Gene description for EZR
Gene name	ezrin
Gene symbol	EZR
Other names/aliases	CVIL CVL HEL-S-105 VIL2
Species	Homo sapiens
Experiment description of studies that identified EZR in Prostate cancer cells
1 Experiment ID 138 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [QTOF]    Supporting data    MSS    PubMed ID 22723089    Organism Homo sapiens Experiment description Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Authors Hosseini-Beheshti E, Guns ES. Journal name MCP Publication year 2012 Sample Prostate cancer cells Sample name DU145 - Rep 2 Isolation/purification methods Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [QTOF] EV-TRACK EV120018: EV-METRIC:38%
2 Experiment ID 139 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [QTOF]    Supporting data    MSS    PubMed ID 22723089    Organism Homo sapiens Experiment description Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Authors Hosseini-Beheshti E, Guns ES. Journal name MCP Publication year 2012 Sample Prostate cancer cells Sample name DU145 - Rep 3 Isolation/purification methods Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [QTOF] EV-TRACK EV120018: EV-METRIC:38%
3 Experiment ID 141 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [QTOF]    Supporting data    MSS    PubMed ID 22723089    Organism Homo sapiens Experiment description Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Authors Hosseini-Beheshti E, Guns ES. Journal name MCP Publication year 2012 Sample Prostate cancer cells Sample name VCaP - Rep 3 Isolation/purification methods Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [QTOF] EV-TRACK EV120018: EV-METRIC:38%
4 Experiment ID 277 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [Q-TOF] PubMed ID 22030351    Organism Homo sapiens Experiment description Expression of PTRF in PC-3 cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways Authors Inder KL, Zheng YZ, Davis MJ, Moon H, Loo D, Nguyen H, Clements JA, Parton RG, Foster LJ, Hill MM Journal name MCP Publication year 2011 Sample Prostate cancer cells Sample name PC-3 Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [QTOF] EV-TRACK -
5 Experiment ID 633 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry [LTQ] PubMed ID 27894104    Organism Homo sapiens Experiment description Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. Authors Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DU145 Isolation/purification methods Differential centrifugation Polymer-based precipitation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] EV-TRACK -
6 Experiment ID 841 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name LNCaP - in CSS - Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
7 Experiment ID 845 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name LNCaP - in CSS with DHT treatment - Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
8 Experiment ID 851 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DUCaP - in CSS - Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
9 Experiment ID 852 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DUCaP - in CSS - Rep 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
10 Experiment ID 853 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DUCaP - in CSS - Rep 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
11 Experiment ID 855 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DUCaP - in CSS with DHT treatment - Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
12 Experiment ID 856 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DUCaP - in CSS with DHT treatment - Rep 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
13 Experiment ID 857 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget Publication year 2016 Sample Prostate cancer cells Sample name DUCaP - in CSS with DHT treatment - Rep 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
14 Experiment ID 887 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25102470    Organism Homo sapiens Experiment description Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro Authors Smyth TJ, Redzic JS, Graner MW, Anchordoquy TJ. Journal name Biochim Biophys Acta Publication year 2014 Sample Prostate cancer cells Sample name PC3 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.10-1.20 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140013: EV-METRIC:56%
15 Experiment ID 963 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25844599    Organism Homo sapiens Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, UlléA, Yachnin J, Nilsson S, Panaretakis T. Journal name Oncotarget Publication year 2015 Sample Prostate cancer cells Sample name DU145 Tax-Sen Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.12-1.19 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV150027: EV-METRIC:11%, 56%
16 Experiment ID 964 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25844599    Organism Homo sapiens Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, UlléA, Yachnin J, Nilsson S, Panaretakis T. Journal name Oncotarget Publication year 2015 Sample Prostate cancer cells Sample name DU145 Tax-Res Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.13-1.18 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV150027: EV-METRIC:11%, 56%
17 Experiment ID 1110 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24391718    Organism Homo sapiens Experiment description Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. Authors Duijvesz D, Burnum-Johnson KE, Gritsenko MA, Hoogland AM, Vredenbregt-van den Berg MS, Willemsen R, Luider T, Pa.a-Toli. L, Jenster G. Journal name PLoS One Publication year 2013 Sample Prostate cancer cells Sample name PC346C- replicate 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130038: EV-METRIC:33%
18 Experiment ID 1111 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24391718    Organism Homo sapiens Experiment description Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. Authors Duijvesz D, Burnum-Johnson KE, Gritsenko MA, Hoogland AM, Vredenbregt-van den Berg MS, Willemsen R, Luider T, Pa.a-Toli. L, Jenster G. Journal name PLoS One Publication year 2013 Sample Prostate cancer cells Sample name PC346C- replicate 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130038: EV-METRIC:33%
19 Experiment ID 1113 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24391718    Organism Homo sapiens Experiment description Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. Authors Duijvesz D, Burnum-Johnson KE, Gritsenko MA, Hoogland AM, Vredenbregt-van den Berg MS, Willemsen R, Luider T, Pa.a-Toli. L, Jenster G. Journal name PLoS One Publication year 2013 Sample Prostate cancer cells Sample name VCaP- replicate 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130038: EV-METRIC:33%
20 Experiment ID 1114 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24391718    Organism Homo sapiens Experiment description Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. Authors Duijvesz D, Burnum-Johnson KE, Gritsenko MA, Hoogland AM, Vredenbregt-van den Berg MS, Willemsen R, Luider T, Pa.a-Toli. L, Jenster G. Journal name PLoS One Publication year 2013 Sample Prostate cancer cells Sample name VCaP- replicate 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130038: EV-METRIC:33%
21 Experiment ID 1115 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24391718    Organism Homo sapiens Experiment description Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. Authors Duijvesz D, Burnum-Johnson KE, Gritsenko MA, Hoogland AM, Vredenbregt-van den Berg MS, Willemsen R, Luider T, Pa.a-Toli. L, Jenster G. Journal name PLoS One Publication year 2013 Sample Prostate cancer cells Sample name VCaP- replicate 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130038: EV-METRIC:33%
22 Experiment ID 1194 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget. Publication year 2016 Sample Prostate cancer cells Sample name DUCaP, DHT treatment Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
23 Experiment ID 1195 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 28881726    Organism Homo sapiens Experiment description Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. Authors Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC. Journal name Oncotarget. Publication year 2016 Sample Prostate cancer cells Sample name DUCaP, EtOH Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%
24 Experiment ID 1260 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24371517    Organism Homo sapiens Experiment description Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. Authors Bijnsdorp IV, Geldof AA, Lavaei M, Piersma SR, van Moorselaar RJ, Jimenez CR. Journal name J Extracell Vesicles. Publication year 2013 Sample Prostate cancer cells Sample name LNCaP Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV130168: EV-METRIC:11%, 11%
25 Experiment ID 1261 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24371517    Organism Homo sapiens Experiment description Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. Authors Bijnsdorp IV, Geldof AA, Lavaei M, Piersma SR, van Moorselaar RJ, Jimenez CR. Journal name J Extracell Vesicles. Publication year 2013 Sample Prostate cancer cells Sample name PC3 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV130168: EV-METRIC:11%, 11%
26 Experiment ID 2324 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Western blotting PubMed ID 31807237    Organism Homo sapiens Experiment description Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement Authors Huang C, Hays FA, Tomasek JJ, Benyajati S, Zhang XA. Journal name J Extracell Vesicles Publication year 2019 Sample Prostate cancer cells Sample name Dul145 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
27 Experiment ID 2325 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Western blotting PubMed ID 31807237    Organism Homo sapiens Experiment description Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement Authors Huang C, Hays FA, Tomasek JJ, Benyajati S, Zhang XA. Journal name J Extracell Vesicles Publication year 2019 Sample Prostate cancer cells Sample name Dul145 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
28 Experiment ID 2326 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Western blotting PubMed ID 31807237    Organism Homo sapiens Experiment description Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement Authors Huang C, Hays FA, Tomasek JJ, Benyajati S, Zhang XA. Journal name J Extracell Vesicles Publication year 2019 Sample Prostate cancer cells Sample name Dul145 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
29 Experiment ID 2327 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Western blotting PubMed ID 31807237    Organism Homo sapiens Experiment description Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement Authors Huang C, Hays FA, Tomasek JJ, Benyajati S, Zhang XA. Journal name J Extracell Vesicles Publication year 2019 Sample Prostate cancer cells Sample name LnCap Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
30 Experiment ID 2328 Identified molecule Protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Western blotting PubMed ID 31807237    Organism Homo sapiens Experiment description Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement Authors Huang C, Hays FA, Tomasek JJ, Benyajati S, Zhang XA. Journal name J Extracell Vesicles Publication year 2019 Sample Prostate cancer cells Sample name LnCap Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -