Gene description for TTR
Gene name	transthyretin
Gene symbol	TTR
Other names/aliases	ATTR CTS CTS1 HEL111 HsT2651 PALB TBPA TTN
Species	Homo sapiens
Experiment description of studies that identified TTR in Plasma
1 Experiment ID 44 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 19028452    Organism Homo sapiens Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ Journal name BBRC Publication year 2009 Sample Plasma Sample name Plasma Isolation/purification methods Filtration Size exclusion chromatography Sucrose density gradient Flotation density 1.15-1.16 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting Immunoelectron microscopy EV-TRACK -
2 Experiment ID 355 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [Orbitrap Velos] PubMed ID 24115447    Organism Homo sapiens Experiment description Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma Authors Mathivanan,S. Journal name Proteomics Publication year 2013 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Immunoaffinity (EpCAM) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [Orbitrap Velos] Western blotting EV-TRACK EV130073: EV-METRIC:0%, 11%, 33%, 33%, 56%
3 Experiment ID 473 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23056467    Organism Homo sapiens Experiment description Cause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy. Authors Al Kaabi A, Traupe T, Stutz M, Buchs N, Heller M. Journal name PLoS One Publication year 2012 Sample Plasma Sample name Patients of external counterpulsation therapy-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
4 Experiment ID 863 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22046311    Organism Mus musculus Experiment description Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections Authors Martin-Jaular L, Nakayasu ES, Ferrer M, Almeida IC, Del Portillo HA. Journal name PLoS One Publication year 2011 Sample Plasma Sample name Peripheral blood plasma - P. yoelii 17X infected Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study FACS Mass spectrometry EV-TRACK EV110102: EV-METRIC:25%, 25%
5 Experiment ID 1223 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 1 Isolation/purification methods Exo-spin Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
6 Experiment ID 1224 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 2 Isolation/purification methods Exo-spin Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
7 Experiment ID 1225 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 3 Isolation/purification methods Exo-spin Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
8 Experiment ID 2848 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-001 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
9 Experiment ID 2849 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-004 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
10 Experiment ID 2850 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name CSB-012 - COVID-19 patient - convalescent phase Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
11 Experiment ID 2851 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name CSB-024 - COVID-19 patient - convalescent phase Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -