Description for Dihydrosphingomyelin (dhSM)
Lipid Dihydrosphingomyelin (dhSM)
Species Mus musculus
 Dihydrosphingomyelin (dhSM) identified in exosomes derived from the following tissue/cell type
Forebrain neurons [Extracellular vesicles] 29348617   
Forebrain neurons [Extracellular vesicles] 29348617   
Neuroblastoma cells [Extracellular vesicles] 29348617   
Neuroblastoma cells [Extracellular vesicles] 29348617   
Neuroblastoma cells [Extracellular vesicles] 29348617   
Primary cortical neurons [Extracellular vesicles] 29348617   
Primary cortical neurons [Extracellular vesicles] 29348617   
 Experiment description of studies that identified Dihydrosphingomyelin (dhSM) in exosomes
1
Experiment ID1645
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SampleForebrain neurons
Sample nameC57BL/6 Pik3c3flox/flox
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -
2
Experiment ID1646
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SampleForebrain neurons
Sample nameC57BL/6 Pik3c3flox/flox crossed with transgenic C57BL/6 CaMKIIα-Cre
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -
3
Experiment ID1631
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SampleNeuroblastoma cells
Sample nameN2a
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -
4
Experiment ID1632
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SampleNeuroblastoma cells
Sample nameN2a
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -
5
Experiment ID1637
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SampleNeuroblastoma cells
Sample nameN2a
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -
6
Experiment ID1629
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SamplePrimary cortical neurons
Sample nameC57BL/6
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -
7
Experiment ID1630
Identified moleculeLipid
Identification method LC-MS
PubMed ID 29348617   
OrganismMus musculus
Experiment descriptionNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AuthorsMiranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.
Journal name Nat Commun
Publication year2018
SamplePrimary cortical neurons
Sample nameC57BL/6
Molecules identified in the studyProtein
Lipid
Methods used in the studyWestern blotting
LC-MS
EV-TRACK -