Gene description for HLA-DQB1
Gene name	major histocompatibility complex, class II, DQ beta 1
Gene symbol	HLA-DQB1
Other names/aliases	CELIAC1 HLA-DQB IDDM1
Species	Homo sapiens
Database cross references - HLA-DQB1
Vesiclepedia	VP_3119
ExoCarta	ExoCarta_3119
Entrez Gene	3119
HGNC	4944
MIM	604305
HLA-DQB1 identified in extracellular vesicles derived from the following tissue/cell type
B cells [Exosomes]      More >>>	12519789
B cells [Exosomes]      More >>>	20458337
B cells [Exosomes]      More >>>	20458337
B cells [Exosomes]      More >>>	20458337
B cells [Microparticles]      More >>>	16342139
B cells [Microparticles]      More >>>	19413345
B cells [Microparticles]      More >>>	19413345
B cells [Microparticles]      More >>>	19413345
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>>	23818640
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>>	23818640
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>>	23818640
B cells [Exosomes/Microvesicles/Oncosomes/Microparticles]      More >>>	23818640
Chronic lymphocytic leukemia cells [Exosomes]      More >>>	26100252
Chronic lymphocytic leukemia cells [Exosomes]      More >>>	26100252
Chronic lymphocytic leukemia cells [Exosomes]      More >>>	26100252
Chronic lymphocytic leukemia cells [Exosomes]      More >>>	26100252
Dendritic cells [Microvesicles]      More >>>	26858453
Dendritic cells [Microvesicles]      More >>>	26858453
Dendritic cells [Exosomes]      More >>>	26858453
Dendritic cells [Exosomes]      More >>>	26858453
Dendritic cells [Extracellular vesicles]      More >>>	26858453
Dendritic cells [Extracellular vesicles]      More >>>	26858453
Dendritic cells [Extracellular vesicles]      More >>>	26858453
Dendritic cells [Extracellular vesicles]      More >>>	26858453
Epithelial cells [Exosomes]      More >>>	25776846
Serum [Exosomes]      More >>>	22808001
Thymus [Exosomes]      More >>>	23844026
Experiment description of studies that identified HLA-DQB1 in extracellular vesicles
1 Experiment ID 11 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [MALDI TOF] Western blotting PubMed ID 12519789    Organism Homo sapiens Experiment description Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. Authors Wubbolts R, Leckie RS, Veenhuizen PT, Schwarzmann G, Mös W, Hoernschemeyer J, Slot JW, Geuze HJ, Stoorvogel W Journal name JBC Publication year 2003 Sample B cells Sample name RN (HLA-DR15+) Isolation/purification methods Differential centrifugation Sucrose density gradient Flotation density 1.15 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [MALDI TOF] Mass spectrometry [QTOF] Western blotting Thin layer chromatography High performance liquid chromatography EV-TRACK -
2 Experiment ID 79 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 20458337    Organism Homo sapiens Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1 Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. Journal name ICB Publication year 2010 Sample B cells Sample name RN (HLA-DR15) Isolation/purification methods Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [FT-ICR] Western blotting EV-TRACK EV100035: EV-METRIC:44%
3 Experiment ID 80 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 20458337    Organism Homo sapiens Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2 Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. Journal name ICB Publication year 2010 Sample B cells Sample name RN (HLA-DR15) Isolation/purification methods Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [FT-ICR] Western blotting EV-TRACK EV100035: EV-METRIC:44%
4 Experiment ID 81 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 20458337    Organism Homo sapiens Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3 Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. Journal name ICB Publication year 2010 Sample B cells Sample name RN (HLA-DR15) Isolation/purification methods Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [FT-ICR] Western blotting EV-TRACK EV100035: EV-METRIC:44%
5 Experiment ID 308 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [Q-TOF] PubMed ID 16342139    Organism Homo sapiens Experiment description Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization Authors Miguet L, Pacaud K, Felden C, Hugel B, Martinez MC, Freyssinet JM, Herbrecht R, Potier N, van Dorsselaer A, Mauvieux L Journal name Proteomics Publication year 2006 Sample B cells Sample name B cells - Chronic B cell lymphoid patient Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [QTOF] EV-TRACK -
6 Experiment ID 395 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry PubMed ID 19413345    Organism Homo sapiens Experiment description Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. Authors Miguet L, Béchade G, Fornecker L, Zink E, Felden C, Gervais C, Herbrecht R, Van Dorsselaer A, Mauvieux L, Sanglier-Cianferani S. Journal name J Proteome Res Publication year 2009 Sample B cells Sample name Patients of chronic lymphocytic leukemia-B cells Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
7 Experiment ID 396 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry PubMed ID 19413345    Organism Homo sapiens Experiment description Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. Authors Miguet L, Béchade G, Fornecker L, Zink E, Felden C, Gervais C, Herbrecht R, Van Dorsselaer A, Mauvieux L, Sanglier-Cianferani S. Journal name J Proteome Res Publication year 2009 Sample B cells Sample name Patients of mantle cell lymphoma-B cells Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
8 Experiment ID 397 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry PubMed ID 19413345    Organism Homo sapiens Experiment description Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. Authors Miguet L, Béchade G, Fornecker L, Zink E, Felden C, Gervais C, Herbrecht R, Van Dorsselaer A, Mauvieux L, Sanglier-Cianferani S. Journal name J Proteome Res Publication year 2009 Sample B cells Sample name Patients of small cell lymphoma-B cells Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
9 Experiment ID 534 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles/Oncosomes/Microparticles Identification method Mass spectrometry PubMed ID 23818640    Organism Homo sapiens Experiment description Modulation of B-cell exosome proteins by gamma herpesvirus infection. Authors Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N. Journal name Proc Natl Acad Sci U S A Publication year 2013 Sample B cells Sample name EBV- and KSHV-infected B cells (JSC-1, BC1) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130064: EV-METRIC:25%
10 Experiment ID 535 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles/Oncosomes/Microparticles Identification method Mass spectrometry PubMed ID 23818640    Organism Homo sapiens Experiment description Modulation of B-cell exosome proteins by gamma herpesvirus infection. Authors Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N. Journal name Proc Natl Acad Sci U S A Publication year 2013 Sample B cells Sample name EBV-infected B cells (#1, HLJ, IM9, CP) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130064: EV-METRIC:25%
11 Experiment ID 536 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles/Oncosomes/Microparticles Identification method Mass spectrometry PubMed ID 23818640    Organism Homo sapiens Experiment description Modulation of B-cell exosome proteins by gamma herpesvirus infection. Authors Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N. Journal name Proc Natl Acad Sci U S A Publication year 2013 Sample B cells Sample name KSHV-infected B cell (JC, BC3, BCP1, BCBL1) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130064: EV-METRIC:25%
12 Experiment ID 537 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles/Oncosomes/Microparticles Identification method Mass spectrometry PubMed ID 23818640    Organism Homo sapiens Experiment description Modulation of B-cell exosome proteins by gamma herpesvirus infection. Authors Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N. Journal name Proc Natl Acad Sci U S A Publication year 2013 Sample B cells Sample name Normal B cells (BJAB) Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130064: EV-METRIC:25%
13 Experiment ID 899 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 26100252    Organism Homo sapiens Experiment description Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts Authors Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim YJ, Adam J, Lichter P, Solary E, Berchem G, Moussay E. Journal name Blood Publication year 2015 Sample Chronic lymphocytic leukemia cells Sample name CLL cells - Rep 1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density 1.15-1.17 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150015: EV-METRIC:22%, 44%
14 Experiment ID 900 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 26100252    Organism Homo sapiens Experiment description Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts Authors Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim YJ, Adam J, Lichter P, Solary E, Berchem G, Moussay E. Journal name Blood Publication year 2015 Sample Chronic lymphocytic leukemia cells Sample name CLL cells - Rep 2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density 1.15-1.17 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150015: EV-METRIC:22%, 44%
15 Experiment ID 901 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 26100252    Organism Homo sapiens Experiment description Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts Authors Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim YJ, Adam J, Lichter P, Solary E, Berchem G, Moussay E. Journal name Blood Publication year 2015 Sample Chronic lymphocytic leukemia cells Sample name JVM-3 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density 1.15-1.17 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150015: EV-METRIC:22%, 44%
16 Experiment ID 902 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 26100252    Organism Homo sapiens Experiment description Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts Authors Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim YJ, Adam J, Lichter P, Solary E, Berchem G, Moussay E. Journal name Blood Publication year 2015 Sample Chronic lymphocytic leukemia cells Sample name MEC-1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density 1.15-1.17 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry FACS Western blotting EV-TRACK EV150015: EV-METRIC:22%, 44%
17 Experiment ID 562 Identified molecule protein Extracellular vesicle type Microvesicles Identification method Mass spectrometry [LTQ] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (F3 10K) Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] EV-TRACK -
18 Experiment ID 563 Identified molecule protein Extracellular vesicle type Microvesicles Identification method Mass spectrometry [LTQ] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (F5 10K) Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.14 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] EV-TRACK -
19 Experiment ID 564 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [LTQ] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (F3 100K) Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] EV-TRACK -
20 Experiment ID 565 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [LTQ ORBITRAP] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (F5 100K) Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.14 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ ORBITRAP] EV-TRACK -
21 Experiment ID 567 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry [LTQ FUSION] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (Igg1 FT) Isolation/purification methods Differential centrifugation Ultracentrifugation Immunobeads (Igg1 FT) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ FUSION] EV-TRACK -
22 Experiment ID 568 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry [LTQ FUSION] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (CD9 PD) Isolation/purification methods Differential centrifugation Ultracentrifugation Immunobeads (CD9 PD) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ FUSION] EV-TRACK -
23 Experiment ID 571 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry [LTQ FUSION] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (CD63 FT) Isolation/purification methods Differential centrifugation Ultracentrifugation Immunobeads (CD63 FT) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ FUSION] EV-TRACK -
24 Experiment ID 573 Identified molecule protein Extracellular vesicle type Extracellular vesicles Identification method Mass spectrometry [LTQ FUSION] PubMed ID 26858453    Organism Homo sapiens Experiment description Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes Authors Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thé C Journal name PNAS Publication year 2016 Sample Dendritic cells Sample name monocyte-derived dendritic cells (CD81 FT) Isolation/purification methods Differential centrifugation Ultracentrifugation Immunobeads (CD81 FT) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ FUSION] EV-TRACK -
25 Experiment ID 861 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 25776846    Organism Homo sapiens Experiment description Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens Authors Skogberg G, Lundberg V, Berglund M, Gudmundsdottir J, Telemo E, Lindgren S, Ekwall O. Journal name Immunol Cell Biol Publication year 2015 Sample Epithelial cells Sample name Thymic tissue - culture 1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150045: EV-METRIC:25%
26 Experiment ID 978 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 22808001    Organism Homo sapiens Experiment description Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. Authors Musante L, Saraswat M, Duriez E, Byrne B, Ravidà, Domon B, Holthofer H. Journal name PLoS One Publication year 2012 Sample Serum Sample name Serum -Tuberculosis patient 8 Isolation/purification methods Filtration ExoQuick Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120006: EV-METRIC:56%
27 Experiment ID 538 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23844026    Organism Homo sapiens Experiment description Characterization of human thymic exosomes. Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandström K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O. Journal name PLoS One Publication year 2013 Sample Thymus Sample name Normal-Thymus Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130018: EV-METRIC:63%