Gene description for EZR
Gene name	ezrin
Gene symbol	EZR
Other names/aliases	CVIL CVL HEL-S-105 VIL2
Species	Homo sapiens
Experiment description of studies that identified EZR in Urine
1 Experiment ID 13 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 15326289    Organism Homo sapiens Experiment description Identification and proteomic profiling of exosomes in human urine. Authors Pisitkun T, Shen RF, Knepper MA Journal name PNAS Publication year 2004 Sample Urine Sample name Urine - Normal Isolation/purification methods Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LCQ DECA XP] Western blotting EV-TRACK -
2 Experiment ID 382 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 18373357    Organism Homo sapiens Experiment description Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. Authors Smalley DM, Sheman NE, Nelson K, Theodorescu D. Journal name J Proteome Res Publication year 2008 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
3 Experiment ID 383 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 18373357    Organism Homo sapiens Experiment description Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. Authors Smalley DM, Sheman NE, Nelson K, Theodorescu D. Journal name J Proteome Res Publication year 2008 Sample Urine Sample name Patients of bladder cancer-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
4 Experiment ID 390 Identified molecule protein Extracellular vesicle type Exosomes/Membrane particles MISEV EVs Identification method Mass spectrometry PubMed ID 19158352    Organism Homo sapiens Experiment description Characterization of PKD protein-positive exosome-like vesicles. Authors Hogan MC, Manganelli L, Woollard JR, Masyuk AI, Masyuk TV, Tammachote R, Huang BQ, Leontovich AA, Beito TG, Madden BJ, Charlesworth MC, Torres VE, LaRusso NF, Harris PC, Ward CJ. Journal name J Am Soc Nephrol Publication year 2009 Sample Urine Sample name Patients of autosomal recessive polycystic kidney disease-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
5 Experiment ID 437 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 22106071    Organism Homo sapiens Experiment description Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Authors Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Journal name Proteomics Publication year 2012 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120168: EV-METRIC:14%
6 Experiment ID 444 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22418980    Organism Homo sapiens Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G. Journal name Kidney Int Publication year 2012 Sample Urine Sample name Normal_high density-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120083: EV-METRIC:22%
7 Experiment ID 445 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22418980    Organism Homo sapiens Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G. Journal name Kidney Int Publication year 2012 Sample Urine Sample name Normal_low density-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120083: EV-METRIC:22%
8 Experiment ID 478 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23082778    Organism Homo sapiens Experiment description Comparative and Targeted Proteomic Analyses of Urinary Microparticles from Bladder Cancer and Hernia Patients. Authors Chen CL, Lai YF, Tang P, Chien KY, Yu JS, Tsai CH, Chen HW, Wu CC, Chung T, Hsu CW, Chen CD, Chang YS, Chang PL, Chen YT. Journal name J Proteome Res Publication year 2012 Sample Urine Sample name Patients of bladder cancer-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120030: EV-METRIC:33%
9 Experiment ID 479 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23082778    Organism Homo sapiens Experiment description Comparative and Targeted Proteomic Analyses of Urinary Microparticles from Bladder Cancer and Hernia Patients. Authors Chen CL, Lai YF, Tang P, Chien KY, Yu JS, Tsai CH, Chen HW, Wu CC, Chung T, Hsu CW, Chen CD, Chang YS, Chang PL, Chen YT. Journal name J Proteome Res Publication year 2012 Sample Urine Sample name Patients of hernia-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120030: EV-METRIC:33%
10 Experiment ID 498 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23376485    Organism Homo sapiens Experiment description Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Authors Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P, Moll S. Journal name J Proteomics Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130051: EV-METRIC:38%
11 Experiment ID 507 Identified molecule protein Extracellular vesicle type Exosomes/Nanovesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23511837    Organism Homo sapiens Experiment description Differential protein profiling of renal cell carcinoma urinary exosomes. Authors Raimondo F, Morosi L, Corbetta S, Chinello C, Brambilla P, Della Mina P, Villa A, Albo G, Battaglia C, Bosari S, Magni F, Pitto M. Journal name Mol Biosyst Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130016: EV-METRIC:44%
12 Experiment ID 508 Identified molecule protein Extracellular vesicle type Exosomes/Nanovesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23511837    Organism Homo sapiens Experiment description Differential protein profiling of renal cell carcinoma urinary exosomes. Authors Raimondo F, Morosi L, Corbetta S, Chinello C, Brambilla P, Della Mina P, Villa A, Albo G, Battaglia C, Bosari S, Magni F, Pitto M. Journal name Mol Biosyst Publication year 2013 Sample Urine Sample name Renal cell carcinoma patient-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130016: EV-METRIC:44%
13 Experiment ID 512 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23533145    Organism Homo sapiens Experiment description In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Authors Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. Journal name Proteomics Publication year 2013 Sample Urine Sample name Low-grade prostate cancer patient-Expressed prostatic secretions in urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130224: EV-METRIC:14%
14 Experiment ID 513 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23533145    Organism Homo sapiens Experiment description In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Authors Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. Journal name Proteomics Publication year 2013 Sample Urine Sample name Normal-Expressed prostatic secretions in urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130224: EV-METRIC:14%
15 Experiment ID 540 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23886663    Organism Homo sapiens Experiment description LRRK2 Secretion in Exosomes is Regulated by 14-3-3. Authors Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Journal name Hum Mol Genet Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130075: EV-METRIC:11%, 11%, 33%
16 Experiment ID 725 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25471207    Organism Homo sapiens Experiment description Intraluminal proteome and peptidome of human urinary extracellular vesicles. Authors Liu X, Chinello C, Musante L, Cazzaniga M, Tataruch D, Calzaferri G, James Smith A, De Sio G, Magni F, Zou H, Holthofer H. Journal name Proteomics Clin Appl. Publication year 2015 Sample Urine Sample name Normal crude urine- Trypsinized Isolation/purification methods Differential centrifugation Hydrostatic filtration dialysis Ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140189: EV-METRIC:25%
17 Experiment ID 751 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29988836    Organism Homo sapiens Experiment description Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine Authors Oeyen E, Van Mol K, Baggerman G, Willems H, Boonen K, Rolfo C, Pauwels P, Jacobs A, Schildermans K, Cho WC, Mertens I. Journal name J Extracell Vesicles Publication year 2018 Sample Urine Sample name Urine - Fraction 8 and 9 pooled Isolation/purification methods Filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170025: EV-METRIC:62%
18 Experiment ID 1027 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24211404    Organism Homo sapiens Experiment description Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis. Authors Zubiri I, Posada-Ayala M, Sanz-Maroto A, Calvo E, Martin-Lorenzo M, Gonzalez-Calero L, de la Cuesta F, Lopez JA, Fernandez-Fernandez B, Ortiz A, Vivanco F, Alvarez-Llamas G. Journal name J Proteomics. Publication year 2014 Sample Urine Sample name Urine - Diabetic nephropathy (DN) patients Isolation/purification methods Ultracentrifugation ExoQuick Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV140245: EV-METRIC:22%, 25%, 22%
19 Experiment ID 1161 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22641613    Organism Homo sapiens Experiment description Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. Authors Pisitkun T, Gandolfo MT, Das S, Knepper MA, Bagnasco SM. Journal name Proteomics Clin Appl Publication year 2012 Sample Urine Sample name Renal allograft recipient with cell-mediated rejection Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120152: EV-METRIC:14%