesiclepedia_2169 | 29643357 | Staphylococcus aureus | Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform | Staphylococcus aureus | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 538 | Vesiclepedia_1670 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Monocytic leukemia cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 539 | Vesiclepedia_3367 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colon cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 540 | Vesiclepedia_2042 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatocytes | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 541 | Vesiclepedia_1905 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 542 | Vesiclepedia_3487 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 543 | Vesiclepedia_3217 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 544 | Vesiclepedia_2078 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 545 | Vesiclepedia_1136 | 23861904 | Homo sapiens | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. | Placental mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration Density gradient centrifugation |
Exosomes | EVs |
| 546 | Vesiclepedia_1441 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 547 | Vesiclepedia_2615 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 548 | Vesiclepedia_1140 | 23454749 | Homo sapiens | BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. | Bone marrow mesenchymal stromal cells | Protein | Differential centrifugation Ultracentrifugation Filtration ExoQuick |
Exosomes | EVs |
| 549 | Vesiclepedia_3253 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 550 | Vesiclepedia_2527 | 34315885 | Mus musculus | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Kidney epithelial cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 551 | Vesiclepedia_718 | 26148937 | Homo sapiens | Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression. | Cholangiocarcinoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 552 | Vesiclepedia_2121 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 553 | Vesiclepedia_3256 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 554 | Vesiclepedia_3074 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 555 | Vesiclepedia_732 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 556 | Vesiclepedia_2820 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 557 | Vesiclepedia_3043 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 558 | Vesiclepedia_2262 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 559 | Vesiclepedia_1190 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 560 | Vesiclepedia_3401 | 31054213 | Homo sapiens | Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma | Cholangiocarcinoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 561 | Vesiclepedia_1500 | 33982667 | Homo sapiens | Exosomal circRNA 0001445 promotes glioma progression through miRNA-127-5p/SNX5 pathway | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 562 | Vesiclepedia_2258 | 37376799 | Bos taurus | Bovine milk-derived extracellular vesicles enhance doxorubicin sensitivity in triple negative breast cancer cells by targeting metabolism and STAT signalling | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 563 | Vesiclepedia_71 | 19801663 | Homo sapiens | Microenvironmental pH is a key factor for exosome traffic in tumor cells. | Melanoma cells |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 564 | Vesiclepedia_671 | 29953960 | Homo sapiens | Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. | Macrophage | Protein | Microfiltration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 565 | Vesiclepedia_2083 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 566 | Vesiclepedia_1554 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 567 | Vesiclepedia_2932 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 568 | Vesiclepedia_2647 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 569 | Vesiclepedia_2833 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 570 | Vesiclepedia_1186 | 28326167 | Homo sapiens | Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment. | Urine | Protein | Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 571 | Vesiclepedia_2366 | 36759608 | Mus musculus | Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo | Adipocytes |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 572 | Vesiclepedia_2420 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 573 | Vesiclepedia_1284 | 22345510 | Rattus norvegicus | Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. | Insulinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 574 | Vesiclepedia_1866 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 575 | Vesiclepedia_2848 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 576 | Vesiclepedia_1690 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 577 | Vesiclepedia_3124 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Kidney cells | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 578 | Vesiclepedia_2481 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 579 | Vesiclepedia_1381 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 580 | Vesiclepedia_2064 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 581 | Vesiclepedia_1153 | 22057275 | Homo sapiens | Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 582 | Vesiclepedia_2656 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 583 | Vesiclepedia_1300 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 584 | Vesiclepedia_1370 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 585 | Vesiclepedia_834 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 586 | Vesiclepedia_2731 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 587 | Vesiclepedia_2383 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 588 | Vesiclepedia_1097 | 24513287 | Mus musculus | Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. | adipocytes | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 589 | Vesiclepedia_41 | 15908444 | Homo sapiens | Exosomal-like vesicles are present in human blood plasma. | Mast cells | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 590 | Vesiclepedia_2572 | 35689797 | Homo sapiens | Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations | Mammary epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 591 | Vesiclepedia_2398 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 592 | Vesiclepedia_2629 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 593 | Vesiclepedia_2883 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 594 | Vesiclepedia_1227 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 595 | Vesiclepedia_2158 | 34140472 | Ixodes scapularis | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Ixodes scapularis | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 596 | Vesiclepedia_1145 | 23173708 | Rattus norvegicus | Wnt3a induces exosome secretion from primary cultured rat microglia. | Primary microglial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 597 | Vesiclepedia_2065 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 598 | Vesiclepedia_2924 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 599 | Vesiclepedia_1058 | 30035390 | Mus musculus | Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. | Mouse embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 600 | Vesiclepedia_2186 | 33792189 | Mus musculus | A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions | Epididymal epithelial cells | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 601 | Vesiclepedia_1386 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 602 | Vesiclepedia_1576 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 603 | Vesiclepedia_993 | 24434149 | Homo sapiens | In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome. | Ovarian cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 604 | Vesiclepedia_1426 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 605 | Vesiclepedia_1540 | 33658392 | Homo sapiens | Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma | Lung cancer cells |
Protein miRNA |
Minute High-Efficiency Exosome Precipitation Reagent Filtration |
Exosomes | Small EVs |
| 606 | Vesiclepedia_1618 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 607 | Vesiclepedia_1049 | 28842968 | Homo sapiens | Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 608 | Vesiclepedia_1498 | 33991177 | Homo sapiens | Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells | Gastric cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Large extracellular vesicles | Large EVs |
| 609 | Vesiclepedia_3364 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 610 | Vesiclepedia_1422 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 611 | Vesiclepedia_3469 | 35393416 | Homo sapiens | CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity | Oral cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 612 | Vesiclepedia_1617 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 613 | Vesiclepedia_469 | 23029346 | Echinostoma caproni | Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells. | Echinostoma caproni | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 614 | Vesiclepedia_2199 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 615 | Vesiclepedia_273 | 12021310 | Homo sapiens | Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles | T cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 616 | Vesiclepedia_2046 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Fibroblasts | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 617 | Vesiclepedia_1258 | 24400796 | Homo sapiens | Exosomal proteins in the aqueous humor as novel biomarkers in patients with neovascular age-related macular degeneration. | Aqueous humor | Protein | ExoQuick | Exosomes | EVs |
| 618 | Vesiclepedia_845 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 619 | Vesiclepedia_594 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 620 | Vesiclepedia_1291 | 19912576 | Homo sapiens | HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. | Lymphoblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 621 | Vesiclepedia_2222 | 34596356 | Homo sapiens | Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer | Primary prostate stromal cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 622 | Vesiclepedia_2079 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 623 | Vesiclepedia_1931 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 624 | Vesiclepedia_699 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 625 | Vesiclepedia_103 | 21763319 | Homo sapiens | Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation |
Exosomes | EVs |
| 626 | Vesiclepedia_2440 | 29335551 | Homo sapiens | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer | Liver cancer cells |
Protein miRNA |
Filtration Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 627 | Vesiclepedia_2688 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 628 | Vesiclepedia_1486 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 629 | Vesiclepedia_1763 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 630 | Vesiclepedia_2677 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic duct epithelial cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 631 | Vesiclepedia_280 | 15499615 | Homo sapiens | Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer | Lung cancer cells |
Protein mRNA |
Differential centrifugation FACS |
Microvesicles | EVs |
| 632 | Vesiclepedia_2479 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 633 | Vesiclepedia_2689 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 634 | Vesiclepedia_3096 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 635 | Vesiclepedia_403 | 19548909 | Homo sapiens | Differential stimulation of monocytic cells results in distinct populations of microparticles. | Monocytes | Protein | - | Microparticles | EVs |
| 636 | Vesiclepedia_791 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 637 | Vesiclepedia_78 | 20224111 | Homo sapiens | Proteomics analysis of bladder cancer exosomes. | Urine | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 638 | Vesiclepedia_1429 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 639 | Vesiclepedia_523 | 23658846 | Mus musculus | Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. | Macrophage | Protein | - | Exosomes | EVs |
| 640 | Vesiclepedia_1280 | 22345510 | Rattus norvegicus | Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. | Insulinoma cells | Protein | Differential centrifugation | Microparticles | EVs |
| 641 | Vesiclepedia_2641 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Cervical cancer cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 642 | Vesiclepedia_2217 | 35753600 | Mus musculus | Outer membrane vesicles derived from heatstroke-associated intestinal microbiota promote multiple organ injury in mice | Faeces | Protein | Differential centrifugation Iodixanol density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 643 | Vesiclepedia_805 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 644 | Vesiclepedia_1242 | 25261722 | Homo sapiens | Inflammatory cytokines, interleukin-1 beta and tumor necrosis factor-alpha, upregulated in glioblastoma multiforme, raise the levels of CRYAB in exosomes secreted by U373 glioma cells. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 645 | Vesiclepedia_2206 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 646 | Vesiclepedia_628 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 647 | Vesiclepedia_162 | 21901833 | Drosophila melanogaster | Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells | Hematocytes |
Protein PTM Ubiquitination |
Differential centrifugation Sucrose density gradient Ultracentrifugation |
Microvesicles | EVs |
| 648 | Vesiclepedia_582 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 649 | Vesiclepedia_2609 | 32383290 | Ovis aries | Quantitative Proteomic Analysis of Seminal Plasma, Sperm Membrane Proteins, and Seminal Extracellular Vesicles Suggests Vesicular Mechanisms Aid in the Removal and Addition of Proteins to the Ram Sperm Membrane | Seminal plasma | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 650 | Vesiclepedia_901 | 26100252 | Homo sapiens | Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts | Chronic lymphocytic leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 651 | Vesiclepedia_1509 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 652 | Vesiclepedia_278 | 10233897 | Homo sapiens | Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia | Platelets |
Protein Lipids |
Differential centrifugation FACS |
Microparticles | EVs |
| 653 | Vesiclepedia_2197 | 33828139 | Bos taurus | Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition | Bovine milk | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 654 | Vesiclepedia_745 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 655 | Vesiclepedia_877 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 656 | Vesiclepedia_3010 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 657 | Vesiclepedia_2195 | 29511463 | Bos taurus | Biocompatibility of highly purified bovine milk-derived extracellular vesicles | Bovine milk | Protein | Acidification Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 658 | Vesiclepedia_626 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 659 | Vesiclepedia_2444 | 34489604 | Mus musculus | Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 | Hepatocytes |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 660 | Vesiclepedia_2898 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 661 | Vesiclepedia_859 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 662 | Vesiclepedia_503 | 23459212 | Bos taurus | Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. | Bovine milk | Protein | - | Exosomes | EVs |
| 663 | Vesiclepedia_3021 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 664 | Vesiclepedia_546 | 23983189 | Homo sapiens | Characterization of Multiple Myeloma Vesicles by Label-Free Relative Quantitation. | B cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 665 | Vesiclepedia_1954 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 666 | Vesiclepedia_1135 | 23861904 | Homo sapiens | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. | Placental mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration Density gradient centrifugation |
Exosomes | EVs |
| 667 | Vesiclepedia_1195 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 668 | Vesiclepedia_2844 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 669 | Vesiclepedia_3316 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 670 | Vesiclepedia_2486 | 34388111 | Homo sapiens | miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis | Monocytic leukemia cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 671 | Vesiclepedia_3071 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 672 | Vesiclepedia_1986 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 673 | Vesiclepedia_1873 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 674 | Vesiclepedia_2171 | 29643357 | Staphylococcus aureus | Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform | Staphylococcus aureus | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 675 | Vesiclepedia_1472 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 676 | Vesiclepedia_3101 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 677 | Vesiclepedia_1948 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 678 | Vesiclepedia_750 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 679 | Vesiclepedia_168 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 680 | Vesiclepedia_1904 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 681 | Vesiclepedia_2799 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 682 | Vesiclepedia_912 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 683 | Vesiclepedia_66 | 19199708 | Homo sapiens | Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). | Saliva | Protein | Differential centrifugation | Exosomes | EVs |
| 684 | Vesiclepedia_467 | 23000592 | Homo sapiens | In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts. | Neonatal myoblast cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 685 | Vesiclepedia_3190 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 686 | Vesiclepedia_2723 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 687 | Vesiclepedia_675 | 29951053 | Mus musculus | Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. | Myeloid-derived suppressor cells | Protein | Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 688 | Vesiclepedia_2631 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 689 | Vesiclepedia_413 | 20535238 | Rattus norvegicus | Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples. | Urine | Protein | - | Exosomes | EVs |
| 690 | Vesiclepedia_195 | 21668449 | Mus musculus | SV31 is a Zn2+-binding synaptic vesicle protein | Pheochromocytoma cells | Protein | Differential centrifugation Sucrose density gradient |
Large dense core vesicles | EVs |
| 691 | Vesiclepedia_1071 | 29937354 | Homo sapiens | Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 692 | Vesiclepedia_284 | 12796750 | Homo sapiens | High levels of circulating endothelial microparticles in patients with acute coronary syndromes | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 693 | Vesiclepedia_779 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 694 | Vesiclepedia_670 | 29953960 | Homo sapiens | Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. | Macrophage | Protein | Microfiltration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 695 | Vesiclepedia_2330 | 32487994 | Homo sapiens | Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence | Plasma | Protein | Centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 696 | Vesiclepedia_2617 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 697 | Vesiclepedia_1440 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 698 | Vesiclepedia_3079 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 699 | Vesiclepedia_2582 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 700 | Vesiclepedia_906 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer | Urothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 701 | Vesiclepedia_1211 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 702 | Vesiclepedia_3187 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 703 | Vesiclepedia_3526 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 704 | Vesiclepedia_886 | 25102470 | Homo sapiens | Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 705 | Vesiclepedia_2077 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 706 | Vesiclepedia_1127 | 24295599 | Mus musculus | Exosomes from myeloid-derived suppressor cells carry biologically active proteins. | Myeloid-derived suppressor cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 707 | Vesiclepedia_428 | 21515422 | Homo sapiens | Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells. | Osteosarcoma cells | Protein | - | Matrix vesicles | EVs |
| 708 | Vesiclepedia_866 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 709 | Vesiclepedia_2034 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 710 | Vesiclepedia_1362 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 711 | Vesiclepedia_730 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 712 | Vesiclepedia_3139 | 34497265 | Homo sapiens | Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer | Plasma |
Protein miRNA |
ExoQuick Kit | Exosomes | EVs |
| 713 | Vesiclepedia_574 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 714 | Vesiclepedia_2724 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 715 | Vesiclepedia_1985 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 716 | Vesiclepedia_2384 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 717 | Vesiclepedia_571 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (CD63 FT) |
Extracellular vesicles | EVs |
| 718 | Vesiclepedia_1404 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 719 | Vesiclepedia_1551 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 720 | Vesiclepedia_604 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Leukemia cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 721 | Vesiclepedia_3024 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 722 | Vesiclepedia_2284 | 30863515 | Homo sapiens | Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles | Lung epithelial cells |
Protein Lipid |
Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 723 | Vesiclepedia_1969 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 724 | Vesiclepedia_1885 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 725 | Vesiclepedia_592 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 726 | Vesiclepedia_3270 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 727 | Vesiclepedia_1645 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Forebrain neurons |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 728 | Vesiclepedia_437 | 22106071 | Homo sapiens | Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). | Urine | Protein | - | Exosomes/Membrane vesicles | EVs |
| 729 | Vesiclepedia_3504 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 730 | Vesiclepedia_1243 | 25261722 | Homo sapiens | Inflammatory cytokines, interleukin-1 beta and tumor necrosis factor-alpha, upregulated in glioblastoma multiforme, raise the levels of CRYAB in exosomes secreted by U373 glioma cells. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 731 | Vesiclepedia_1037 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
miRCURY Exosome Isolation Kit | Extracellular vesicles | EVs |
| 732 | Vesiclepedia_3138 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 733 | Vesiclepedia_160 | 21630462 | Homo sapiens | Proteomic analysis of microvesicles derived from human colorectal cancer ascites | Ascites | Protein | Differential centrifugation Sucrose density gradient OptiPrep density gradient |
Microvesicles | EVs |
| 734 | Vesiclepedia_955 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 735 | Vesiclepedia_3442 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 736 | Vesiclepedia_2892 | 28928431 | Mus musculus | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 | Lung cancer cells | Protein | Centrifugal ultrafiltration ExoQuick Kit |
Extracellular vesicles | EVs |
| 737 | Vesiclepedia_1257 | 24400796 | Homo sapiens | Exosomal proteins in the aqueous humor as novel biomarkers in patients with neovascular age-related macular degeneration. | Retinal pigment epithelial cells | Protein | ExoQuick | Exosomes | EVs |
| 738 | Vesiclepedia_3523 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 739 | Vesiclepedia_3176 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 740 | Vesiclepedia_2533 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 741 | Vesiclepedia_3037 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 742 | Vesiclepedia_2087 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 743 | Vesiclepedia_663 | 29956871 | Homo sapiens | Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 744 | Vesiclepedia_749 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 745 | Vesiclepedia_631 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 746 | Vesiclepedia_1147 | 23173708 | Rattus norvegicus | Wnt3a induces exosome secretion from primary cultured rat microglia. | Primary microglial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 747 | Vesiclepedia_1857 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 748 | Vesiclepedia_1594 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 749 | Vesiclepedia_1806 | 36517516 | Homo sapiens | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes | Serum | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 750 | Vesiclepedia_820 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 751 | Vesiclepedia_3373 | 33510128 | Mus musculus | Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia | Colon cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 752 | Vesiclepedia_736 | 25285581 | Mus musculus | Ubiquitinated proteins in exosomes secreted by myeloid-derived suppressor cells. | Myeloid-derived suppressor cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 753 | Vesiclepedia_707 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 754 | Vesiclepedia_2715 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 755 | Vesiclepedia_1572 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 756 | Vesiclepedia_3521 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 757 | Vesiclepedia_210 | 21368175 | Homo sapiens | Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells | Breast cancer cells | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 758 | Vesiclepedia_2183 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 759 | Vesiclepedia_3496 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 760 | Vesiclepedia_11 | 12519789 | Homo sapiens | Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. | B cells |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 761 | Vesiclepedia_632 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 762 | Vesiclepedia_1963 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 763 | Vesiclepedia_2890 | 28928431 | Mus musculus | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 | Lung cancer cells | Protein | Centrifugal ultrafiltration ExoQuick Kit |
Extracellular vesicles | EVs |
| 764 | Vesiclepedia_1356 | 32438511 | Homo sapiens | Exosomes Derived from the Human Primary Colorectal Cancer Cell Line SW480 Orchestrate Fibroblast-Led Cancer Invasion | Colorectal cancer cells | Protein | Differential centrifugation Filtration OptiPrep density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 765 | Vesiclepedia_1217 | 27872147 | Rattus norvegicus | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Islets | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 766 | Vesiclepedia_923 | 25483805 | Homo sapiens | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 767 | Vesiclepedia_2435 | 29320704 | Homo sapiens | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Plasma | Protein | Centrifugation | Extracellular vesicles | EVs |
| 768 | Vesiclepedia_3477 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 769 | Vesiclepedia_1935 | 36103526 | Homo sapiens | Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases | Hepatic stellate cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 770 | Vesiclepedia_2257 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 771 | Vesiclepedia_920 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 772 | Vesiclepedia_402 | 19548909 | Homo sapiens | Differential stimulation of monocytic cells results in distinct populations of microparticles. | Monocytes | Protein | - | Microparticles | EVs |
| 773 | Vesiclepedia_125 | 21059916 | Homo sapiens | Human tumor virus utilizes exosomes for intercellular communication. | Nasopharyngeal carcinoma cells | Protein | Differential centrifugation | Exosomes | EVs |
| 774 | Vesiclepedia_2720 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 775 | Vesiclepedia_2709 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 776 | Vesiclepedia_2516 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 777 | Vesiclepedia_3422 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 778 | Vesiclepedia_1048 | 28725021 | Bos taurus | Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 779 | Vesiclepedia_3077 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 780 | Vesiclepedia_9 | 12626558 | Mus musculus | Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. | Macrophage | Protein | Differential centrifugation | Exosomes | EVs |
| 781 | Vesiclepedia_1366 | 32132711 | Mus musculus | Decoy exosomes provide protection against bacterial toxins | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 782 | Vesiclepedia_872 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 783 | Vesiclepedia_324 | 20079801 | Mus musculus | Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription | Lung cells |
Protein miRNA |
Differential centrifugation FACS |
Microvesicles | EVs |
| 784 | Vesiclepedia_2401 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 785 | Vesiclepedia_1938 | 36193887 | Homo sapiens | Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 786 | Vesiclepedia_3453 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 787 | Vesiclepedia_2364 | 36748335 | Homo sapiens | Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α | Oral cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 788 | Vesiclepedia_2107 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 789 | Vesiclepedia_909 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer | Transitional carcinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 790 | Vesiclepedia_544 | 23977379 | Listeria monocytogenes | Transcription Factor σ(B) Plays an Important Role in the Production of Extracellular Membrane-Derived Vesicles in Listeria monocytogenes. | Listeria monocytogenes | Protein | - | Membrane vesicles | EVs |
| 791 | Vesiclepedia_2881 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 792 | Vesiclepedia_2080 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 793 | Vesiclepedia_2055 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 794 | Vesiclepedia_1629 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 795 | Vesiclepedia_2755 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 796 | Vesiclepedia_918 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 797 | Vesiclepedia_484 | 23214914 | Trypanosoma cruzi | Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins. | Epimastigotes | Protein | - | Exosomes/Extracellular vesicles/Ectosomes | EVs |
| 798 | Vesiclepedia_627 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 799 | Vesiclepedia_1050 | 28842968 | Homo sapiens | Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 800 | Vesiclepedia_1783 | 35932288 | Homo sapiens | Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 801 | Vesiclepedia_1402 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 802 | Vesiclepedia_2885 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 803 | Vesiclepedia_3360 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Breast cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 804 | Vesiclepedia_616 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 805 | Vesiclepedia_369 | 16212402 | Homo sapiens | The platelet microparticle proteome. | Platelets | Protein | - | Microparticles | EVs |
| 806 | Vesiclepedia_279 | 16192427 | Homo sapiens | Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 807 | Vesiclepedia_1919 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Lung cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 808 | Vesiclepedia_3430 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 809 | Vesiclepedia_970 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Serum | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 810 | Vesiclepedia_3098 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 811 | Vesiclepedia_925 | 25483805 | Homo sapiens | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 812 | Vesiclepedia_47 | 17641064 | Homo sapiens | Exosomes with immune modulatory features are present in human breast milk. | B cells | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 813 | Vesiclepedia_193 | 21575145 | Homo sapiens | Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants | Placenta | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 814 | Vesiclepedia_3180 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 815 | Vesiclepedia_486 | 23230278 | Homo sapiens | Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. | Colorectal cancer cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 816 | Vesiclepedia_181 | 20668554 | Homo sapiens | Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs | Mesenchymal stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 817 | Vesiclepedia_2633 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 818 | Vesiclepedia_1171 | 29881354 | Rattus norvegicus | Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content. | Serum |
Protein miRNA |
ExoQuick | Extracellular vesicles | EVs |
| 819 | Vesiclepedia_2392 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 820 | Vesiclepedia_1267 | 24218614 | Homo sapiens | Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 821 | Vesiclepedia_789 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 822 | Vesiclepedia_2621 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 823 | Vesiclepedia_829 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 824 | Vesiclepedia_987 | 25261472 | Homo sapiens | Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes/Microvesicles | EVs |
| 825 | Vesiclepedia_2535 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 826 | Vesiclepedia_2561 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 827 | Vesiclepedia_2851 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 828 | Vesiclepedia_3349 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Breast cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 829 | Vesiclepedia_3449 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 830 | Vesiclepedia_2418 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 831 | Vesiclepedia_2989 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 832 | Vesiclepedia_1984 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 833 | Vesiclepedia_2928 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 834 | Vesiclepedia_3351 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 835 | Vesiclepedia_161 | 21901833 | Drosophila melanogaster | Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells | Hematocytes |
Protein PTM Ubiquitination |
Differential centrifugation Sucrose density gradient Ultracentrifugation |
Microvesicles | EVs |
| 836 | Vesiclepedia_2211 | 37043568 | Bos taurus | Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 837 | Vesiclepedia_1238 | 25329303 | Homo sapiens | Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins. | Urine | Protein | Ultracentrifugation | Extracellular vesicles | EVs |
| 838 | Vesiclepedia_1923 | 36214496 | Mus musculus | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Motor neuron-like cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 839 | Vesiclepedia_2978 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Iodixanol density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 840 | Vesiclepedia_2704 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 841 | Vesiclepedia_1231 | 25503107 | Homo sapiens | Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN. | Breast cancer cells | Protein | Ultracentrifugation Filtration Density gradient centrifugation |
Microvesicles | EVs |
| 842 | Vesiclepedia_3059 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 843 | Vesiclepedia_1894 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 844 | Vesiclepedia_2672 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 845 | Vesiclepedia_3424 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 846 | Vesiclepedia_141 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 847 | Vesiclepedia_992 | 24434149 | Homo sapiens | In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome. | Ovarian cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 848 | Vesiclepedia_3065 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Serum | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 849 | Vesiclepedia_3345 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 850 | Vesiclepedia_1270 | 24218614 | Homo sapiens | Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 851 | Vesiclepedia_3125 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Kidney cells | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 852 | Vesiclepedia_244 | 22148876 | Homo sapiens | Proteomic analysis of microvesicles derived from human mesenchymal stem cells | Mesenchymal stem cells | Protein | Differential centrifugation Ultrafiltration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 853 | Vesiclepedia_623 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 854 | Vesiclepedia_2417 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 855 | Vesiclepedia_967 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Serum | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 856 | Vesiclepedia_956 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 857 | Vesiclepedia_512 | 23533145 | Homo sapiens | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. | Urine | Protein | - | Exosomes/Microvesicles | EVs |
| 858 | Vesiclepedia_2643 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Mammary epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 859 | Vesiclepedia_1285 | 21871517 | Burkholderia pseudomallei | A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection. | Burkholderia pseudomallei | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Outer membrane vesicles | EVs |
| 860 | Vesiclepedia_1726 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 861 | Vesiclepedia_2556 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 862 | Vesiclepedia_876 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 863 | Vesiclepedia_1392 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva | Protein | Differential centrifugation Tangential flow filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 864 | Vesiclepedia_2429 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 865 | Vesiclepedia_3498 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 866 | Vesiclepedia_1210 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 867 | Vesiclepedia_942 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 868 | Vesiclepedia_2805 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 869 | Vesiclepedia_1076 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 870 | Vesiclepedia_3254 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 871 | Vesiclepedia_1887 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 872 | Vesiclepedia_1314 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 873 | Vesiclepedia_2741 | 35173168 | Mus musculus | Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression | Serum |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 874 | Vesiclepedia_2563 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 875 | Vesiclepedia_1024 | 22327366 | Homo sapiens | Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. | Vascular endothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 876 | Vesiclepedia_100 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 877 | Vesiclepedia_3182 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 878 | Vesiclepedia_1065 | 29963299 | Homo sapiens | Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography. | Synovial fluid | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 879 | Vesiclepedia_773 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation | Apoptotic bodies | EVs |
| 880 | Vesiclepedia_990 | 25261472 | Homo sapiens | Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes/Microvesicles | EVs |
| 881 | Vesiclepedia_1363 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 882 | Vesiclepedia_24 | 11231627 | Homo sapiens | Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. | Melanoma cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 883 | Vesiclepedia_311 | 22148876 | Homo sapiens | Proteomic analysis of microvesicles derived from human mesenchymal stem cells | Mesenchymal stem cells | Protein | Differential centrifugation Ultrafiltration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 884 | Vesiclepedia_2511 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 885 | Vesiclepedia_1324 | 33431899 | Mus musculus | High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance | Faeces |
Protein Lipid miRNA |
Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 886 | Vesiclepedia_1511 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 887 | Vesiclepedia_1313 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 888 | Vesiclepedia_3036 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 889 | Vesiclepedia_742 | 28524762 | Rattus norvegicus | Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage | Mesenchymal stem cells | Protein | miRCURY Exosome Isolation Kit | Exosomes | EVs |
| 890 | Vesiclepedia_2290 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Acute lymphoblastic leukemia cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 891 | Vesiclepedia_857 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 892 | Vesiclepedia_217 | 21293856 | Homo sapiens | Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC | Serum | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 893 | Vesiclepedia_253 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | Leukemia cells | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 894 | Vesiclepedia_61 | 17133577 | Mus musculus | Association of citrullinated proteins with synovial exosomes. | Synovial fluid | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 895 | Vesiclepedia_1265 | 24310399 | Homo sapiens | Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. | Glioblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | EVs |
| 896 | Vesiclepedia_1886 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 897 | Vesiclepedia_2094 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 898 | Vesiclepedia_2550 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 899 | Vesiclepedia_3214 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanocytes | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 900 | Vesiclepedia_792 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 901 | Vesiclepedia_465 | 22909304 | Pseudomonas aeruginosa | Identification of proteins associated with the Pseudomonas aeruginosa biofilm extracellular matrix. | Pseudomonas aeruginosa | Protein | - | Membrane vesicles | EVs |
| 902 | Vesiclepedia_809 | 29932869 | Mus musculus | Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy | Schwann cells | protein | Filtration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 903 | Vesiclepedia_1966 | 35915084 | Mus musculus | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 904 | Vesiclepedia_108 | 21601258 | Homo sapiens | Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. | Ascites |
Protein miRNA |
Differential centrifugation Sucrose density gradient Immunobeads (EpCAM, CD24) |
Exosomes | EVs |
| 905 | Vesiclepedia_3002 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 906 | Vesiclepedia_3492 | 31278254 | Mus musculus | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 907 | Vesiclepedia_596 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 908 | Vesiclepedia_1129 | 23954818 | Homo sapiens | Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state. | Squamous carcinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 909 | Vesiclepedia_998 | 24355714 | Homo sapiens | Proteomic analysis and immune properties of exosomes released by macrophages infected with Mycobacterium avium. | Leukemia cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 910 | Vesiclepedia_381 | 18346024 | Homo sapiens | The proteome of red cell membranes and vesicles during storage in blood bank conditions. | Red blood cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 911 | Vesiclepedia_3150 | 29438363 | Homo sapiens | CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells | Fibroblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 912 | Vesiclepedia_764 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 913 | Vesiclepedia_2143 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 914 | Vesiclepedia_1933 | 36103526 | Homo sapiens | Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases | Hepatic stellate cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 915 | Vesiclepedia_2190 | 36592640 | Escherichia coli | Outer membrane vesicles from Escherichia coli are efficiently internalized by macrophage cells and alter their inflammatory response | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 916 | Vesiclepedia_2662 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 917 | Vesiclepedia_58 | 17700640 | Homo sapiens | CD24 is a marker of exosomes secreted into urine and amniotic fluid. | Amniotic fluid | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 918 | Vesiclepedia_20 | 17956143 | Homo sapiens | Proteomic analysis of microvesicles derived from human colorectal cancer cells. | Colorectal cancer cells | Protein | Differential centrifugation Sucrose density gradient Diafiltration |
Exosomes | EVs |
| 919 | Vesiclepedia_2945 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 920 | Vesiclepedia_3286 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 921 | Vesiclepedia_2863 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 922 | Vesiclepedia_376 | 18346024 | Homo sapiens | The proteome of red cell membranes and vesicles during storage in blood bank conditions. | Red blood cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 923 | Vesiclepedia_2126 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 924 | Vesiclepedia_2630 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 925 | Vesiclepedia_480 | 23161513 | Homo sapiens | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Colorectal cancer cells | Protein | - | Exosomes | EVs |
| 926 | Vesiclepedia_386 | 18563738 | Homo sapiens | Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. | Endothelial cells | Protein | - | Microparticles | EVs |
| 927 | Vesiclepedia_1796 | 36594832 | Mus musculus | Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia | Neuroblastoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 928 | Vesiclepedia_189 | 21741384 | Homo sapiens | A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma | Plasma | Protein | Differential centrifugation Filtration |
Exosomes | EVs |
| 929 | Vesiclepedia_1155 | 21212511 | Homo sapiens | Proteomic analysis of two types of exosomes in human whole saliva. | Saliva | Protein | Differential centrifugation Filtration Ultracentrifugation Gel filtration |
Exosomes | EVs |
| 930 | Vesiclepedia_243 | 22149170 | Homo sapiens | The Protein Interaction Network of Extracellular Vesicles Derived from Human Colorectal Cancer Cells | Colorectal cancer cells | Protein | Differential centrifugation Ultrafiltration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 931 | Vesiclepedia_2614 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 932 | Vesiclepedia_2904 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 933 | Vesiclepedia_2532 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 934 | Vesiclepedia_1574 | 33785738 | Homo sapiens | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Osteosarcoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 935 | Vesiclepedia_3105 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 936 | Vesiclepedia_33 | 21136642 | Mus musculus | Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons? | Oligodendrocytes | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 937 | Vesiclepedia_705 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles/Apoptotic bodies | EVs |
| 938 | Vesiclepedia_2635 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 939 | Vesiclepedia_3209 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 940 | Vesiclepedia_415 | 20687614 | Myxococcus xanthus | Profiling the outer membrane proteome during growth and development of the social bacterium Myxococcus xanthus by selective biotinylation and analyses of outer membrane vesicles. | Myxococcus xanthus | Protein | - | Membrane vesicles | EVs |
| 941 | Vesiclepedia_2101 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 942 | Vesiclepedia_353 | 24115447 | Homo sapiens | Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 943 | Vesiclepedia_806 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 944 | Vesiclepedia_1744 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 945 | Vesiclepedia_835 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 946 | Vesiclepedia_2992 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 947 | Vesiclepedia_586 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 948 | Vesiclepedia_1755 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 949 | Vesiclepedia_630 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 950 | Vesiclepedia_126 | - | Homo sapiens | Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy? | Mesenchymal stem cells | Protein | HPLC | Exosomes | EVs |
| 951 | Vesiclepedia_2269 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 952 | Vesiclepedia_1983 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 953 | Vesiclepedia_2931 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 954 | Vesiclepedia_1435 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 955 | Vesiclepedia_581 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 956 | Vesiclepedia_1633 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 957 | Vesiclepedia_1134 | 23861904 | Homo sapiens | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. | Placental mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration Density gradient centrifugation |
Exosomes | EVs |
| 958 | Vesiclepedia_1912 | 36270983 | Mus musculus | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer | Lung cancer cells | Protein | Centrifugation Exosome Isolation Reagent |
Exosomes | Small EVs |
| 959 | Vesiclepedia_419 | 21136642 | Mus musculus | Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons? | Oligodendrocytes | Protein | - | Exosomes | EVs |
| 960 | Vesiclepedia_2428 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 961 | Vesiclepedia_1757 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 962 | Vesiclepedia_885 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 963 | Vesiclepedia_2100 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 964 | Vesiclepedia_10 | 11390481 | Mus musculus | Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. | Dendritic cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 965 | Vesiclepedia_1383 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 966 | Vesiclepedia_3327 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 967 | Vesiclepedia_269 | 12757771 | Homo sapiens | Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis | Endothelial cells | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 968 | Vesiclepedia_3352 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 969 | Vesiclepedia_908 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer | Transitional carcinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 970 | Vesiclepedia_856 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 971 | Vesiclepedia_2939 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 972 | Vesiclepedia_952 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 973 | Vesiclepedia_3269 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 974 | Vesiclepedia_1194 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 975 | Vesiclepedia_134 | 15304316 | Rattus norvegicus | PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes | Basophilic leukemia cells |
Protein Lipids |
Differential centrifugation | Exosomes | EVs |
| 976 | Vesiclepedia_1033 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
qEV size-exclusion column | Extracellular vesicles | EVs |
| 977 | Vesiclepedia_549 | 24009881 | Homo sapiens | Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. | Colorectal cancer cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles/Ectosomes | EVs |
| 978 | Vesiclepedia_107 | 21763319 | Homo sapiens | Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation |
Exosomes | EVs |
| 979 | Vesiclepedia_3251 | 34545097 | Homo sapiens | Exosome-mediated stable epigenetic repression of HIV-1 | Embryonic kidney cells |
Protein mRNA |
Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 980 | Vesiclepedia_3503 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 981 | Vesiclepedia_45 | 18589210 | Homo sapiens | MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. | Serum |
Protein miRNA |
Ultracentrifugation Immunobeads (EpCAM) |
Exosomes | EVs |
| 982 | Vesiclepedia_664 | 29956871 | Homo sapiens | Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation Filtration |
Microvesicles | EVs |
| 983 | Vesiclepedia_1247 | 25167841 | Homo sapiens | Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes. | Serum | Protein | CD9 antibody to Mass Spectrometric Immunoassay monolith pipette tips | Exosomes | EVs |
| 984 | Vesiclepedia_2317 | 31762962 | Homo sapiens | Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers | Plasma |
Protein small RNA |
ExoQuick Kit | Extracellular vesicles/Exosomes | EVs |
| 985 | Vesiclepedia_1358 | 32438511 | Homo sapiens | Exosomes Derived from the Human Primary Colorectal Cancer Cell Line SW480 Orchestrate Fibroblast-Led Cancer Invasion | Colorectal cancer cells | Protein | Differential centrifugation Filtration OptiPrep density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 986 | Vesiclepedia_42 | 15908444 | Homo sapiens | Exosomal-like vesicles are present in human blood plasma. | Bone marrow cells | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 987 | Vesiclepedia_2132 | 36515353 | Homo sapiens | Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin | Plasma |
Metabolite Protein |
ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 988 | Vesiclepedia_3191 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 989 | Vesiclepedia_3041 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 990 | Vesiclepedia_36 | 19367702 | Mus musculus | Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes. | Hepatocytes | Protein | Differential centrifugation Filtration |
Exosomes | EVs |
| 991 | Vesiclepedia_3018 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 992 | Vesiclepedia_1380 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 993 | Vesiclepedia_380 | 18346024 | Homo sapiens | The proteome of red cell membranes and vesicles during storage in blood bank conditions. | Red blood cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 994 | Vesiclepedia_2876 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 995 | Vesiclepedia_2019 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation | Medium extracellular vesicles | Large EVs |
| 996 | Vesiclepedia_1545 | 33767144 | Homo sapiens | Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 997 | Vesiclepedia_307 | 16342139 | Homo sapiens | Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization | T cells | Protein | Differential centrifugation | Microparticles | EVs |
| 998 | Vesiclepedia_1543 | 33767144 | Homo sapiens | Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 999 | Vesiclepedia_2880 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1000 | Vesiclepedia_2934 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1001 | Vesiclepedia_3073 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1002 | Vesiclepedia_3529 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1003 | Vesiclepedia_1564 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1004 | Vesiclepedia_3137 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1005 | Vesiclepedia_225 | 10393703 | Homo sapiens | In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant | Plasma | Protein | Differential centrifugation | Microparticles | EVs |
| 1006 | Vesiclepedia_712 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Apoptotic bodies | EVs |
| 1007 | Vesiclepedia_3427 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1008 | Vesiclepedia_219 | 10694520 | Homo sapiens | Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes | Plasma | Protein | Immunoaffinity [Annexin-V] | Microparticles | EVs |
| 1009 | Vesiclepedia_2979 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1010 | Vesiclepedia_2276 | 29295981 | Homo sapiens | Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis | Plasma |
Protein miRNA |
Differential centrifugation Polyethylene glycol-based precipitation Centrifugation |
Exosomes | Small EVs |
| 1011 | Vesiclepedia_1651 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1012 | Vesiclepedia_576 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Breast cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1013 | Vesiclepedia_2166 | 35674493 | Aeromonas hydrophila | Quantitative Proteomics Reveals That the Protein Components of Outer Membrane Vesicles (OMVs) in Aeromonas hydrophila Play Protective Roles in Antibiotic Resistance | Aeromonas hydrophila | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1014 | Vesiclepedia_1711 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1015 | Vesiclepedia_1599 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 1016 | Vesiclepedia_934 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Bladder cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1017 | Vesiclepedia_213 | 21372807 | Rattus norvegicus | Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes | Adipocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 1018 | Vesiclepedia_2273 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 1019 | Vesiclepedia_3147 | 34497265 | Homo sapiens | Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1020 | Vesiclepedia_2583 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1021 | Vesiclepedia_3355 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Retinal endothelial cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 1022 | Vesiclepedia_2182 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1023 | Vesiclepedia_1842 | 36408942 | Homo sapiens | Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells | Mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1024 | Vesiclepedia_276 | 12021310 | Homo sapiens | Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1025 | Vesiclepedia_3179 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1026 | Vesiclepedia_787 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1027 | Vesiclepedia_2410 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Hepatocytes | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1028 | Vesiclepedia_2861 | 33579909 | Mus musculus | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1029 | Vesiclepedia_2165 | 34140472 | Ixodes scapularis | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Salivary glands | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1030 | Vesiclepedia_2128 | 36515353 | Homo sapiens | Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin | Plasma | Protein | ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 1031 | Vesiclepedia_2393 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1032 | Vesiclepedia_1891 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1033 | Vesiclepedia_2411 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Leukocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1034 | Vesiclepedia_556 | 24069378 | Homo sapiens | Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression. | Neuroblastoma cells | Protein | - | Exosomes/Membrane vesicles | EVs |
| 1035 | Vesiclepedia_3515 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1036 | Vesiclepedia_2235 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1037 | Vesiclepedia_1946 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1038 | Vesiclepedia_1039 | 27770278 | Homo sapiens | Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1039 | Vesiclepedia_2634 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1040 | Vesiclepedia_3368 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colon cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exosomes | Small EVs |
| 1041 | Vesiclepedia_2571 | 35689797 | Homo sapiens | Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations | Mammary epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1042 | Vesiclepedia_591 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1043 | Vesiclepedia_2360 | 36708245 | Homo sapiens | Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases | Blood |
Protein Lipid |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1044 | Vesiclepedia_3318 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1045 | Vesiclepedia_349 | 22285593 | Homo sapiens | Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1046 | Vesiclepedia_1063 | 30006486 | Homo sapiens | The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells. | Astrocytoma cells | Protein | Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1047 | Vesiclepedia_832 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 1048 | Vesiclepedia_2587 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1049 | Vesiclepedia_526 | 23660474 | Homo sapiens | Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. | Neutrophils | Protein | - | Microparticles | EVs |
| 1050 | Vesiclepedia_2814 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1051 | Vesiclepedia_3347 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation |
Non-vesicular nanoparticles | EV-like nanoparticles |
| 1052 | Vesiclepedia_1325 | 33431899 | Homo sapiens | High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance | Faeces |
Protein Lipid |
Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1053 | Vesiclepedia_1976 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1054 | Vesiclepedia_2963 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1055 | Vesiclepedia_315 | 15499615 | Homo sapiens | Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer | Lung cancer cells | Protein | Differential centrifugation FACS |
Microvesicles | EVs |
| 1056 | Vesiclepedia_1731 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1057 | Vesiclepedia_1146 | 23173708 | Rattus norvegicus | Wnt3a induces exosome secretion from primary cultured rat microglia. | Primary microglial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1058 | Vesiclepedia_1780 | 35932288 | Homo sapiens | Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1059 | Vesiclepedia_2059 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1060 | Vesiclepedia_3023 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1061 | Vesiclepedia_367 | 12746840 | Homo sapiens | Proteomic analysis of human prostasomes. | Seminal fluid | Protein | - | Prostasomes | EVs |
| 1062 | Vesiclepedia_2923 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1063 | Vesiclepedia_1249 | 24939845 | Homo sapiens | Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. | Leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1064 | Vesiclepedia_932 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Bladder cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1065 | Vesiclepedia_2259 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1066 | Vesiclepedia_1108 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1067 | Vesiclepedia_1883 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1068 | Vesiclepedia_502 | 23436686 | Homo sapiens | A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells. | Endothelial cells | Protein | - | Membrane vesicles/Extracellular vesicles | EVs |
| 1069 | Vesiclepedia_3399 | 31054213 | Homo sapiens | Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma | Cholangiocarcinoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1070 | Vesiclepedia_3342 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Plasma | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 1071 | Vesiclepedia_1565 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1072 | Vesiclepedia_1068 | 29937354 | Homo sapiens | Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. | Glioblastoma cells | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 1073 | Vesiclepedia_1493 | 33991177 | Homo sapiens | Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells | Gastric cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1074 | Vesiclepedia_2839 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1075 | Vesiclepedia_3255 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1076 | Vesiclepedia_3324 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1077 | Vesiclepedia_26 | 19109410 | Mus musculus | Proteomic and immunologic analyses of brain tumor exosomes. | Brain cancer cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1078 | Vesiclepedia_3452 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1079 | Vesiclepedia_2036 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1080 | Vesiclepedia_2977 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Iodixanol density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1081 | Vesiclepedia_169 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 1082 | Vesiclepedia_2797 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1083 | Vesiclepedia_377 | 18346024 | Homo sapiens | The proteome of red cell membranes and vesicles during storage in blood bank conditions. | Red blood cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 1084 | Vesiclepedia_2929 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1085 | Vesiclepedia_3108 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1086 | Vesiclepedia_303 | 19930720 | Homo sapiens | Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells | Colorectal cancer cells |
Protein mRNA |
Differential centrifugation Ultrafiltration OptiPrep density gradient |
Microvesicles | EVs |
| 1087 | Vesiclepedia_2682 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1088 | Vesiclepedia_2850 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1089 | Vesiclepedia_1544 | 33767144 | Homo sapiens | Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1090 | Vesiclepedia_37 | 10878338 | Homo sapiens | Direct immunosuppressive effects of EBV-encoded latent membrane protein 1. | B cells | Protein | Differential centrifugation | Exosomes | EVs |
| 1091 | Vesiclepedia_1730 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1092 | Vesiclepedia_305 | 17478559 | Rattus norvegicus | Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth 8-associated microvesicles | Adipocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 1093 | Vesiclepedia_2048 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Plasma | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1094 | Vesiclepedia_2644 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Mammary epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1095 | Vesiclepedia_3276 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1096 | Vesiclepedia_1042 | 27770278 | Homo sapiens | Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1097 | Vesiclepedia_299 | 12796750 | Homo sapiens | High levels of circulating endothelial microparticles in patients with acute coronary syndromes | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1098 | Vesiclepedia_2326 | 31807237 | Homo sapiens | Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1099 | Vesiclepedia_1165 | 29904572 | Bos taurus | A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk. | Bovine milk |
Protein miRNA |
Differential centrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1100 | Vesiclepedia_2855 | 33579909 | Homo sapiens | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1101 | Vesiclepedia_390 | 19158352 | Homo sapiens | Characterization of PKD protein-positive exosome-like vesicles. | Urine | Protein | - | Exosomes/Membrane particles | EVs |
| 1102 | Vesiclepedia_1120 | 24347249 | Homo sapiens | Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 1103 | Vesiclepedia_1855 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1104 | Vesiclepedia_2712 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Kidney cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1105 | Vesiclepedia_1007 | 23463506 | Mus musculus | The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. | T cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1106 | Vesiclepedia_1423 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1107 | Vesiclepedia_2030 | 35986010 | Homo sapiens | Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12 | Glial cells |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1108 | Vesiclepedia_1571 | 33738083 | Homo sapiens | Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1109 | Vesiclepedia_889 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1110 | Vesiclepedia_2778 | 35304471 | Homo sapiens | Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox | Bone | Protein | Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1111 | Vesiclepedia_605 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Leukemia cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1112 | Vesiclepedia_2699 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1113 | Vesiclepedia_2794 | 37309723 | Mus musculus | Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells | Colon cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1114 | Vesiclepedia_447 | 22444574 | Homo sapiens | Proteomic analysis of microvesicles in human saliva by gel electrophoresis with liquid chromatography-mass spectrometry. | Saliva | Protein | - | Exosomes/Microvesicles | EVs |
| 1115 | Vesiclepedia_2796 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1116 | Vesiclepedia_2877 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1117 | Vesiclepedia_597 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1118 | Vesiclepedia_3326 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1119 | Vesiclepedia_3268 | 34654817 | Rattus norvegicus | Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors | Plasma | Protein | ExoQuick Kit | Small extracellular vesicles | EVs |
| 1120 | Vesiclepedia_3417 | 33391636 | Homo sapiens | Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus | Embryonic kidney cells | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1121 | Vesiclepedia_2224 | 34596356 | Homo sapiens | Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer | Primary prostate stromal cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1122 | Vesiclepedia_949 | 28819550 | Mus musculus | Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses. | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1123 | Vesiclepedia_926 | 25483805 | Homo sapiens | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1124 | Vesiclepedia_2492 | 34370714 | Homo sapiens | MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression | Wound fluid |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1125 | Vesiclepedia_3000 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1126 | Vesiclepedia_913 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1127 | Vesiclepedia_1648 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1128 | Vesiclepedia_1575 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1129 | Vesiclepedia_1051 | 29115712 | Mus musculus | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1130 | Vesiclepedia_2005 | 34112803 | Mus musculus | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 1131 | Vesiclepedia_2618 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1132 | Vesiclepedia_1729 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1133 | Vesiclepedia_893 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1134 | Vesiclepedia_1863 | 35931686 | Homo sapiens | Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression | Chondrocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1135 | Vesiclepedia_2853 | 33579909 | Homo sapiens | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1136 | Vesiclepedia_1361 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Large EVs |
| 1137 | Vesiclepedia_2247 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1138 | Vesiclepedia_3485 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1139 | Vesiclepedia_1877 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1140 | Vesiclepedia_2223 | 34596356 | Homo sapiens | Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer | Primary prostate stromal cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1141 | Vesiclepedia_1138 | 23707955 | Homo sapiens | Prostasomes from four different species are able to produce extracellular adenosine triphosphate (ATP). | Seminal plasma | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Prostasomes | EVs |
| 1142 | Vesiclepedia_3353 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1143 | Vesiclepedia_292 | 10415024 | Homo sapiens | Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles | T cells | Protein | Differential centrifugation Ultracentrifugation FACS |
Microvesicles | EVs |
| 1144 | Vesiclepedia_2033 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1145 | Vesiclepedia_2999 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1146 | Vesiclepedia_1674 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1147 | Vesiclepedia_1742 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1148 | Vesiclepedia_1473 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1149 | Vesiclepedia_16 | 9685355 | Homo sapiens | Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. | B cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1150 | Vesiclepedia_1987 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1151 | Vesiclepedia_882 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1152 | Vesiclepedia_2146 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1153 | Vesiclepedia_202 | 21601655 | Homo sapiens | Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis | Placenta | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1154 | Vesiclepedia_1787 | 36594832 | Mus musculus | Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia | Primary cortical neurons |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1155 | Vesiclepedia_2270 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 1156 | Vesiclepedia_290 | 12196479 | Homo sapiens | Type 1 and type 2 diabetic patients display different patterns of cellular microparticles | Plasma |
Protein Lipids |
Differential centrifugation FACS |
Microparticles | EVs |
| 1157 | Vesiclepedia_388 | 18570454 | Homo sapiens | Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. | Neural stem cells | Protein | - | Exosomes/Membrane vesicles | EVs |
| 1158 | Vesiclepedia_1900 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1159 | Vesiclepedia_1737 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1160 | Vesiclepedia_3321 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1161 | Vesiclepedia_1934 | 36103526 | Homo sapiens | Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases | Hepatic stellate cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1162 | Vesiclepedia_840 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1163 | Vesiclepedia_3393 | 31827089 | Lactobacillus gasseri | Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues | Lactobacillus gasseri |
Protein Metabolite |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1164 | Vesiclepedia_260 | 10888925 | Homo sapiens | Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection | Mononuclear cells | Protein | Differential centrifugation Filtration |
Microparticles | EVs |
| 1165 | Vesiclepedia_3170 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1166 | Vesiclepedia_1625 | 34012515 | Homo sapiens | CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells | Melanoma cells | Protein | Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1167 | Vesiclepedia_1686 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography |
Exosomes | Small EVs |
| 1168 | Vesiclepedia_2482 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1169 | Vesiclepedia_2088 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1170 | Vesiclepedia_2831 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1171 | Vesiclepedia_1029 | 26378940 | Homo sapiens | Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1172 | Vesiclepedia_3057 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1173 | Vesiclepedia_3361 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Breast cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1174 | Vesiclepedia_3350 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Breast cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1175 | Vesiclepedia_507 | 23511837 | Homo sapiens | Differential protein profiling of renal cell carcinoma urinary exosomes. | Urine | Protein | - | Exosomes/Nanovesicles | EVs |
| 1176 | Vesiclepedia_1988 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1177 | Vesiclepedia_945 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1178 | Vesiclepedia_2916 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1179 | Vesiclepedia_1634 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1180 | Vesiclepedia_2325 | 31807237 | Homo sapiens | Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1181 | Vesiclepedia_3211 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1182 | Vesiclepedia_3295 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1183 | Vesiclepedia_2272 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 1184 | Vesiclepedia_3338 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 1185 | Vesiclepedia_3135 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1186 | Vesiclepedia_2170 | 29643357 | Staphylococcus aureus | Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform | Staphylococcus aureus | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1187 | Vesiclepedia_3363 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 1188 | Vesiclepedia_3099 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1189 | Vesiclepedia_2485 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1190 | Vesiclepedia_2422 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1191 | Vesiclepedia_2921 | 33661579 | Homo sapiens | Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size | T lymphoblast | Protein | Differential centrifugation | Apoptotic bodies | Large EVs |
| 1192 | Vesiclepedia_2761 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 1193 | Vesiclepedia_3174 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1194 | Vesiclepedia_258 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | Leukemia cells | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 1195 | Vesiclepedia_1106 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1196 | Vesiclepedia_275 | 12021310 | Homo sapiens | Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1197 | Vesiclepedia_3266 | 34654817 | Rattus norvegicus | Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1198 | Vesiclepedia_2534 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 1199 | Vesiclepedia_146 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 1200 | Vesiclepedia_2082 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1201 | Vesiclepedia_2531 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 1202 | Vesiclepedia_2356 | 36708245 | Homo sapiens | Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases | Faeces |
Protein Lipid |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1203 | Vesiclepedia_2292 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Breast cancer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 1204 | Vesiclepedia_298 | 12796750 | Homo sapiens | High levels of circulating endothelial microparticles in patients with acute coronary syndromes | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1205 | Vesiclepedia_3044 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 1206 | Vesiclepedia_2076 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1207 | Vesiclepedia_751 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1208 | Vesiclepedia_2161 | 34140472 | Ixodes scapularis | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Ixodes scapularis | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1209 | Vesiclepedia_1043 | 27770278 | Homo sapiens | Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1210 | Vesiclepedia_2513 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | exoEasy Maxi Kit | Extracellular vesicles | EVs |
| 1211 | Vesiclepedia_3172 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1212 | Vesiclepedia_2245 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1213 | Vesiclepedia_1207 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1214 | Vesiclepedia_151 | 22075275 | Homo sapiens | Methodology for isolation, identification and characterization of microvesicles in peripheral blood | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 1215 | Vesiclepedia_1675 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1216 | Vesiclepedia_3210 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1217 | Vesiclepedia_2679 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1218 | Vesiclepedia_1754 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1219 | Vesiclepedia_1638 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1220 | Vesiclepedia_2062 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1221 | Vesiclepedia_1026 | 22327366 | Homo sapiens | Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. | Vascular endothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1222 | Vesiclepedia_2362 | 36748335 | Homo sapiens | Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α | Oral cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1223 | Vesiclepedia_347 | 22285593 | Homo sapiens | Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1224 | Vesiclepedia_95 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1225 | Vesiclepedia_2236 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1226 | Vesiclepedia_1119 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1227 | Vesiclepedia_2804 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1228 | Vesiclepedia_2925 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1229 | Vesiclepedia_1107 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1230 | Vesiclepedia_3201 | 36754903 | Mus musculus | An extracellular vesicular mutant KRAS-associated protein complex promotes lung inflammation and tumor growth | Lung epithelial cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1231 | Vesiclepedia_438 | 22114730 | Staphylococcus aureus | Staphylococcus aureus produces membrane-derived vesicles that induce host cell death. | Staphylococcus aureus | Protein | - | Membrane vesicles/Nanovesicles | EVs |
| 1232 | Vesiclepedia_3223 | 32111843 | Homo sapiens | A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA | Breast cancer cells | Protein | Differential centrifugation Tangential flow filtration Filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1233 | Vesiclepedia_2267 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1234 | Vesiclepedia_5 | 11145662 | Mus musculus | Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. | Mast cells | Protein | Differential centrifugation | Exosomes | EVs |
| 1235 | Vesiclepedia_2601 | 35351860 | Homo sapiens | Bone marrow mesenchymal stem cell-derived exosomal microRNA-381-3p alleviates vascular calcification in chronic kidney disease by targeting NFAT5 | Bone marrow mesenchymal stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1236 | Vesiclepedia_1614 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 1237 | Vesiclepedia_2359 | 36708245 | Homo sapiens | Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases | Blood |
Protein Lipid |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1238 | Vesiclepedia_752 | 29963269 | Homo sapiens | Mining of potential microRNAs with clinical correlation - regulation of syndecan-1 expression by miR-122-5p altered mobility of breast cancer cells and possible correlation with liver injury | Hepatoma cells | Protein | Total Exosome Isolation Kit Differential centrifugation |
Exosomes | EVs |
| 1239 | Vesiclepedia_2652 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1240 | Vesiclepedia_3488 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1241 | Vesiclepedia_3140 | 34497265 | Homo sapiens | Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer | Plasma |
Protein miRNA |
ExoQuick Kit | Exosomes | EVs |
| 1242 | Vesiclepedia_3104 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1243 | Vesiclepedia_2002 | 34112803 | Homo sapiens | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Plasma | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 1244 | Vesiclepedia_598 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1245 | Vesiclepedia_1502 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum |
Protein miRNA |
ExoQuick Kit | Extracellular vesicles | Small EVs |
| 1246 | Vesiclepedia_1287 | 20880880 | Homo sapiens | Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1247 | Vesiclepedia_401 | 19548909 | Homo sapiens | Differential stimulation of monocytic cells results in distinct populations of microparticles. | Monocytes | Protein | - | Microparticles | EVs |
| 1248 | Vesiclepedia_1053 | 29115712 | Mus musculus | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1249 | Vesiclepedia_229 | 2942561 | Homo sapiens | Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery | Plasma | Protein | Differential centrifugation | Microparticles | EVs |
| 1250 | Vesiclepedia_172 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 1251 | Vesiclepedia_218 | 10694520 | Homo sapiens | Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes | Plasma | Protein | Immunoaffinity [Annexin-V] | Microparticles | EVs |
| 1252 | Vesiclepedia_566 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (Igg1 PD) |
Extracellular vesicles | EVs |
| 1253 | Vesiclepedia_2022 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation | Medium extracellular vesicles | Large EVs |
| 1254 | Vesiclepedia_1382 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1255 | Vesiclepedia_392 | 19351151 | Mus musculus | Characterization of vesicles secreted from insulinoma NIT-1 cells. | Pancreatic cells | Protein | - | Exosomes | EVs |
| 1256 | Vesiclepedia_2425 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1257 | Vesiclepedia_2553 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1258 | Vesiclepedia_3491 | 31278254 | Mus musculus | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1259 | Vesiclepedia_3213 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1260 | Vesiclepedia_733 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 1261 | Vesiclepedia_1549 | 33638284 | Canis lupus familiaris | Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial-mesenchymal transition | Kidney cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1262 | Vesiclepedia_903 | 25053844 | Homo sapiens | Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons | Neuroblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 1263 | Vesiclepedia_1710 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1264 | Vesiclepedia_2122 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1265 | Vesiclepedia_1850 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1266 | Vesiclepedia_1673 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1267 | Vesiclepedia_1122 | 24347249 | Homo sapiens | Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 1268 | Vesiclepedia_1093 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 1269 | Vesiclepedia_714 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 1270 | Vesiclepedia_1045 | 28725021 | Bos taurus | Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1271 | Vesiclepedia_1902 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1272 | Vesiclepedia_1920 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Glioma cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1273 | Vesiclepedia_2612 | 35443745 | Homo sapiens | Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts | Colorectal cancer cells |
Protein miRNA |
Ultracentrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 1274 | Vesiclepedia_1187 | 28326167 | Homo sapiens | Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment. | Urine | Protein | Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1275 | Vesiclepedia_1760 | 35918900 | Homo sapiens | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1276 | Vesiclepedia_774 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation | Apoptotic bodies | EVs |
| 1277 | Vesiclepedia_1189 | 28326167 | Homo sapiens | Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment. | Urine | Protein | Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1278 | Vesiclepedia_1125 | 24347249 | Homo sapiens | Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 1279 | Vesiclepedia_498 | 23376485 | Homo sapiens | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. | Urine | Protein | - | Exosomes/Membrane vesicles | EVs |
| 1280 | Vesiclepedia_1193 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1281 | Vesiclepedia_1613 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 1282 | Vesiclepedia_1139 | 23707955 | Bos taurus | Prostasomes from four different species are able to produce extracellular adenosine triphosphate (ATP). | Seminal plasma | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Prostasomes | EVs |
| 1283 | Vesiclepedia_1881 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1284 | Vesiclepedia_1246 | 25167841 | Homo sapiens | Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes. | Serum | Protein | CD9 antibody to Mass Spectrometric Immunoassay monolith pipette tips | Exosomes | EVs |
| 1285 | Vesiclepedia_473 | 23056467 | Homo sapiens | Cause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy. | Plasma | Protein | - | Microparticles | EVs |
| 1286 | Vesiclepedia_1035 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
Exo-spin | Extracellular vesicles | EVs |
| 1287 | Vesiclepedia_2208 | 36013250 | Escherichia coli | Proteomic Profiling of Outer Membrane Vesicles Released by Escherichia coli LPS Mutants Defective in Heptose Biosynthesis | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1288 | Vesiclepedia_686 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 1289 | Vesiclepedia_709 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Apoptotic bodies | EVs |
| 1290 | Vesiclepedia_2995 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1291 | Vesiclepedia_1504 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1292 | Vesiclepedia_2701 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1293 | Vesiclepedia_2377 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1294 | Vesiclepedia_2830 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1295 | Vesiclepedia_1950 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1296 | Vesiclepedia_2441 | 36591510 | Homo sapiens | Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1297 | Vesiclepedia_2522 | 34315885 | Mus musculus | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Kidney epithelial cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1298 | Vesiclepedia_963 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1299 | Vesiclepedia_1746 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1300 | Vesiclepedia_2769 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Membrane affinity purification |
Exosomes | Small EVs |
| 1301 | Vesiclepedia_2198 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1302 | Vesiclepedia_2424 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1303 | Vesiclepedia_91 | 21252909 | Homo sapiens | Diacylglycerol kinase a regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes | T cells |
Protein Lipids |
Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1304 | Vesiclepedia_488 | 23230278 | Homo sapiens | Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. | Colorectal cancer cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 1305 | Vesiclepedia_971 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 1306 | Vesiclepedia_2116 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 1307 | Vesiclepedia_2045 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1308 | Vesiclepedia_2502 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | ExoQuick Kit | Extracellular vesicles | EVs |
| 1309 | Vesiclepedia_3520 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1310 | Vesiclepedia_2540 | 34293122 | Mus musculus | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets |
Protein Lipid |
Centrifugation | Extracellular vesicles | Large EVs |
| 1311 | Vesiclepedia_960 | 26047123 | Bos taurus | Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Filtration |
Extracellular vesicles | EVs |
| 1312 | Vesiclepedia_534 | 23818640 | Homo sapiens | Modulation of B-cell exosome proteins by gamma herpesvirus infection. | B cells | Protein | - | Exosomes/Microvesicles/Oncosomes/Microparticles | EVs |
| 1313 | Vesiclepedia_2537 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 1314 | Vesiclepedia_1951 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1315 | Vesiclepedia_2944 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1316 | Vesiclepedia_2914 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1317 | Vesiclepedia_2138 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Serum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1318 | Vesiclepedia_2935 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1319 | Vesiclepedia_1974 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1320 | Vesiclepedia_2781 | 35304471 | Mus musculus | Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox | Bone | Protein | Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1321 | Vesiclepedia_2772 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Saliva | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 1322 | Vesiclepedia_99 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1323 | Vesiclepedia_378 | 18346024 | Homo sapiens | The proteome of red cell membranes and vesicles during storage in blood bank conditions. | Red blood cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 1324 | Vesiclepedia_3334 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Lung cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1325 | Vesiclepedia_1743 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1326 | Vesiclepedia_3402 | 31054213 | Homo sapiens | Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma | Cholangiocarcinoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1327 | Vesiclepedia_2231 | 36648227 | Mus musculus | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1328 | Vesiclepedia_1703 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1329 | Vesiclepedia_3440 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1330 | Vesiclepedia_606 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Leukemia cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1331 | Vesiclepedia_138 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 1332 | Vesiclepedia_681 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 1333 | Vesiclepedia_2573 | 35689797 | Homo sapiens | Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations | Mammary epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1334 | Vesiclepedia_2381 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1335 | Vesiclepedia_737 | 25220352 | Mus musculus | Surface functionalization of exosomes using click chemistry. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1336 | Vesiclepedia_2913 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1337 | Vesiclepedia_878 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1338 | Vesiclepedia_2823 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1339 | Vesiclepedia_1672 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1340 | Vesiclepedia_1861 | 35931686 | Homo sapiens | Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression | Chondrocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1341 | Vesiclepedia_776 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 1342 | Vesiclepedia_25 | 15111327 | Homo sapiens | Proteomic analysis of exosomes secreted by human mesothelioma cells. | Mesothelioma cells | Protein | Differential centrifugation | Exosomes | EVs |
| 1343 | Vesiclepedia_2865 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1344 | Vesiclepedia_2857 | 33579909 | Mus musculus | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1345 | Vesiclepedia_2015 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Centrifugation | Large extracellular vesicles | Large EVs |
| 1346 | Vesiclepedia_1456 | 31969559 | Homo sapiens | Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1347 | Vesiclepedia_1480 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1348 | Vesiclepedia_1074 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 1349 | Vesiclepedia_3258 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1350 | Vesiclepedia_2765 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Tangential flow filtration | Exosomes | Small EVs |
| 1351 | Vesiclepedia_917 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1352 | Vesiclepedia_2762 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 1353 | Vesiclepedia_449 | 22448133 | Pseudomonas aeruginosa | Vesiculation from Pseudomonas aeruginosa under SOS. | Pseudomonas aeruginosa | Protein | - | Membrane vesicles | EVs |
| 1354 | Vesiclepedia_104 | 21763319 | Homo sapiens | Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation |
Exosomes | EVs |
| 1355 | Vesiclepedia_3494 | 31278254 | Mus musculus | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1356 | Vesiclepedia_3332 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Lung cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1357 | Vesiclepedia_3088 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1358 | Vesiclepedia_1865 | 35931686 | Homo sapiens | Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression | Chondrocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1359 | Vesiclepedia_3516 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1360 | Vesiclepedia_2187 | 33792189 | Mus musculus | A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions | Epididymal epithelial cells | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1361 | Vesiclepedia_111 | 21601258 | Homo sapiens | Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. | Serum |
Protein miRNA |
Differential centrifugation Sucrose density gradient Immunobeads (CD24) |
Exosomes | EVs |
| 1362 | Vesiclepedia_851 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1363 | Vesiclepedia_2994 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1364 | Vesiclepedia_777 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1365 | Vesiclepedia_652 | 28290293 | Homo sapiens | Comparative proteomic analysis of milk-derived exosomes in human and bovine colostrum and mature milk samples by iTRAQ-coupled LC-MS/MS. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 1366 | Vesiclepedia_3531 | 30936474 | Homo sapiens | Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells | Macrophage |
Protein lncRNA |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1367 | Vesiclepedia_868 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 1368 | Vesiclepedia_3126 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Kidney cells | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1369 | Vesiclepedia_981 | 25458527 | Homo sapiens | Benchtop isolation and characterization of functional exosomes by sequential filtration | Breast cancer cells | Protein | Sequential filtration | Exosomes | EVs |
| 1370 | Vesiclepedia_1804 | 35917363 | Homo sapiens | CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1371 | Vesiclepedia_1229 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 1372 | Vesiclepedia_2523 | 34315885 | Homo sapiens | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Urine | Protein | Centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1373 | Vesiclepedia_1640 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1374 | Vesiclepedia_237 | 21293856 | Homo sapiens | Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC | Melanoma cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 1375 | Vesiclepedia_726 | 25471207 | Homo sapiens | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | Urine | Protein | Differential centrifugation Hydrostatic filtration dialysis Ultrafiltration |
Exosomes | EVs |
| 1376 | Vesiclepedia_426 | 21386968 | Acinetobacter baumannii | Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles. | Acinetobacter baumannii | Protein | - | Membrane vesicles | EVs |
| 1377 | Vesiclepedia_951 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1378 | Vesiclepedia_1805 | 36517516 | Homo sapiens | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes | Serum |
Protein miRNA |
ExoQuick Kit | Exosomes | Small EVs |
| 1379 | Vesiclepedia_3204 | 34596354 | Homo sapiens | Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p | Mesenchymal stem cells | Protein | Tangential flow filtration | Extracellular vesicles | Small EVs |
| 1380 | Vesiclepedia_2539 | 34293122 | Mus musculus | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 1381 | Vesiclepedia_2167 | 35674493 | Aeromonas hydrophila | Quantitative Proteomics Reveals That the Protein Components of Outer Membrane Vesicles (OMVs) in Aeromonas hydrophila Play Protective Roles in Antibiotic Resistance | Aeromonas hydrophila | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1382 | Vesiclepedia_833 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 1383 | Vesiclepedia_81 | 20458337 | Homo sapiens | MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3 | B cells | Protein | Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) |
Exosomes | EVs |
| 1384 | Vesiclepedia_2675 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1385 | Vesiclepedia_858 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1386 | Vesiclepedia_2147 | 35605283 | Escherichia coli | Phytochemical Engineered Bacterial Outer Membrane Vesicles for Photodynamic Effects Promoted Immunotherapy | Escherichia coli | Protein | Centrifugation Centrifugal ultrafiltration Filtration Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1387 | Vesiclepedia_2827 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1388 | Vesiclepedia_3005 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1389 | Vesiclepedia_3304 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1390 | Vesiclepedia_2261 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1391 | Vesiclepedia_3436 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1392 | Vesiclepedia_634 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Prostate cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1393 | Vesiclepedia_3146 | 34497265 | Homo sapiens | Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1394 | Vesiclepedia_1419 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1395 | Vesiclepedia_354 | 24115447 | Homo sapiens | Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1396 | Vesiclepedia_293 | 10415024 | Homo sapiens | Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles | T cells | Protein | Differential centrifugation Ultracentrifugation FACS |
Microvesicles | EVs |
| 1397 | Vesiclepedia_958 | 26196085 | Homo sapiens | Identification of prostate cancer biomarkers in urinary exosomes. | Urine | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 1398 | Vesiclepedia_3004 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1399 | Vesiclepedia_3323 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1400 | Vesiclepedia_1274 | 23807490 | Homo sapiens | Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. | Glioblastoma cells |
Protein miRNA |
Differential centrifugation | Microvesicles | EVs |
| 1401 | Vesiclepedia_2982 | 30089911 | Mus musculus | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1402 | Vesiclepedia_1331 | 33431899 | Mus musculus | High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1403 | Vesiclepedia_944 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1404 | Vesiclepedia_1282 | 22345510 | Rattus norvegicus | Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. | Insulinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1405 | Vesiclepedia_2569 | 35260554 | Homo sapiens | Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis | Gastric cancer cells | Protein | Centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1406 | Vesiclepedia_825 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 1407 | Vesiclepedia_2061 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1408 | Vesiclepedia_3475 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Cystic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1409 | Vesiclepedia_1776 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1410 | Vesiclepedia_2024 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Osteosarcoma cells | Protein | Centrifugation | Large extracellular vesicles | Large EVs |
| 1411 | Vesiclepedia_389 | 18819103 | Homo sapiens | Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen. | Seminal fluid | Protein | - | Exosomes/Prostasomes | EVs |
| 1412 | Vesiclepedia_739 | 25157233 | Homo sapiens | Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration. | Placenta | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1413 | Vesiclepedia_759 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1414 | Vesiclepedia_264 | 18425114 | Homo sapiens | Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | Epidermoid cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1415 | Vesiclepedia_1088 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 1416 | Vesiclepedia_2693 | 35210436 | Homo sapiens | M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway | Macrophage |
Protein mRNA |
Total Exosome Isolation Reagent | Exosomes | Small EVs |
| 1417 | Vesiclepedia_1848 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1418 | Vesiclepedia_3308 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1419 | Vesiclepedia_2580 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1420 | Vesiclepedia_3216 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1421 | Vesiclepedia_968 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Serum | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1422 | Vesiclepedia_1095 | 24976626 | Homo sapiens | Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. | Renal proximal tubule cells | Protein | Differential centrifugation Ultracentrifugation Immunoaffinity |
Exosomes | EVs |
| 1423 | Vesiclepedia_2135 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Serum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1424 | Vesiclepedia_2507 | 34322206 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | MagCapture Exosome Isolation Kit PS | Extracellular vesicles | EVs |
| 1425 | Vesiclepedia_2671 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1426 | Vesiclepedia_2955 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1427 | Vesiclepedia_946 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1428 | Vesiclepedia_2227 | 32494663 | Homo sapiens | miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1 | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1429 | Vesiclepedia_1561 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1430 | Vesiclepedia_890 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1431 | Vesiclepedia_2685 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic duct epithelial cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 1432 | Vesiclepedia_1708 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1433 | Vesiclepedia_286 | 12417540 | Homo sapiens | Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1434 | Vesiclepedia_1252 | 24939845 | Homo sapiens | Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1435 | Vesiclepedia_793 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1436 | Vesiclepedia_3272 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 1437 | Vesiclepedia_1408 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1438 | Vesiclepedia_1732 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1439 | Vesiclepedia_2154 | 30488570 | Helicobacter pylori | Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles | Helicobacter pylori | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 1440 | Vesiclepedia_1142 | 23454749 | Homo sapiens | BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. | Bone marrow mesenchymal stromal cells | Protein | Differential centrifugation Ultracentrifugation Filtration ExoQuick |
Exosomes | EVs |
| 1441 | Vesiclepedia_1066 | 29963299 | Homo sapiens | Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography. | Synovial fluid | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 1442 | Vesiclepedia_595 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1443 | Vesiclepedia_622 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1444 | Vesiclepedia_2519 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1445 | Vesiclepedia_2220 | 31493501 | Klebsiella pneumoniae | Isolation, characterization and analysis of pro-inflammatory potential of Klebsiella pneumoniae outer membrane vesicles | Klebsiella pneumoniae | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1446 | Vesiclepedia_1782 | 35932288 | Homo sapiens | Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1447 | Vesiclepedia_1011 | 23185418 | Homo sapiens | Improved flow cytometric assessment reveals distinct microvesicle (cell-derived microparticle) signatures in joint diseases. | Synovial fluid | Protein | Filtration Ultracentrifugation |
Microvesicles | EVs |
| 1448 | Vesiclepedia_613 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1449 | Vesiclepedia_1550 | 33638284 | Canis lupus familiaris | Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial-mesenchymal transition | Kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1450 | Vesiclepedia_1596 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 1451 | Vesiclepedia_2200 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1452 | Vesiclepedia_2622 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1453 | Vesiclepedia_1716 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1454 | Vesiclepedia_2655 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1455 | Vesiclepedia_1956 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1456 | Vesiclepedia_1232 | 25475747 | Homo sapiens | Identification of Biomarkers for PKD1 Using Urinary Exosomes | Urine | Protein | Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1457 | Vesiclepedia_28 | 19109410 | Homo sapiens | Proteomic and immunologic analyses of brain tumor exosomes. | Glioma cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1458 | Vesiclepedia_2476 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1459 | Vesiclepedia_1682 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1460 | Vesiclepedia_698 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1461 | Vesiclepedia_2549 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1462 | Vesiclepedia_1994 | 34188787 | Mus musculus | Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation | Epididymal epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1463 | Vesiclepedia_2092 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1464 | Vesiclepedia_1173 | 29881354 | Rattus norvegicus | Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content. | Serum |
Protein miRNA |
ExoQuick | Extracellular vesicles | EVs |
| 1465 | Vesiclepedia_2984 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1466 | Vesiclepedia_2327 | 31807237 | Homo sapiens | Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1467 | Vesiclepedia_1843 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Normal colon fibroblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1468 | Vesiclepedia_1781 | 35932288 | Homo sapiens | Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1469 | Vesiclepedia_2918 | 33661579 | Homo sapiens | Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size | T lymphoblast | Protein | Differential centrifugation | Apoptotic bodies | Large EVs |
| 1470 | Vesiclepedia_3001 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1471 | Vesiclepedia_2249 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1472 | Vesiclepedia_1303 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1473 | Vesiclepedia_1655 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Glioblastoma cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1474 | Vesiclepedia_1506 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1475 | Vesiclepedia_1027 | 24211404 | Homo sapiens | Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis. | Urine | Protein | Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 1476 | Vesiclepedia_794 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1477 | Vesiclepedia_3070 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1478 | Vesiclepedia_1872 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Plasma | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1479 | Vesiclepedia_1172 | 29881354 | Rattus norvegicus | Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content. | Serum |
Protein miRNA |
ExoQuick | Extracellular vesicles | EVs |
| 1480 | Vesiclepedia_804 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1481 | Vesiclepedia_2674 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1482 | Vesiclepedia_2678 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1483 | Vesiclepedia_1385 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1484 | Vesiclepedia_587 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1485 | Vesiclepedia_2541 | 34293122 | Mus musculus | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets |
Protein Lipid |
Centrifugation | Extracellular vesicles | Large EVs |
| 1486 | Vesiclepedia_1631 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1487 | Vesiclepedia_3435 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1488 | Vesiclepedia_1023 | 22327366 | Homo sapiens | Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. | Vascular endothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1489 | Vesiclepedia_2073 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1490 | Vesiclepedia_1056 | 30035390 | Mus musculus | Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. | Mouse embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1491 | Vesiclepedia_254 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | Leukemia cells | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 1492 | Vesiclepedia_1725 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1493 | Vesiclepedia_1704 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1494 | Vesiclepedia_813 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 1495 | Vesiclepedia_2318 | 31762962 | Homo sapiens | Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers | Plasma |
Protein small RNA |
ExoQuick Kit | Extracellular vesicles/Exosomes | EVs |
| 1496 | Vesiclepedia_798 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1497 | Vesiclepedia_1312 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1498 | Vesiclepedia_2562 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1499 | Vesiclepedia_382 | 18373357 | Homo sapiens | Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. | Urine | Protein | - | Microparticles | EVs |
| 1500 | Vesiclepedia_1851 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1501 | Vesiclepedia_1250 | 24939845 | Homo sapiens | Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. | Leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1502 | Vesiclepedia_1993 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1503 | Vesiclepedia_2903 | 33732415 | Mus musculus | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Lung cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1504 | Vesiclepedia_633 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Prostate cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1505 | Vesiclepedia_2579 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1506 | Vesiclepedia_3166 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1507 | Vesiclepedia_501 | 23410224 | Neisseria meningitidis | Quantitative proteomics reveals distinct differences in the protein content of outer membrane vesicle vaccines. | Neisseria meningitidis | Protein | - | Membrane vesicles | EVs |
| 1508 | Vesiclepedia_1111 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1509 | Vesiclepedia_1661 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic duct epithelial cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1510 | Vesiclepedia_731 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 1511 | Vesiclepedia_32 | 18452139 | Homo sapiens | Primary human keratinocytes externalize stratifin protein via exosomes. | Keratinocytes | Protein | Differential centrifugation Sucrose density gradient Diafiltration |
Exosomes | EVs |
| 1512 | Vesiclepedia_1735 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1513 | Vesiclepedia_1100 | 24513287 | Mus musculus | Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. | adipocytes | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 1514 | Vesiclepedia_2557 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1515 | Vesiclepedia_770 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1516 | Vesiclepedia_2874 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1517 | Vesiclepedia_3060 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic duct epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1518 | Vesiclepedia_1030 | 26378940 | Homo sapiens | Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1519 | Vesiclepedia_1248 | 24939845 | Homo sapiens | Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. | Leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1520 | Vesiclepedia_802 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1521 | Vesiclepedia_839 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1522 | Vesiclepedia_899 | 26100252 | Homo sapiens | Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts | Chronic lymphocytic leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1523 | Vesiclepedia_154 | 21966536 | Mus musculus | Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide | Plasma | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 1524 | Vesiclepedia_786 | 29953723 | Oncorhynchus tshawytscha | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1525 | Vesiclepedia_3171 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1526 | Vesiclepedia_1128 | 23954818 | Homo sapiens | Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state. | Squamous carcinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1527 | Vesiclepedia_2031 | 36123372 | Homo sapiens | Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells | Umbilical vein endothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1528 | Vesiclepedia_1997 | 34112803 | Mus musculus | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 1529 | Vesiclepedia_1995 | 34188787 | Mus musculus | Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation | Epididymal epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1530 | Vesiclepedia_3093 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1531 | Vesiclepedia_861 | 25776846 | Homo sapiens | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens | Epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1532 | Vesiclepedia_924 | 25483805 | Homo sapiens | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1533 | Vesiclepedia_57 | 17700640 | Homo sapiens | CD24 is a marker of exosomes secreted into urine and amniotic fluid. | Urine | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1534 | Vesiclepedia_2271 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 1535 | Vesiclepedia_3089 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1536 | Vesiclepedia_601 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1537 | Vesiclepedia_3219 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1538 | Vesiclepedia_719 | 26148937 | Homo sapiens | Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression. | Cholangiocarcinoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 1539 | Vesiclepedia_619 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1540 | Vesiclepedia_617 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1541 | Vesiclepedia_2266 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1542 | Vesiclepedia_1099 | 24513287 | Mus musculus | Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. | adipocytes | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 1543 | Vesiclepedia_1767 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1544 | Vesiclepedia_2164 | 34140472 | Ixodes scapularis | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Ixodes scapularis | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1545 | Vesiclepedia_1371 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 1546 | Vesiclepedia_1003 | 23785420 | Bos taurus | CD9-positive microvesicles mediate the transfer of molecules to Bovine Spermatozoa during epididymal maturation. | Epididymal fluid | Protein | Differential centrifugation Ultracentrifugation Immunoaffinity [CD9] |
Microvesicles | EVs |
| 1547 | Vesiclepedia_842 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1548 | Vesiclepedia_2207 | 36013250 | Escherichia coli | Proteomic Profiling of Outer Membrane Vesicles Released by Escherichia coli LPS Mutants Defective in Heptose Biosynthesis | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1549 | Vesiclepedia_1534 | 33589572 | Homo sapiens | Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis | Plasma |
Protein lncRNA |
Centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 1550 | Vesiclepedia_782 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1551 | Vesiclepedia_2412 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1552 | Vesiclepedia_2419 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1553 | Vesiclepedia_407 | 19834908 | Staphylococcus aureus | Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. | Staphylococcus aureus | Protein | - | Membrane vesicles | EVs |
| 1554 | Vesiclepedia_1665 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Normal mammary epithelial cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1555 | Vesiclepedia_740 | 25157233 | Homo sapiens | Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration. | Placenta choriocarcinoma cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1556 | Vesiclepedia_2845 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1557 | Vesiclepedia_1695 | 34108659 | Mus musculus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1558 | Vesiclepedia_2274 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 1559 | Vesiclepedia_3512 | 31068461 | Homo sapiens | Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1560 | Vesiclepedia_259 | 18425114 | Homo sapiens | Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | Glioma cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1561 | Vesiclepedia_1225 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Exo-spin | Extracellular vesicles | EVs |
| 1562 | Vesiclepedia_1853 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1563 | Vesiclepedia_3356 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Retinal endothelial cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1564 | Vesiclepedia_973 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 1565 | Vesiclepedia_1085 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 1566 | Vesiclepedia_1608 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 1567 | Vesiclepedia_708 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 1568 | Vesiclepedia_1537 | 33523480 | Homo sapiens | Human fibroblast-derived extracellular vesicles promote hair growth in cultured human hair follicles | Fibroblasts | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1569 | Vesiclepedia_2706 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1570 | Vesiclepedia_765 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1571 | Vesiclepedia_277 | 22030351 | Homo sapiens | Expression of PTRF in PC-3 cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways | Prostate cancer cells | Protein | Differential centrifugation | Exosomes | EVs |
| 1572 | Vesiclepedia_55 | 12147373 | Homo sapiens | Malignant effusions and immunogenic tumour-derived exosomes. | Malignant pleural effusions | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1573 | Vesiclepedia_1166 | 29904572 | Bos taurus | A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk. | Bovine milk |
Protein miRNA |
Differential centrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1574 | Vesiclepedia_3267 | 34654817 | Rattus norvegicus | Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1575 | Vesiclepedia_2608 | 32383290 | Ovis aries | Quantitative Proteomic Analysis of Seminal Plasma, Sperm Membrane Proteins, and Seminal Extracellular Vesicles Suggests Vesicular Mechanisms Aid in the Removal and Addition of Proteins to the Ram Sperm Membrane | Seminal plasma | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1576 | Vesiclepedia_2512 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | ExoQuick Kit | Extracellular vesicles | EVs |
| 1577 | Vesiclepedia_2477 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1578 | Vesiclepedia_2397 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1579 | Vesiclepedia_1208 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1580 | Vesiclepedia_841 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1581 | Vesiclepedia_2938 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1582 | Vesiclepedia_371 | 16456881 | Neisseria meningitidis | Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles. | Neisseria meningitidis | Protein | - | Membrane vesicles | EVs |
| 1583 | Vesiclepedia_3333 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Lung cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 1584 | Vesiclepedia_102 | 21082674 | Homo sapiens | Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1585 | Vesiclepedia_142 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 1586 | Vesiclepedia_3061 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1587 | Vesiclepedia_2230 | 36648227 | Mus musculus | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1588 | Vesiclepedia_2801 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1589 | Vesiclepedia_1570 | 33738083 | Homo sapiens | Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1590 | Vesiclepedia_179 | 20686450 | Homo sapiens | Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome | Urine | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1591 | Vesiclepedia_434 | 22014850 | Rattus norvegicus | Proteomics of microparticles after experimental pulmonary embolism. | Plasma | Protein | - | Microparticles | EVs |
| 1592 | Vesiclepedia_1374 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 1593 | Vesiclepedia_2866 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1594 | Vesiclepedia_3447 | 32341770 | Mus musculus | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Plasma | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1595 | Vesiclepedia_680 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 1596 | Vesiclepedia_14 | 16081791 | Mus musculus | Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. | Microglia | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1597 | Vesiclepedia_2729 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1598 | Vesiclepedia_1721 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1599 | Vesiclepedia_3025 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1600 | Vesiclepedia_1060 | 30006486 | Homo sapiens | The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells. | Astrocytoma cells | Protein | Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1601 | Vesiclepedia_2858 | 33579909 | Mus musculus | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1602 | Vesiclepedia_3343 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Plasma | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1603 | Vesiclepedia_224 | 10393703 | Homo sapiens | In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant | Plasma | Protein | Differential centrifugation | Microparticles | EVs |
| 1604 | Vesiclepedia_994 | 24434149 | Homo sapiens | In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome. | Ovarian cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1605 | Vesiclepedia_2692 | 35210436 | Homo sapiens | M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway | Macrophage |
Protein mRNA |
Total Exosome Isolation Reagent | Exosomes | Small EVs |
| 1606 | Vesiclepedia_1038 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
miRCURY Exosome Isolation Kit | Extracellular vesicles | EVs |
| 1607 | Vesiclepedia_2624 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1608 | Vesiclepedia_236 | 10648405 | Homo sapiens | Cellular origin and procoagulant properties of microparticles in meningococcal sepsis | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1609 | Vesiclepedia_2405 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1610 | Vesiclepedia_2174 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1611 | Vesiclepedia_2051 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1612 | Vesiclepedia_1771 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1613 | Vesiclepedia_2900 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Gastric cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1614 | Vesiclepedia_2895 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1615 | Vesiclepedia_2529 | 34293122 | Homo sapiens | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets |
Protein Lipid |
Centrifugation | Extracellular vesicles | Large EVs |
| 1616 | Vesiclepedia_3069 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Serum | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 1617 | Vesiclepedia_3444 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1618 | Vesiclepedia_930 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Bladder cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1619 | Vesiclepedia_1101 | 24513287 | Mus musculus | Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. | Serum | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 1620 | Vesiclepedia_251 | 9396452 | Homo sapiens | Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant | Plasma |
Protein Lipids |
Differential centrifugation | Microparticles | EVs |
| 1621 | Vesiclepedia_3122 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Brain | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1622 | Vesiclepedia_1344 | 33009394 | Homo sapiens | Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p | Platelets |
Protein miRNA |
Ficoll-Hypaque density gradient centrifugation Differential centrifugation Filtration |
Platelet-derived microparticles | EV-like nanoparticles |
| 1623 | Vesiclepedia_1586 | 33692129 | Macaca fascicularis | Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates | Mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 1624 | Vesiclepedia_1827 | 36494333 | Homo sapiens | Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis | Lung cancer cells |
Protein miRNA |
Centrifugation Filtration ExoQuick Kit |
Exosomes | Small EVs |
| 1625 | Vesiclepedia_1289 | 19912576 | Homo sapiens | HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. | Cervical cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1626 | Vesiclepedia_1471 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1627 | Vesiclepedia_2010 | 36417867 | Homo sapiens | Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1628 | Vesiclepedia_1932 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1629 | Vesiclepedia_772 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1630 | Vesiclepedia_2178 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1631 | Vesiclepedia_672 | 29953960 | Homo sapiens | Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. | Macrophage | Protein | Microfiltration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1632 | Vesiclepedia_2942 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1633 | Vesiclepedia_267 | 12757771 | Homo sapiens | Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis | Endothelial cells | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1634 | Vesiclepedia_716 | 26317203 | Homo sapiens | Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis. | Osteosarcoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1635 | Vesiclepedia_1253 | 24939845 | Homo sapiens | Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1636 | Vesiclepedia_479 | 23082778 | Homo sapiens | Comparative and Targeted Proteomic Analyses of Urinary Microparticles from Bladder Cancer and Hernia Patients. | Urine | Protein | - | Exosomes/Membrane vesicles | EVs |
| 1637 | Vesiclepedia_2102 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 1638 | Vesiclepedia_2993 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | Large EVs |
| 1639 | Vesiclepedia_2828 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1640 | Vesiclepedia_3087 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1641 | Vesiclepedia_803 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1642 | Vesiclepedia_2137 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1643 | Vesiclepedia_2981 | 30089911 | Mus musculus | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1644 | Vesiclepedia_2684 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic duct epithelial cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 1645 | Vesiclepedia_1775 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1646 | Vesiclepedia_687 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 1647 | Vesiclepedia_3194 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1648 | Vesiclepedia_2691 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 1649 | Vesiclepedia_2907 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1650 | Vesiclepedia_1016 | 22711894 | Homo sapiens | Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. | Macrophage |
Protein Lipids |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1651 | Vesiclepedia_1414 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1652 | Vesiclepedia_1306 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1653 | Vesiclepedia_748 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1654 | Vesiclepedia_2145 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1655 | Vesiclepedia_2142 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Serum | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1656 | Vesiclepedia_2160 | 34140472 | Ixodes scapularis | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Salivary glands | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1657 | Vesiclepedia_1588 | 33692129 | Macaca fascicularis | Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates | Mesenchymal stem cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1658 | Vesiclepedia_1141 | 23454749 | Homo sapiens | BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. | Bone marrow mesenchymal stromal cells | Protein | Differential centrifugation Ultracentrifugation Filtration ExoQuick |
Exosomes | EVs |
| 1659 | Vesiclepedia_246 | 18425114 | Homo sapiens | Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1660 | Vesiclepedia_1219 | 27872147 | Homo sapiens | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Islets | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1661 | Vesiclepedia_2490 | 34388111 | Homo sapiens | miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis | Monocytic leukemia cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1662 | Vesiclepedia_1751 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1663 | Vesiclepedia_3283 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 1664 | Vesiclepedia_2072 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1665 | Vesiclepedia_2096 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1666 | Vesiclepedia_614 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1667 | Vesiclepedia_1040 | 27770278 | Homo sapiens | Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1668 | Vesiclepedia_862 | 25776846 | Homo sapiens | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens | Epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1669 | Vesiclepedia_2940 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1670 | Vesiclepedia_3097 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1671 | Vesiclepedia_3006 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1672 | Vesiclepedia_3479 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1673 | Vesiclepedia_2542 | 34293122 | Mus musculus | Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules | Platelets |
Protein Lipid |
Centrifugation | Extracellular vesicles | Large EVs |
| 1674 | Vesiclepedia_2221 | 34596356 | Homo sapiens | Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer | Primary prostate stromal cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1675 | Vesiclepedia_336 | 20976003 | Homo sapiens | Selective release of microRNA species from normal and malignant mammary epithelial cells | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration |
Exosomes | EVs |
| 1676 | Vesiclepedia_1000 | 24079734 | Mus musculus | Immunostimulatory activity of murine keratinocyte-derived exosomes. | Keratinocytes | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1677 | Vesiclepedia_808 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1678 | Vesiclepedia_612 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1679 | Vesiclepedia_2264 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1680 | Vesiclepedia_897 | 26100252 | Homo sapiens | Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts | Chronic lymphocytic leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1681 | Vesiclepedia_738 | 25157233 | Homo sapiens | Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration. | Placenta choriocarcinoma cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1682 | Vesiclepedia_3152 | 34887361 | Mus musculus | Endothelial cell-derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway | Endothelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1683 | Vesiclepedia_2860 | 33579909 | Mus musculus | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1684 | Vesiclepedia_2215 | 35953855 | Bos taurus | Milk-derived small extracellular vesicles: nanomaterials to promote bone formation | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1685 | Vesiclepedia_847 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1686 | Vesiclepedia_1535 | 33589572 | Homo sapiens | Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis | Lung cancer cells | Protein | Centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 1687 | Vesiclepedia_800 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 1688 | Vesiclepedia_3301 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1689 | Vesiclepedia_29 | 19109410 | Homo sapiens | Proteomic and immunologic analyses of brain tumor exosomes. | Serum | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1690 | Vesiclepedia_3020 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1691 | Vesiclepedia_2869 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1692 | Vesiclepedia_2846 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1693 | Vesiclepedia_1603 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1694 | Vesiclepedia_1619 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1695 | Vesiclepedia_466 | 22966805 | Acinetobacter baumannii | Extracellular proteome of a highly invasive multidrug-resistant clinical strain of Acinetobacter baumannii. | Acinetobacter baumannii | Protein | - | Membrane vesicles | EVs |
| 1696 | Vesiclepedia_2554 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1697 | Vesiclepedia_3470 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1698 | Vesiclepedia_285 | 12796750 | Homo sapiens | High levels of circulating endothelial microparticles in patients with acute coronary syndromes | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1699 | Vesiclepedia_372 | 17096383 | Mus musculus | Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts. | Osteoblasts | Protein | - | Matrix vesicles | EVs |
| 1700 | Vesiclepedia_2439 | 29335551 | Homo sapiens | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer | Liver cancer cells |
Protein miRNA |
Filtration Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1701 | Vesiclepedia_2387 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1702 | Vesiclepedia_3040 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 1703 | Vesiclepedia_910 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1704 | Vesiclepedia_199 | 21609964 | Homo sapiens | Characterization of extracellular circulating microRNA | Plasma | Protein | Differential centrifugation Filtration |
Exosomes | EVs |
| 1705 | Vesiclepedia_3432 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1706 | Vesiclepedia_2069 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1707 | Vesiclepedia_3397 | 31054213 | Homo sapiens | Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma | Cholangiocarcinoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1708 | Vesiclepedia_468 | 23000592 | Homo sapiens | In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts. | Neonatal myoblast cells | Protein | - | Microvesicles/Nanovesicles | EVs |
| 1709 | Vesiclepedia_2331 | 36635419 | Homo sapiens | Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy | Fibroblasts |
Protein mRNA |
Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 1710 | Vesiclepedia_3336 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 1711 | Vesiclepedia_2627 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1712 | Vesiclepedia_472 | 23043909 | Pseudomonas syringae | Virulence factors are released in association with outer membrane vesicles of Pseudomonas syringae pv. tomato T1 during normal growth. | Pseudomonas syringae | Protein | - | Membrane vesicles | EVs |
| 1713 | Vesiclepedia_1457 | 31969559 | Homo sapiens | Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1714 | Vesiclepedia_1778 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1715 | Vesiclepedia_988 | 25261472 | Homo sapiens | Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes/Microvesicles | EVs |
| 1716 | Vesiclepedia_433 | 22014850 | Rattus norvegicus | Proteomics of microparticles after experimental pulmonary embolism. | Plasma | Protein | - | Microparticles | EVs |
| 1717 | Vesiclepedia_1235 | 25421927 | Heligmosomoides polygyrus | Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. | Heligmosomoides polygyrus |
miRNA Protein |
Filtration Ultracentrifugation |
Exosomes | EVs |
| 1718 | Vesiclepedia_1895 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1719 | Vesiclepedia_570 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (CD63 PD) |
Extracellular vesicles | EVs |
| 1720 | Vesiclepedia_2414 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1721 | Vesiclepedia_2756 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 1722 | Vesiclepedia_2192 | 35229476 | Lactococcus lactis | Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage-encoded holin-lysin system | Lactococcus lactis | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1723 | Vesiclepedia_722 | 25802036 | Homo sapiens | Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1724 | Vesiclepedia_75 | 19381331 | Homo sapiens | High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. | Plasma | Protein | Differential centrifugation | Exosomes | EVs |
| 1725 | Vesiclepedia_51 | 14975938 | Homo sapiens | Proteomic analysis of exosomes isolated from human malignant pleural effusions. | Malignant pleural effusions | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1726 | Vesiclepedia_1261 | 24371517 | Homo sapiens | Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1727 | Vesiclepedia_2870 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1728 | Vesiclepedia_3003 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1729 | Vesiclepedia_1427 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1730 | Vesiclepedia_844 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1731 | Vesiclepedia_3297 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1732 | Vesiclepedia_3339 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 1733 | Vesiclepedia_2937 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1734 | Vesiclepedia_2021 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Centrifugation | Large extracellular vesicles | Large EVs |
| 1735 | Vesiclepedia_3131 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1736 | Vesiclepedia_3437 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | Large EVs |
| 1737 | Vesiclepedia_1929 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 1738 | Vesiclepedia_2205 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1739 | Vesiclepedia_1494 | 33991177 | Homo sapiens | Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells | Gastric cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1740 | Vesiclepedia_2153 | 36781972 | Pseudomonas aeruginosa | The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition | Pseudomonas aeruginosa | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 1741 | Vesiclepedia_618 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1742 | Vesiclepedia_2201 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1743 | Vesiclepedia_272 | 8896411 | Homo sapiens | High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles | Platelets |
Protein Lipids |
Differential centrifugation FACS |
Microparticles | EVs |
| 1744 | Vesiclepedia_306 | 16342139 | Homo sapiens | Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization | T cells | Protein | Differential centrifugation | Microparticles | EVs |
| 1745 | Vesiclepedia_2265 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1746 | Vesiclepedia_2433 | 29320704 | Homo sapiens | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Plasma | Protein | Centrifugation | Extracellular vesicles | EVs |
| 1747 | Vesiclepedia_2896 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1748 | Vesiclepedia_3173 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1749 | Vesiclepedia_818 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 1750 | Vesiclepedia_63 | 19056867 | Homo sapiens | Large-scale proteomics and phosphoproteomics of urinary exosomes. | Urine | Protein | Differential centrifugation | Exosomes | EVs |
| 1751 | Vesiclepedia_2012 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Centrifugation | Large extracellular vesicles | Large EVs |
| 1752 | Vesiclepedia_404 | 19548909 | Homo sapiens | Differential stimulation of monocytic cells results in distinct populations of microparticles. | Monocytes | Protein | - | Microparticles | EVs |
| 1753 | Vesiclepedia_487 | 23230278 | Homo sapiens | Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. | Colorectal cancer cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 1754 | Vesiclepedia_3431 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1755 | Vesiclepedia_3281 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 1756 | Vesiclepedia_852 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1757 | Vesiclepedia_2202 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1758 | Vesiclepedia_1841 | 36408942 | Rattus norvegicus | Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells | Bone marrow mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1759 | Vesiclepedia_3148 | 29438363 | Homo sapiens | CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells | Fibroblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1760 | Vesiclepedia_2112 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1761 | Vesiclepedia_999 | 24355714 | Homo sapiens | Proteomic analysis and immune properties of exosomes released by macrophages infected with Mycobacterium avium. | Leukemia cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1762 | Vesiclepedia_2909 | 33732415 | Mus musculus | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Lung cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1763 | Vesiclepedia_653 | 28290293 | Homo sapiens | Comparative proteomic analysis of milk-derived exosomes in human and bovine colostrum and mature milk samples by iTRAQ-coupled LC-MS/MS. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 1764 | Vesiclepedia_98 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1765 | Vesiclepedia_2552 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1766 | Vesiclepedia_2565 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1767 | Vesiclepedia_1840 | 36408942 | Rattus norvegicus | Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells | Bone marrow mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1768 | Vesiclepedia_3340 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1769 | Vesiclepedia_1484 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1770 | Vesiclepedia_2452 | 34465793 | Homo sapiens | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer | Breast cancer cells |
Protein miRNA |
Centrifugation | Apoptotic bodies | Large EVs |
| 1771 | Vesiclepedia_3114 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Podocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1772 | Vesiclepedia_1999 | 34112803 | Homo sapiens | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 1773 | Vesiclepedia_788 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1774 | Vesiclepedia_1112 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1775 | Vesiclepedia_521 | 23645497 | Canis lupus familiaris | Oncogenic H-Ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition. | Kidney cells | Protein | - | Exosomes/Extracellular vesicles | EVs |
| 1776 | Vesiclepedia_1548 | 33638284 | Canis lupus familiaris | Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial-mesenchymal transition | Kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1777 | Vesiclepedia_2727 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1778 | Vesiclepedia_2298 | 29339034 | Homo sapiens | Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer | Pancreatic duct fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1779 | Vesiclepedia_1981 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1780 | Vesiclepedia_2936 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1781 | Vesiclepedia_79 | 20458337 | Homo sapiens | MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1 | B cells | Protein | Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) |
Exosomes | EVs |
| 1782 | Vesiclepedia_1059 | 30006486 | Homo sapiens | The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells. | Astrocytoma cells | Protein | Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1783 | Vesiclepedia_2558 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1784 | Vesiclepedia_1025 | 22327366 | Homo sapiens | Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. | Vascular endothelial cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1785 | Vesiclepedia_2702 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1786 | Vesiclepedia_1109 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1787 | Vesiclepedia_744 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1788 | Vesiclepedia_186 | 22116803 | Equus caballus | Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle | Follicular fluid |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 1789 | Vesiclepedia_2090 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1790 | Vesiclepedia_2093 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1791 | Vesiclepedia_1276 | 23344851 | Rattus norvegicus | Urinary exosomes and diabetic nephropathy: a proteomic approach. | Urine | Protein | Ultracentrifugation | Exosomes | EVs |
| 1792 | Vesiclepedia_599 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1793 | Vesiclepedia_2115 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 1794 | Vesiclepedia_2120 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1795 | Vesiclepedia_1647 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1796 | Vesiclepedia_1031 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
exoEasy columns | Extracellular vesicles | EVs |
| 1797 | Vesiclepedia_2986 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1798 | Vesiclepedia_2891 | 28928431 | Mus musculus | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 | Lung cancer cells | Protein | Centrifugal ultrafiltration ExoQuick Kit |
Extracellular vesicles | EVs |
| 1799 | Vesiclepedia_3275 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1800 | Vesiclepedia_715 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Apoptotic bodies | EVs |
| 1801 | Vesiclepedia_2514 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 1802 | Vesiclepedia_170 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 1803 | Vesiclepedia_2285 | 30863515 | Homo sapiens | Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles | Lung epithelial cells |
Protein Lipid |
Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1804 | Vesiclepedia_226 | 12514112 | Homo sapiens | Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets | Platelets | Protein | Differential centrifugation | Microvesicles | EVs |
| 1805 | Vesiclepedia_1512 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1806 | Vesiclepedia_1507 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1807 | Vesiclepedia_1081 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 1808 | Vesiclepedia_1794 | 36594832 | Mus musculus | Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia | Neuroblastoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1809 | Vesiclepedia_540 | 23886663 | Homo sapiens | LRRK2 Secretion in Exosomes is Regulated by 14-3-3. | Urine | Protein | - | Exosomes/Microvesicles | EVs |
| 1810 | Vesiclepedia_1373 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 1811 | Vesiclepedia_854 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1812 | Vesiclepedia_1662 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | T lymphocytes |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1813 | Vesiclepedia_291 | 15072974 | Rattus norvegicus | Endothelium-derived microparticles impair endothelial function in vitro | Endothelial cells | Protein | Differential centrifugation Ultracentrifugation FACS |
Microparticles | EVs |
| 1814 | Vesiclepedia_2371 | 36759608 | Homo sapiens | Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo | Stromal vascular fraction | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1815 | Vesiclepedia_1526 | 33479185 | Homo sapiens | Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke | Mesenchymal stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1816 | Vesiclepedia_3429 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 1817 | Vesiclepedia_1901 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1818 | Vesiclepedia_82 | 20949044 | Homo sapiens | Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line | Stomach cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1819 | Vesiclepedia_1222 | 26272980 | Homo sapiens | Proteomic Profiling of Detergent Resistant Membranes (Lipid Rafts) of Prostasomes | Seminal plasma | Protein | Ultracentrifugation Density gradient centrifugation |
Prostasomes | EVs |
| 1820 | Vesiclepedia_2700 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1821 | Vesiclepedia_1403 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 1822 | Vesiclepedia_2859 | 33579909 | Mus musculus | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1823 | Vesiclepedia_1411 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1824 | Vesiclepedia_1130 | 23954818 | Homo sapiens | Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state. | Squamous carcinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1825 | Vesiclepedia_769 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1826 | Vesiclepedia_3296 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1827 | Vesiclepedia_940 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1828 | Vesiclepedia_2837 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1829 | Vesiclepedia_2443 | 34489604 | Mus musculus | Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 | Hepatocytes |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1830 | Vesiclepedia_2375 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | exoEasy Maxi Kit | Extracellular vesicles | Small EVs |
| 1831 | Vesiclepedia_373 | 17787032 | Escherichia coli | Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli. | Escherichia coli | Protein | - | Membrane vesicles | EVs |
| 1832 | Vesiclepedia_136 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 1833 | Vesiclepedia_52 | 14975938 | Homo sapiens | Proteomic analysis of exosomes isolated from human malignant pleural effusions. | Malignant pleural effusions | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1834 | Vesiclepedia_2248 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1835 | Vesiclepedia_827 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 1836 | Vesiclepedia_120 | 21362503 | Homo sapiens | Protein profile of exosomes from trabecular meshwork cells. | Aqueous humor | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1837 | Vesiclepedia_3369 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colon cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exosomes | Small EVs |
| 1838 | Vesiclepedia_2771 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Phosphatidylserine affinity purification |
Exosomes | Small EVs |
| 1839 | Vesiclepedia_1728 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1840 | Vesiclepedia_2882 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1841 | Vesiclepedia_907 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer | Transitional papilloma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1842 | Vesiclepedia_3472 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1843 | Vesiclepedia_1860 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1844 | Vesiclepedia_2368 | 36759608 | Mus musculus | Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo | Adipocytes |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1845 | Vesiclepedia_1740 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1846 | Vesiclepedia_1859 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1847 | Vesiclepedia_2363 | 36748335 | Homo sapiens | Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α | Oral cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1848 | Vesiclepedia_2661 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1849 | Vesiclepedia_1869 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1850 | Vesiclepedia_1118 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1851 | Vesiclepedia_2434 | 29320704 | Homo sapiens | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Plasma | Protein | Centrifugation | Extracellular vesicles | EVs |
| 1852 | Vesiclepedia_2852 | 33579909 | Homo sapiens | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1853 | Vesiclepedia_2611 | 30788085 | Homo sapiens | Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma | Oral mucosa | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1854 | Vesiclepedia_1266 | 24310399 | Homo sapiens | Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. | Glioblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | EVs |
| 1855 | Vesiclepedia_346 | 22965126 | Mus musculus | Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells. | Neuronal cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1856 | Vesiclepedia_3045 | 34294888 | Homo sapiens | Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2 | Plasma |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1857 | Vesiclepedia_2809 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1858 | Vesiclepedia_3514 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1859 | Vesiclepedia_2111 | 36482876 | Mus musculus | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1860 | Vesiclepedia_600 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Kidney cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1861 | Vesiclepedia_985 | 25287304 | Candida albicans | Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans. | Candida albicans | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1862 | Vesiclepedia_1949 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1863 | Vesiclepedia_651 | 29188495 | Homo sapiens | Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury. | Cerebrospinal fluid | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Extracellular vesicles | EVs |
| 1864 | Vesiclepedia_1156 | 21212511 | Homo sapiens | Proteomic analysis of two types of exosomes in human whole saliva. | Saliva | Protein | Differential centrifugation Filtration Ultracentrifugation Gel filtration |
Exosomes | EVs |
| 1865 | Vesiclepedia_2179 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1866 | Vesiclepedia_3441 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1867 | Vesiclepedia_541 | 23935504 | Homo sapiens | A Novel Role for Pro-Coagulant Microvesicles in the Early Host Defense against Streptococcus pyogenes. | Peripheral blood mononucelar cells | Protein | - | Microvesicles | EVs |
| 1868 | Vesiclepedia_1124 | 24347249 | Homo sapiens | Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 1869 | Vesiclepedia_1876 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1870 | Vesiclepedia_2949 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1871 | Vesiclepedia_2721 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1872 | Vesiclepedia_1206 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1873 | Vesiclepedia_3056 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1874 | Vesiclepedia_1719 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1875 | Vesiclepedia_1759 | 35918900 | Homo sapiens | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1876 | Vesiclepedia_2649 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1877 | Vesiclepedia_1658 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1878 | Vesiclepedia_812 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 1879 | Vesiclepedia_1075 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 1880 | Vesiclepedia_1251 | 24939845 | Homo sapiens | Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. | Leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1881 | Vesiclepedia_187 | 22116803 | Equus caballus | Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle | Serum | Protein | Differential centrifugation ExoQuick |
Exosomes | EVs |
| 1882 | Vesiclepedia_302 | 1321158 | Rattus norvegicus | Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. | Pancreatic cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 1883 | Vesiclepedia_2181 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1884 | Vesiclepedia_2825 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1885 | Vesiclepedia_2713 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1886 | Vesiclepedia_1304 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1887 | Vesiclepedia_2097 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1888 | Vesiclepedia_1958 | 36475545 | Homo sapiens | Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis | Breast cancer cells | Protein | Centrifugation Filtration |
Microvesicles | Large EVs |
| 1889 | Vesiclepedia_1157 | 20662102 | Mus musculus | Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages. | Macrophage | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1890 | Vesiclepedia_1676 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1891 | Vesiclepedia_3495 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 1892 | Vesiclepedia_838 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 1893 | Vesiclepedia_724 | 25471207 | Homo sapiens | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | Urine | Protein | Differential centrifugation Hydrostatic filtration dialysis Ultrafiltration |
Exosomes | EVs |
| 1894 | Vesiclepedia_2607 | 36581340 | Homo sapiens | Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer | Gastric cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1895 | Vesiclepedia_3031 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1896 | Vesiclepedia_677 | 29951053 | Mus musculus | Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. | Dendritic cells | Protein | Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1897 | Vesiclepedia_2669 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1898 | Vesiclepedia_2242 | 36648227 | Mus musculus | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1899 | Vesiclepedia_1990 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1900 | Vesiclepedia_1957 | 36475545 | Homo sapiens | Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis | Breast cancer cells | Protein | Centrifugation Filtration |
Microvesicles | Large EVs |
| 1901 | Vesiclepedia_2991 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1902 | Vesiclepedia_3486 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 1903 | Vesiclepedia_2639 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Cervical cancer cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1904 | Vesiclepedia_3068 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Serum | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 1905 | Vesiclepedia_2175 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 1906 | Vesiclepedia_3370 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colon cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1907 | Vesiclepedia_1753 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1908 | Vesiclepedia_1072 | 29937354 | Homo sapiens | Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1909 | Vesiclepedia_3215 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanocytes | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1910 | Vesiclepedia_2194 | 29511463 | Bos taurus | Biocompatibility of highly purified bovine milk-derived extracellular vesicles | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1911 | Vesiclepedia_863 | 22046311 | Mus musculus | Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1912 | Vesiclepedia_1533 | 33589572 | Homo sapiens | Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis | Plasma |
Protein lncRNA |
Centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 1913 | Vesiclepedia_2875 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1914 | Vesiclepedia_1653 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Glioblastoma cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1915 | Vesiclepedia_1418 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1916 | Vesiclepedia_941 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1917 | Vesiclepedia_2297 | 29339034 | Homo sapiens | Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer | Pancreatic duct fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1918 | Vesiclepedia_763 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1919 | Vesiclepedia_1621 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1920 | Vesiclepedia_1014 | 22711894 | Homo sapiens | Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. | Macrophage |
Protein Lipids |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1921 | Vesiclepedia_313 | 15499615 | Homo sapiens | Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer | Lung cancer cells | Protein | Differential centrifugation FACS |
Microvesicles | EVs |
| 1922 | Vesiclepedia_2367 | 36759608 | Mus musculus | Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo | Adipocytes | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1923 | Vesiclepedia_1768 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 1924 | Vesiclepedia_235 | 10648405 | Homo sapiens | Cellular origin and procoagulant properties of microparticles in meningococcal sepsis | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1925 | Vesiclepedia_2760 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 1926 | Vesiclepedia_200 | 21606166 | Homo sapiens | Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1 | Serum | Protein | Size exclusion chromatography Ultracentrifugation |
Microvesicles | EVs |
| 1927 | Vesiclepedia_1992 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1928 | Vesiclepedia_3261 | 34654817 | Rattus norvegicus | Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors | Plasma |
Protein miRNA |
ExoQuick Kit | Small extracellular vesicles | EVs |
| 1929 | Vesiclepedia_234 | 10648405 | Homo sapiens | Cellular origin and procoagulant properties of microparticles in meningococcal sepsis | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 1930 | Vesiclepedia_2664 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1931 | Vesiclepedia_1465 | 35054579 | Gallus gallus | Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus | Trachea | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1932 | Vesiclepedia_573 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (CD81 FT) |
Extracellular vesicles | EVs |
| 1933 | Vesiclepedia_2156 | 30488570 | Helicobacter pylori | Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles | Helicobacter pylori | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 1934 | Vesiclepedia_7 | 12626558 | Mus musculus | Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. | Mast cells | Protein | Differential centrifugation | Exosomes | EVs |
| 1935 | Vesiclepedia_1699 | 34108659 | Bos taurus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 1936 | Vesiclepedia_1044 | 27770278 | Homo sapiens | Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1937 | Vesiclepedia_131 | 19188015 | Homo sapiens | Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes | Ascites |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1938 | Vesiclepedia_2053 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1939 | Vesiclepedia_3426 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1940 | Vesiclepedia_96 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1941 | Vesiclepedia_761 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 1942 | Vesiclepedia_2086 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 1943 | Vesiclepedia_2763 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 1944 | Vesiclepedia_1167 | 29907695 | Mus musculus | Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. | Melanoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1945 | Vesiclepedia_3507 | 31110292 | Mus musculus | The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency | Liver cancer cells | Protein | Differential centrifugation | Microparticles | Large EVs |
| 1946 | Vesiclepedia_109 | 21601258 | Homo sapiens | Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. | Malignant pleural effusions |
Protein miRNA |
Differential centrifugation Sucrose density gradient Immunobeads (EpCAM) |
Exosomes | EVs |
| 1947 | Vesiclepedia_2626 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1948 | Vesiclepedia_294 | 2071604 | Homo sapiens | Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets | Platelets | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 1949 | Vesiclepedia_865 | 22046311 | Mus musculus | Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections | Reticulocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1950 | Vesiclepedia_983 | 25367658 | Candida albicans | Proteomics unravels extracellular vesicles as carriers of classical cytoplasmic proteins in Candida albicans. | Candida albicans | Protein | Differential centrifugation Ultracentrifugation Filtration |
Extracellular vesicles | EVs |
| 1951 | Vesiclepedia_3513 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1952 | Vesiclepedia_1604 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1953 | Vesiclepedia_2546 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1954 | Vesiclepedia_3315 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1955 | Vesiclepedia_2899 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1956 | Vesiclepedia_8 | 12626558 | Mus musculus | Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. | B cells | Protein | Differential centrifugation | Exosomes | EVs |
| 1957 | Vesiclepedia_982 | 25458527 | Homo sapiens | Benchtop isolation and characterization of functional exosomes by sequential filtration | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1958 | Vesiclepedia_3285 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 1959 | Vesiclepedia_196 | 21668449 | Mus musculus | SV31 is a Zn2+-binding synaptic vesicle protein | Pheochromocytoma cells | Protein | Differential centrifugation Sucrose density gradient |
Large dense core vesicles | EVs |
| 1960 | Vesiclepedia_3117 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Brain | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 1961 | Vesiclepedia_1062 | 30006486 | Homo sapiens | The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells. | Astrocytoma cells | Protein | Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 1962 | Vesiclepedia_1431 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1963 | Vesiclepedia_1308 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1964 | Vesiclepedia_113 | 21557262 | Homo sapiens | Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1965 | Vesiclepedia_3016 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 1966 | Vesiclepedia_2645 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Mammary epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1967 | Vesiclepedia_1875 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1968 | Vesiclepedia_1632 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1969 | Vesiclepedia_3199 | 34690112 | Homo sapiens | Exosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling | Ovarian cancer cells | Protein | ExoQuick Kit | Exosomes | EVs |
| 1970 | Vesiclepedia_1323 | 33431899 | Mus musculus | High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance | Faeces |
Protein Lipid miRNA |
Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 1971 | Vesiclepedia_3497 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 1972 | Vesiclepedia_1019 | 21734072 | Mus musculus | Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. | Insulinoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1973 | Vesiclepedia_1215 | 27872147 | Rattus norvegicus | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Islets | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1974 | Vesiclepedia_2798 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small Evs |
| 1975 | Vesiclepedia_2868 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1976 | Vesiclepedia_1689 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 1977 | Vesiclepedia_3039 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 1978 | Vesiclepedia_3042 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 1979 | Vesiclepedia_3346 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 1980 | Vesiclepedia_1747 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 1981 | Vesiclepedia_2369 | 36759608 | Mus musculus | Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo | Adipocytes | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 1982 | Vesiclepedia_2483 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1983 | Vesiclepedia_383 | 18373357 | Homo sapiens | Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. | Urine | Protein | - | Microparticles | EVs |
| 1984 | Vesiclepedia_781 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 1985 | Vesiclepedia_850 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 1986 | Vesiclepedia_1867 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1987 | Vesiclepedia_67 | 19619303 | Homo sapiens | Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer. | Ovarian cancer cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1988 | Vesiclepedia_2650 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 1989 | Vesiclepedia_1162 | 22641613 | Homo sapiens | Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 1990 | Vesiclepedia_1888 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1991 | Vesiclepedia_2020 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 1992 | Vesiclepedia_828 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 1993 | Vesiclepedia_1590 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugation | Extracellular vesicles | Large EVs |
| 1994 | Vesiclepedia_1566 | 33523942 | Homo sapiens | Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models | Embryonic kidney cells | Protein | Centrifugation Filtration Size exclusion chromatography |
Exosomes | Small EVs |
| 1995 | Vesiclepedia_59 | 17700640 | Mus musculus | CD24 is a marker of exosomes secreted into urine and amniotic fluid. | Amniotic fluid | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 1996 | Vesiclepedia_167 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 1997 | Vesiclepedia_2551 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 1998 | Vesiclepedia_1706 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 1999 | Vesiclepedia_3181 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2000 | Vesiclepedia_2879 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2001 | Vesiclepedia_2686 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 2002 | Vesiclepedia_2887 | 30918259 | Mus musculus | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2003 | Vesiclepedia_1889 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2004 | Vesiclepedia_3111 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2005 | Vesiclepedia_3450 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2006 | Vesiclepedia_398 | 19530224 | Homo sapiens | Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes. | Keratinocytes | Protein | - | Exosomes | EVs |
| 2007 | Vesiclepedia_947 | 28819550 | Mus musculus | Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses. | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2008 | Vesiclepedia_957 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2009 | Vesiclepedia_2840 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2010 | Vesiclepedia_1133 | 23861904 | Homo sapiens | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. | Placental mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration Density gradient centrifugation |
Exosomes | EVs |
| 2011 | Vesiclepedia_1467 | 32132543 | Homo sapiens | Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension | Pulmonary artery endothelial cells | Protein | miRCURY Exosome Isolation Kit Centrifugation Sonication |
Exosomes | Small EVs |
| 2012 | Vesiclepedia_2188 | 33792189 | Mus musculus | A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions | Epididymal epithelial cells | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2013 | Vesiclepedia_3027 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 2014 | Vesiclepedia_1928 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 2015 | Vesiclepedia_1188 | 28326167 | Homo sapiens | Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment. | Urine | Protein | Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2016 | Vesiclepedia_703 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Apoptotic bodies | EVs |
| 2017 | Vesiclepedia_3379 | 31848325 | Rattus norvegicus | Insulin-like growth factor-1 enchances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism | Neural stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2018 | Vesiclepedia_883 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2019 | Vesiclepedia_1884 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2020 | Vesiclepedia_3013 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2021 | Vesiclepedia_446 | 22428779 | Klebsiella pneumoniae | Klebsiella pneumoniae secretes outer membrane vesicles that induce the innate immune response. | Klebsiella pneumoniae | Protein | - | Membrane vesicles | EVs |
| 2022 | Vesiclepedia_3202 | 34596354 | Homo sapiens | Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p | Mesenchymal stem cells |
Protein miRNA |
Tangential flow filtration | Extracellular vesicles | Small EVs |
| 2023 | Vesiclepedia_46 | 17641064 | Homo sapiens | Exosomes with immune modulatory features are present in human breast milk. | Breast milk | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 2024 | Vesiclepedia_1123 | 24347249 | Homo sapiens | Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation ExoQuick |
Exosomes | EVs |
| 2025 | Vesiclepedia_2628 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2026 | Vesiclepedia_1259 | 24400796 | Rattus norvegicus | Exosomal proteins in the aqueous humor as novel biomarkers in patients with neovascular age-related macular degeneration. | Retinal glial cells | Protein | ExoQuick | Exosomes | EVs |
| 2027 | Vesiclepedia_1256 | 24400796 | Homo sapiens | Exosomal proteins in the aqueous humor as novel biomarkers in patients with neovascular age-related macular degeneration. | Retinal pigment epithelial cells | Protein | ExoQuick | Exosomes | EVs |
| 2028 | Vesiclepedia_843 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2029 | Vesiclepedia_2124 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2030 | Vesiclepedia_3362 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2031 | Vesiclepedia_589 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2032 | Vesiclepedia_3312 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2033 | Vesiclepedia_3428 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2034 | Vesiclepedia_2525 | 34315885 | Mus musculus | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Embryonic kidney cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2035 | Vesiclepedia_2658 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2036 | Vesiclepedia_585 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2037 | Vesiclepedia_1741 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 2038 | Vesiclepedia_3086 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2039 | Vesiclepedia_3082 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic duct epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2040 | Vesiclepedia_2971 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2041 | Vesiclepedia_2109 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2042 | Vesiclepedia_1487 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2043 | Vesiclepedia_453 | 22635005 | Homo sapiens | Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. | Melanoma cells | Protein | - | Exosomes | EVs |
| 2044 | Vesiclepedia_2172 | 30536591 | Homo sapiens | A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2045 | Vesiclepedia_3205 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2046 | Vesiclepedia_3359 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Breast cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2047 | Vesiclepedia_3406 | 31666321 | Drosophila melanogaster | Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia | Hemolymph |
Protein miRNA |
Differential centrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 2048 | Vesiclepedia_1368 | 32132711 | Mus musculus | Decoy exosomes provide protection against bacterial toxins | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2049 | Vesiclepedia_3303 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2050 | Vesiclepedia_1012 | 22711894 | Homo sapiens | Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. | Macrophage | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles/Exosomes | EVs |
| 2051 | Vesiclepedia_3273 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 2052 | Vesiclepedia_1970 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2053 | Vesiclepedia_2654 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2054 | Vesiclepedia_2889 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2055 | Vesiclepedia_180 | 20686450 | Homo sapiens | Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome | Urine | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography Filtration |
Microvesicles | EVs |
| 2056 | Vesiclepedia_3136 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2057 | Vesiclepedia_74 | 19381331 | Homo sapiens | High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. | Melanoma cells | Protein | Differential centrifugation | Exosomes | EVs |
| 2058 | Vesiclepedia_114 | 21557262 | Homo sapiens | Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2059 | Vesiclepedia_1766 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2060 | Vesiclepedia_2177 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 2061 | Vesiclepedia_2957 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2062 | Vesiclepedia_1375 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 2063 | Vesiclepedia_370 | 16456881 | Neisseria meningitidis | Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles. | Neisseria meningitidis | Protein | - | Membrane vesicles | EVs |
| 2064 | Vesiclepedia_3177 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2065 | Vesiclepedia_518 | 23585443 | Homo sapiens | Proteome profiling of exosomes derived from human primary and metastatic colorectal cells reveal differential expression of key metastatic factors and signal transduction components. | Colorectal cancer cells | Protein | - | Exosomes/Membrane vesicles | EVs |
| 2066 | Vesiclepedia_762 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2067 | Vesiclepedia_1664 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2068 | Vesiclepedia_655 | 28290293 | Bos taurus | Comparative proteomic analysis of milk-derived exosomes in human and bovine colostrum and mature milk samples by iTRAQ-coupled LC-MS/MS. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 2069 | Vesiclepedia_304 | 17478559 | Mus musculus | Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth 8-associated microvesicles | Adipocytes | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 2070 | Vesiclepedia_115 | 21505438 | Homo sapiens | Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. | T cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2071 | Vesiclepedia_3277 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2072 | Vesiclepedia_995 | 24434149 | Homo sapiens | In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome. | Ovarian cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2073 | Vesiclepedia_2646 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2074 | Vesiclepedia_2402 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2075 | Vesiclepedia_490 | 23264574 | Francisella novicida | Production of Outer Membrane Vesicles and Outer Membrane Tubes by Francisella novicida. | Francisella novicida | Protein | - | Membrane vesicles | EVs |
| 2076 | Vesiclepedia_746 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2077 | Vesiclepedia_625 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2078 | Vesiclepedia_2415 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2079 | Vesiclepedia_88 | 20949044 | Homo sapiens | Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line | Stomach cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2080 | Vesiclepedia_1774 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2081 | Vesiclepedia_3420 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2082 | Vesiclepedia_2873 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2083 | Vesiclepedia_3092 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2084 | Vesiclepedia_1002 | 24211404 | Mus musculus | Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice. | Lung tissue | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2085 | Vesiclepedia_2105 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2086 | Vesiclepedia_271 | 10903724 | Homo sapiens | Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface | B cells | Protein | Differential centrifugation | Exosomes | EVs |
| 2087 | Vesiclepedia_54 | 14975938 | Homo sapiens | Proteomic analysis of exosomes isolated from human malignant pleural effusions. | Malignant pleural effusions | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2088 | Vesiclepedia_2123 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2089 | Vesiclepedia_1663 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Mammary cancer-associated fibroblasts |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2090 | Vesiclepedia_2413 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2091 | Vesiclepedia_2757 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2092 | Vesiclepedia_979 | 25471885 | Drosophila melanogaster | The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. | Drosophila wing imaginal Disc | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2093 | Vesiclepedia_3299 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2094 | Vesiclepedia_1914 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Colorectal cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2095 | Vesiclepedia_3250 | 34545097 | Homo sapiens | Exosome-mediated stable epigenetic repression of HIV-1 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 2096 | Vesiclepedia_1630 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2097 | Vesiclepedia_721 | 26148937 | Homo sapiens | Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression. | Cholangiocarcinoma cells | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 2098 | Vesiclepedia_1070 | 29937354 | Homo sapiens | Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2099 | Vesiclepedia_318 | 19483673 | Homo sapiens | Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen | Monocytes | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 2100 | Vesiclepedia_975 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 2101 | Vesiclepedia_1089 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 2102 | Vesiclepedia_2574 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2103 | Vesiclepedia_1606 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2104 | Vesiclepedia_3448 | 32341770 | Mus musculus | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Plasma | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2105 | Vesiclepedia_2606 | 36581340 | Homo sapiens | Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer | Gastric cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2106 | Vesiclepedia_768 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2107 | Vesiclepedia_929 | 25483805 | Gallus gallus | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Notochord cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2108 | Vesiclepedia_6 | 11306949 | Mus musculus | Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes. | Mast cells | Protein | - | Exosomes | EVs |
| 2109 | Vesiclepedia_157 | 21630462 | Homo sapiens | Proteomic analysis of microvesicles derived from human colorectal cancer ascites | Ascites | Protein | Differential centrifugation Sucrose density gradient OptiPrep density gradient |
Microvesicles | EVs |
| 2110 | Vesiclepedia_2906 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2111 | Vesiclepedia_679 | 29951053 | Mus musculus | Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. | Myeloid-derived suppressor cells | Protein | Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2112 | Vesiclepedia_1389 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2113 | Vesiclepedia_1271 | 24058411 | Homo sapiens | Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine. | Proximal tubular epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2114 | Vesiclepedia_203 | 19011622 | Homo sapiens | Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | Glioblastoma cells |
Protein miRNA mRNA |
Differential centrifugation Ultracentrifugation Filtration |
Microvesicles | EVs |
| 2115 | Vesiclepedia_2232 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2116 | Vesiclepedia_1784 | 35927827 | Mus musculus | Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles | Dendritic cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2117 | Vesiclepedia_969 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Serum | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2118 | Vesiclepedia_1627 | 34012515 | Homo sapiens | CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells | Melanoma cells |
Protein Lipid |
Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2119 | Vesiclepedia_3481 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2120 | Vesiclepedia_921 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2121 | Vesiclepedia_3287 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2122 | Vesiclepedia_1612 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2123 | Vesiclepedia_953 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2124 | Vesiclepedia_1953 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2125 | Vesiclepedia_2028 | 36455873 | Homo sapiens | Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF | Plasma |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2126 | Vesiclepedia_1691 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2127 | Vesiclepedia_1622 | 34796683 | Homo sapiens | High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2128 | Vesiclepedia_2252 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2129 | Vesiclepedia_368 | 16103114 | Neisseria meningitidis | Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B. | Neisseria meningitidis | Protein | - | Membrane vesicles | EVs |
| 2130 | Vesiclepedia_2238 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2131 | Vesiclepedia_2058 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2132 | Vesiclepedia_2152 | 36781972 | Pseudomonas aeruginosa | The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition | Pseudomonas aeruginosa | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 2133 | Vesiclepedia_1263 | 24371517 | Homo sapiens | Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2134 | Vesiclepedia_1209 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2135 | Vesiclepedia_355 | 24115447 | Homo sapiens | Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation Immunoaffinity (EpCAM) |
Exosomes | EVs |
| 2136 | Vesiclepedia_1947 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2137 | Vesiclepedia_2948 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2138 | Vesiclepedia_1483 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2139 | Vesiclepedia_928 | 25483805 | Gallus gallus | Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties | Notochord cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2140 | Vesiclepedia_1701 | 34108659 | Capra hircus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2141 | Vesiclepedia_2856 | 33579909 | Homo sapiens | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2142 | Vesiclepedia_673 | 29953960 | Homo sapiens | Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. | Macrophage | Protein | Microfiltration Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2143 | Vesiclepedia_767 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2144 | Vesiclepedia_1286 | 20880880 | Homo sapiens | Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2145 | Vesiclepedia_2719 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2146 | Vesiclepedia_2253 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2147 | Vesiclepedia_1991 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2148 | Vesiclepedia_1168 | 29907695 | Mus musculus | Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. | Melanoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2149 | Vesiclepedia_1803 | 35917363 | Homo sapiens | CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2150 | Vesiclepedia_1475 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2151 | Vesiclepedia_1578 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2152 | Vesiclepedia_1707 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2153 | Vesiclepedia_3482 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2154 | Vesiclepedia_135 | 2777884 | Cavia porcellus | Asymmetric Distribution of Phospholipids in the Membrane of Vesicles Released During In Vitro Maturation of Guinea Pig Reticulocytes: Evidence Precluding a Role for Aminophospholipid Translocase | Reticulocytes |
Proteins Lipids |
Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2155 | Vesiclepedia_1009 | 23185418 | Homo sapiens | Improved flow cytometric assessment reveals distinct microvesicle (cell-derived microparticle) signatures in joint diseases. | Synovial fluid | Protein | Filtration Ultracentrifugation |
Microvesicles | EVs |
| 2156 | Vesiclepedia_527 | 23660474 | Homo sapiens | Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. | Neutrophils | Protein | - | Microparticles | EVs |
| 2157 | Vesiclepedia_1918 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Epidermoid cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2158 | Vesiclepedia_1376 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 2159 | Vesiclepedia_1191 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2160 | Vesiclepedia_70 | 19812188 | Rattus norvegicus | Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII. | Dendritic cells | Protein | Differential centrifugation | Exosomes | EVs |
| 2161 | Vesiclepedia_348 | 22285593 | Homo sapiens | Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. | Colorectal cancer cells | Protein | Differential centrifugation Filtration Immunoaffinity (EpCAM) Ultracentrifugation |
Exosomes | EVs |
| 2162 | Vesiclepedia_1082 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 2163 | Vesiclepedia_2358 | 36708245 | Homo sapiens | Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases | Blood |
Protein Lipid |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2164 | Vesiclepedia_3198 | 34690112 | Homo sapiens | Exosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling | Plasma |
Protein lncRNA |
ExoQuick Kit | Exosomes | EVs |
| 2165 | Vesiclepedia_2244 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2166 | Vesiclepedia_807 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2167 | Vesiclepedia_312 | 15499615 | Homo sapiens | Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer | Lung cancer cells | Protein | Differential centrifugation FACS |
Microvesicles | EVs |
| 2168 | Vesiclepedia_2286 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Natural killer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2169 | Vesiclepedia_974 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 2170 | Vesiclepedia_2293 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Prostate cancer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2171 | Vesiclepedia_2361 | 36717543 | Rattus norvegicus | Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury | Schwann cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2172 | Vesiclepedia_263 | 12805058 | Homo sapiens | Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes | Plasma | Protein | Differential centrifugation Ultracentrifugation FACS |
Microparticles | EVs |
| 2173 | Vesiclepedia_2777 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2174 | Vesiclepedia_3260 | 34654817 | Rattus norvegicus | Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors | Plasma |
Protein miRNA |
ExoQuick Kit | Small extracellular vesicles | EVs |
| 2175 | Vesiclepedia_620 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2176 | Vesiclepedia_2782 | 35304471 | Mus musculus | Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox | Hypertrophic chondrocytes | Protein | Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2177 | Vesiclepedia_2722 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2178 | Vesiclepedia_3400 | 31054213 | Homo sapiens | Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma | Cholangiocarcinoma cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 2179 | Vesiclepedia_1234 | 25421927 | Mus musculus | Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. | Serum |
miRNA Protein |
Filtration Ultracentrifugation |
Exosomes | EVs |
| 2180 | Vesiclepedia_1764 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2181 | Vesiclepedia_3445 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2182 | Vesiclepedia_300 | 19234131 | Homo sapiens | Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR | Epidermoid cancer cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 2183 | Vesiclepedia_830 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2184 | Vesiclepedia_3032 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2185 | Vesiclepedia_2912 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2186 | Vesiclepedia_837 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2187 | Vesiclepedia_2228 | 32494663 | Homo sapiens | miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1 | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2188 | Vesiclepedia_1117 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2189 | Vesiclepedia_3517 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2190 | Vesiclepedia_2616 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2191 | Vesiclepedia_2517 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 2192 | Vesiclepedia_3300 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2193 | Vesiclepedia_977 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 2194 | Vesiclepedia_1391 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva | Protein | Centrifugation Filtration Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2195 | Vesiclepedia_1288 | 20399774 | Mus musculus | C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction. | Mouse myoblast | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 2196 | Vesiclepedia_1470 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2197 | Vesiclepedia_3106 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2198 | Vesiclepedia_1610 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2199 | Vesiclepedia_702 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Apoptotic bodies | EVs |
| 2200 | Vesiclepedia_563 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient |
Microvesicles | EVs |
| 2201 | Vesiclepedia_1892 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2202 | Vesiclepedia_1541 | 33658392 | Homo sapiens | Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma | Lung cancer cells |
Protein miRNA |
Minute High-Efficiency Exosome Precipitation Reagent Filtration |
Exosomes | Small EVs |
| 2203 | Vesiclepedia_2243 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2204 | Vesiclepedia_2818 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2205 | Vesiclepedia_2962 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2206 | Vesiclepedia_1713 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2207 | Vesiclepedia_1916 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Gastric cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2208 | Vesiclepedia_1765 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2209 | Vesiclepedia_1281 | 22345510 | Rattus norvegicus | Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. | Insulinoma cells | Protein | Differential centrifugation | Microparticles | EVs |
| 2210 | Vesiclepedia_3149 | 29438363 | Homo sapiens | CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells | Fibroblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2211 | Vesiclepedia_1398 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2212 | Vesiclepedia_711 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 2213 | Vesiclepedia_1903 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2214 | Vesiclepedia_2239 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2215 | Vesiclepedia_2438 | 29335551 | Homo sapiens | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer | Liver cancer cells |
Protein miRNA |
Filtration Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2216 | Vesiclepedia_1098 | 24513287 | Mus musculus | Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. | adipocytes | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 2217 | Vesiclepedia_1685 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2218 | Vesiclepedia_197 | 21616097 | Homo sapiens | Release of podocalyxin into the extracellular space. Role of metalloproteinases | Testicular cancer cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 2219 | Vesiclepedia_2480 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2220 | Vesiclepedia_288 | 12196479 | Homo sapiens | Type 1 and type 2 diabetic patients display different patterns of cellular microparticles | Plasma |
Protein Lipids |
Differential centrifugation FACS |
Microparticles | EVs |
| 2221 | Vesiclepedia_914 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2222 | Vesiclepedia_2130 | 36515353 | Homo sapiens | Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin | Plasma |
Metabolite Protein |
ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 2223 | Vesiclepedia_1399 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2224 | Vesiclepedia_391 | 19327352 | Bos taurus | Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes. | Serum | Protein | - | Exosomes | EVs |
| 2225 | Vesiclepedia_1499 | 33982667 | Homo sapiens | Exosomal circRNA 0001445 promotes glioma progression through miRNA-127-5p/SNX5 pathway | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2226 | Vesiclepedia_396 | 19413345 | Homo sapiens | Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. | B cells | Protein | - | Microparticles | EVs |
| 2227 | Vesiclepedia_2044 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2228 | Vesiclepedia_880 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2229 | Vesiclepedia_3510 | 31068461 | Mus musculus | Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2230 | Vesiclepedia_747 | 29988836 | Homo sapiens | Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine | Urine | Protein | Filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2231 | Vesiclepedia_485 | 23214914 | Trypanosoma cruzi | Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins. | Metacyclic trypomastigotes | Protein | - | Exosomes/Extracellular vesicles/Ectosomes | EVs |
| 2232 | Vesiclepedia_1143 | 23454749 | Homo sapiens | BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. | Bone marrow mesenchymal stromal cells | Protein | Differential centrifugation Ultracentrifugation Filtration ExoQuick |
Exosomes | EVs |
| 2233 | Vesiclepedia_2983 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2234 | Vesiclepedia_1915 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Colorectal cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2235 | Vesiclepedia_1611 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2236 | Vesiclepedia_1542 | 33767144 | Homo sapiens | Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2237 | Vesiclepedia_2568 | 35260554 | Homo sapiens | Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis | Gastric cancer cells |
Protein mRNA |
Centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2238 | Vesiclepedia_2640 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Cervical cancer cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2239 | Vesiclepedia_93 | 20124479 | Rattus norvegicus | Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. | Pancreatic cancer cells |
Protein mRNA |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2240 | Vesiclepedia_1503 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum |
Protein miRNA |
ExoQuick Kit | Extracellular vesicles | Small EVs |
| 2241 | Vesiclepedia_2089 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2242 | Vesiclepedia_393 | 19369228 | Homo sapiens | Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. | Endothelial cells | Protein | - | Microparticles | EVs |
| 2243 | Vesiclepedia_1466 | 35054579 | Gallus gallus | Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus | Trachea | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2244 | Vesiclepedia_610 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2245 | Vesiclepedia_1761 | 35918900 | Homo sapiens | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2246 | Vesiclepedia_1034 | 29887978 | Homo sapiens | Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. | Serum |
Protein miRNA |
qEV size-exclusion column | Extracellular vesicles | EVs |
| 2247 | Vesiclepedia_729 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 2248 | Vesiclepedia_216 | 21293856 | Homo sapiens | Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC | Breast cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2249 | Vesiclepedia_2260 | 35661560 | Homo sapiens | Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2250 | Vesiclepedia_2505 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Large EVs |
| 2251 | Vesiclepedia_2775 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2252 | Vesiclepedia_31 | 10572093 | Homo sapiens | Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. | Platelets | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2253 | Vesiclepedia_1086 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 2254 | Vesiclepedia_1105 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2255 | Vesiclepedia_421 | 21136987 | Helicobacter pylori | Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori. | Helicobacter pylori | Protein | - | Membrane vesicles | EVs |
| 2256 | Vesiclepedia_2133 | 36515353 | Homo sapiens | Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin | Plasma |
Metabolite Protein |
ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 2257 | Vesiclepedia_1597 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2258 | Vesiclepedia_1159 | 20409149 | Homo sapiens | Transdifferentiated circulating monocytes release exosomes containing 14-3-3 proteins with matrix metalloproteinase-1 stimulating effect for dermal fibroblasts. | Keratinocytes | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2259 | Vesiclepedia_274 | 12021310 | Homo sapiens | Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 2260 | Vesiclepedia_1154 | 22057275 | Homo sapiens | Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. | Cerebrospinal fluid | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2261 | Vesiclepedia_2560 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2262 | Vesiclepedia_935 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2263 | Vesiclepedia_1163 | 29904572 | Bos taurus | A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk. | Bovine milk |
Protein miRNA |
Differential centrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2264 | Vesiclepedia_1474 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2265 | Vesiclepedia_1890 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2266 | Vesiclepedia_1436 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2267 | Vesiclepedia_2176 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 2268 | Vesiclepedia_1748 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 2269 | Vesiclepedia_1244 | 25167841 | Homo sapiens | Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes. | Serum | Protein | CD9 antibody to Mass Spectrometric Immunoassay monolith pipette tips | Exosomes | EVs |
| 2270 | Vesiclepedia_2496 | 34368811 | Homo sapiens | Isolation and characterization of extracellular vesicles in saliva of children with asthma | Saliva | Protein | ExoQuick Kit Centrifugation |
Extracellular vesicles | EVs |
| 2271 | Vesiclepedia_2287 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Natural killer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2272 | Vesiclepedia_778 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2273 | Vesiclepedia_1169 | 29907695 | Mus musculus | Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. | Melanoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2274 | Vesiclepedia_1724 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2275 | Vesiclepedia_333 | 20976003 | Homo sapiens | Selective release of microRNA species from normal and malignant mammary epithelial cells | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration |
Exosomes | EVs |
| 2276 | Vesiclepedia_119 | 21362503 | Homo sapiens | Protein profile of exosomes from trabecular meshwork cells. | Urine | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2277 | Vesiclepedia_2980 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 2278 | Vesiclepedia_2841 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2279 | Vesiclepedia_3474 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2280 | Vesiclepedia_2776 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2281 | Vesiclepedia_3091 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2282 | Vesiclepedia_3438 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | Large EVs |
| 2283 | Vesiclepedia_1688 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2284 | Vesiclepedia_1379 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2285 | Vesiclepedia_265 | 18425114 | Homo sapiens | Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | Endothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 2286 | Vesiclepedia_1696 | 34108659 | Mus musculus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic fibroblasts | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2287 | Vesiclepedia_1087 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 2288 | Vesiclepedia_700 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 2289 | Vesiclepedia_1739 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 2290 | Vesiclepedia_1174 | 29881354 | Rattus norvegicus | Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content. | Serum |
Protein miRNA |
ExoQuick | Extracellular vesicles | EVs |
| 2291 | Vesiclepedia_176 | 21788507 | Homo sapiens | Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells | Glioblastoma cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 2292 | Vesiclepedia_2919 | 33661579 | Homo sapiens | Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size | T lymphoblast | Protein | Differential centrifugation | Apoptotic bodies | Large EVs |
| 2293 | Vesiclepedia_257 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | Leukemia cells | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 2294 | Vesiclepedia_3116 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Brain | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2295 | Vesiclepedia_461 | 22848702 | Homo sapiens | Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. | Medulloblastoma cells | Protein | - | Exosomes/Membrane vesicles/Extracellular vesicles | EVs |
| 2296 | Vesiclepedia_1334 | 33368224 | Homo sapiens | Colorectal cancer prompted adipose tissue browning and cancer cachexia through transferring exosomal miR-146b-5p | Colorectal cancer cells |
Protein mRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2297 | Vesiclepedia_1917 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Gastric cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2298 | Vesiclepedia_3083 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic duct epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2299 | Vesiclepedia_1692 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2300 | Vesiclepedia_1061 | 30006486 | Homo sapiens | The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells. | Astrocytoma cells | Protein | Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2301 | Vesiclepedia_384 | 18482993 | Homo sapiens | Protein composition of human epididymosomes collected during surgical vasectomy reversal: a proteomic and genomic approach. | Epididymal fluid | Protein | - | Prostasomes | EVs |
| 2302 | Vesiclepedia_2834 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2303 | Vesiclepedia_2893 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2304 | Vesiclepedia_1925 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2305 | Vesiclepedia_1214 | 29127410 | Homo sapiens | Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies. | Bronchial epithelial cells | Protein | Ultracentrifugation | Extracellular vesicles | EVs |
| 2306 | Vesiclepedia_1221 | 27872147 | Rattus norvegicus | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Insulinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2307 | Vesiclepedia_2212 | 37043568 | Homo sapiens | Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis | Breast milk | Protein | Differential centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2308 | Vesiclepedia_2162 | 34140472 | Ixodes ricinus | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Saliva | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2309 | Vesiclepedia_375 | 18095356 | Gallus gallus | Proteome analysis of matrix vesicles isolated from femurs of chicken embryo. | 17-day-old embryo leg bone | Protein | - | Matrix vesicles | EVs |
| 2310 | Vesiclepedia_2423 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2311 | Vesiclepedia_1508 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2312 | Vesiclepedia_2026 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Osteosarcoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2313 | Vesiclepedia_2139 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2314 | Vesiclepedia_127 | 21828046 | Rattus norvegicus | Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2315 | Vesiclepedia_1968 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2316 | Vesiclepedia_525 | 23658846 | Mus musculus | Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. | Macrophage | Protein | - | Exosomes | EVs |
| 2317 | Vesiclepedia_3446 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2318 | Vesiclepedia_1772 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2319 | Vesiclepedia_431 | 21595033 | Homo sapiens | Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. | Urine | Protein | - | Exosomes | EVs |
| 2320 | Vesiclepedia_3423 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2321 | Vesiclepedia_884 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2322 | Vesiclepedia_1495 | 33991177 | Homo sapiens | Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells | Gastric cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2323 | Vesiclepedia_1161 | 22641613 | Homo sapiens | Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2324 | Vesiclepedia_1922 | 36253358 | Mus musculus | Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM | Mesenchymal stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2325 | Vesiclepedia_2453 | 34465793 | Homo sapiens | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer | Breast cancer cells |
Protein miRNA |
Centrifugation Ultracentrifugation |
Microvesicles | Large EVs |
| 2326 | Vesiclepedia_3302 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2327 | Vesiclepedia_2710 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2328 | Vesiclepedia_580 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2329 | Vesiclepedia_701 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 2330 | Vesiclepedia_2219 | 32854612 | Escherichia coli | Probiotic Escherichia coli Nissle 1917-derived outer membrane vesicles enhance immunomodulation and antimicrobial activity in RAW264.7 macrophages | Escherichia coli | Protein | Centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 2331 | Vesiclepedia_3012 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2332 | Vesiclepedia_458 | 22740476 | Homo sapiens | Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4. | Colorectal cancer cells | Protein | - | Exosomes | EVs |
| 2333 | Vesiclepedia_493 | 23333927 | Homo sapiens | Characterization and proteomic analysis of ovarian cancer-derived exosomes. | Ovarian cancer cells | Protein | - | Exosomes | EVs |
| 2334 | Vesiclepedia_801 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2335 | Vesiclepedia_2663 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2336 | Vesiclepedia_771 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2337 | Vesiclepedia_3309 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2338 | Vesiclepedia_2911 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2339 | Vesiclepedia_1079 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 2340 | Vesiclepedia_2577 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2341 | Vesiclepedia_2946 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2342 | Vesiclepedia_799 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 2343 | Vesiclepedia_3415 | 33391636 | Homo sapiens | Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus | Colorectal cancer cells | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2344 | Vesiclepedia_2380 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2345 | Vesiclepedia_2987 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2346 | Vesiclepedia_13 | 15326289 | Homo sapiens | Identification and proteomic profiling of exosomes in human urine. | Urine | Protein | Ultracentrifugation | Exosomes | EVs |
| 2347 | Vesiclepedia_334 | 20976003 | Homo sapiens | Selective release of microRNA species from normal and malignant mammary epithelial cells | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration |
Exosomes | EVs |
| 2348 | Vesiclepedia_1587 | 33692129 | Macaca fascicularis | Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates | Mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 2349 | Vesiclepedia_2758 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2350 | Vesiclepedia_2976 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Iodixanol density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2351 | Vesiclepedia_2581 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2352 | Vesiclepedia_2437 | 29335551 | Homo sapiens | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer | Liver cancer cells |
Protein miRNA |
Filtration Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2353 | Vesiclepedia_575 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Breast cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2354 | Vesiclepedia_262 | 12805058 | Homo sapiens | Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes | Plasma |
Protein Lipids |
Differential centrifugation Ultracentrifugation FACS |
Microparticles | EVs |
| 2355 | Vesiclepedia_445 | 22418980 | Homo sapiens | A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. | Urine | Protein | - | Exosomes | EVs |
| 2356 | Vesiclepedia_1464 | 35054579 | Gallus gallus | Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus | Trachea | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2357 | Vesiclepedia_1637 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells |
Protein Lipid |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2358 | Vesiclepedia_3490 | 31278254 | Mus musculus | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2359 | Vesiclepedia_2509 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | EVs |
| 2360 | Vesiclepedia_241 | 16192427 | Homo sapiens | Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 2361 | Vesiclepedia_1497 | 33991177 | Homo sapiens | Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells | Gastric cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Large extracellular vesicles | Large EVs |
| 2362 | Vesiclepedia_741 | 25157233 | Homo sapiens | Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration. | Placenta | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2363 | Vesiclepedia_1560 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2364 | Vesiclepedia_3419 | 33391636 | Homo sapiens | Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus | Embryonic kidney cells | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2365 | Vesiclepedia_1982 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2366 | Vesiclepedia_1230 | 25503107 | Homo sapiens | Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN. | Breast cancer cells | Protein | Ultracentrifugation Filtration Density gradient centrifugation |
Microvesicles | EVs |
| 2367 | Vesiclepedia_481 | 23161513 | Homo sapiens | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Colorectal cancer cells | Protein | - | Exosomes | EVs |
| 2368 | Vesiclepedia_3102 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2369 | Vesiclepedia_895 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2370 | Vesiclepedia_214 | 21364924 | Homo sapiens | Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells | T cells | Protein | Differential centrifugation Ultracentrifugation Filtration Sucrose density gradient FACS |
Exosomes | EVs |
| 2371 | Vesiclepedia_2038 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2372 | Vesiclepedia_310 | 22148876 | Homo sapiens | Proteomic analysis of microvesicles derived from human mesenchymal stem cells | Mesenchymal stem cells | Protein | Differential centrifugation Ultrafiltration Ultracentrifugation Density gradient centrifugation |
Microvesicles | EVs |
| 2373 | Vesiclepedia_1355 | 32438511 | Homo sapiens | Exosomes Derived from the Human Primary Colorectal Cancer Cell Line SW480 Orchestrate Fibroblast-Led Cancer Invasion | Colorectal cancer cells | Protein | Differential centrifugation Filtration OptiPrep density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2374 | Vesiclepedia_936 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2375 | Vesiclepedia_725 | 25471207 | Homo sapiens | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | Urine | Protein | Differential centrifugation Hydrostatic filtration dialysis Ultrafiltration |
Exosomes | EVs |
| 2376 | Vesiclepedia_1683 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2377 | Vesiclepedia_1394 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva |
Protein Lipid |
Differential centrifugation Tangential flow filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2378 | Vesiclepedia_2566 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2379 | Vesiclepedia_650 | 29188495 | Homo sapiens | Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury. | Cerebrospinal fluid | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Extracellular vesicles | EVs |
| 2380 | Vesiclepedia_696 | 28842968 | Homo sapiens | Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 2381 | Vesiclepedia_583 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2382 | Vesiclepedia_3365 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colon cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2383 | Vesiclepedia_2766 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2384 | Vesiclepedia_2029 | 35986010 | Homo sapiens | Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12 | Glioblastoma cells |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2385 | Vesiclepedia_3011 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2386 | Vesiclepedia_522 | 23645497 | Canis lupus familiaris | Oncogenic H-Ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition. | Kidney cells | Protein | - | Exosomes/Extracellular vesicles | EVs |
| 2387 | Vesiclepedia_1412 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2388 | Vesiclepedia_230 | 2294986 | Homo sapiens | Direct detection of activated platelets and platelet-derived microparticles in humans | Plasma | Protein | FACS | Microparticles | EVs |
| 2389 | Vesiclepedia_3484 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2390 | Vesiclepedia_1365 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2391 | Vesiclepedia_542 | 23935504 | Homo sapiens | A Novel Role for Pro-Coagulant Microvesicles in the Early Host Defense against Streptococcus pyogenes. | Peripheral blood mononucelar cells | Protein | - | Microvesicles | EVs |
| 2392 | Vesiclepedia_1592 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2393 | Vesiclepedia_1326 | 33431899 | Homo sapiens | High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance | Faeces |
Protein Lipid |
Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Exosomes | Small EVs |
| 2394 | Vesiclepedia_2023 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2395 | Vesiclepedia_1591 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2396 | Vesiclepedia_1301 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2397 | Vesiclepedia_101 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2398 | Vesiclepedia_831 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2399 | Vesiclepedia_2421 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2400 | Vesiclepedia_1847 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2401 | Vesiclepedia_1080 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 2402 | Vesiclepedia_1733 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2403 | Vesiclepedia_3416 | 33391636 | Homo sapiens | Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus | Lung cancer cells | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2404 | Vesiclepedia_2897 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Esophageal cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2405 | Vesiclepedia_2717 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2406 | Vesiclepedia_2902 | 33732415 | Homo sapiens | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Pancreatic cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2407 | Vesiclepedia_1942 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2408 | Vesiclepedia_3153 | 34789738 | Homo sapiens | P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells | Melanoma cells |
Protein miRNA |
Differential centrifugation | Microvesicles | Large EVs |
| 2409 | Vesiclepedia_2812 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2410 | Vesiclepedia_1807 | 36517516 | Homo sapiens | Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes | Breast cancer cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2411 | Vesiclepedia_1116 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2412 | Vesiclepedia_2127 | 36649440 | Homo sapiens | Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells | Brain endothelial cells | Protein | ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 2413 | Vesiclepedia_821 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose and deuterium oxide density cushion |
Exosomes | EVs |
| 2414 | Vesiclepedia_1944 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2415 | Vesiclepedia_1652 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2416 | Vesiclepedia_2052 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2417 | Vesiclepedia_1962 | 36417505 | Homo sapiens | A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER) | Plasma | Protein | Acoustic nanoscale separation via wave-pillar excitation resonance (ANSWER) | Exosomes | Small EVs |
| 2418 | Vesiclepedia_2810 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2419 | Vesiclepedia_448 | 22448133 | Pseudomonas aeruginosa | Vesiculation from Pseudomonas aeruginosa under SOS. | Pseudomonas aeruginosa | Protein | - | Membrane vesicles | EVs |
| 2420 | Vesiclepedia_422 | 21138299 | Francisella philomiragia | Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine. | Francisella philomiragia | Protein | - | Membrane vesicles | EVs |
| 2421 | Vesiclepedia_2843 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2422 | Vesiclepedia_822 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2423 | Vesiclepedia_3081 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2424 | Vesiclepedia_249 | 15741221 | Homo sapiens | Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation | Monocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 2425 | Vesiclepedia_2951 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2426 | Vesiclepedia_2636 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2427 | Vesiclepedia_2319 | 31762962 | Homo sapiens | Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers | Plasma |
Protein small RNA |
ExoQuick Kit | Extracellular vesicles/Exosomes | EVs |
| 2428 | Vesiclepedia_1955 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2429 | Vesiclepedia_3090 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2430 | Vesiclepedia_1352 | 32938681 | Homo sapiens | Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis | Smooth muscle cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2431 | Vesiclepedia_1067 | 29937354 | Homo sapiens | Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. | Glioblastoma cells | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 2432 | Vesiclepedia_1979 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2433 | Vesiclepedia_867 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 2434 | Vesiclepedia_3354 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Retinal endothelial cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2435 | Vesiclepedia_3084 | 35665306 | Mus musculus | Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles | Serum | Protein | Size exclusion chromatography Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2436 | Vesiclepedia_2666 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2437 | Vesiclepedia_3328 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2438 | Vesiclepedia_2016 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation | Medium extracellular vesicles | Large EVs |
| 2439 | Vesiclepedia_943 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2440 | Vesiclepedia_3058 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2441 | Vesiclepedia_2997 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2442 | Vesiclepedia_133 | 19188015 | Homo sapiens | Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes | Ovarian cancer cells |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2443 | Vesiclepedia_212 | 21372807 | Rattus norvegicus | Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes | Adipocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 2444 | Vesiclepedia_1858 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2445 | Vesiclepedia_1360 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2446 | Vesiclepedia_1413 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2447 | Vesiclepedia_2585 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2448 | Vesiclepedia_2518 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 2449 | Vesiclepedia_1556 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2450 | Vesiclepedia_215 | 21364924 | Homo sapiens | Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells | B cells | Protein | Differential centrifugation Ultracentrifugation Filtration Sucrose density gradient FACS |
Exosomes | EVs |
| 2451 | Vesiclepedia_892 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2452 | Vesiclepedia_1908 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2453 | Vesiclepedia_1428 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2454 | Vesiclepedia_520 | 23601281 | Homo sapiens | Proteomic characterization of human platelet-derived microparticles. | Platelets | Protein | - | Microparticles | EVs |
| 2455 | Vesiclepedia_247 | 15741221 | Homo sapiens | Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation | Plasma | Protein | Differential centrifugation Immunobeads (TF) |
Microvesicles | EVs |
| 2456 | Vesiclepedia_140 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 2457 | Vesiclepedia_2204 | 33732416 | Homo sapiens | Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses | Breast milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2458 | Vesiclepedia_2129 | 36515353 | Homo sapiens | Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin | Plasma | Protein | ExoQuick Kit Centrifugation |
Extracellular vesicles | Small EVs |
| 2459 | Vesiclepedia_1666 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2460 | Vesiclepedia_966 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Serum | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2461 | Vesiclepedia_3451 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2462 | Vesiclepedia_2173 | 30536591 | Homo sapiens | A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2463 | Vesiclepedia_1004 | 23463506 | Homo sapiens | The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. | T cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2464 | Vesiclepedia_3014 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2465 | Vesiclepedia_2110 | 36482876 | Mus musculus | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2466 | Vesiclepedia_3330 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2467 | Vesiclepedia_53 | 14975938 | Homo sapiens | Proteomic analysis of exosomes isolated from human malignant pleural effusions. | Malignant pleural effusions | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2468 | Vesiclepedia_989 | 25261472 | Homo sapiens | Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes/Microvesicles | EVs |
| 2469 | Vesiclepedia_695 | 28842968 | Homo sapiens | Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Microvesicles | EVs |
| 2470 | Vesiclepedia_1961 | 36417505 | Homo sapiens | A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER) | Plasma | Protein | Acoustic nanoscale separation via wave-pillar excitation resonance (ANSWER) | Exomeres | EV-like nanoparticles |
| 2471 | Vesiclepedia_323 | 20304794 | Homo sapiens | Functional delivery of viral miRNAs via exosomes | B cells | Protein | Differential centrifugation | Exosomes | EVs |
| 2472 | Vesiclepedia_2998 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2473 | Vesiclepedia_2950 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2474 | Vesiclepedia_608 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2475 | Vesiclepedia_2017 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Vascular smooth muscle cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2476 | Vesiclepedia_551 | 24009886 | Homo sapiens | Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. | Endothelial cells | Protein | - | Exosomes/Extracellular vesicles | EVs |
| 2477 | Vesiclepedia_2524 | 34315885 | Homo sapiens | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Urine | Protein | Centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2478 | Vesiclepedia_2515 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2479 | Vesiclepedia_661 | 29956871 | Homo sapiens | Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 2480 | Vesiclepedia_3066 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic duct epithelial cells | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 2481 | Vesiclepedia_723 | 25802036 | Homo sapiens | Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. | Glioblastoma cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2482 | Vesiclepedia_2289 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Neuroblastoma cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2483 | Vesiclepedia_654 | 28290293 | Bos taurus | Comparative proteomic analysis of milk-derived exosomes in human and bovine colostrum and mature milk samples by iTRAQ-coupled LC-MS/MS. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 2484 | Vesiclepedia_1028 | 26378940 | Homo sapiens | Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2485 | Vesiclepedia_2436 | 29320704 | Homo sapiens | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Plasma | Protein | Centrifugation | Extracellular vesicles | EVs |
| 2486 | Vesiclepedia_621 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Melanoma cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2487 | Vesiclepedia_2770 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Size exclusion chromatography |
Exosomes | Small EVs |
| 2488 | Vesiclepedia_34 | 19190083 | Homo sapiens | Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. | Tracheobronchial cells |
Protein mRNA |
Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 2489 | Vesiclepedia_3155 | 34789738 | Homo sapiens | P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells | Melanoma cells |
Protein miRNA |
Differential centrifugation | Microvesicles | Large EVs |
| 2490 | Vesiclepedia_2965 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2491 | Vesiclepedia_49 | 14582906 | Homo sapiens | Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Immunobeads (EpCAM) |
Exosomes | EVs |
| 2492 | Vesiclepedia_2406 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2493 | Vesiclepedia_1307 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2494 | Vesiclepedia_1015 | 22711894 | Homo sapiens | Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. | Macrophage |
Protein Lipids |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2495 | Vesiclepedia_1641 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2496 | Vesiclepedia_2370 | 36759608 | Homo sapiens | Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo | Adipocytes | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2497 | Vesiclepedia_986 | 25261472 | Homo sapiens | Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes/Microvesicles | EVs |
| 2498 | Vesiclepedia_1952 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2499 | Vesiclepedia_609 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Lung cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2500 | Vesiclepedia_692 | 28170197 | Homo sapiens | Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21 | Adipose-derived mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2501 | Vesiclepedia_879 | 29955024 | Homo sapiens | Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells | Myeloid leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2502 | Vesiclepedia_905 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer | Bladder cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2503 | Vesiclepedia_1233 | 25469510 | Homo sapiens | GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2504 | Vesiclepedia_2268 | 36624553 | Homo sapiens | Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles | Plasma | Protein | Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration |
Small extracellular vesicles | Small EVs |
| 2505 | Vesiclepedia_412 | 20156641 | Homo sapiens | Proteomics of microparticles after deep venous thrombosis. | Plasma | Protein | - | Membrane vesicles/Microparticles | EVs |
| 2506 | Vesiclepedia_1940 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2507 | Vesiclepedia_3263 | 34654817 | Rattus norvegicus | Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors | Plasma | Protein | ExoQuick Kit | Small extracellular vesicles | EVs |
| 2508 | Vesiclepedia_132 | 19188015 | Homo sapiens | Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes | Ovarian cancer cells |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2509 | Vesiclepedia_1910 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2510 | Vesiclepedia_870 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 2511 | Vesiclepedia_1090 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 2512 | Vesiclepedia_17 | 11907077 | Homo sapiens | TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. | T cells | Protein | Filtration Ultracentrifugation |
Exosomes | EVs |
| 2513 | Vesiclepedia_1642 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2514 | Vesiclepedia_2773 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Saliva | Protein | Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2515 | Vesiclepedia_3095 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2516 | Vesiclepedia_2025 | 36433666 | Homo sapiens | Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization | Osteosarcoma cells | Protein | Differential centrifugation | Medium extracellular vesicles | Large EVs |
| 2517 | Vesiclepedia_2690 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells | Protein | EVtrap | Extracellular vesicles | Small EVs |
| 2518 | Vesiclepedia_2403 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2519 | Vesiclepedia_1417 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2520 | Vesiclepedia_2365 | 36748335 | Homo sapiens | Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α | Oral cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2521 | Vesiclepedia_2071 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2522 | Vesiclepedia_1114 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2523 | Vesiclepedia_2620 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2524 | Vesiclepedia_3271 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 2525 | Vesiclepedia_3471 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ovarian cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2526 | Vesiclepedia_2824 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2527 | Vesiclepedia_3294 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2528 | Vesiclepedia_2510 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2529 | Vesiclepedia_3282 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 2530 | Vesiclepedia_1264 | 24371517 | Homo sapiens | Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2531 | Vesiclepedia_1838 | 36408942 | Rattus norvegicus | Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells | Bone marrow mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2532 | Vesiclepedia_1160 | 22641613 | Homo sapiens | Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2533 | Vesiclepedia_297 | 12796750 | Homo sapiens | High levels of circulating endothelial microparticles in patients with acute coronary syndromes | Plasma | Protein | Differential centrifugation FACS |
Microparticles | EVs |
| 2534 | Vesiclepedia_2006 | 34112803 | Mus musculus | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 2535 | Vesiclepedia_2586 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2536 | Vesiclepedia_2074 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2537 | Vesiclepedia_1345 | 33009394 | Mus musculus | Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p | Platelets | Protein | Differential centrifugation | Platelet-derived microparticles | EV-like nanoparticles |
| 2538 | Vesiclepedia_1926 | 36214496 | Homo sapiens | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2539 | Vesiclepedia_1302 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2540 | Vesiclepedia_48 | 17641064 | Homo sapiens | Exosomes with immune modulatory features are present in human breast milk. | Breast milk | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 2541 | Vesiclepedia_1557 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2542 | Vesiclepedia_1224 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Exo-spin | Extracellular vesicles | EVs |
| 2543 | Vesiclepedia_819 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2544 | Vesiclepedia_23 | 11231627 | Mus musculus | Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. | Breast cancer cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2545 | Vesiclepedia_2849 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2546 | Vesiclepedia_2968 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2547 | Vesiclepedia_1977 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2548 | Vesiclepedia_972 | 22808001 | Homo sapiens | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | Serum | Protein | Filtration ExoQuick |
Exosomes | EVs |
| 2549 | Vesiclepedia_2294 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Cervical cancer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2550 | Vesiclepedia_1311 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2551 | Vesiclepedia_919 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2552 | Vesiclepedia_2619 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2553 | Vesiclepedia_1424 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2554 | Vesiclepedia_1734 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2555 | Vesiclepedia_593 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2556 | Vesiclepedia_2180 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 2557 | Vesiclepedia_80 | 20458337 | Homo sapiens | MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2 | B cells | Protein | Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) |
Exosomes | EVs |
| 2558 | Vesiclepedia_691 | 28170197 | Homo sapiens | Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21 | Endometrium-derived mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2559 | Vesiclepedia_900 | 26100252 | Homo sapiens | Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts | Chronic lymphocytic leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2560 | Vesiclepedia_3026 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 2561 | Vesiclepedia_2815 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk |
Protein mRNA miRNA tRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2562 | Vesiclepedia_3502 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 2563 | Vesiclepedia_888 | 24946052 | Homo sapiens | Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2564 | Vesiclepedia_1854 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2565 | Vesiclepedia_406 | 19806257 | Homo sapiens | Proteomic and functional characterisation of platelet microparticle size classes. | Platelets | Protein | - | Microparticles | EVs |
| 2566 | Vesiclepedia_2996 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2567 | Vesiclepedia_68 | 19619303 | Homo sapiens | Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer. | Plasma | Protein | Differential centrifugation | Exosomes | EVs |
| 2568 | Vesiclepedia_220 | 10694520 | Homo sapiens | Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes | Plasma | Protein | Immunoaffinity [Annexin-V] | Microparticles | EVs |
| 2569 | Vesiclepedia_1609 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2570 | Vesiclepedia_1351 | 32938681 | Homo sapiens | Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis | Smooth muscle cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2571 | Vesiclepedia_817 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2572 | Vesiclepedia_2063 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2573 | Vesiclepedia_3293 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2574 | Vesiclepedia_2386 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2575 | Vesiclepedia_2427 | 35939247 | Homo sapiens | Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2576 | Vesiclepedia_56 | 12147373 | Homo sapiens | Malignant effusions and immunogenic tumour-derived exosomes. | Ascites | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2577 | Vesiclepedia_15 | 17486113 | Mus musculus Homo sapiens |
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Mast cells |
Protein mRNA miRNA |
Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2578 | Vesiclepedia_1738 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 2579 | Vesiclepedia_40 | 15908444 | Homo sapiens | Exosomal-like vesicles are present in human blood plasma. | Plasma | Protein | Differential centrifugation Filtration Sucrose density gradient |
Exosomes | EVs |
| 2580 | Vesiclepedia_3055 | 33827783 | Mus musculus | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic duct epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2581 | Vesiclepedia_3522 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2582 | Vesiclepedia_308 | 16342139 | Homo sapiens | Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization | B cells | Protein | Differential centrifugation | Microparticles | EVs |
| 2583 | Vesiclepedia_2739 | 35513391 | Homo sapiens | Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1 | Posterior longitudinal ligament |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2584 | Vesiclepedia_2707 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2585 | Vesiclepedia_1678 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography |
Exosomes | Small EVs |
| 2586 | Vesiclepedia_2838 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2587 | Vesiclepedia_2667 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2588 | Vesiclepedia_1945 | 36604402 | Homo sapiens | Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer | Faeces | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2589 | Vesiclepedia_2035 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2590 | Vesiclepedia_3358 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Plasma | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 2591 | Vesiclepedia_3439 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2592 | Vesiclepedia_3468 | 35393416 | Homo sapiens | CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity | Oral cancer cells | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2593 | Vesiclepedia_902 | 26100252 | Homo sapiens | Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts | Chronic lymphocytic leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2594 | Vesiclepedia_2150 | 34901247 | Haemophilus parasuis | Proteome Analysis of Outer Membrane Vesicles From a Highly Virulent Strain of Haemophilus parasuis | Haemophilus parasuis | Protein | Centrifugation Centrifugal ultrafiltration Filtration Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 2595 | Vesiclepedia_3188 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2596 | Vesiclepedia_2811 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2597 | Vesiclepedia_2295 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Liver cancer cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2598 | Vesiclepedia_1878 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2599 | Vesiclepedia_2254 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2600 | Vesiclepedia_1538 | 33658392 | Homo sapiens | Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma | Lung cancer cells |
Protein miRNA |
Minute High-Efficiency Exosome Precipitation Reagent Filtration |
Exosomes | Small EVs |
| 2601 | Vesiclepedia_2862 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Mammary epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2602 | Vesiclepedia_2376 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2603 | Vesiclepedia_1770 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2604 | Vesiclepedia_537 | 23818640 | Homo sapiens | Modulation of B-cell exosome proteins by gamma herpesvirus infection. | B cells | Protein | - | Exosomes/Microvesicles/Oncosomes/Microparticles | EVs |
| 2605 | Vesiclepedia_270 | 10903724 | Homo sapiens | Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface | Dendritic cells | Protein | - | Microvesicles | EVs |
| 2606 | Vesiclepedia_482 | 23161513 | Homo sapiens | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Colorectal cancer cells | Protein | - | Exosomes | EVs |
| 2607 | Vesiclepedia_3100 | 36631249 | Homo sapiens | S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos | Liver cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2608 | Vesiclepedia_3366 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colon cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Exomeres | EV-like nanoparticles |
| 2609 | Vesiclepedia_400 | 19548894 | Acinetobacter baumannii | Proteome analysis of outer membrane vesicles from a clinical Acinetobacter baumannii isolate. | Acinetobacter baumannii | Protein | - | Membrane vesicles | EVs |
| 2610 | Vesiclepedia_1718 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2611 | Vesiclepedia_2754 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Urine | Protein | Filtration Exosome detection via ultrafast-isolation system (EXODUS) |
Exosomes | Small EVs |
| 2612 | Vesiclepedia_430 | 21595033 | Homo sapiens | Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. | Urine | Protein | - | Exosomes | EVs |
| 2613 | Vesiclepedia_409 | 20031610 | Homo sapiens | Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques. | Carotid atherosclerotic plaques | Protein | - | Microparticles | EVs |
| 2614 | Vesiclepedia_183 | 21741384 | Homo sapiens | A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma | Plasma | Protein | Differential centrifugation Filtration |
Microvesicles | EVs |
| 2615 | Vesiclepedia_112 | 21601258 | Homo sapiens | Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. | Serum |
Protein miRNA |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2616 | Vesiclepedia_1598 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2617 | Vesiclepedia_2099 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2618 | Vesiclepedia_153 | 22022598 | Homo sapiens | Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity | Placenta | Protein | Differential centrifugation | Microvesicles | EVs |
| 2619 | Vesiclepedia_2144 | 36658400 | Mus musculus | Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2620 | Vesiclepedia_2478 | 34401050 | Homo sapiens | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis | Hepatocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2621 | Vesiclepedia_916 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2622 | Vesiclepedia_683 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 2623 | Vesiclepedia_19 | 16302729 | Homo sapiens | Purification, characterization and biological significance of tumor-derived exosomes. | Breast cancer cells | Protein | Differential centrifugation Sucrose density gradient Filtration Immunobeads(HER2) |
Exosomes | EVs |
| 2624 | Vesiclepedia_1277 | 23344851 | Rattus norvegicus | Urinary exosomes and diabetic nephropathy: a proteomic approach. | Urine | Protein | Ultracentrifugation | Exosomes | EVs |
| 2625 | Vesiclepedia_106 | 21763319 | Homo sapiens | Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation |
Exosomes | EVs |
| 2626 | Vesiclepedia_584 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Brain cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2627 | Vesiclepedia_2332 | 36640325 | Mus musculus | Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis | Adipocytes |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2628 | Vesiclepedia_1137 | 23861904 | Homo sapiens | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. | Placental mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration Density gradient centrifugation |
Exosomes | EVs |
| 2629 | Vesiclepedia_2508 | 34322205 | Homo sapiens | Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin | Monocytic leukemia cells | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | EVs |
| 2630 | Vesiclepedia_1856 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2631 | Vesiclepedia_545 | 23983189 | Homo sapiens | Characterization of Multiple Myeloma Vesicles by Label-Free Relative Quantitation. | B cells | Protein | - | Exosomes/Extracellular vesicles/Microvesicles | EVs |
| 2632 | Vesiclepedia_848 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2633 | Vesiclepedia_221 | 9918520 | Homo sapiens | Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity | Atherosclerotic plaques |
Protein Lipids |
Differential centrifugation Immunoaffinity [Annexin-V] |
Apoptotic bodies | EVs |
| 2634 | Vesiclepedia_1170 | 29907695 | Mus musculus | Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. | Melanoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2635 | Vesiclepedia_948 | 28819550 | Mus musculus | Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses. | Bronchoalveolar lavage fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2636 | Vesiclepedia_2967 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2637 | Vesiclepedia_1909 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2638 | Vesiclepedia_385 | 18563738 | Homo sapiens | Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. | Endothelial cells | Protein | - | Microparticles | EVs |
| 2639 | Vesiclepedia_3022 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2640 | Vesiclepedia_2446 | 34489604 | Mus musculus | Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 | Hepatocytes |
Protein miRNA |
Centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2641 | Vesiclepedia_1837 | 36408942 | Homo sapiens | Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells | Mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2642 | Vesiclepedia_2068 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2643 | Vesiclepedia_3341 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Plasma | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2644 | Vesiclepedia_2886 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2645 | Vesiclepedia_1727 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2646 | Vesiclepedia_1585 | 33692129 | Macaca fascicularis | Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates | Mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Small extracellular vesicles | Small EVs |
| 2647 | Vesiclepedia_1964 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2648 | Vesiclepedia_1849 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2649 | Vesiclepedia_535 | 23818640 | Homo sapiens | Modulation of B-cell exosome proteins by gamma herpesvirus infection. | B cells | Protein | - | Exosomes/Microvesicles/Oncosomes/Microparticles | EVs |
| 2650 | Vesiclepedia_2057 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2651 | Vesiclepedia_1973 | 35915084 | Mus musculus | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2652 | Vesiclepedia_1980 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2653 | Vesiclepedia_3305 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2654 | Vesiclepedia_1786 | 35927827 | Mus musculus | Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles | Dendritic cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2655 | Vesiclepedia_1055 | 30035390 | Mus musculus | Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. | Mouse embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2656 | Vesiclepedia_3206 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2657 | Vesiclepedia_223 | 10393703 | Homo sapiens | In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant | Endothelial cells | Protein | Differential centrifugation Ultracentrifugation |
Microparticles | EVs |
| 2658 | Vesiclepedia_1846 | 36068649 | Mus musculus | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Colorectal cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2659 | Vesiclepedia_1573 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2660 | Vesiclepedia_2544 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2661 | Vesiclepedia_1828 | 36494333 | Homo sapiens | Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis | Lung cancer cells |
Protein miRNA |
Centrifugation Filtration ExoQuick Kit |
Exosomes | Small EVs |
| 2662 | Vesiclepedia_1104 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2663 | Vesiclepedia_1052 | 29115712 | Mus musculus | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2664 | Vesiclepedia_1680 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2665 | Vesiclepedia_2613 | 35443745 | Homo sapiens | Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts | Colorectal cancer cells |
Protein miRNA |
Ultracentrifugation ExoQuick Kit |
Exosomes | Small EVs |
| 2666 | Vesiclepedia_1020 | 21734072 | Mus musculus | Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. | Insulinoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2667 | Vesiclepedia_1620 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2668 | Vesiclepedia_2075 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2669 | Vesiclepedia_2168 | 29643357 | Staphylococcus aureus | Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform | Staphylococcus aureus | Protein | Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2670 | Vesiclepedia_826 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2671 | Vesiclepedia_2930 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2672 | Vesiclepedia_2835 | 35058437 | Homo sapiens | Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2673 | Vesiclepedia_2917 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2674 | Vesiclepedia_1407 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2675 | Vesiclepedia_1216 | 27872147 | Rattus norvegicus | Primary Human and Rat .-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. | Islets | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2676 | Vesiclepedia_1393 | 32939236 | Homo sapiens | Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection | Saliva | Protein | Differential centrifugation Tangential flow filtration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2677 | Vesiclepedia_309 | 17536014 | Homo sapiens | Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of Mrna | Endothelial cells |
Protein mRNA |
Differential centrifugation Ultracentrifugation FACS |
Microvesicles | EVs |
| 2678 | Vesiclepedia_1149 | 22807456 | Homo sapiens | Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells. | Lymphocytes | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2679 | Vesiclepedia_1005 | 23463506 | Homo sapiens | The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. | T cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2680 | Vesiclepedia_1681 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2681 | Vesiclepedia_2193 | 29511463 | Bos taurus | Biocompatibility of highly purified bovine milk-derived extracellular vesicles | Bovine milk | Protein | Acidification Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2682 | Vesiclepedia_1623 | 34796683 | Homo sapiens | High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2683 | Vesiclepedia_1852 | 36068649 | Homo sapiens | Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway | Plasma | Protein | Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2684 | Vesiclepedia_727 | 25359493 | Homo sapiens | Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. | Osteoblasts | Protein | Differential centrifugation Ultracentrifugation |
Matrix vesicles | EVs |
| 2685 | Vesiclepedia_2108 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2686 | Vesiclepedia_2915 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2687 | Vesiclepedia_2625 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2688 | Vesiclepedia_1510 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2689 | Vesiclepedia_1369 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 2690 | Vesiclepedia_2095 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2691 | Vesiclepedia_3218 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2692 | Vesiclepedia_3335 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2693 | Vesiclepedia_1017 | 22711894 | Homo sapiens | Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. | Macrophage |
Protein Lipids |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2694 | Vesiclepedia_1279 | 22345510 | Rattus norvegicus | Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. | Insulinoma cells | Protein | Differential centrifugation | Microparticles | EVs |
| 2695 | Vesiclepedia_1694 | 34108659 | Mus musculus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2696 | Vesiclepedia_3476 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2697 | Vesiclepedia_2956 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2698 | Vesiclepedia_2610 | 30788085 | Homo sapiens | Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma | Oral mucosa | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2699 | Vesiclepedia_145 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 2700 | Vesiclepedia_2399 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2701 | Vesiclepedia_1283 | 22345510 | Rattus norvegicus | Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. | Insulinoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2702 | Vesiclepedia_50 | 14582906 | Homo sapiens | Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. | Dendritic cells | Protein | Differential centrifugation Immunobeads (EpCAM) |
Exosomes | EVs |
| 2703 | Vesiclepedia_3154 | 34789738 | Homo sapiens | P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells | Melanoma cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2704 | Vesiclepedia_1650 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2705 | Vesiclepedia_1046 | 28725021 | Bos taurus | Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2706 | Vesiclepedia_1353 | 32938681 | Homo sapiens | Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis | Valvular interstitial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2707 | Vesiclepedia_3337 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Colorectal cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Supermeres | EV-like nanoparticles |
| 2708 | Vesiclepedia_2113 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2709 | Vesiclepedia_27 | 19109410 | Homo sapiens | Proteomic and immunologic analyses of brain tumor exosomes. | Medulloblastoma cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2710 | Vesiclepedia_454 | 22669077 | Homo sapiens | The proteome of erythrocyte-derived microparticles from plasma: new clues for erythrocyte aging and vesiculation. | Plasma | Protein | - | Microparticles | EVs |
| 2711 | Vesiclepedia_1602 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2712 | Vesiclepedia_43 | 17076679 | Homo sapiens | Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences. | Plasma | Protein | Size exclusion chromatography Ultracentrifugation Immunobeads (CD3, CD19, CD56, CD83, PLAP) |
Exosomes | EVs |
| 2713 | Vesiclepedia_2605 | 36581340 | Homo sapiens | Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer | Gastric cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2714 | Vesiclepedia_1432 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2715 | Vesiclepedia_3072 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2716 | Vesiclepedia_1971 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2717 | Vesiclepedia_539 | 23853596 | Trichomonas vaginalis | Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host∶Parasite Interactions. | Trichomonas vaginalis | Protein | - | Exosomes/Microvesicles | EVs |
| 2718 | Vesiclepedia_3331 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colon epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2719 | Vesiclepedia_2813 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2720 | Vesiclepedia_2218 | 35753600 | Mus musculus | Outer membrane vesicles derived from heatstroke-associated intestinal microbiota promote multiple organ injury in mice | Faeces | Protein | Differential centrifugation Iodixanol density gradient centrifugation |
Outer membrane vesicles | Small EVs |
| 2721 | Vesiclepedia_2943 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2722 | Vesiclepedia_1552 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2723 | Vesiclepedia_1758 | 35918900 | Homo sapiens | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2724 | Vesiclepedia_1442 | 29472616 | Homo sapiens | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 | Colorectal cancer cells |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2725 | Vesiclepedia_12 | 15478216 | Homo sapiens | Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. | Melanoma cells | Protein | Filtration Ultracentrifugation Sucrose density gradient |
Exosomes | EVs |
| 2726 | Vesiclepedia_2567 | 33805332 | Bos taurus | Temporal Quantitative Proteomics Analysis of Neuroblastoma Cells Treated with Bovine Milk-Derived Extracellular Vesicles Highlights the Anti-Proliferative Properties of Milk-Derived Extracellular Vesicles | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Filtration |
Extracellular vesicles | Small EVs |
| 2727 | Vesiclepedia_282 | 19234131 | Homo sapiens | Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR | Lung cancer cells | Protein | Differential centrifugation | Microvesicles | EVs |
| 2728 | Vesiclepedia_3038 | 33893753 | Homo sapiens | Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy | Fibroblasts | Protein | Centrifugation Polyethylene glycol-based precipitation |
Extracellular vesicles | EVs |
| 2729 | Vesiclepedia_3344 | 34887515 | Homo sapiens | Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets | Pancreatic cancer cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2730 | Vesiclepedia_3524 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2731 | Vesiclepedia_1236 | 25421927 | Heligmosomoides polygyrus | Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. | Heligmosomoides polygyrus |
miRNA Protein |
Filtration Ultracentrifugation |
Exosomes | EVs |
| 2732 | Vesiclepedia_896 | 26100252 | Homo sapiens | Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts | Chronic lymphocytic leukemia cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2733 | Vesiclepedia_2328 | 31807237 | Homo sapiens | Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2734 | Vesiclepedia_3259 | 34580290 | Mus musculus | Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles | Kidney medullary cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2735 | Vesiclepedia_3078 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2736 | Vesiclepedia_1773 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2737 | Vesiclepedia_231 | 2294986 | Homo sapiens | Direct detection of activated platelets and platelet-derived microparticles in humans | Plasma | Protein | FACS | Microparticles | EVs |
| 2738 | Vesiclepedia_2027 | 36455873 | Homo sapiens | Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF | Plasma |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2739 | Vesiclepedia_2237 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2740 | Vesiclepedia_3186 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2741 | Vesiclepedia_2683 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2742 | Vesiclepedia_508 | 23511837 | Homo sapiens | Differential protein profiling of renal cell carcinoma urinary exosomes. | Urine | Protein | - | Exosomes/Nanovesicles | EVs |
| 2743 | Vesiclepedia_1870 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2744 | Vesiclepedia_2559 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2745 | Vesiclepedia_3528 | 30948809 | Homo sapiens | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers | Plasma | Protein | Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2746 | Vesiclepedia_2708 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2747 | Vesiclepedia_2673 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2748 | Vesiclepedia_1893 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2749 | Vesiclepedia_2037 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2750 | Vesiclepedia_397 | 19413345 | Homo sapiens | Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. | B cells | Protein | - | Microparticles | EVs |
| 2751 | Vesiclepedia_704 | 28811610 | Homo sapiens | Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. | T cells | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Microvesicles/Apoptotic bodies | EVs |
| 2752 | Vesiclepedia_1406 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2753 | Vesiclepedia_1580 | 33785738 | Mus musculus | Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2754 | Vesiclepedia_513 | 23533145 | Homo sapiens | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. | Urine | Protein | - | Exosomes/Microvesicles | EVs |
| 2755 | Vesiclepedia_682 | 29148239 | Homo sapiens | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | Umblical cord mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Sonication Filtration |
Microvesicles | EVs |
| 2756 | Vesiclepedia_3222 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2757 | Vesiclepedia_2234 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2758 | Vesiclepedia_660 | 29964051 | Homo sapiens | Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway | Adipose tissue-derived stem cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2759 | Vesiclepedia_3288 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2760 | Vesiclepedia_1018 | 22399603 | Homo sapiens | Proteomic analysis of exosome-like vesicles derived from breast cancer cells. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2761 | Vesiclepedia_3380 | 31848325 | Rattus norvegicus | Insulin-like growth factor-1 enchances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism | Neural stem cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2762 | Vesiclepedia_1430 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2763 | Vesiclepedia_811 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2764 | Vesiclepedia_3067 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Total Exosome isolation Kit | Exosomes | EVs |
| 2765 | Vesiclepedia_3192 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2766 | Vesiclepedia_3421 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2767 | Vesiclepedia_1693 | 34108659 | Mus musculus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2768 | Vesiclepedia_152 | 22064971 | Homo sapiens | Oxidized low-density lipoprotein-dependent platelet-derived microvesicles trigger procoagulant effects and amplify oxidative stress | Platelets | Protein | Differential centrifugation | Microvesicles | EVs |
| 2769 | Vesiclepedia_2941 | 35106941 | Cricetulus griseus | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Ovarian epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2770 | Vesiclepedia_1278 | 22437826 | Drosophila melanogaster | Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons. | Drosophila S2 cells | Protein | Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2771 | Vesiclepedia_2854 | 33579909 | Homo sapiens | Sulfisoxazole does not inhibit the secretion of small extracellular vesicles | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2772 | Vesiclepedia_483 | 23214914 | Trypanosoma cruzi | Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins. | Epimastigotes | Protein | - | Exosomes/Extracellular vesicles/Ectosomes | EVs |
| 2773 | Vesiclepedia_3175 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2774 | Vesiclepedia_3121 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Kidney cells | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2775 | Vesiclepedia_2498 | 34329193 | Homo sapiens | CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis | Breast cancer cells |
Protein miRNA circRNA |
Total Exosome Isolation Reagent | Exosomes | EVs |
| 2776 | Vesiclepedia_374 | 18039940 | Cryptococcus neoformans | Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence. | Cryptococcus neoformans | Protein | - | Exosomes/Extracellular vesicles | EVs |
| 2777 | Vesiclepedia_73 | 18494037 | Mus musculus | Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes. | Embryonic fibroblasts | Protein | Differential centrifugation | Exosomes | EVs |
| 2778 | Vesiclepedia_3212 | 34957415 | Homo sapiens | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2779 | Vesiclepedia_1378 | 33144925 | Homo sapiens | Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer | Oral epithelial cells | Protein | Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent |
Extracellular vesicles | Small EVs |
| 2780 | Vesiclepedia_3511 | 31068461 | Homo sapiens | Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2781 | Vesiclepedia_780 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Leukocytes | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2782 | Vesiclepedia_1144 | 23454749 | Homo sapiens | BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. | Bone marrow mesenchymal stromal cells | Protein | Differential centrifugation Ultracentrifugation Filtration ExoQuick |
Exosomes | EVs |
| 2783 | Vesiclepedia_2774 | 33432243 | Homo sapiens | Exosome detection via the ultrafast-isolation system: EXODUS | Saliva | Protein | Filtration Polyethylene glycol-based precipitation |
Exosomes | Small EVs |
| 2784 | Vesiclepedia_1671 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography |
Exosomes | Small EVs |
| 2785 | Vesiclepedia_2910 | 26061593 | Homo sapiens | Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2786 | Vesiclepedia_629 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Ovarian cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2787 | Vesiclepedia_2975 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Melanoma cells | Protein | Differential centrifugation Iodixanol density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2788 | Vesiclepedia_1409 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2789 | Vesiclepedia_1668 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Pluripotent stem cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2790 | Vesiclepedia_3532 | 30936474 | Homo sapiens | Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells | Macrophage | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2791 | Vesiclepedia_1669 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Lymphoma cells |
Protein mRNA |
Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2792 | Vesiclepedia_124 | 21235781 | Homo sapiens | Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. | Breast milk | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2793 | Vesiclepedia_123 | 21235781 | Homo sapiens | Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. | Plasma | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2794 | Vesiclepedia_423 | 21138299 | Francisella tularensis | Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine. | Francisella tularensis | Protein | - | Membrane vesicles | EVs |
| 2795 | Vesiclepedia_3193 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2796 | Vesiclepedia_1777 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2797 | Vesiclepedia_2718 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2798 | Vesiclepedia_1425 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2799 | Vesiclepedia_1639 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2800 | Vesiclepedia_1367 | 32132711 | Mus musculus | Decoy exosomes provide protection against bacterial toxins | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2801 | Vesiclepedia_2378 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2802 | Vesiclepedia_3169 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2803 | Vesiclepedia_178 | 20686450 | Homo sapiens | Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome | Urine | Protein | Differential centrifugation Ultrafiltration |
Microvesicles | EVs |
| 2804 | Vesiclepedia_1022 | 19665478 | Salmo salar | CpG-induced secretion of MHCIIbeta and exosomes from salmon (Salmo salar) APCs. | Head kidney leukocytes | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2805 | Vesiclepedia_90 | 21828046 | Rattus norvegicus | The proteo-lipidic composition of exosomes changes during reticulocyte maturation. | Reticulocytes |
Protein Lipids |
Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2806 | Vesiclepedia_3372 | 33510128 | Mus musculus | Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2807 | Vesiclepedia_1354 | 32938681 | Homo sapiens | Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis | Valvular interstitial cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2808 | Vesiclepedia_869 | 24614226 | Ovis aries | Extracellular vesicles in luminal fluid of the ovine uterus | Uterine luminal fluid | Protein | Differential centrifugation Filtration ExoQuick |
Extracellular vesicles | EVs |
| 2809 | Vesiclepedia_3185 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2810 | Vesiclepedia_579 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Breast cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2811 | Vesiclepedia_2668 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2812 | Vesiclepedia_1054 | 29115712 | Mus musculus | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2813 | Vesiclepedia_2826 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2814 | Vesiclepedia_144 | 22723089 | Homo sapiens | Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. | Prostate cancer cells | Protein | Sucrose density gradient | Exosomes | EVs |
| 2815 | Vesiclepedia_3508 | 31110292 | Mus musculus | The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency | Liver cancer cells | Protein | Differential centrifugation | Microparticles | Large EVs |
| 2816 | Vesiclepedia_89 | 20424270 | Rattus norvegicus | Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. | Basophilic leukemia cells |
Protein Lipids |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2817 | Vesiclepedia_911 | 28687758 | Sus scrofa | Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers | Polarised retinal pigmented epithelial cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2818 | Vesiclepedia_1335 | 33199621 | Mus musculus | Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice | Plasma |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2819 | Vesiclepedia_2657 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2820 | Vesiclepedia_836 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2821 | Vesiclepedia_2185 | 34276573 | Escherichia coli | Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation |
Outer membrane vesicles | Small EVs |
| 2822 | Vesiclepedia_2054 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2823 | Vesiclepedia_3080 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2824 | Vesiclepedia_1226 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 2825 | Vesiclepedia_1700 | 34108659 | Equus caballus | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Serum | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2826 | Vesiclepedia_1305 | - | Saccharomyces cerevisiae | Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling | Saccharomyces cerevisiae | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2827 | Vesiclepedia_2806 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2828 | Vesiclepedia_3221 | 34957415 | Mus musculus | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2829 | Vesiclepedia_1723 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2830 | Vesiclepedia_564 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient |
Exosomes | EVs |
| 2831 | Vesiclepedia_429 | 21595033 | Homo sapiens | Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. | Urine | Protein | - | Exosomes | EVs |
| 2832 | Vesiclepedia_173 | 21859146 | Homo sapiens | Identification of a conserved glycan signature for microvesicles | Breast milk | Protein | Differential centrifugation Filtration Ultracentrifugation |
Microvesicles | EVs |
| 2833 | Vesiclepedia_1749 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Plasma | Protein | Centrifugal filtration OptiPrep density gradient centrifugation |
Extracellular vesicles | EVs |
| 2834 | Vesiclepedia_997 | 24392111 | Mus musculus | Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk? | Murine myotubues | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2835 | Vesiclepedia_1601 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2836 | Vesiclepedia_1907 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2837 | Vesiclepedia_3404 | 31712780 | Bos taurus | Non-reversible tissue fixation retains extracellular vesicles for in situ imaging | Vitreous | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2838 | Vesiclepedia_1871 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Plasma | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2839 | Vesiclepedia_2637 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2840 | Vesiclepedia_938 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2841 | Vesiclepedia_965 | 25844599 | Homo sapiens | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | Serum | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2842 | Vesiclepedia_2497 | 34329193 | Homo sapiens | CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis | Breast cancer cells |
Protein miRNA circRNA |
Total Exosome Isolation Reagent | Exosomes | EVs |
| 2843 | Vesiclepedia_1978 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2844 | Vesiclepedia_2296 | 29339034 | Homo sapiens | Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer | Pancreatic duct fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2845 | Vesiclepedia_937 | 29207636 | Homo sapiens | Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. | Urine | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2846 | Vesiclepedia_2251 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2847 | Vesiclepedia_860 | 25776846 | Homo sapiens | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens | Epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2848 | Vesiclepedia_4 | 11487543 | Homo sapiens | Intestinal epithelial cells secrete exosome-like vesicles. | Epithelial cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2849 | Vesiclepedia_2333 | 36640325 | Mus musculus | Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis | Adipocytes |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2850 | Vesiclepedia_1482 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2851 | Vesiclepedia_2163 | 34140472 | Homo sapiens | Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection | Leukemia cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2852 | Vesiclepedia_543 | 23977379 | Listeria monocytogenes | Transcription Factor σ(B) Plays an Important Role in the Production of Extracellular Membrane-Derived Vesicles in Listeria monocytogenes. | Listeria monocytogenes | Protein | - | Membrane vesicles | EVs |
| 2853 | Vesiclepedia_3378 | 36581870 | Mus musculus | Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway | Colon cancer cells | Protein | Differential centrifugation Ultracentrifugation Qiagen Exosome Purification Kit |
Extracellular vesicles | EVs |
| 2854 | Vesiclepedia_3120 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Kidney cells | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2855 | Vesiclepedia_2821 | 34168137 | Homo sapiens | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2856 | Vesiclepedia_1643 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Primary cortical neurons | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2857 | Vesiclepedia_3395 | 31792209 | Homo sapiens | Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2858 | Vesiclepedia_590 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Colorectal cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2859 | Vesiclepedia_2703 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2860 | Vesiclepedia_1677 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2861 | Vesiclepedia_3123 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Brain | Protein | Differential centrifugation Filtration Sucrose density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2862 | Vesiclepedia_1555 | 32082513 | Homo sapiens | Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles | Liver cancer cells | Protein | Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2863 | Vesiclepedia_1400 | 35165262 | Homo sapiens | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Colon cancer cells | Protein | Differential centrifugation Tangential flow filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2864 | Vesiclepedia_185 | 22116803 | Equus caballus | Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle | Follicular fluid |
Protein miRNA |
Differential centrifugation ExoQuick |
Exosomes | EVs |
| 2865 | Vesiclepedia_2066 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2866 | Vesiclepedia_1084 | 25104112 | Homo sapiens | Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. | Plasma | Protein | Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation |
Exosomes | EVs |
| 2867 | Vesiclepedia_1420 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2868 | Vesiclepedia_1906 | 36266345 | Homo sapiens | Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2869 | Vesiclepedia_2084 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Macrophage | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2870 | Vesiclepedia_565 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient |
Exosomes | EVs |
| 2871 | Vesiclepedia_816 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2872 | Vesiclepedia_1868 | 36063142 | Mus musculus | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Embryonic fibroblasts | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2873 | Vesiclepedia_3483 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2874 | Vesiclepedia_3128 | 30967557 | Mus musculus | KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a | Hippocampal neuronal cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2875 | Vesiclepedia_198 | 21555566 | Homo sapiens | Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer | Plasma | Protein | Differential centrifugation Ultracentrifugation Gel chromatography |
Microvesicles | EVs |
| 2876 | Vesiclepedia_1937 | 36193887 | Homo sapiens | Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2877 | Vesiclepedia_846 | 28881726 | Homo sapiens | Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2878 | Vesiclepedia_1092 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 2879 | Vesiclepedia_2638 | 35649370 | Homo sapiens | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Cervical cancer cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2880 | Vesiclepedia_1091 | 25065644 | Homo sapiens | Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. | Duodenal cancer cells | Protein | Differential centrifugation Filtration Ultrafiltration |
Exosomes | EVs |
| 2881 | Vesiclepedia_2954 | 31101910 | Homo sapiens | Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death | Monocytes | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2882 | Vesiclepedia_2355 | 36708245 | Homo sapiens | Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases | Faeces |
Protein Lipid |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2883 | Vesiclepedia_2732 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2884 | Vesiclepedia_420 | 21136987 | Helicobacter pylori | Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori. | Helicobacter pylori | Protein | - | Membrane vesicles | EVs |
| 2885 | Vesiclepedia_30 | 16446100 | Rattus norvegicus | Exosomes are released by cultured cortical neurones. | Cortical neurons | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2886 | Vesiclepedia_3189 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2887 | Vesiclepedia_954 | 27601599 | Homo sapiens | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | Breast milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2888 | Vesiclepedia_255 | 9126269 | Homo sapiens | Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations | Burkitt's lymphoma | Protein | Differential centrifugation Sucrose density gradient |
Microvesicles | EVs |
| 2889 | Vesiclepedia_2246 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2890 | Vesiclepedia_1008 | 23463506 | Homo sapiens | The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. | T cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2891 | Vesiclepedia_2926 | 35106941 | Homo sapiens | K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis | Human embryonic kidney cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2892 | Vesiclepedia_1115 | 24391718 | Homo sapiens | Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2893 | Vesiclepedia_3033 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2894 | Vesiclepedia_2659 | 35649370 | Canis lupus familiaris | Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells | Kidney epithelial cells | Protein | Differential centrifugation Filtration Immunoaffinity capture Ultracentrifugation |
Exosomes | Small EVs |
| 2895 | Vesiclepedia_1496 | 33991177 | Homo sapiens | Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells | Gastric cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Large extracellular vesicles | Large EVs |
| 2896 | Vesiclepedia_432 | 21751344 | Pseudomonas aeruginosa | Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa. | Pseudomonas aeruginosa | Protein | - | Exosomes/Membrane vesicles | EVs |
| 2897 | Vesiclepedia_572 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation Immunobeads (CD81 PD) |
Extracellular vesicles | EVs |
| 2898 | Vesiclepedia_1709 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Induced pluripotent stem cell-derived neurons | Protein | Differential centrifugation Ultracentrifugation Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2899 | Vesiclepedia_177 | 19567368 | Homo sapiens | Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells | Epithelial cells | Protein | Differential centrifugation | Membrane blebs | EVs |
| 2900 | Vesiclepedia_3062 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2901 | Vesiclepedia_3434 | 32341770 | Homo sapiens | DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination | Pancreatic cancer cells | Protein | Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | Small EVs |
| 2902 | Vesiclepedia_159 | 21630462 | Homo sapiens | Proteomic analysis of microvesicles derived from human colorectal cancer ascites | Ascites | Protein | Differential centrifugation Sucrose density gradient OptiPrep density gradient |
Microvesicles | EVs |
| 2903 | Vesiclepedia_1357 | 32438511 | Homo sapiens | Exosomes Derived from the Human Primary Colorectal Cancer Cell Line SW480 Orchestrate Fibroblast-Led Cancer Invasion | Colorectal cancer cells | Protein | Differential centrifugation Filtration OptiPrep density gradient centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2904 | Vesiclepedia_3280 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 2905 | Vesiclepedia_2040 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2906 | Vesiclepedia_1960 | 36475545 | Homo sapiens | Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis | Breast cancer cells | Protein | Centrifugation Filtration |
Microvesicles | Large EVs |
| 2907 | Vesiclepedia_76 | 20224111 | Homo sapiens | Proteomics analysis of bladder cancer exosomes. | Bladder cancer cells | Protein | Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2908 | Vesiclepedia_1390 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2909 | Vesiclepedia_1260 | 24371517 | Homo sapiens | Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. | Prostate cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2910 | Vesiclepedia_2680 | 35656858 | Homo sapiens | A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells | Pancreatic cancer cells |
Protein Lipid Metabolite |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2911 | Vesiclepedia_1959 | 36475545 | Homo sapiens | Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis | Breast cancer cells | Protein | Centrifugation Filtration |
Microvesicles | Large EVs |
| 2912 | Vesiclepedia_814 | 23376832 | Rattus norvegicus | Cardiac myocyte exosomes: stability, HSP60, and proteomics | Cardiomyocytes | Protein | Differential centrifugation Filtration ExoQuick Ultracentrifugation |
Exosomes | EVs |
| 2913 | Vesiclepedia_2878 | 30918259 | Homo sapiens | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | Melanoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2914 | Vesiclepedia_3076 | 33827783 | Homo sapiens | Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment | Pancreatic cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2915 | Vesiclepedia_1921 | 36303008 | Homo sapiens | A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples | Lung cancer cells | Protein | Filtration Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2916 | Vesiclepedia_2256 | 36648227 | Escherichia coli | Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes | Escherichia coli | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2917 | Vesiclepedia_2816 | 34168137 | Bos taurus | Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis | Bovine milk | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2918 | Vesiclepedia_3130 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2919 | Vesiclepedia_2779 | 35304471 | Homo sapiens | Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox | Bone | Protein | Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation |
Extracellular vesicles | Small EVs |
| 2920 | Vesiclepedia_174 | 21842121 | Mus musculus | Oligodendroglioma cells shed microvesicles which contain TRAIL as well as molecular chaperones and induce cell death in astrocytes | Oligodendrocytes | Protein | Differential centrifugation | Microvesicles | EVs |
| 2921 | Vesiclepedia_2564 | 31819794 | Homo sapiens | Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2922 | Vesiclepedia_3478 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2923 | Vesiclepedia_3313 | 32139701 | Homo sapiens | Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2924 | Vesiclepedia_2060 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2925 | Vesiclepedia_3292 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2926 | Vesiclepedia_562 | 26858453 | Homo sapiens | Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes | Dendritic cells | Protein | Differential centrifugation Ultracentrifugation OptiPrep density gradient |
Microvesicles | EVs |
| 2927 | Vesiclepedia_1410 | 36706192 | Homo sapiens | Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2928 | Vesiclepedia_2001 | 34112803 | Homo sapiens | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Plasma | Protein | Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 2929 | Vesiclepedia_1359 | 32132711 | Homo sapiens | Decoy exosomes provide protection against bacterial toxins | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2930 | Vesiclepedia_158 | 21630462 | Homo sapiens | Proteomic analysis of microvesicles derived from human colorectal cancer ascites | Ascites | Protein | Differential centrifugation Sucrose density gradient OptiPrep density gradient |
Microvesicles | EVs |
| 2931 | Vesiclepedia_1879 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Plasma | Protein | Differential centrifugation ExoQuick Kit |
Extracellular vesicles | Small EVs |
| 2932 | Vesiclepedia_3274 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Total Exosome Isolation Reagent |
Exosomes | EVs |
| 2933 | Vesiclepedia_3291 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2934 | Vesiclepedia_1714 | 34092791 | Homo sapiens | L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma | Cerebrospinal fluid | Protein | Centrifugal filtration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2935 | Vesiclepedia_1679 | 34108659 | Homo sapiens | Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation |
Exosomes | Small EVs |
| 2936 | Vesiclepedia_785 | 29953723 | Salmo salar | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2937 | Vesiclepedia_228 | 2942561 | Homo sapiens | Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery | Serum | Protein | Differential centrifugation | Microparticles | EVs |
| 2938 | Vesiclepedia_1595 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2939 | Vesiclepedia_2705 | 35333565 | Homo sapiens | LAMP2A regulates the loading of proteins into exosomes | Retinal pigment epithelial cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2940 | Vesiclepedia_2584 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung epithelial cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2941 | Vesiclepedia_1047 | 28725021 | Bos taurus | Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth. | Bovine milk | Protein | Differential centrifugation Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2942 | Vesiclepedia_2299 | 29339034 | Homo sapiens | Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer | Pancreatic duct fluid | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2943 | Vesiclepedia_3200 | 34690112 | Homo sapiens | Exosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling | Ovarian cancer cells | Protein | ExoQuick Kit | Exosomes | EVs |
| 2944 | Vesiclepedia_1624 | 34012515 | Homo sapiens | CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells | Melanoma cells | Protein | Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography |
Extracellular vesicles | EVs |
| 2945 | Vesiclepedia_1481 | 32024826 | Mus musculus | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload | Hepatocytes |
Protein miRNA |
Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2946 | Vesiclepedia_3035 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Plasma | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2947 | Vesiclepedia_443 | 22329422 | Homo sapiens | Quantitative proteome profiling of normal human circulating microparticles. | Plasma | Protein | - | Microparticles | EVs |
| 2948 | Vesiclepedia_2521 | 34315885 | Mus musculus | Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease | Kidney epithelial cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2949 | Vesiclepedia_3501 | 31160588 | Homo sapiens | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Platelets | Protein | Differential centrifugation | Extracellular vesicles | EVs |
| 2950 | Vesiclepedia_2394 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2951 | Vesiclepedia_2039 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2952 | Vesiclepedia_1228 | 26154623 | Homo sapiens | Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | EVs |
| 2953 | Vesiclepedia_577 | 27894104 | Homo sapiens | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | Breast cancer cells | Protein | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Extracellular vesicles | EVs |
| 2954 | Vesiclepedia_2003 | 34112803 | Mus musculus | Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution | Breast cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Exosomes | Small EVs |
| 2955 | Vesiclepedia_797 | 29953723 | Homo sapiens | Stimulation of exosome release by extracellular DNA is conserved across multiple cell types | Embryonic kidney cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | EVs |
| 2956 | Vesiclepedia_1132 | 23861904 | Homo sapiens | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. | Placental mesenchymal stem cells | Protein | Differential centrifugation Ultracentrifugation Ultrafiltration Density gradient centrifugation |
Exosomes | EVs |
| 2957 | Vesiclepedia_2489 | 34388111 | Homo sapiens | miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis | Monocytic leukemia cells |
Protein miRNA |
Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2958 | Vesiclepedia_3252 | 34545097 | Homo sapiens | Exosome-mediated stable epigenetic repression of HIV-1 | Embryonic kidney cells |
Protein mRNA |
Differential centrifugation Ultracentrifugation Filtration |
Exosomes | EVs |
| 2959 | Vesiclepedia_1593 | 34282141 | Homo sapiens | Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 | Cervical cancer cells | Protein | Centrifugal ultrafiltration Immunoaffinity capture |
Extracellular vesicles | EVs |
| 2960 | Vesiclepedia_3480 | 31278254 | Homo sapiens | Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma | Ascitic fluid | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2961 | Vesiclepedia_1913 | 36270983 | Mus musculus | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer | Lung epithelial cells | Protein | Centrifugation Exosome Isolation Reagent |
Exosomes | Small EVs |
| 2962 | Vesiclepedia_2920 | 33661579 | Homo sapiens | Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size | T lymphoblast | Protein | Differential centrifugation | Apoptotic bodies | Large EVs |
| 2963 | Vesiclepedia_2125 | 36482876 | Homo sapiens | Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels | Lung cancer cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2964 | Vesiclepedia_1924 | 36214496 | Mus musculus | Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA | Motor neuron-like cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2965 | Vesiclepedia_3183 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2966 | Vesiclepedia_3306 | 32848136 | Homo sapiens | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2967 | Vesiclepedia_3132 | 34500436 | Homo sapiens | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2968 | Vesiclepedia_2576 | 35136055 | Homo sapiens | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells | Lung cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Small extracellular vesicles | Small EVs |
| 2969 | Vesiclepedia_1505 | 33953168 | Homo sapiens | Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Serum | Protein | Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2970 | Vesiclepedia_2041 | 36192599 | Mus musculus | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2971 | Vesiclepedia_1769 | 35933512 | Mus musculus | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis | Vasculature lavage fluid | Protein | Differential centrifugation | Extracellular vesicles | Large EVs |
| 2972 | Vesiclepedia_1064 | 30006486 | Homo sapiens | The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells. | Astrocytoma cells | Protein | Filtration Ultracentrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2973 | Vesiclepedia_1839 | 36408942 | Rattus norvegicus | Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells | Bone marrow mesenchymal stem cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Exosomes | Small EVs |
| 2974 | Vesiclepedia_2291 | 30891164 | Homo sapiens | Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells | Glioma cells | Protein | Polyethylene glycol-based precipitation Centrifugation Dialysis |
Extracellular vesicles | Small EVs |
| 2975 | Vesiclepedia_3418 | 33391636 | Homo sapiens | Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus | Embryonic kidney cells | Protein | Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration |
Extracellular vesicles | Small EVs |
| 2976 | Vesiclepedia_2008 | 35979935 | Homo sapiens | Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients | Serum |
Protein Lipid |
Differential centrifugation | Extracellular vesicles | EVs |
| 2977 | Vesiclepedia_1158 | 20662102 | Mus musculus | Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages. | Macrophage | Protein | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Exosomes | EVs |
| 2978 | Vesiclepedia_2098 | 36192599 | Homo sapiens | HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma | Hepatic stellate cells | Protein | Differential centrifugation | Large extracellular vesicles | Large EVs |
| 2979 | Vesiclepedia_1388 | 33135636 | Mus musculus | CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis | Macrophage | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2980 | Vesiclepedia_3278 | 34593794 | Mus musculus | A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis | Melanoma cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | Small EVs |
| 2981 | Vesiclepedia_2388 | 34355211 | Homo sapiens | A size-exclusion-based approach for purifying extracellular vesicles from human plasma | Plasma | Protein | Size exclusion chromatography | Extracellular vesicles | Small EVs |
| 2982 | Vesiclepedia_250 | 9396452 | Homo sapiens | Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant | Plasma |
Protein Lipids |
Differential centrifugation | Microparticles | EVs |
| 2983 | Vesiclepedia_110 | 21601258 | Homo sapiens | Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. | Ascites |
Protein miRNA |
Differential centrifugation Sucrose density gradient |
Exosomes | EVs |
| 2984 | Vesiclepedia_2908 | 33732415 | Mus musculus | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway | Lung cancer cells | Protein | Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2985 | Vesiclepedia_1874 | 36063142 | Homo sapiens | Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL | Colorectal cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2986 | Vesiclepedia_1636 | 29348617 | Mus musculus | Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures | Neuroblastoma cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2987 | Vesiclepedia_3167 | 34743199 | Homo sapiens | CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles | Lymphoma cells | Protein | Differential centrifugation Filtration Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2988 | Vesiclepedia_1989 | 35915084 | Homo sapiens | Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling | Breast cancer cells | Protein | Differential centrifugation Ultracentrifugation |
Extracellular vesicles | Small EVs |
| 2989 | Vesiclepedia_3007 | 30089911 | Homo sapiens | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Lung cancer cells | Protein | Differential centrifugation | Microvesicles | Large EVs |
| 2990 | Vesiclepedia_1148 | 23173708 | Rattus norvegicus | Wnt3a induces exosome secretion from primary cultured rat microglia. | Primary microglial cells | Protein | Differential centrifugation Ultracentrifugation |
Exosomes | EVs |
| 2991 | Vesiclepedia_1245 | 25167841 | Homo sapiens | Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes. | Serum | Protein | CD9 antibody to Mass Spectrometric Immunoassay monolith pipette tips | Exosomes | EVs |
| 2992 | Vesiclepedia_2189 | 33792189 | Mus musculus | A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions | Epididymal fluid | Protein | Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation |
Epididymosomes | Small EVs |
| 2993 | Vesiclepedia_1164 | 29904572 | Bos taurus | A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk. | Bovine milk |
Protein miRNA |
Differential centrifugation Density gradient centrifugation |
Extracellular vesicles | EVs |
| 2994 | Vesiclepedia_335 | 20976003 | Homo sapiens | Selective release of microRNA species from normal and malignant mammary epithelial cells | Breast cancer cells |
Protein miRNA |
Differential centrifugation Filtration |
Exosomes | EVs |