Gene description for ITGB3
Gene name	integrin subunit beta 3
Gene symbol	ITGB3
Other names/aliases	BDPLT16 BDPLT2 BDPLT24 CD61 GP3A GPIIIa GT GT2
Species	Homo sapiens
Experiment description of studies that identified ITGB3 in Platelets
1 Experiment ID 278 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 10233897    Organism Homo sapiens Experiment description Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia Authors Hugel B, Socié, Vu T, Toti F, Gluckman E, Freyssinet JM, Scrobohaci ML Journal name Blood Publication year 1999 Sample Platelets Sample name Platelets - Normal Isolation/purification methods Differential centrifugation FACS Flotation density - Molecules identified in the study Protein Lipids Methods used in the study FACS EV-TRACK -
2 Experiment ID 294 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Western blotting PubMed ID 2071604    Organism Homo sapiens Experiment description Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets Authors Fox JE, Austin CD, Reynolds CC, Steffen PK Journal name J Biol Chem Publication year 1991 Sample Platelets Sample name Platelets Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
3 Experiment ID 369 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 16212402    Organism Homo sapiens Experiment description The platelet microparticle proteome. Authors Garcia BA, Smalley DM, Cho H, Shabanowitz J, Ley K, Hunt DF. Journal name J Proteome Res Publication year 2005 Sample Platelets Sample name Normal donors-Platelets Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
4 Experiment ID 406 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 19806257    Organism Homo sapiens Experiment description Proteomic and functional characterisation of platelet microparticle size classes. Authors Dean WL, Lee MJ, Cummins TD, Schultz DJ, Powell DW. Journal name Thromb Haemost Publication year 2009 Sample Platelets Sample name Normal donors-Platelets Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
5 Experiment ID 520 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23601281    Organism Homo sapiens Experiment description Proteomic characterization of human platelet-derived microparticles. Authors Capriotti AL, Caruso G, Cavaliere C, Piovesana S, Samperi R, Laganà A. Journal name Anal Chim Acta Publication year 2013 Sample Platelets Sample name Platelets purifird from blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
6 Experiment ID 1344 Identified molecule protein Extracellular vesicle type Platelet-derived microparticles MISEV EV-like nanoparticles Identification method Flow cytometry PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood Isolation/purification methods Ficoll-Hypaque density gradient centrifugation Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Flow cytometry Western blotting qPCR EV-TRACK -