Gene description for GP1BA
Gene name glycoprotein Ib (platelet), alpha polypeptide
Gene symbol GP1BA
Other names/aliases BDPLT1
BDPLT3
BSS
CD42B
CD42b-alpha
DBPLT3
GP1B
GPIbA
VWDP
Species Homo sapiens
 Database cross references - GP1BA
Vesiclepedia VP_2811
ExoCarta ExoCarta_2811
Entrez Gene 2811
HGNC 4439
MIM 606672
 GP1BA identified in extracellular vesicles derived from the following tissue/cell type
Colorectal cancer cells [Microvesicles]      More >>> 19930720   
Endothelial cells [Microparticles]      More >>> 19369228   
Plasma [Microparticles]      More >>> 10694520   
Plasma [Microparticles]      More >>> 10694520   
Plasma [Microparticles]      More >>> 10694520   
Plasma [Microvesicles]      More >>> 12514112   
Plasma [Microparticles]      More >>> 2942561   
Plasma [Microparticles]      More >>> 2294986   
Plasma [Microparticles]      More >>> 2294986   
Plasma [Microparticles]      More >>> 12796750   
Plasma [Microparticles]      More >>> 12796750   
Plasma [Microparticles]      More >>> 22669077   
Plasma [Microparticles]      More >>> 23056467   
Platelets [Microparticles]      More >>> 10233897   
Platelets [Microparticles]      More >>> 10233897   
Platelets [Microvesicles]      More >>> 2071604   
Platelets [Microparticles]      More >>> 16212402   
Platelets [Microparticles]      More >>> 23601281   
Serum [Microparticles]      More >>> 2942561   
T cells [Exosomes]      More >>> 23463506   
Umblical cord mesenchymal stem cells [Microvesicles]      More >>> 29148239   
Umblical cord mesenchymal stem cells [Microvesicles]      More >>> 29148239   
Umblical cord mesenchymal stem cells [Microvesicles]      More >>> 29148239   
Umblical cord mesenchymal stem cells [Microvesicles]      More >>> 29148239   
Umblical cord mesenchymal stem cells [Microvesicles]      More >>> 29148239   
Umblical cord mesenchymal stem cells [Microvesicles]      More >>> 29148239   
Urine [Exosomes/Microvesicles]      More >>> 23533145   
Urine [Exosomes/Microvesicles]      More >>> 23533145   
 Experiment description of studies that identified GP1BA in extracellular vesicles
1
Experiment ID303
Identified moleculemrna
Extracellular vesicle typeMicrovesicles
Identification method Microarray [Illumina]
PubMed ID 19930720   
OrganismHomo sapiens
Experiment descriptionColorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells
AuthorsHong BS, Cho JH, Kim H, Choi EJ, Rho S, Kim J, Kim JH, Choi DS, Kim YK, Hwang D, Gho YS
Journal name BMC Genomics
Publication year2009
SampleColorectal cancer cells
Sample nameSW480
Isolation/purification methodsDifferential centrifugation
Ultrafiltration
OptiPrep density gradient
Flotation density1.09 g/mL
Molecules identified in the studyProtein
mRNA
Methods used in the studyWestern blotting
RT-PCR
Microarray [Illumina]
EV-TRACK -
2
Experiment ID393
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Mass spectrometry
PubMed ID 19369228   
OrganismHomo sapiens
Experiment descriptionProteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures.
AuthorsProkopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M.
Journal name Blood
Publication year2009
SampleEndothelial cells
Sample nameNormal-Endothelial progenitor cells
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
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3
Experiment ID218
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Immunoaffinity
PubMed ID 10694520   
OrganismHomo sapiens
Experiment descriptionElevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes
AuthorsMallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM, Tedgui A
Journal name Circulation
Publication year2000
SamplePlasma
Sample namePlasma - Stable angina
Isolation/purification methodsImmunoaffinity [Annexin-V]
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyImmunoaffinity
EV-TRACK -
4
Experiment ID219
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Immunoaffinity
PubMed ID 10694520   
OrganismHomo sapiens
Experiment descriptionElevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes
AuthorsMallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM, Tedgui A
Journal name Circulation
Publication year2000
SamplePlasma
Sample namePlasma - Acute coronary syndromes
Isolation/purification methodsImmunoaffinity [Annexin-V]
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyImmunoaffinity
EV-TRACK -
5
Experiment ID220
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Immunoaffinity
PubMed ID 10694520   
OrganismHomo sapiens
Experiment descriptionElevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes
AuthorsMallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM, Tedgui A
Journal name Circulation
Publication year2000
SamplePlasma
Sample namePlasma - Noncoronary heart disease
Isolation/purification methodsImmunoaffinity [Annexin-V]
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyImmunoaffinity
EV-TRACK -
6
Experiment ID222
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method FACS
PubMed ID 12514112   
OrganismHomo sapiens
Experiment descriptionIntravascular tissue factor initiates coagulation via circulating microvesicles and platelets
AuthorsMüI, Klocke A, Alex M, Kotzsch M, Luther T, Morgenstern E, Zieseniss S, Zahler S, Preissner K, Engelmann B
Journal name FASEB J
Publication year2003
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
FACS
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyImmunoelectron microscopy
FACS
Western blotting
EV-TRACK -
7
Experiment ID227
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Antibody based methods
PubMed ID 2942561   
OrganismHomo sapiens
Experiment descriptionPlatelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery
AuthorsGeorge JN, Pickett EB, Saucerman S, McEver RP, Kunicki TJ, Kieffer N, Newman PJ
Journal name J Clin Invest
Publication year1986
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyAntibody based methods
EV-TRACK -
8
Experiment ID230
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method FACS
PubMed ID 2294986   
OrganismHomo sapiens
Experiment descriptionDirect detection of activated platelets and platelet-derived microparticles in humans
AuthorsAbrams CS, Ellison N, Budzynski AZ, Shattil SJ
Journal name Blood
Publication year1990
SamplePlasma
Sample namePlasma - Cardiopulmonary bypass
Isolation/purification methodsFACS
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
EV-TRACK -
9
Experiment ID231
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method FACS
PubMed ID 2294986   
OrganismHomo sapiens
Experiment descriptionDirect detection of activated platelets and platelet-derived microparticles in humans
AuthorsAbrams CS, Ellison N, Budzynski AZ, Shattil SJ
Journal name Blood
Publication year1990
SamplePlasma
Sample namePlasma - Standardized bleeding time
Isolation/purification methodsFACS
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
EV-TRACK -
10
Experiment ID296
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method FACS
PubMed ID 12796750   
OrganismHomo sapiens
Experiment descriptionHigh levels of circulating endothelial microparticles in patients with acute coronary syndromes
AuthorsBernal-Mizrachi L, Jy W, Jimenez JJ, Pastor J, Mauro LM, Horstman LL, de Marchena E, Ahn YS
Journal name Am Heart J
Publication year2003
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
FACS
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
EV-TRACK -
11
Experiment ID299
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method FACS
PubMed ID 12796750   
OrganismHomo sapiens
Experiment descriptionHigh levels of circulating endothelial microparticles in patients with acute coronary syndromes
AuthorsBernal-Mizrachi L, Jy W, Jimenez JJ, Pastor J, Mauro LM, Horstman LL, de Marchena E, Ahn YS
Journal name Am Heart J
Publication year2003
SamplePlasma
Sample namePlasma - Myocardial infarction
Isolation/purification methodsDifferential centrifugation
FACS
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
EV-TRACK -
12
Experiment ID454
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Mass spectrometry
PubMed ID 22669077   
OrganismHomo sapiens
Experiment descriptionThe proteome of erythrocyte-derived microparticles from plasma: new clues for erythrocyte aging and vesiculation.
AuthorsBosman GJ, Lasonder E, Groenen-Döpp YA, Willekens FL, Werre JM.
Journal name J Proteomics
Publication year2012
SamplePlasma
Sample nameNormal-Blood
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
13
Experiment ID473
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Mass spectrometry
PubMed ID 23056467   
OrganismHomo sapiens
Experiment descriptionCause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy.
AuthorsAl Kaabi A, Traupe T, Stutz M, Buchs N, Heller M.
Journal name PLoS One
Publication year2012
SamplePlasma
Sample namePatients of external counterpulsation therapy-Blood
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
14
Experiment ID278
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method FACS
PubMed ID 10233897   
OrganismHomo sapiens
Experiment descriptionElevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia
AuthorsHugel B, Socié, Vu T, Toti F, Gluckman E, Freyssinet JM, Scrobohaci ML
Journal name Blood
Publication year1999
SamplePlatelets
Sample namePlatelets - Normal
Isolation/purification methodsDifferential centrifugation
FACS
Flotation density-
Molecules identified in the studyProtein
Lipids
Methods used in the studyFACS
EV-TRACK -
15
Experiment ID240
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method FACS
PubMed ID 10233897   
OrganismHomo sapiens
Experiment descriptionElevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia
AuthorsHugel B, Socié, Vu T, Toti F, Gluckman E, Freyssinet JM, Scrobohaci ML
Journal name Blood
Publication year1999
SamplePlatelets
Sample namePlatelets - Paroxysmal nocturnal hemoglobinuria patients
Isolation/purification methodsDifferential centrifugation
FACS
Flotation density-
Molecules identified in the studyProtein
Lipids
Methods used in the studyFACS
EV-TRACK -
16
Experiment ID294
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Western blotting
PubMed ID 2071604   
OrganismHomo sapiens
Experiment descriptionEvidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets
AuthorsFox JE, Austin CD, Reynolds CC, Steffen PK
Journal name J Biol Chem
Publication year1991
SamplePlatelets
Sample namePlatelets
Isolation/purification methodsDifferential centrifugation
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -
17
Experiment ID369
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Mass spectrometry
PubMed ID 16212402   
OrganismHomo sapiens
Experiment descriptionThe platelet microparticle proteome.
AuthorsGarcia BA, Smalley DM, Cho H, Shabanowitz J, Ley K, Hunt DF.
Journal name J Proteome Res
Publication year2005
SamplePlatelets
Sample nameNormal donors-Platelets
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
18
Experiment ID520
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Mass spectrometry
PubMed ID 23601281   
OrganismHomo sapiens
Experiment descriptionProteomic characterization of human platelet-derived microparticles.
AuthorsCapriotti AL, Caruso G, Cavaliere C, Piovesana S, Samperi R, Laganà A.
Journal name Anal Chim Acta
Publication year2013
SamplePlatelets
Sample namePlatelets purifird from blood
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
19
Experiment ID228
Identified moleculeprotein
Extracellular vesicle typeMicroparticles
Identification method Antibody based methods
PubMed ID 2942561   
OrganismHomo sapiens
Experiment descriptionPlatelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery
AuthorsGeorge JN, Pickett EB, Saucerman S, McEver RP, Kunicki TJ, Kieffer N, Newman PJ
Journal name J Clin Invest
Publication year1986
SampleSerum
Sample nameSerum - Normal
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyAntibody based methods
EV-TRACK -
20
Experiment ID1008
Identified moleculeprotein
Extracellular vesicle typeExosomes
Identification method Mass spectrometry
PubMed ID 23463506   
OrganismHomo sapiens
Experiment descriptionThe intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes.
AuthorsPerez-Hernandez D, Gutiéez-Váuez C, Jorge I, Ló-MartíS, Ursa A, Sáhez-Madrid F, Váuez J, Yáz-Mó
Journal name J Biol Chem.
Publication year2013
SampleT cells
Sample nameT lymphoblasts
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130110: EV-METRIC:22%
21
Experiment ID680
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry
PubMed ID 29148239   
OrganismHomo sapiens
Experiment descriptionMetabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.
AuthorsBruschi M, Santucci L, Ravera S, Bartolucci M, Petretto A, Calzia D, Ghiggeri GM, Ramenghi LA, Candiano G, Panfoli I.
Journal name Proteomics Clin Appl
Publication year2018
SampleUmblical cord mesenchymal stem cells
Sample namePreterm newborns- replicate 1
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Sonication
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
22
Experiment ID681
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry
PubMed ID 29148239   
OrganismHomo sapiens
Experiment descriptionMetabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.
AuthorsBruschi M, Santucci L, Ravera S, Bartolucci M, Petretto A, Calzia D, Ghiggeri GM, Ramenghi LA, Candiano G, Panfoli I.
Journal name Proteomics Clin Appl
Publication year2018
SampleUmblical cord mesenchymal stem cells
Sample namePreterm newborns- replicate 2
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Sonication
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
23
Experiment ID682
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry
PubMed ID 29148239   
OrganismHomo sapiens
Experiment descriptionMetabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.
AuthorsBruschi M, Santucci L, Ravera S, Bartolucci M, Petretto A, Calzia D, Ghiggeri GM, Ramenghi LA, Candiano G, Panfoli I.
Journal name Proteomics Clin Appl
Publication year2018
SampleUmblical cord mesenchymal stem cells
Sample namePreterm newborns- replicate 3
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Sonication
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
24
Experiment ID683
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry
PubMed ID 29148239   
OrganismHomo sapiens
Experiment descriptionMetabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.
AuthorsBruschi M, Santucci L, Ravera S, Bartolucci M, Petretto A, Calzia D, Ghiggeri GM, Ramenghi LA, Candiano G, Panfoli I.
Journal name Proteomics Clin Appl
Publication year2018
SampleUmblical cord mesenchymal stem cells
Sample nameTerm infants- replicate 1
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Sonication
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
25
Experiment ID684
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry
PubMed ID 29148239   
OrganismHomo sapiens
Experiment descriptionMetabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.
AuthorsBruschi M, Santucci L, Ravera S, Bartolucci M, Petretto A, Calzia D, Ghiggeri GM, Ramenghi LA, Candiano G, Panfoli I.
Journal name Proteomics Clin Appl
Publication year2018
SampleUmblical cord mesenchymal stem cells
Sample nameTerm infants- replicate 2
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Sonication
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
26
Experiment ID685
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
Identification method Mass spectrometry
PubMed ID 29148239   
OrganismHomo sapiens
Experiment descriptionMetabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.
AuthorsBruschi M, Santucci L, Ravera S, Bartolucci M, Petretto A, Calzia D, Ghiggeri GM, Ramenghi LA, Candiano G, Panfoli I.
Journal name Proteomics Clin Appl
Publication year2018
SampleUmblical cord mesenchymal stem cells
Sample nameTerm infants- replicate 3
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Sonication
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -
27
Experiment ID512
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles
Identification method Mass spectrometry
PubMed ID 23533145   
OrganismHomo sapiens
Experiment descriptionIn-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
AuthorsPrincipe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR.
Journal name Proteomics
Publication year2013
SampleUrine
Sample nameLow-grade prostate cancer patient-Expressed prostatic secretions in urine
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130224: EV-METRIC:14%
28
Experiment ID513
Identified moleculeprotein
Extracellular vesicle typeExosomes/Microvesicles
Identification method Mass spectrometry
PubMed ID 23533145   
OrganismHomo sapiens
Experiment descriptionIn-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
AuthorsPrincipe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR.
Journal name Proteomics
Publication year2013
SampleUrine
Sample nameNormal-Expressed prostatic secretions in urine
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130224: EV-METRIC:14%