Gene description for ITGA2B
Gene name	integrin subunit alpha 2b
Gene symbol	ITGA2B
Other names/aliases	BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GT1 GTA HPA3 PPP1R93
Species	Homo sapiens
Experiment description of studies that identified ITGA2B in Plasma
1 Experiment ID 40 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method FACS Western blotting PubMed ID 15908444    Organism Homo sapiens Experiment description Exosomal-like vesicles are present in human blood plasma. Authors Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C Journal name INTIMM Publication year 2005 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Filtration Sucrose density gradient Flotation density 1.15-1.27 g/mL Molecules identified in the study Protein Methods used in the study Western blotting FACS Immunoelectron microscopy EV-TRACK -
2 Experiment ID 44 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 19028452    Organism Homo sapiens Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ Journal name BBRC Publication year 2009 Sample Plasma Sample name Plasma Isolation/purification methods Filtration Size exclusion chromatography Sucrose density gradient Flotation density 1.15-1.16 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting Immunoelectron microscopy EV-TRACK -
3 Experiment ID 224 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS Confocal microscopy PubMed ID 10393703    Organism Homo sapiens Experiment description In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant Authors Combes V, Simon AC, Grau GE, Arnoux D, Camoin L, Sabatier F, Mutin M, Sanmarco M, Sampol J, Dignat-George F Journal name J Clin Invest Publication year 1999 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Confocal microscopy FACS EV-TRACK -
4 Experiment ID 227 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Antibody based methods PubMed ID 2942561    Organism Homo sapiens Experiment description Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery Authors George JN, Pickett EB, Saucerman S, McEver RP, Kunicki TJ, Kieffer N, Newman PJ Journal name J Clin Invest Publication year 1986 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Antibody based methods EV-TRACK -
5 Experiment ID 229 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Antibody based methods PubMed ID 2942561    Organism Homo sapiens Experiment description Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery Authors George JN, Pickett EB, Saucerman S, McEver RP, Kunicki TJ, Kieffer N, Newman PJ Journal name J Clin Invest Publication year 1986 Sample Plasma Sample name Plasma - Adult respiratory distress syndrome Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Antibody based methods EV-TRACK -
6 Experiment ID 261 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 12805058    Organism Homo sapiens Experiment description Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes Authors Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N, Koopmeiners L, Key NS, Hebbel RP. Journal name Blood Publication year 2003 Sample Plasma Sample name Plasma - Sickle cell patients - Crisis Isolation/purification methods Differential centrifugation Ultracentrifugation FACS Flotation density - Molecules identified in the study Protein Lipids Methods used in the study FACS Annexin V-FITC EV-TRACK -
7 Experiment ID 262 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 12805058    Organism Homo sapiens Experiment description Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes Authors Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N, Koopmeiners L, Key NS, Hebbel RP. Journal name Blood Publication year 2003 Sample Plasma Sample name Plasma - Sickle cell patients - Steady state Isolation/purification methods Differential centrifugation Ultracentrifugation FACS Flotation density - Molecules identified in the study Protein Lipids Methods used in the study FACS Annexin V-FITC EV-TRACK -
8 Experiment ID 263 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 12805058    Organism Homo sapiens Experiment description Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes Authors Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N, Koopmeiners L, Key NS, Hebbel RP. Journal name Blood Publication year 2003 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Ultracentrifugation FACS Flotation density - Molecules identified in the study Protein Methods used in the study FACS EV-TRACK -
9 Experiment ID 241 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 16192427    Organism Homo sapiens Experiment description Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure Authors Amabile N, Guén AP, Leroyer A, Mallat Z, Nguyen C, Boddaert J, London GM, Tedgui A, Boulanger CM Journal name J Am Soc Nephrol Publication year 2005 Sample Plasma Sample name Plasma - End-stage renal failure patients Isolation/purification methods Differential centrifugation FACS Flotation density - Molecules identified in the study Protein Methods used in the study FACS EV-TRACK -
10 Experiment ID 279 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 16192427    Organism Homo sapiens Experiment description Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure Authors Amabile N, Guén AP, Leroyer A, Mallat Z, Nguyen C, Boddaert J, London GM, Tedgui A, Boulanger CM Journal name J Am Soc Nephrol Publication year 2005 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation FACS Flotation density - Molecules identified in the study Protein Methods used in the study FACS EV-TRACK -
11 Experiment ID 288 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 12196479    Organism Homo sapiens Experiment description Type 1 and type 2 diabetic patients display different patterns of cellular microparticles Authors Sabatier F, Darmon P, Hugel B, Combes V, Sanmarco M, Velut JG, Arnoux D, Charpiot P, Freyssinet JM, Oliver C, Sampol J, Dignat-George F Journal name Diabetes Publication year 2002 Sample Plasma Sample name Plasma - Healthy donors Isolation/purification methods Differential centrifugation FACS Flotation density - Molecules identified in the study Protein Lipids Methods used in the study FACS Annexin V-FITC EV-TRACK -
12 Experiment ID 289 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 12196479    Organism Homo sapiens Experiment description Type 1 and type 2 diabetic patients display different patterns of cellular microparticles Authors Sabatier F, Darmon P, Hugel B, Combes V, Sanmarco M, Velut JG, Arnoux D, Charpiot P, Freyssinet JM, Oliver C, Sampol J, Dignat-George F Journal name Diabetes Publication year 2002 Sample Plasma Sample name Plasma - Type 1 diabetes Isolation/purification methods Differential centrifugation FACS Flotation density - Molecules identified in the study Protein Lipids Methods used in the study FACS Annexin V-FITC EV-TRACK -
13 Experiment ID 290 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method FACS PubMed ID 12196479    Organism Homo sapiens Experiment description Type 1 and type 2 diabetic patients display different patterns of cellular microparticles Authors Sabatier F, Darmon P, Hugel B, Combes V, Sanmarco M, Velut JG, Arnoux D, Charpiot P, Freyssinet JM, Oliver C, Sampol J, Dignat-George F Journal name Diabetes Publication year 2002 Sample Plasma Sample name Plasma - Type 2 diabetes Isolation/purification methods Differential centrifugation FACS Flotation density - Molecules identified in the study Protein Lipids Methods used in the study FACS Annexin V-FITC EV-TRACK -
14 Experiment ID 354 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [Orbitrap Velos] PubMed ID 24115447    Organism Homo sapiens Experiment description Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma Authors Mathivanan,S. Journal name Proteomics Publication year 2013 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [Orbitrap Velos] Western blotting EV-TRACK EV130073: EV-METRIC:0%, 11%, 33%, 33%, 56%
15 Experiment ID 443 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 22329422    Organism Homo sapiens Experiment description Quantitative proteome profiling of normal human circulating microparticles. Authors Østergaard O, Nielsen CT, Iversen LV, Jacobsen S, Tanassi JT, Heegaard NH. Journal name J Proteome Res Publication year 2012 Sample Plasma Sample name Normal-Platelet-poor plasma Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
16 Experiment ID 454 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 22669077    Organism Homo sapiens Experiment description The proteome of erythrocyte-derived microparticles from plasma: new clues for erythrocyte aging and vesiculation. Authors Bosman GJ, Lasonder E, Groenen-Döpp YA, Willekens FL, Werre JM. Journal name J Proteomics Publication year 2012 Sample Plasma Sample name Normal-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
17 Experiment ID 473 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23056467    Organism Homo sapiens Experiment description Cause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy. Authors Al Kaabi A, Traupe T, Stutz M, Buchs N, Heller M. Journal name PLoS One Publication year 2012 Sample Plasma Sample name Patients of external counterpulsation therapy-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
18 Experiment ID 863 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22046311    Organism Mus musculus Experiment description Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections Authors Martin-Jaular L, Nakayasu ES, Ferrer M, Almeida IC, Del Portillo HA. Journal name PLoS One Publication year 2011 Sample Plasma Sample name Peripheral blood plasma - P. yoelii 17X infected Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study FACS Mass spectrometry EV-TRACK EV110102: EV-METRIC:25%, 25%
19 Experiment ID 1226 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 1 fr7+8 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
20 Experiment ID 2172 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 30536591    Organism Homo sapiens Experiment description A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients Authors Barrachina MN, Sueiro AM, Casas V, Izquierdo I, Hermida-Nogueira L, Guitián E, Casanueva FF, Abián J, Carrascal M, Pardo M, García Á. Journal name Proteomics Publication year 2019 Sample Plasma Sample name Obese Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
21 Experiment ID 2173 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 30536591    Organism Homo sapiens Experiment description A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients Authors Barrachina MN, Sueiro AM, Casas V, Izquierdo I, Hermida-Nogueira L, Guitián E, Casanueva FF, Abián J, Carrascal M, Pardo M, García Á. Journal name Proteomics Publication year 2019 Sample Plasma Sample name Lean (control) Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
22 Experiment ID 2329 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 32487994    Organism Homo sapiens Experiment description Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Authors Toda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA. Journal name Nat Commun Publication year 2020 Sample Plasma Sample name Healthy donors Isolation/purification methods Centrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry Flow cytometry EV-TRACK -
23 Experiment ID 2330 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 32487994    Organism Homo sapiens Experiment description Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Authors Toda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA. Journal name Nat Commun Publication year 2020 Sample Plasma Sample name Plasmodium vivax (Malaria) patients Isolation/purification methods Centrifugation Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry Flow cytometry EV-TRACK -
24 Experiment ID 2433 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29320704    Organism Homo sapiens Experiment description Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise Authors Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA. Journal name Cell Metab Publication year 2018 Sample Plasma Sample name Plasma Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
25 Experiment ID 2434 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29320704    Organism Homo sapiens Experiment description Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise Authors Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA. Journal name Cell Metab Publication year 2018 Sample Plasma Sample name Plasma Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
26 Experiment ID 2848 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-001 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
27 Experiment ID 2849 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-004 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
28 Experiment ID 2851 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name CSB-024 - COVID-19 patient - convalescent phase Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -