Gene description for CD63
Gene name CD63 molecule
Gene symbol CD63
Other names/aliases AD1
HOP-26
ME491
MLA1
OMA81H
Pltgp40
TSPAN30
Species Homo sapiens
 Experiment description of studies that identified CD63 in Platelets

1
Experiment ID31
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method FACS
Immunoelectron Microscopy
PubMed ID 10572093   
OrganismHomo sapiens
Experiment descriptionActivated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
AuthorsHeijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ
Journal name BLOOD
Publication year1999
SamplePlatelets
Sample namePlatelets
Isolation/purification methodsDifferential centrifugation
Sucrose density gradient
Flotation density1.14-1.18 g/mL
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
FACS
Immunoelectron microscopy
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2
Experiment ID1344
Identified moleculeprotein
Extracellular vesicle typePlatelet-derived microparticles
MISEVEV-like nanoparticles
Identification method Western blotting
PubMed ID 33009394   
OrganismHomo sapiens
Experiment descriptionPlatelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
AuthorsQu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X.
Journal name Nat Commun
Publication year2020
SamplePlatelets
Sample namePlatelets derived from umbilical cord blood
Isolation/purification methodsFicoll-Hypaque density gradient centrifugation
Differential centrifugation
Filtration
Flotation density-
Molecules identified in the studyProtein
miRNA
Methods used in the studyFlow cytometry
Western blotting
qPCR
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3
Experiment ID3504
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Western blotting
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
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4
Experiment ID3505
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Western blotting
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
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5
Experiment ID3495
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometryWestern blotting
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Flow cytometry
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6
Experiment ID3498
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
Western blotting
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Flow cytometry
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7
Experiment ID3496
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
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8
Experiment ID3497
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
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9
Experiment ID3499
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
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10
Experiment ID3500
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
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11
Experiment ID3501
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
EV-TRACK -

12
Experiment ID3502
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
EV-TRACK -

13
Experiment ID3503
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 31160588   
OrganismHomo sapiens
Experiment descriptionExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
AuthorsSung PS, Huang TF, Hsieh SL.
Journal name Nat Commun
Publication year2019
SamplePlatelets
Sample namePeripheral blood of healthy donors
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
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