Gene description for Hist1h4b
Gene name	histone cluster 1, H4b
Gene symbol	Hist1h4b
Other names/aliases	H1ft Hist1h4m Hist4 Hist4h4
Species	Rattus norvegicus
Database cross references - Hist1h4b
Vesiclepedia	VP_64627
ExoCarta	ExoCarta_64627
Entrez Gene	64627
Hist1h4b identified in extracellular vesicles derived from the following tissue/cell type
B cells [Microparticles]      More >>>	16342139
Hepatocytes [Exosomes]      More >>>	19367702
Insulinoma cells [Microparticles]      More >>>	22345510
Insulinoma cells [Microparticles]      More >>>	22345510
Insulinoma cells [Microparticles]      More >>>	22345510
Insulinoma cells [Exosomes]      More >>>	22345510
Insulinoma cells [Exosomes]      More >>>	22345510
Insulinoma cells [Exosomes]      More >>>	22345510
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Reticulocytes [Exosomes]      More >>>	21828046
Retinal glial cells [Exosomes]      More >>>	24400796
T cells [Microparticles]      More >>>	16342139
T cells [Microparticles]      More >>>	16342139
Urine [Exosomes]      More >>>	23344851
Experiment description of studies that identified Hist1h4b in extracellular vesicles
1 Experiment ID 308 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [Q-TOF] PubMed ID 16342139    Organism Homo sapiens Experiment description Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization Authors Miguet L, Pacaud K, Felden C, Hugel B, Martinez MC, Freyssinet JM, Herbrecht R, Potier N, van Dorsselaer A, Mauvieux L Journal name Proteomics Publication year 2006 Sample B cells Sample name B cells - Chronic B cell lymphoid patient Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [QTOF] EV-TRACK -
2 Experiment ID 35 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 19367702    Organism Rattus norvegicus Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes. Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM Journal name JPR Publication year 2008 Sample Hepatocytes Sample name Hepatocytes Isolation/purification methods Differential centrifugation Filtration Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [QTOF] Western blotting EV-TRACK -
3 Experiment ID 1279 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry PubMed ID 22345510    Organism Rattus norvegicus Experiment description Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. Authors Palmisano G, Jensen SS, Le Bihan MC, Lainé, McGuire JN, Pociot F, Larsen MR. Journal name Mol Cell Proteomics. Publication year 2012 Sample Insulinoma cells Sample name NHI 6F Tu28, cytokine-stimulated Replicate 1 Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120151: EV-METRIC:14%, 0%
4 Experiment ID 1280 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry PubMed ID 22345510    Organism Rattus norvegicus Experiment description Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. Authors Palmisano G, Jensen SS, Le Bihan MC, Lainé, McGuire JN, Pociot F, Larsen MR. Journal name Mol Cell Proteomics. Publication year 2012 Sample Insulinoma cells Sample name NHI 6F Tu28, cytokine-stimulated Replicate 2 Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120151: EV-METRIC:14%, 0%
5 Experiment ID 1281 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry PubMed ID 22345510    Organism Rattus norvegicus Experiment description Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. Authors Palmisano G, Jensen SS, Le Bihan MC, Lainé, McGuire JN, Pociot F, Larsen MR. Journal name Mol Cell Proteomics. Publication year 2012 Sample Insulinoma cells Sample name NHI 6F Tu28, cytokine-stimulated Replicate 3 Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120151: EV-METRIC:14%, 0%
6 Experiment ID 1282 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 22345510    Organism Rattus norvegicus Experiment description Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. Authors Palmisano G, Jensen SS, Le Bihan MC, Lainé, McGuire JN, Pociot F, Larsen MR. Journal name Mol Cell Proteomics. Publication year 2012 Sample Insulinoma cells Sample name NHI 6F Tu28, cytokine-stimulated Replicate 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120151: EV-METRIC:14%, 0%
7 Experiment ID 1283 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 22345510    Organism Rattus norvegicus Experiment description Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. Authors Palmisano G, Jensen SS, Le Bihan MC, Lainé, McGuire JN, Pociot F, Larsen MR. Journal name Mol Cell Proteomics. Publication year 2012 Sample Insulinoma cells Sample name NHI 6F Tu28, cytokine-stimulated Replicate 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120151: EV-METRIC:14%, 0%
8 Experiment ID 1284 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 22345510    Organism Rattus norvegicus Experiment description Characterization of membrane-shed microvesicles from cytokine-stimulated .-cells using proteomics strategies. Authors Palmisano G, Jensen SS, Le Bihan MC, Lainé, McGuire JN, Pociot F, Larsen MR. Journal name Mol Cell Proteomics. Publication year 2012 Sample Insulinoma cells Sample name NHI 6F Tu28, cytokine-stimulated Replicate 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120151: EV-METRIC:14%, 0%
9 Experiment ID 90 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [Orbitrap] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D2 Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.16-1.21 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
10 Experiment ID 94 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [Orbitrap] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D4 Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.16-1.21 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
11 Experiment ID 95 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [Orbitrap] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D7 Rep 1 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.13-1.25 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
12 Experiment ID 96 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [Orbitrap] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D2 Rep 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.16-1.21 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
13 Experiment ID 97 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [Orbitrap] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D4 Rep 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.16-1.21 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
14 Experiment ID 98 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [Orbitrap] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D7 Rep 2 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.13-1.25 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
15 Experiment ID 99 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [QSTAR] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D2 Rep 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.16-1.21 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
16 Experiment ID 100 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [QSTAR] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D4 Rep 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.16-1.21 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
17 Experiment ID 101 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry [QSTAR] PubMed ID 21828046    Organism Rattus norvegicus Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation. Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salomé, Joly E. Journal name JBC Publication year 2011 Sample Reticulocytes Sample name Reticulocytes - D7 Rep 3 Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density 1.13-1.25 g/mL Molecules identified in the study Protein Lipids Methods used in the study Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting EV-TRACK EV110005: EV-METRIC:44%
18 Experiment ID 1259 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 24400796    Organism Rattus norvegicus Experiment description Exosomal proteins in the aqueous humor as novel biomarkers in patients with neovascular age-related macular degeneration. Authors Kang GY, Bang JY, Choi AJ, Yoon J, Lee WC, Choi S, Yoon S, Kim HC, Baek JH, Park HS, Lim HJ, Chung H. Journal name J Proteome Res. Publication year 2014 Sample Retinal glial cells Sample name Mücells Isolation/purification methods ExoQuick Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140174: EV-METRIC:13%, 13%
19 Experiment ID 306 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [Q-TOF] PubMed ID 16342139    Organism Homo sapiens Experiment description Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization Authors Miguet L, Pacaud K, Felden C, Hugel B, Martinez MC, Freyssinet JM, Herbrecht R, Potier N, van Dorsselaer A, Mauvieux L Journal name Proteomics Publication year 2006 Sample T cells Sample name CEM T cell - PHA activation Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [QTOF] EV-TRACK -
20 Experiment ID 307 Identified molecule protein Extracellular vesicle type Microparticles Identification method Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [Q-TOF] PubMed ID 16342139    Organism Homo sapiens Experiment description Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization Authors Miguet L, Pacaud K, Felden C, Hugel B, Martinez MC, Freyssinet JM, Herbrecht R, Potier N, van Dorsselaer A, Mauvieux L Journal name Proteomics Publication year 2006 Sample T cells Sample name CEM T cell - ActD activation Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [MALDI TOF/TOF] Mass spectrometry [QTOF] EV-TRACK -
21 Experiment ID 1277 Identified molecule protein Extracellular vesicle type Exosomes Identification method Mass spectrometry PubMed ID 23344851    Organism Rattus norvegicus Experiment description Urinary exosomes and diabetic nephropathy: a proteomic approach. Authors Raimondo F, Corbetta S, Morosi L, Chinello C, Gianazza E, Castoldi G, Di Gioia C, Bombardi C, Stella A, Battaglia C, Bianchi C, Magni F, Pitto M. Journal name Mol Biosyst. Publication year 2013 Sample Urine Sample name Diabetic Isolation/purification methods Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV130052: EV-METRIC:22%