Gene description for AQP2
Gene name	aquaporin 2
Gene symbol	AQP2
Other names/aliases	AQP-CD NDI2 WCH-CD
Species	Homo sapiens
Experiment description of studies that identified AQP2 in Urine
1 Experiment ID 13 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 15326289    Organism Homo sapiens Experiment description Identification and proteomic profiling of exosomes in human urine. Authors Pisitkun T, Shen RF, Knepper MA Journal name PNAS Publication year 2004 Sample Urine Sample name Urine - Normal Isolation/purification methods Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LCQ DECA XP] Western blotting EV-TRACK -
2 Experiment ID 57 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Western blotting PubMed ID 17700640    Organism Homo sapiens Experiment description CD24 is a marker of exosomes secreted into urine and amniotic fluid. Authors Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P, Altevogt P Journal name KI Publication year 2007 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Sucrose density gradient Flotation density 1.05-1.15 g/mL Molecules identified in the study Protein Methods used in the study Western blotting FACS EV-TRACK -
3 Experiment ID 63 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 19056867    Organism Homo sapiens Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes. Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA Journal name JASN Publication year 2009 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting EV-TRACK -
4 Experiment ID 102 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Immunoelectron microscopy PubMed ID 21082674    Organism Homo sapiens Experiment description Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Authors Zhang Y, Li Y, Qiu F, Qiu Z. Journal name ELEC Publication year 2010 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting Immunoelectron microscopy EV-TRACK EV100097: EV-METRIC:14%
5 Experiment ID 113 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Immunoelectron microscopy PubMed ID 21557262    Organism Homo sapiens Experiment description Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. Authors Li Y, Zhang Y, Qiu F, Qiu Z. Journal name ELEC Publication year 2011 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV110101: EV-METRIC:14%
6 Experiment ID 114 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Immunoelectron microscopy PubMed ID 21557262    Organism Homo sapiens Experiment description Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. Authors Li Y, Zhang Y, Qiu F, Qiu Z. Journal name ELEC Publication year 2011 Sample Urine Sample name Urine - Lung cancer Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV110101: EV-METRIC:14%
7 Experiment ID 180 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Western blotting PubMed ID 20686450    Organism Homo sapiens Experiment description Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome Authors Rood IM, Deegens JK, Merchant ML, Tamboer WP, Wilkey DW, Wetzels JF, Klein JB Journal name Kidney Int Publication year 2010 Sample Urine Sample name Urine - SEC Isolation/purification methods Differential centrifugation Ultracentrifugation Size exclusion chromatography Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry [MALDI TOF] EV-TRACK EV100026: EV-METRIC:33%, 25%, 44%
8 Experiment ID 327 Identified molecule mrna Extracellular vesicle type Exosomes MISEV EVs Identification method RT-PCR PubMed ID 20428099    Organism Homo sapiens Experiment description Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease Authors Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, Brown D, Russo LM Journal name Kidney Int Publication year 2010 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study mRNA Methods used in the study RT-PCR EV-TRACK EV100070: EV-METRIC:0%, 0%, 0%, 0%, 29%
9 Experiment ID 382 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 18373357    Organism Homo sapiens Experiment description Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. Authors Smalley DM, Sheman NE, Nelson K, Theodorescu D. Journal name J Proteome Res Publication year 2008 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
10 Experiment ID 383 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 18373357    Organism Homo sapiens Experiment description Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. Authors Smalley DM, Sheman NE, Nelson K, Theodorescu D. Journal name J Proteome Res Publication year 2008 Sample Urine Sample name Patients of bladder cancer-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
11 Experiment ID 390 Identified molecule protein Extracellular vesicle type Exosomes/Membrane particles MISEV EVs Identification method Mass spectrometry PubMed ID 19158352    Organism Homo sapiens Experiment description Characterization of PKD protein-positive exosome-like vesicles. Authors Hogan MC, Manganelli L, Woollard JR, Masyuk AI, Masyuk TV, Tammachote R, Huang BQ, Leontovich AA, Beito TG, Madden BJ, Charlesworth MC, Torres VE, LaRusso NF, Harris PC, Ward CJ. Journal name J Am Soc Nephrol Publication year 2009 Sample Urine Sample name Patients of autosomal recessive polycystic kidney disease-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
12 Experiment ID 429 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 21595033    Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. Journal name Proteomics Publication year 2011 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV110019: EV-METRIC:44%
13 Experiment ID 430 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 21595033    Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. Journal name Proteomics Publication year 2011 Sample Urine Sample name Patients of basement membrane nephropathy-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV110019: EV-METRIC:44%
14 Experiment ID 431 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 21595033    Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. Journal name Proteomics Publication year 2011 Sample Urine Sample name Patients of early IgA nephropathy-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV110019: EV-METRIC:44%
15 Experiment ID 437 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 22106071    Organism Homo sapiens Experiment description Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Authors Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Journal name Proteomics Publication year 2012 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120168: EV-METRIC:14%
16 Experiment ID 444 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22418980    Organism Homo sapiens Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G. Journal name Kidney Int Publication year 2012 Sample Urine Sample name Normal_high density-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120083: EV-METRIC:22%
17 Experiment ID 445 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22418980    Organism Homo sapiens Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G. Journal name Kidney Int Publication year 2012 Sample Urine Sample name Normal_low density-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120083: EV-METRIC:22%
18 Experiment ID 478 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23082778    Organism Homo sapiens Experiment description Comparative and Targeted Proteomic Analyses of Urinary Microparticles from Bladder Cancer and Hernia Patients. Authors Chen CL, Lai YF, Tang P, Chien KY, Yu JS, Tsai CH, Chen HW, Wu CC, Chung T, Hsu CW, Chen CD, Chang YS, Chang PL, Chen YT. Journal name J Proteome Res Publication year 2012 Sample Urine Sample name Patients of bladder cancer-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120030: EV-METRIC:33%
19 Experiment ID 479 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23082778    Organism Homo sapiens Experiment description Comparative and Targeted Proteomic Analyses of Urinary Microparticles from Bladder Cancer and Hernia Patients. Authors Chen CL, Lai YF, Tang P, Chien KY, Yu JS, Tsai CH, Chen HW, Wu CC, Chung T, Hsu CW, Chen CD, Chang YS, Chang PL, Chen YT. Journal name J Proteome Res Publication year 2012 Sample Urine Sample name Patients of hernia-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120030: EV-METRIC:33%
20 Experiment ID 498 Identified molecule protein Extracellular vesicle type Exosomes/Membrane vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23376485    Organism Homo sapiens Experiment description Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Authors Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P, Moll S. Journal name J Proteomics Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130051: EV-METRIC:38%
21 Experiment ID 507 Identified molecule protein Extracellular vesicle type Exosomes/Nanovesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23511837    Organism Homo sapiens Experiment description Differential protein profiling of renal cell carcinoma urinary exosomes. Authors Raimondo F, Morosi L, Corbetta S, Chinello C, Brambilla P, Della Mina P, Villa A, Albo G, Battaglia C, Bosari S, Magni F, Pitto M. Journal name Mol Biosyst Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130016: EV-METRIC:44%
22 Experiment ID 508 Identified molecule protein Extracellular vesicle type Exosomes/Nanovesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23511837    Organism Homo sapiens Experiment description Differential protein profiling of renal cell carcinoma urinary exosomes. Authors Raimondo F, Morosi L, Corbetta S, Chinello C, Brambilla P, Della Mina P, Villa A, Albo G, Battaglia C, Bosari S, Magni F, Pitto M. Journal name Mol Biosyst Publication year 2013 Sample Urine Sample name Renal cell carcinoma patient-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130016: EV-METRIC:44%
23 Experiment ID 512 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23533145    Organism Homo sapiens Experiment description In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Authors Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. Journal name Proteomics Publication year 2013 Sample Urine Sample name Low-grade prostate cancer patient-Expressed prostatic secretions in urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130224: EV-METRIC:14%
24 Experiment ID 513 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23533145    Organism Homo sapiens Experiment description In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Authors Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. Journal name Proteomics Publication year 2013 Sample Urine Sample name Normal-Expressed prostatic secretions in urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130224: EV-METRIC:14%
25 Experiment ID 540 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23886663    Organism Homo sapiens Experiment description LRRK2 Secretion in Exosomes is Regulated by 14-3-3. Authors Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Journal name Hum Mol Genet Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130075: EV-METRIC:11%, 11%, 33%
26 Experiment ID 725 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25471207    Organism Homo sapiens Experiment description Intraluminal proteome and peptidome of human urinary extracellular vesicles. Authors Liu X, Chinello C, Musante L, Cazzaniga M, Tataruch D, Calzaferri G, James Smith A, De Sio G, Magni F, Zou H, Holthofer H. Journal name Proteomics Clin Appl. Publication year 2015 Sample Urine Sample name Normal crude urine- Trypsinized Isolation/purification methods Differential centrifugation Hydrostatic filtration dialysis Ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140189: EV-METRIC:25%
27 Experiment ID 751 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29988836    Organism Homo sapiens Experiment description Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine Authors Oeyen E, Van Mol K, Baggerman G, Willems H, Boonen K, Rolfo C, Pauwels P, Jacobs A, Schildermans K, Cho WC, Mertens I. Journal name J Extracell Vesicles Publication year 2018 Sample Urine Sample name Urine - Fraction 8 and 9 pooled Isolation/purification methods Filtration Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV170025: EV-METRIC:62%
28 Experiment ID 958 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 26196085    Organism Homo sapiens Experiment description Identification of prostate cancer biomarkers in urinary exosomes. Authors "Overbye A, Skotland T, Koehler CJ, Thiede B, Seierstad T, Berge V, Sandvig K, Llorente A. Journal name Oncotarget Publication year 2015 Sample Urine Sample name Urine - prostate cancer control Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV150029: EV-METRIC:33%
29 Experiment ID 959 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 26196085    Organism Homo sapiens Experiment description Identification of prostate cancer biomarkers in urinary exosomes. Authors "Overbye A, Skotland T, Koehler CJ, Thiede B, Seierstad T, Berge V, Sandvig K, Llorente A. Journal name Oncotarget Publication year 2015 Sample Urine Sample name Urine - prostate cancer patients Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV150029: EV-METRIC:33%