Gene description for APP
Gene name	amyloid beta precursor protein
Gene symbol	APP
Other names/aliases	AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 alpha-sAPP preA4
Species	Homo sapiens
Experiment description of studies that identified APP in Plasma
1 Experiment ID 473 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23056467    Organism Homo sapiens Experiment description Cause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy. Authors Al Kaabi A, Traupe T, Stutz M, Buchs N, Heller M. Journal name PLoS One Publication year 2012 Sample Plasma Sample name Patients of external counterpulsation therapy-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
2 Experiment ID 2329 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 32487994    Organism Homo sapiens Experiment description Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Authors Toda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA. Journal name Nat Commun Publication year 2020 Sample Plasma Sample name Healthy donors Isolation/purification methods Centrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry Flow cytometry EV-TRACK -
3 Experiment ID 2330 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 32487994    Organism Homo sapiens Experiment description Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Authors Toda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA. Journal name Nat Commun Publication year 2020 Sample Plasma Sample name Plasmodium vivax (Malaria) patients Isolation/purification methods Centrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry Flow cytometry EV-TRACK -
4 Experiment ID 2848 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-001 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
5 Experiment ID 2130 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method ELISA PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (enriched) Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Metabolite Protein Methods used in the study Mass spectometry Luciferase assay ELISA EV-TRACK -
6 Experiment ID 2131 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method ELISA PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (enriched) Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Metabolite Protein Methods used in the study Mass spectometry Luciferase assay ELISA EV-TRACK -
7 Experiment ID 2132 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method ELISA PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (enriched) - responders Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Metabolite Protein Methods used in the study ELISA EV-TRACK -
8 Experiment ID 2133 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method ELISA PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (enriched) - responders Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Metabolite Protein Methods used in the study ELISA EV-TRACK -