Gene description for FGR
Gene name Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Gene symbol FGR
Other names/aliases SRC2
c-fgr
c-src2
p55-Fgr
p55c-fgr
p58-Fgr
p58c-fgr
Species Homo sapiens
 Database cross references - FGR
Vesiclepedia VP_2268
ExoCarta ExoCarta_2268
Entrez Gene 2268
HGNC 3697
MIM 164940
 FGR identified in extracellular vesicles derived from the following tissue/cell type
B cells [Exosomes]      More >>> 20458337   
B cells [Exosomes]      More >>> 20458337   
B cells [Microparticles]      More >>> 16342139   
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>> 23818640   
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>> 23818640   
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>> 23818640   
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>> 23818640   
Breast cancer cells [Exosomes]      More >>> 25102470   
Chronic lymphocytic leukemia cells [Exosomes]      More >>> 26100252   
Colorectal cancer cells [Exosomes]      More >>> 22285593   
Colorectal cancer cells [Exosomes/Membrane vesicles]      More >>> 23585443   
Colorectal cancer cells [Exosomes/Membrane vesicles]      More >>> 23585443   
Dendritic cells [Microvesicles]      More >>> 26858453   
Dendritic cells [Microvesicles]      More >>> 26858453   
Dendritic cells [Exosomes]      More >>> 26858453   
Dendritic cells [Exosomes]      More >>> 26858453   
Dendritic cells [Extracellular vesicles]      More >>> 26858453   
Dendritic cells [Extracellular vesicles]      More >>> 26858453   
Dendritic cells [Extracellular vesicles]      More >>> 26858453   
Malignant pleural effusions [Exosomes/Microvesicles/Ectosomes/Microparticles]      More >>> 23585444   
Squamous carcinoma cells [Exosomes]      More >>> 20124223   
T cells [Exosomes]      More >>> 23463506   
 Experiment description of studies that identified FGR in extracellular vesicles
1
Experiment ID79
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 20458337   
OrganismHomo sapiens
Experiment descriptionMHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
AuthorsBuschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year2010
SampleB cells
Sample nameRN (HLA-DR15)
Isolation/purification methodsDifferential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [FT-ICR]
Western blotting
EV-TRACK EV100035: EV-METRIC:44%
2
Experiment ID81
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 20458337   
OrganismHomo sapiens
Experiment descriptionMHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
AuthorsBuschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year2010
SampleB cells
Sample nameRN (HLA-DR15)
Isolation/purification methodsDifferential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [FT-ICR]
Western blotting
EV-TRACK EV100035: EV-METRIC:44%
3
Experiment ID308
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Mass spectrometry [MALDI TOF/TOF]
Mass spectrometry [Q-TOF]
PubMed ID 16342139   
OrganismHomo sapiens
Experiment descriptionProteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization
AuthorsMiguet L, Pacaud K, Felden C, Hugel B, Martinez MC, Freyssinet JM, Herbrecht R, Potier N, van Dorsselaer A, Mauvieux L
Journal name Proteomics
Publication year2006
SampleB cells
Sample nameB cells - Chronic B cell lymphoid patient
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [MALDI TOF/TOF]
Mass spectrometry [QTOF]
EV-TRACK -
4
Experiment ID534
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles/Oncosomes/Microparticles
Identification method Mass spectrometry
PubMed ID 23818640   
OrganismHomo sapiens
Experiment descriptionModulation of B-cell exosome proteins by gamma herpesvirus infection.
AuthorsMeckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.
Journal name Proc Natl Acad Sci U S A
Publication year2013
SampleB cells
Sample nameEBV- and KSHV-infected B cells (JSC-1, BC1)
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130064: EV-METRIC:25%
5
Experiment ID535
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles/Oncosomes/Microparticles
Identification method Mass spectrometry
PubMed ID 23818640   
OrganismHomo sapiens
Experiment descriptionModulation of B-cell exosome proteins by gamma herpesvirus infection.
AuthorsMeckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.
Journal name Proc Natl Acad Sci U S A
Publication year2013
SampleB cells
Sample nameEBV-infected B cells (#1, HLJ, IM9, CP)
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130064: EV-METRIC:25%
6
Experiment ID536
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles/Oncosomes/Microparticles
Identification method Mass spectrometry
PubMed ID 23818640   
OrganismHomo sapiens
Experiment descriptionModulation of B-cell exosome proteins by gamma herpesvirus infection.
AuthorsMeckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.
Journal name Proc Natl Acad Sci U S A
Publication year2013
SampleB cells
Sample nameKSHV-infected B cell (JC, BC3, BCP1, BCBL1)
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130064: EV-METRIC:25%
7
Experiment ID537
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles/Oncosomes/Microparticles
Identification method Mass spectrometry
PubMed ID 23818640   
OrganismHomo sapiens
Experiment descriptionModulation of B-cell exosome proteins by gamma herpesvirus infection.
AuthorsMeckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.
Journal name Proc Natl Acad Sci U S A
Publication year2013
SampleB cells
Sample nameNormal B cells (BJAB)
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130064: EV-METRIC:25%
8
Experiment ID886
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 25102470   
OrganismHomo sapiens
Experiment descriptionExamination of the specificity of tumor cell derived exosomes with tumor cells in vitro
AuthorsSmyth TJ, Redzic JS, Graner MW, Anchordoquy TJ.
Journal name Biochim Biophys Acta
Publication year2014
SampleBreast cancer cells
Sample nameMCF-7
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density1.10-1.20 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK EV140013: EV-METRIC:56%
9
Experiment ID902
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 26100252   
OrganismHomo sapiens
Experiment descriptionExosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts
AuthorsPaggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim YJ, Adam J, Lichter P, Solary E, Berchem G, Moussay E.
Journal name Blood
Publication year2015
SampleChronic lymphocytic leukemia cells
Sample nameMEC-1
Isolation/purification methodsDifferential centrifugation
Filtration
Ultracentrifugation
Density gradient centrifugation
Flotation density1.15-1.17 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
FACS
Western blotting
EV-TRACK EV150015: EV-METRIC:22%, 44%
10
Experiment ID349
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry [Orbitrap]
PubMed ID 22285593   
OrganismHomo sapiens
Experiment descriptionComparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.
AuthorsTauro BJ, Greening DW, Mathias RA, Ji H, Mathivanan S, Scott AM, Simpson RJ
Journal name Methods
Publication year2012
SampleColorectal cancer cells
Sample nameLIM1863 - OptiPrep density gradient
Isolation/purification methodsDifferential centrifugation
Filtration
Ultracentrifugation
Density gradient centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [Orbitrap]
Western blotting
EV-TRACK EV120024: EV-METRIC:25%, 33%, 50%
11
Experiment ID517
Identified moleculeprotein
Extracellular vesicle typeExosomes/Membrane vesicles
Identification method Mass spectrometry
PubMed ID 23585443   
OrganismHomo sapiens
Experiment descriptionProteome profiling of exosomes derived from human primary and metastatic colorectal cells reveal differential expression of key metastatic factors and signal transduction components.
AuthorsJi H, Greening DW, Barnes TW, Lim JW, Tauro BJ, Rai A, Xu R, Adda C, Mathivanan S, Zhao W, Xue Y, Xu T, Zhu HJ, Simpson RJ.
Journal name Proteomics
Publication year2013
SampleColorectal cancer cells
Sample nameSW480
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130010: EV-METRIC:44%
12
Experiment ID518
Identified moleculeprotein
Extracellular vesicle typeExosomes/Membrane vesicles
Identification method Mass spectrometry
PubMed ID 23585443   
OrganismHomo sapiens
Experiment descriptionProteome profiling of exosomes derived from human primary and metastatic colorectal cells reveal differential expression of key metastatic factors and signal transduction components.
AuthorsJi H, Greening DW, Barnes TW, Lim JW, Tauro BJ, Rai A, Xu R, Adda C, Mathivanan S, Zhao W, Xue Y, Xu T, Zhu HJ, Simpson RJ.
Journal name Proteomics
Publication year2013
SampleColorectal cancer cells
Sample nameSW620
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130010: EV-METRIC:44%
13
Experiment ID562
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry [LTQ]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (F3 10K)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ]
EV-TRACK -
14
Experiment ID563
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry [LTQ]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (F5 10K)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density1.14 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ]
EV-TRACK -
15
Experiment ID564
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry [LTQ]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (F3 100K)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ]
EV-TRACK -
16
Experiment ID565
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry [LTQ ORBITRAP]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (F5 100K)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density1.14 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ ORBITRAP]
EV-TRACK -
17
Experiment ID568
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
Identification method Mass spectrometry [LTQ FUSION]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (CD9 PD)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Immunobeads (CD9 PD)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ FUSION]
EV-TRACK -
18
Experiment ID570
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
Identification method Mass spectrometry [LTQ FUSION]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (CD63 PD)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Immunobeads (CD63 PD)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ FUSION]
EV-TRACK -
19
Experiment ID573
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
Identification method Mass spectrometry [LTQ FUSION]
PubMed ID 26858453   
OrganismHomo sapiens
Experiment descriptionProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
AuthorsKowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C
Journal name PNAS
Publication year2016
SampleDendritic cells
Sample namemonocyte-derived dendritic cells (CD81 FT)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Immunobeads (CD81 FT)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ FUSION]
EV-TRACK -
20
Experiment ID519
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles/Ectosomes/Microparticles
Identification method Mass spectrometry
PubMed ID 23585444   
OrganismHomo sapiens
Experiment descriptionIdentification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions.
AuthorsPark JO, Choi DY, Choi DS, Kim HJ, Kang JW, Jung JH, Lee JH, Kim J, Freeman MR, Lee KY, Gho YS, Kim KP.
Journal name Proteomics
Publication year2013
SampleMalignant pleural effusions
Sample nameNon-small cell lung cancer patient-Lung cancer pleural effusion
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130049: EV-METRIC:38%
21
Experiment ID411
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 20124223   
OrganismHomo sapiens
Experiment descriptionHypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
AuthorsPark JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year2010
SampleSquamous carcinoma cells
Sample nameSquamous carcinoma cell (A431)
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV100050: EV-METRIC:22%
22
Experiment ID1008
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 23463506   
OrganismHomo sapiens
Experiment descriptionThe intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes.
AuthorsPerez-Hernandez D, Gutiéez-Váuez C, Jorge I, Ló-MartíS, Ursa A, Sáhez-Madrid F, Váuez J, Yáz-Mó
Journal name J Biol Chem.
Publication year2013
SampleT cells
Sample nameT lymphoblasts
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130110: EV-METRIC:22%