Gene description for Msn
Gene name	moesin
Gene symbol	Msn
Other names/aliases	C78546
Species	Mus musculus
Database cross references - Msn
Vesiclepedia	VP_17698
ExoCarta	ExoCarta_17698
Entrez Gene	17698
Msn identified in extracellular vesicles derived from the following tissue/cell type
Breast cancer cells [Exosomes]      More >>>	25220352
Breast cancer cells [Exosomes]      More >>>	29115712
Breast cancer cells [Exosomes]      More >>>	29115712
Breast cancer cells [Exosomes]      More >>>	29115712
Breast cancer cells [Exosomes]      More >>>	29115712
Embryonic fibroblasts [Exosomes]      More >>>	18494037
Fibroblasts [Exosomes]      More >>>	23260141
Macrophages [Exosomes]      More >>>	23658846
Macrophages [Exosomes]      More >>>	23658846
Macrophages [Exosomes]      More >>>	23658846
Mast cells [Exosomes]      More >>>	17486113
Melanoma cells [Extracellular vesicles]      More >>>	29907695
Microglia [Exosomes]      More >>>	16081791
Mouse embryonic fibroblasts [Extracellular vesicles]      More >>>	30035390
Mouse embryonic fibroblasts [Extracellular vesicles]      More >>>	30035390
Mouse embryonic fibroblasts [Extracellular vesicles]      More >>>	30035390
Mouse embryonic fibroblasts [Extracellular vesicles]      More >>>	30035390
Mov neuroglial cell [Exosomes]      More >>>	15210972
Murine myoblast [Extracellular vesicles]      More >>>	24392111
Murine myotubues [Extracellular vesicles]      More >>>	24392111
Myeloid-derived suppressor cells [Exosomes]      More >>>	29951053
Myeloid-derived suppressor cells [Exosomes]      More >>>	29951053
Myeloid-derived suppressor cells [Exosomes]      More >>>	24295599
Myeloid-derived suppressor cells [Exosomes]      More >>>	24295599
Osteoblasts [Matrix vesicles]      More >>>	17096383
T cells [Exosomes]      More >>>	23463506
Thymus [Microvesicles]      More >>>	21635979
Thymus [Apoptotic bodies]      More >>>	21635979
Experiment description of studies that identified Msn in extracellular vesicles
1 Experiment ID 737 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 25220352    Organism Mus musculus Experiment description Surface functionalization of exosomes using click chemistry. Authors Smyth T, Petrova K, Payton NM, Persaud I, Redzic JS, Graner MW, Smith-Jones P, Anchordoquy TJ. Journal name Bioconjug Chem Publication year 2014 Sample Breast cancer cells Sample name 4T1 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.1-1.2 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140392: EV-METRIC:14%
2 Experiment ID 1051 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 29115712    Organism Mus musculus Experiment description Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. Authors Gangoda L, Liem M, Ang CS, Keerthikumar S, Adda CG, Parker BS, Mathivanan S. Journal name Proteomics. Publication year 2017 Sample Breast cancer cells Sample name 67NR Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
3 Experiment ID 1052 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 29115712    Organism Mus musculus Experiment description Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. Authors Gangoda L, Liem M, Ang CS, Keerthikumar S, Adda CG, Parker BS, Mathivanan S. Journal name Proteomics. Publication year 2017 Sample Breast cancer cells Sample name 66cl4 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
4 Experiment ID 1053 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 29115712    Organism Mus musculus Experiment description Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. Authors Gangoda L, Liem M, Ang CS, Keerthikumar S, Adda CG, Parker BS, Mathivanan S. Journal name Proteomics. Publication year 2017 Sample Breast cancer cells Sample name 4T1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
5 Experiment ID 1054 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 29115712    Organism Mus musculus Experiment description Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential. Authors Gangoda L, Liem M, Ang CS, Keerthikumar S, Adda CG, Parker BS, Mathivanan S. Journal name Proteomics. Publication year 2017 Sample Breast cancer cells Sample name 4T1.2 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
6 Experiment ID 73 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 18494037    Organism Mus musculus Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes. Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ Journal name ELEC Publication year 2008 Sample Embryonic fibroblasts Sample name NIH3T3 Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LCQ DECA] Western blotting EV-TRACK -
7 Experiment ID 489 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23260141    Organism Mus musculus Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration. Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL. Journal name Cell Publication year 2012 Sample Fibroblasts Sample name Normal-Fibroblasts (L cells) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120034: EV-METRIC:44%, 38%
8 Experiment ID 523 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23658846    Organism Mus musculus Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. Authors Hassani K, Olivier M. Journal name PLoS Negl Trop Dis Publication year 2013 Sample Macrophages Sample name Leishmania-infected-Macrophage (J774A.1) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130144: EV-METRIC:0%, 33%
9 Experiment ID 524 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23658846    Organism Mus musculus Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. Authors Hassani K, Olivier M. Journal name PLoS Negl Trop Dis Publication year 2013 Sample Macrophages Sample name LPS-treated-Macrophage (J774A.1) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130144: EV-METRIC:0%, 33%
10 Experiment ID 525 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23658846    Organism Mus musculus Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. Authors Hassani K, Olivier M. Journal name PLoS Negl Trop Dis Publication year 2013 Sample Macrophages Sample name Normal-Macrophage (J774A.1) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130144: EV-METRIC:0%, 33%
11 Experiment ID 15 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 17486113    Organism Mus musculus Homo sapiens Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Authors Valadi H, Ekströ, Bossios A, Sjöand M, Lee JJ, Lotvall JO Journal name NCB Publication year 2007 Sample Mast cells Sample name MC9 Bone marrow-derived mast cells HMC-1 Isolation/purification methods Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.11-1.21 g/mL Molecules identified in the study Protein mRNA miRNA Methods used in the study Mass spectrometry [MALDI TOF] Western blotting Microarray MicroRNA array [miRCURY LNA Array] EV-TRACK -
12 Experiment ID 1169 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 29907695    Organism Mus musculus Experiment description Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. Authors Steenbeek SC, Pham TV, de Ligt J, Zomer A, Knol JC, Piersma SR, Schelfhorst T, Huisjes R, Schiffelers RM, Cuppen E, Jimenez CR, van Rheenen J. Journal name EMBO J. Publication year 2018 Sample Melanoma cells Sample name B16F1 (100 K) Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Mass spectrometry RNA sequencing EV-TRACK -
13 Experiment ID 14 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 16081791    Organism Mus musculus Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L Journal name JIMMU Publication year 2005 Sample Microglia Sample name N9 Isolation/purification methods Differential centrifugation Sucrose density gradient Flotation density 1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LCQ DECA XP] Western blotting EV-TRACK -
14 Experiment ID 1055 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 30035390    Organism Mus musculus Experiment description Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. Authors Anand S, Foot N, Ang CS, Gembus KM, Keerthikumar S, Adda CG, Mathivanan S, Kumar S. Journal name Proteomics. Publication year 2018 Sample Mouse embryonic fibroblasts Sample name MEFs - WT 10K Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
15 Experiment ID 1056 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 30035390    Organism Mus musculus Experiment description Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. Authors Anand S, Foot N, Ang CS, Gembus KM, Keerthikumar S, Adda CG, Mathivanan S, Kumar S. Journal name Proteomics. Publication year 2018 Sample Mouse embryonic fibroblasts Sample name MEFs - WT exosomes Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
16 Experiment ID 1057 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 30035390    Organism Mus musculus Experiment description Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. Authors Anand S, Foot N, Ang CS, Gembus KM, Keerthikumar S, Adda CG, Mathivanan S, Kumar S. Journal name Proteomics. Publication year 2018 Sample Mouse embryonic fibroblasts Sample name MEFs - Arrdc1 KO 10K Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
17 Experiment ID 1058 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 30035390    Organism Mus musculus Experiment description Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles. Authors Anand S, Foot N, Ang CS, Gembus KM, Keerthikumar S, Adda CG, Mathivanan S, Kumar S. Journal name Proteomics. Publication year 2018 Sample Mouse embryonic fibroblasts Sample name MEFs - Arrdc1 KO exosomes Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
18 Experiment ID 39 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 15210972    Organism Mus musculus Experiment description Cells release prions in association with exosomes. Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G Journal name PNAS Publication year 2004 Sample Mov neuroglial cell Sample name Mov neuroglial cell Isolation/purification methods Differential centrifugation Sucrose density gradient Flotation density 1.14 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [QSTAR] Western blotting Immunoelectron microscopy EV-TRACK -
19 Experiment ID 996 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 24392111    Organism Mus musculus Experiment description Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk? Authors Forterre A, Jalabert A, Berger E, Baudet M, Chikh K, Errazuriz E, De Larichaudy J, Chanon S, Weiss-Gayet M, Hesse AM, Record M, Geloen A, Lefai E, Vidal H, Couté, Rome S. Journal name PLoS One. Publication year 2014 Sample Murine myoblast Sample name C2C12 - MB Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV140002: EV-METRIC:67%
20 Experiment ID 997 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry PubMed ID 24392111    Organism Mus musculus Experiment description Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk? Authors Forterre A, Jalabert A, Berger E, Baudet M, Chikh K, Errazuriz E, De Larichaudy J, Chanon S, Weiss-Gayet M, Hesse AM, Record M, Geloen A, Lefai E, Vidal H, Couté, Rome S. Journal name PLoS One. Publication year 2014 Sample Murine myotubues Sample name C2C12 - MT Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV140002: EV-METRIC:67%
21 Experiment ID 678 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 29951053    Organism Mus musculus Experiment description Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. Authors Zör M, Zhao K, Kutlu N, Bauer N, Provaznik J, Hackert T, Schnör M. Journal name Front Immunol Publication year 2018 Sample Myeloid-derived suppressor cells Sample name In-vitro- Alopecia areata affected C3H/HeJ mice BMC derived Isolation/purification methods Ultracentrifugation Density gradient centrifugation Flotation density Not provided Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
22 Experiment ID 679 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 29951053    Organism Mus musculus Experiment description Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. Authors Zör M, Zhao K, Kutlu N, Bauer N, Provaznik J, Hackert T, Schnör M. Journal name Front Immunol Publication year 2018 Sample Myeloid-derived suppressor cells Sample name Ex-vivo- Alopecia areata affected C3H/HeJ mice Isolation/purification methods Ultracentrifugation Density gradient centrifugation Flotation density Not provided Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
23 Experiment ID 1126 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 24295599    Organism Mus musculus Experiment description Exosomes from myeloid-derived suppressor cells carry biologically active proteins. Authors Burke M, Choksawangkarn W, Edwards N, Ostrand-Rosenberg S, Fenselau C. Journal name J Proteome Res Publication year 2014 Sample Myeloid-derived suppressor cells Sample name Conventional MDSC's-BALB/c mice injected with 4T1 cells Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140063: EV-METRIC:71%
24 Experiment ID 1127 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 24295599    Organism Mus musculus Experiment description Exosomes from myeloid-derived suppressor cells carry biologically active proteins. Authors Burke M, Choksawangkarn W, Edwards N, Ostrand-Rosenberg S, Fenselau C. Journal name J Proteome Res Publication year 2014 Sample Myeloid-derived suppressor cells Sample name Inflammatory MDSC's-BALB/c mice injected with 4T1 cells expressing IL-1. Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140063: EV-METRIC:71%
25 Experiment ID 372 Identified molecule protein Extracellular vesicle type Matrix vesicles Identification method Mass spectrometry PubMed ID 17096383    Organism Mus musculus Experiment description Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts. Authors Xiao Z, Camalier CE, Nagashima K, Chan KC, Lucas DA, de la Cruz MJ, Gignac M, Lockett S, Issaq HJ, Veenstra TD, Conrads TP, Beck GR Jr. Journal name J Cell Physiol Publication year 2007 Sample Osteoblasts Sample name MC3T3-E1 Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
26 Experiment ID 1007 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23463506    Organism Mus musculus Experiment description The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. Authors Perez-Hernandez D, Gutiéez-Váuez C, Jorge I, Ló-MartíS, Ursa A, Sáhez-Madrid F, Váuez J, Yáz-Mó Journal name J Biol Chem. Publication year 2013 Sample T cells Sample name T lymphoblasts - CD81 KO mice Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV130110: EV-METRIC:22%
27 Experiment ID 191 Identified molecule protein Extracellular vesicle type Microvesicles Identification method Mass spectrometry [QTOF] PubMed ID 21635979    Organism Mus musculus Experiment description Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice Authors TuriáL, MisjáP, Szabó, Aradi B, Páczi K, Ozohanics O, Drahos L, Kittel A, Falus A, BuzáEI, Véy K Journal name J Proteomics Publication year 2011 Sample Thymus Sample name Thymocytes - Normal Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting FACS Mass spectrometry [QTOF] EV-TRACK EV110117: EV-METRIC:11%, 11%
28 Experiment ID 192 Identified molecule protein Extracellular vesicle type Apoptotic bodies Identification method Mass spectrometry [QTOF] PubMed ID 21635979    Organism Mus musculus Experiment description Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice Authors TuriáL, MisjáP, Szabó, Aradi B, Páczi K, Ozohanics O, Drahos L, Kittel A, Falus A, BuzáEI, Véy K Journal name J Proteomics Publication year 2011 Sample Thymus Sample name Thymocytes - Normal Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting FACS Mass spectrometry [QTOF] EV-TRACK EV110117: EV-METRIC:11%, 11%