Gene description for TSC2
Gene name	TSC complex subunit 2
Gene symbol	TSC2
Other names/aliases	LAM PPP1R160 TSC4
Species	Homo sapiens
Experiment description of studies that identified TSC2 in Urine
1 Experiment ID 429 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 21595033    Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. Journal name Proteomics Publication year 2011 Sample Urine Sample name Normal donors-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV110019: EV-METRIC:44%
2 Experiment ID 430 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 21595033    Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. Journal name Proteomics Publication year 2011 Sample Urine Sample name Patients of basement membrane nephropathy-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV110019: EV-METRIC:44%
3 Experiment ID 431 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 21595033    Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. Journal name Proteomics Publication year 2011 Sample Urine Sample name Patients of early IgA nephropathy-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV110019: EV-METRIC:44%
4 Experiment ID 540 Identified molecule protein Extracellular vesicle type Exosomes/Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23886663    Organism Homo sapiens Experiment description LRRK2 Secretion in Exosomes is Regulated by 14-3-3. Authors Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Journal name Hum Mol Genet Publication year 2013 Sample Urine Sample name Normal-Urine Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV130075: EV-METRIC:11%, 11%, 33%
5 Experiment ID 1027 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 24211404    Organism Homo sapiens Experiment description Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis. Authors Zubiri I, Posada-Ayala M, Sanz-Maroto A, Calvo E, Martin-Lorenzo M, Gonzalez-Calero L, de la Cuesta F, Lopez JA, Fernandez-Fernandez B, Ortiz A, Vivanco F, Alvarez-Llamas G. Journal name J Proteomics. Publication year 2014 Sample Urine Sample name Urine - Diabetic nephropathy (DN) patients Isolation/purification methods Ultracentrifugation ExoQuick Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV140245: EV-METRIC:22%, 25%, 22%
6 Experiment ID 1162 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22641613    Organism Homo sapiens Experiment description Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. Authors Pisitkun T, Gandolfo MT, Das S, Knepper MA, Bagnasco SM. Journal name Proteomics Clin Appl Publication year 2012 Sample Urine Sample name Renal allograft recipient with acute inflamatory response Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV120152: EV-METRIC:14%