Gene description for GSN
Gene name	gelsolin
Gene symbol	GSN
Other names/aliases	ADF AGEL
Species	Homo sapiens
Experiment description of studies that identified GSN in Urine
1 Experiment ID 63 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 19056867    Organism Homo sapiens Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes. Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA Journal name JASN Publication year 2009 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting EV-TRACK -
2 Experiment ID 390 Identified molecule protein Extracellular vesicle type Exosomes/Membrane particles MISEV EVs Identification method Mass spectrometry PubMed ID 19158352    Organism Homo sapiens Experiment description Characterization of PKD protein-positive exosome-like vesicles. Authors Hogan MC, Manganelli L, Woollard JR, Masyuk AI, Masyuk TV, Tammachote R, Huang BQ, Leontovich AA, Beito TG, Madden BJ, Charlesworth MC, Torres VE, LaRusso NF, Harris PC, Ward CJ. Journal name J Am Soc Nephrol Publication year 2009 Sample Urine Sample name Patients of autosomal recessive polycystic kidney disease-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
3 Experiment ID 437 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 22106071    Organism Homo sapiens Experiment description Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Authors Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Journal name Proteomics Publication year 2012 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120168: EV-METRIC:14%
4 Experiment ID 444 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22418980    Organism Homo sapiens Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G. Journal name Kidney Int Publication year 2012 Sample Urine Sample name Normal_high density-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120083: EV-METRIC:22%
5 Experiment ID 445 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22418980    Organism Homo sapiens Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G. Journal name Kidney Int Publication year 2012 Sample Urine Sample name Normal_low density-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120083: EV-METRIC:22%
6 Experiment ID 498 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23376485    Organism Homo sapiens Experiment description Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Authors Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P, Moll S. Journal name J Proteomics Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130051: EV-METRIC:38%
7 Experiment ID 512 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23533145    Organism Homo sapiens Experiment description In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Authors Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. Journal name Proteomics Publication year 2013 Sample Urine Sample name Low-grade prostate cancer patient-Expressed prostatic secretions in urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130224: EV-METRIC:14%
8 Experiment ID 513 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23533145    Organism Homo sapiens Experiment description In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Authors Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. Journal name Proteomics Publication year 2013 Sample Urine Sample name Normal-Expressed prostatic secretions in urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130224: EV-METRIC:14%
9 Experiment ID 725 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25471207    Organism Homo sapiens Experiment description Intraluminal proteome and peptidome of human urinary extracellular vesicles. Authors Liu X, Chinello C, Musante L, Cazzaniga M, Tataruch D, Calzaferri G, James Smith A, De Sio G, Magni F, Zou H, Holthofer H. Journal name Proteomics Clin Appl. Publication year 2015 Sample Urine Sample name Normal crude urine- Trypsinized Isolation/purification methods Differential centrifugation Hydrostatic filtration dialysis Ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140189: EV-METRIC:25%
10 Experiment ID 751 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29988836    Organism Homo sapiens Experiment description Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine Authors Oeyen E, Van Mol K, Baggerman G, Willems H, Boonen K, Rolfo C, Pauwels P, Jacobs A, Schildermans K, Cho WC, Mertens I. Journal name J Extracell Vesicles Publication year 2018 Sample Urine Sample name Urine - Fraction 8 and 9 pooled Isolation/purification methods Filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170025: EV-METRIC:62%
11 Experiment ID 1027 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24211404    Organism Homo sapiens Experiment description Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis. Authors Zubiri I, Posada-Ayala M, Sanz-Maroto A, Calvo E, Martin-Lorenzo M, Gonzalez-Calero L, de la Cuesta F, Lopez JA, Fernandez-Fernandez B, Ortiz A, Vivanco F, Alvarez-Llamas G. Journal name J Proteomics. Publication year 2014 Sample Urine Sample name Urine - Diabetic nephropathy (DN) patients Isolation/purification methods Ultracentrifugation ExoQuick Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV140245: EV-METRIC:22%, 25%, 22%