Gene description for PPIA
Gene name	peptidylprolyl isomerase A
Gene symbol	PPIA
Other names/aliases	CYPA CYPH HEL-S-69p
Species	Homo sapiens
Experiment description of studies that identified PPIA in Plasma
1 Experiment ID 354 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [Orbitrap Velos] PubMed ID 24115447    Organism Homo sapiens Experiment description Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma Authors Mathivanan,S. Journal name Proteomics Publication year 2013 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [Orbitrap Velos] Western blotting EV-TRACK EV130073: EV-METRIC:0%, 11%, 33%, 33%, 56%
2 Experiment ID 454 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 22669077    Organism Homo sapiens Experiment description The proteome of erythrocyte-derived microparticles from plasma: new clues for erythrocyte aging and vesiculation. Authors Bosman GJ, Lasonder E, Groenen-Döpp YA, Willekens FL, Werre JM. Journal name J Proteomics Publication year 2012 Sample Plasma Sample name Normal-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
3 Experiment ID 473 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23056467    Organism Homo sapiens Experiment description Cause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy. Authors Al Kaabi A, Traupe T, Stutz M, Buchs N, Heller M. Journal name PLoS One Publication year 2012 Sample Plasma Sample name Patients of external counterpulsation therapy-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
4 Experiment ID 1226 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 1 fr7+8 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
5 Experiment ID 2329 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 32487994    Organism Homo sapiens Experiment description Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Authors Toda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA. Journal name Nat Commun Publication year 2020 Sample Plasma Sample name Healthy donors Isolation/purification methods Centrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry Flow cytometry EV-TRACK -
6 Experiment ID 2330 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 32487994    Organism Homo sapiens Experiment description Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Authors Toda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA. Journal name Nat Commun Publication year 2020 Sample Plasma Sample name Plasmodium vivax (Malaria) patients Isolation/purification methods Centrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry Flow cytometry EV-TRACK -
7 Experiment ID 2386 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Column 1 Fraction 14-15 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
8 Experiment ID 2387 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Fraction Column 1 16-17 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
9 Experiment ID 2388 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Fraction Column 1 18-19 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
10 Experiment ID 2389 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Column 1 Fraction 20-21 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
11 Experiment ID 2390 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Column 2 Fraction 14-15 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
12 Experiment ID 2391 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Fraction Column 2 16-17 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
13 Experiment ID 2392 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Fraction Column 2 18-19 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
14 Experiment ID 2393 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Column 2 Fraction 20-21 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
15 Experiment ID 2394 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Column 3 Fraction 14-15 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
16 Experiment ID 2395 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Fraction Column 3 16-17 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
17 Experiment ID 2396 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Fraction Column 3 18-19 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
18 Experiment ID 2397 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 34355211    Organism Homo sapiens Experiment description A size-exclusion-based approach for purifying extracellular vesicles from human plasma Authors Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. Journal name Cell Rep Methods Publication year 2021 Sample Plasma Sample name SEC Column 3 Fraction 20-21 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
19 Experiment ID 2433 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29320704    Organism Homo sapiens Experiment description Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise Authors Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA. Journal name Cell Metab Publication year 2018 Sample Plasma Sample name Plasma Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
20 Experiment ID 2434 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29320704    Organism Homo sapiens Experiment description Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise Authors Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA. Journal name Cell Metab Publication year 2018 Sample Plasma Sample name Plasma Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
21 Experiment ID 2848 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-001 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
22 Experiment ID 2849 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-004 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -