Gene description for L1CAM
Gene name	L1 cell adhesion molecule
Gene symbol	L1CAM
Other names/aliases	CAML1 CD171 HSAS HSAS1 HYCX MASA MIC5 N-CAM-L1 N-CAML1 NCAM-L1 S10 SPG1
Species	Homo sapiens
Experiment description of studies that identified L1CAM in Plasma
1 Experiment ID 2128 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (enriched) Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
2 Experiment ID 2129 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (total) Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
3 Experiment ID 1726 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 8 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA ELISA EV-TRACK -
4 Experiment ID 1727 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 9 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA ELISA EV-TRACK -
5 Experiment ID 1728 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 10 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
6 Experiment ID 1729 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 11 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
7 Experiment ID 1730 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 12 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
8 Experiment ID 1731 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 13 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
9 Experiment ID 1732 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 14 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
10 Experiment ID 1733 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 15 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
11 Experiment ID 1734 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 16 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
12 Experiment ID 1735 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 17 Isolation/purification methods Centrifugal filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
13 Experiment ID 1747 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 1 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.012 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
14 Experiment ID 1748 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 2 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.028 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
15 Experiment ID 1749 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 3 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.045 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
16 Experiment ID 1750 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 4 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.056 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
17 Experiment ID 1751 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 5 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.065 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
18 Experiment ID 1752 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 6 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.076 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -
19 Experiment ID 1753 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method SIMOA PubMed ID 34092791    Organism Homo sapiens Experiment description L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma Authors Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. Journal name Nat Methods Publication year 2021 Sample Plasma Sample name Fraction 7 Isolation/purification methods Centrifugal filtration OptiPrep density gradient centrifugation Flotation density 1.097 g/mL Molecules identified in the study Protein Methods used in the study SIMOA EV-TRACK -