Extracellular vesicles (EVs) are released by various cell types into the extracellular space and are known to play a crucial role in intercellular communication. Subtypes of EVs include exosomes, ectosomes/microvesicles, migrasomes, apoptotic bodies, exophers and large oncosomes. In addition to EVs, cells also secrete Extracellular particles (EPs) including exomeres and supermeres. With the ignited interest on EVs and EPs due to their critical role in cellular homeostasis, pathogenesis, drug, vaccine and gene-vector delivery and as possible reservoirs of biomarkers, the amount of data generated has increased exponentially. Vesiclepedia is a manually curated compendium of molecular data (lipids, metabolites, nucleic acids and proteins) identified in different classes of Extracellular vesicles and particles.