Gene description for PLEC
Gene name	plectin
Gene symbol	PLEC
Other names/aliases	EBS1 EBS5A EBS5B EBS5C EBS5D EBSMD EBSND EBSO EBSOG EBSPA HD1 LGMD2Q LGMDR17 PCN PLEC1 PLEC1b PLTN
Species	Homo sapiens
Experiment description of studies that identified PLEC in Pancreatic cancer cells
1 Experiment ID 1270 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24218614    Organism Homo sapiens Experiment description Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. Authors Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA. Journal name Proc Natl Acad Sci U S A. Publication year 2013 Sample Pancreatic cancer cells Sample name L3.6pl- plectin knockdown Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV130114: EV-METRIC:33%, 0%, 17%
2 Experiment ID 1267 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Western blotting PubMed ID 24218614    Organism Homo sapiens Experiment description Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. Authors Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA. Journal name Proc Natl Acad Sci U S A. Publication year 2013 Sample Pancreatic cancer cells Sample name Bxpc 3 Cells Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK EV130114: EV-METRIC:33%, 0%, 17%
3 Experiment ID 1268 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Western blotting PubMed ID 24218614    Organism Homo sapiens Experiment description Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. Authors Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA. Journal name Proc Natl Acad Sci U S A. Publication year 2013 Sample Pancreatic cancer cells Sample name Panc-1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK EV130114: EV-METRIC:33%, 0%, 17%
4 Experiment ID 1269 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Western blotting PubMed ID 24218614    Organism Homo sapiens Experiment description Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. Authors Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA. Journal name Proc Natl Acad Sci U S A. Publication year 2013 Sample Pancreatic cancer cells Sample name L3.6pl- wild type cells Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV130114: EV-METRIC:33%, 0%, 17%
5 Experiment ID 1658 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Mass spectrometry PubMed ID 34108659    Organism Homo sapiens Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R. Journal name Nat Cell Biol Publication year 2021 Sample Pancreatic cancer cells Sample name BxPC3 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein mRNA Methods used in the study RT-qPCR Western blotting Mass spectrometry Flow cytometry EV-TRACK -
6 Experiment ID 1667 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Mass spectrometry PubMed ID 34108659    Organism Homo sapiens Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R. Journal name Nat Cell Biol Publication year 2021 Sample Pancreatic cancer cells Sample name PANC-1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein mRNA Methods used in the study RT-qPCR Western blotting Mass spectrometry Flow cytometry EV-TRACK -
7 Experiment ID 1686 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Mass spectrometry PubMed ID 34108659    Organism Homo sapiens Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R. Journal name Nat Cell Biol Publication year 2021 Sample Pancreatic cancer cells Sample name PANC-1 - Exo-rich fractions 7-10 pooled Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
8 Experiment ID 1687 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Mass spectrometry PubMed ID 34108659    Organism Homo sapiens Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R. Journal name Nat Cell Biol Publication year 2021 Sample Pancreatic cancer cells Sample name PANC-1 - Exo-rich fractions 1-6 pooled Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
9 Experiment ID 2678 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name PANC-1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Lipid Metabolite Methods used in the study Western blotting Mass spectrometry EV-TRACK -
10 Experiment ID 2679 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name MiaPaCa-2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Lipid Metabolite Methods used in the study Western blotting Mass spectrometry EV-TRACK -
11 Experiment ID 2680 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name Capan-1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Lipid Metabolite Methods used in the study Western blotting Mass spectrometry EV-TRACK -
12 Experiment ID 2681 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name SW-1990 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Lipid Metabolite Methods used in the study Western blotting Mass spectrometry EV-TRACK -
13 Experiment ID 2682 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name PPCL-68 (PDX) Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Lipid Metabolite Methods used in the study Western blotting Mass spectrometry EV-TRACK -
14 Experiment ID 2683 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name PPCL-46 (PDX) Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Lipid Metabolite Methods used in the study Western blotting Mass spectrometry EV-TRACK -
15 Experiment ID 2686 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name PANC-1 Isolation/purification methods EVtrap Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
16 Experiment ID 2687 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name MiaPaCa-2 Isolation/purification methods EVtrap Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
17 Experiment ID 2688 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name Capan-1 Isolation/purification methods EVtrap Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
18 Experiment ID 2689 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name SW-1990 Isolation/purification methods EVtrap Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
19 Experiment ID 2690 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name PPCL-68 (PDX) Isolation/purification methods EVtrap Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
20 Experiment ID 2691 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35656858    Organism Homo sapiens Experiment description A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells Authors Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. Journal name J Extracell Vesicles Publication year 2022 Sample Pancreatic cancer cells Sample name PPCL-46 (PDX) Isolation/purification methods EVtrap Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
21 Experiment ID 3346 Identified molecule protein Extracellular vesicle type Supermeres MISEV EV-like nanoparticles Identification method Mass spectrometry PubMed ID 34887515    Organism Homo sapiens Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Journal name Nat Cell Biol Publication year 2021 Sample Pancreatic cancer cells Sample name PANC-1 Isolation/purification methods Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry ELISA EV-TRACK -