Gene description for CD63
Gene name CD63 molecule
Gene symbol CD63
Other names/aliases AD1
HOP-26
ME491
MLA1
OMA81H
Pltgp40
TSPAN30
Species Homo sapiens
 Experiment description of studies that identified CD63 in Plasma

1
Experiment ID40
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Immunoelectron Microscopy
FACS
Western blotting
PubMed ID 15908444   
OrganismHomo sapiens
Experiment descriptionExosomal-like vesicles are present in human blood plasma.
AuthorsCaby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C
Journal name INTIMM
Publication year2005
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
Filtration
Sucrose density gradient
Flotation density1.15-1.27 g/mL
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
FACS
Immunoelectron microscopy
EV-TRACK -

2
Experiment ID75
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
FACS
ELISA
PubMed ID 19381331   
OrganismHomo sapiens
Experiment descriptionHigh levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients.
AuthorsLogozzi M, De Milito A, Lugini L, Borghi M, Calabrò Spada M, Perdicchio M, Marino ML, Federici C, Iessi E, Brambilla D, Venturi G, Lozupone F, Santinami M, Huber V, Maio M, Rivoltini L, Fais S
Journal name PLOS1
Publication year2009
SamplePlasma
Sample namePlasma - melanoma
Isolation/purification methodsDifferential centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
ELISA
FACS
EV-TRACK -

3
Experiment ID123
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Immunoelectron microscopy
PubMed ID 21235781   
OrganismHomo sapiens
Experiment descriptionHuman saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages.
AuthorsLäer C, Alikhani VS, Ekströ, Eldh M, Paredes PT, Bossios A, Sjöand M, Gabrielsson S, Löll J, Valadi H.
Journal name JTM
Publication year2011
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
Filtration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
Immunoelectron microscopy
Western blotting
EV-TRACK EV110029: EV-METRIC:14%, 29%, 14%

4
Experiment ID183
Identified moleculeprotein
Extracellular vesicle typeMicrovesicles
MISEVEVs
Identification method FACS
PubMed ID 21741384   
OrganismHomo sapiens
Experiment descriptionA filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma
AuthorsGrant R, Ansa-Addo E, Stratton D, Antwi-Baffour S, Jorfi S, Kholia S, Krige L, Lange S, Inal J
Journal name J Immunol Methods
Publication year2011
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
ELISA
EV-TRACK EV110077: EV-METRIC:0%, 0%, 33%

5
Experiment ID189
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method FACS
PubMed ID 21741384   
OrganismHomo sapiens
Experiment descriptionA filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma
AuthorsGrant R, Ansa-Addo E, Stratton D, Antwi-Baffour S, Jorfi S, Kholia S, Krige L, Lange S, Inal J
Journal name J Immunol Methods
Publication year2011
SamplePlasma
Sample namePlasma - Normal
Isolation/purification methodsDifferential centrifugation
Filtration
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFACS
ELISA
EV-TRACK EV110077: EV-METRIC:0%, 0%, 33%

6
Experiment ID1079
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 6)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

7
Experiment ID1080
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 7)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

8
Experiment ID1081
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 8)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

9
Experiment ID1082
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 9)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

10
Experiment ID1083
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 10)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

11
Experiment ID1084
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 11)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

12
Experiment ID1085
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method ELISA
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameHealthy pregnant women (week 12)
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyELISA
EV-TRACK EV140094: EV-METRIC:56%

13
Experiment ID858
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method TR-FIA
PubMed ID 28881726   
OrganismHomo sapiens
Experiment descriptionModulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer
AuthorsSoekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC.
Journal name Oncotarget
Publication year2016
SamplePlasma
Sample namePlasma - prostrate cancer patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyTime-resolved fluorescence immunoassay
EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%

14
Experiment ID859
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method TR-FIA
PubMed ID 28881726   
OrganismHomo sapiens
Experiment descriptionModulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer
AuthorsSoekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM; Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC.
Journal name Oncotarget
Publication year2016
SamplePlasma
Sample namePlasma - benign prostate hyperplasia patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyTime-resolved fluorescence immunoassay
EV-TRACK EV170047: EV-METRIC:44%, 0%, 44%, 44%, 44%, 33%, 33%, 33%

15
Experiment ID1073
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameFresh plasma- healthy women
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK EV140094: EV-METRIC:56%

16
Experiment ID1074
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 25104112   
OrganismHomo sapiens
Experiment descriptionPlacenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.
AuthorsSarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C.
Journal name J Transl Med
Publication year2014
SamplePlasma
Sample nameStored plasma(freeze/thaw) plasma- healthy women
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK EV140094: EV-METRIC:56%

17
Experiment ID3086
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
Immuno-EM
PubMed ID 36631249   
OrganismHomo sapiens
Experiment descriptionS100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos
AuthorsWang X, Huang H, Sze KM, Wang J, Tian L, Lu J, Tsui YM, Ma HT, Lee E, Chen A, Lee J, Wang Y, Yam JWP, Cheung TT, Guan X, Ng IO.
Journal name Gut
Publication year2023
SamplePlasma
Sample nameHealthy donors
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

18
Experiment ID1533
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVSmall EVs
Identification method Western blotting
PubMed ID 33589572   
OrganismHomo sapiens
Experiment descriptionExosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis
AuthorsLv X, Lian Y, Liu Z, Xiao J, Zhang D, Yin X.
Journal name Aging
Publication year2021
SamplePlasma
Sample nameNon-small cell lung cancer
Isolation/purification methodsCentrifugation
ExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
lncRNA
Methods used in the studyqRT-PCR
Western blotting
EV-TRACK -

19
Experiment ID1534
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVSmall EVs
Identification method Western blotting
PubMed ID 33589572   
OrganismHomo sapiens
Experiment descriptionExosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis
AuthorsLv X, Lian Y, Liu Z, Xiao J, Zhang D, Yin X.
Journal name Aging
Publication year2021
SamplePlasma
Sample nameHealthy
Isolation/purification methodsCentrifugation
ExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
lncRNA
Methods used in the studyqRT-PCR
Western blotting
EV-TRACK -

20
Experiment ID1879
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 36063142   
OrganismHomo sapiens
Experiment descriptionNecroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL
AuthorsGupta K, Brown KA, Hsieh ML, Hoover BM, Wang J, Khoury MK, Pilli VSS, Beyer RSH, Voruganti NR, Chaudhary S, Roberts DS, Murphy RM, Hong S, Ge Y, Liu B.
Journal name J Extracell Vesicles
Publication year2022
SamplePlasma
Sample namePlasma
Isolation/purification methodsDifferential centrifugation
ExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

21
Experiment ID1961
Identified moleculeprotein
Extracellular vesicle typeExomeres
MISEVEV-like nanoparticles
Identification method Western blotting
PubMed ID 36417505   
OrganismHomo sapiens
Experiment descriptionA solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER)
AuthorsZhang J, Chen C, Becker R, Rufo J, Yang S, Mai J, Zhang P, Gu Y, Wang Z, Ma Z, Xia J, Hao N, Tian Z, Wong DTW, Sadovsky Y, Lee LP, Huang TJ.
Journal name Sci Adv
Publication year2022
SamplePlasma
Sample namePlasma
Isolation/purification methodsAcoustic nanoscale separation via wave-pillar excitation resonance (ANSWER)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

22
Experiment ID1962
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVSmall EVs
Identification method Western blotting
PubMed ID 36417505   
OrganismHomo sapiens
Experiment descriptionA solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER)
AuthorsZhang J, Chen C, Becker R, Rufo J, Yang S, Mai J, Zhang P, Gu Y, Wang Z, Ma Z, Xia J, Hao N, Tian Z, Wong DTW, Sadovsky Y, Lee LP, Huang TJ.
Journal name Sci Adv
Publication year2022
SamplePlasma
Sample namePlasma
Isolation/purification methodsAcoustic nanoscale separation via wave-pillar excitation resonance (ANSWER)
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

23
Experiment ID2276
Identified moleculeProtein
Extracellular vesicle typeExosomes
MISEVSmall EVs
Identification method Western blotting
PubMed ID 29295981   
OrganismHomo sapiens
Experiment descriptionCirculating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
AuthorsKimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T.
Journal name Nat Commun
Publication year2018
SamplePlasma
Sample nameHealthy controls
Isolation/purification methodsDifferential centrifugation
Polyethylene glycol-based precipitation
Centrifugation
Flotation density-
Molecules identified in the studyProtein
miRNA
Methods used in the studyWestern blotting
Microarray
RT-qPCR
EV-TRACK -

24
Experiment ID2912
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 26061593   
OrganismHomo sapiens
Experiment descriptionPathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue
AuthorsSagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D.
Journal name Gut
Publication year2017
SamplePlasma
Sample nameNon-pancreatic cancer control
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

25
Experiment ID2913
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 26061593   
OrganismHomo sapiens
Experiment descriptionPathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue
AuthorsSagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D.
Journal name Gut
Publication year2017
SamplePlasma
Sample namePancreatic cancer patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

26
Experiment ID3045
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 34294888   
OrganismHomo sapiens
Experiment descriptionExosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2
AuthorsXue P, Huang S, Han X, Zhang C, Yang L, Xiao W, Fu J, Li H, Zhou Y.
Journal name Cell Death Differ
Publication year2022
SamplePlasma
Sample nameMedulloblastoma patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
miRNA
Methods used in the studyWestern blotting
RNA sequencing
RT-qPCR
EV-TRACK -

27
Experiment ID3046
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 34294888   
OrganismHomo sapiens
Experiment descriptionExosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2
AuthorsXue P, Huang S, Han X, Zhang C, Yang L, Xiao W, Fu J, Li H, Zhou Y.
Journal name Cell Death Differ
Publication year2022
SamplePlasma
Sample nameHealthy controls
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
miRNA
Methods used in the studyWestern blotting
RNA sequencing
RT-qPCR
EV-TRACK -

28
Experiment ID3087
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 36631249   
OrganismHomo sapiens
Experiment descriptionS100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos
AuthorsWang X, Huang H, Sze KM, Wang J, Tian L, Lu J, Tsui YM, Ma HT, Lee E, Chen A, Lee J, Wang Y, Yam JWP, Cheung TT, Guan X, Ng IO.
Journal name Gut
Publication year2023
SamplePlasma
Sample nameHepatocellular carcinoma patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Immuno-EM
EV-TRACK -

29
Experiment ID3139
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 34497265   
OrganismHomo sapiens
Experiment descriptionTumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer
AuthorsMa Z, Wei K, Yang F, Guo Z, Pan C, He Y, Wang J, Li Z, Chen L, Chen Y, Xia Y.
Journal name Cell Death Dis
Publication year2021
SamplePlasma
Sample nameNon-small cell lung carcinoma patients
Isolation/purification methodsExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
miRNA
Methods used in the studyWestern blotting
Microarray
EV-TRACK -

30
Experiment ID3140
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 34497265   
OrganismHomo sapiens
Experiment descriptionTumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer
AuthorsMa Z, Wei K, Yang F, Guo Z, Pan C, He Y, Wang J, Li Z, Chen L, Chen Y, Xia Y.
Journal name Cell Death Dis
Publication year2021
SamplePlasma
Sample nameHealthy controls
Isolation/purification methodsExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
miRNA
Methods used in the studyWestern blotting
Microarray
EV-TRACK -

31
Experiment ID3197
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 34690112   
OrganismHomo sapiens
Experiment descriptionExosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling
AuthorsLai Y, Dong L, Jin H, Li H, Sun M, Li J.
Journal name Aging
Publication year2021
SamplePlasma
Sample nameHealthy donors
Isolation/purification methodsExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
lncRNA
Methods used in the studyWestern blotting
lncRNA profiling
qPCR
EV-TRACK -

32
Experiment ID3198
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Western blotting
PubMed ID 34690112   
OrganismHomo sapiens
Experiment descriptionExosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling
AuthorsLai Y, Dong L, Jin H, Li H, Sun M, Li J.
Journal name Aging
Publication year2021
SamplePlasma
Sample nameOvarian cancer patients
Isolation/purification methodsExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
lncRNA
Methods used in the studyWestern blotting
lncRNA profiling
qPCR
EV-TRACK -

33
Experiment ID3307
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 32139701   
OrganismHomo sapiens
Experiment descriptionPrimary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
AuthorsJi Q, Zhou L, Sui H, Yang L, Wu X, Song Q, Jia R, Li R, Sun J, Wang Z, Liu N, Feng Y, Sun X, Cai G, Feng Y, Cai J, Cao Y, Cai G, Wang Y, Li Q.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample nameHealthy volunteers
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
ELISA
EV-TRACK -

34
Experiment ID3308
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 32139701   
OrganismHomo sapiens
Experiment descriptionPrimary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
AuthorsJi Q, Zhou L, Sui H, Yang L, Wu X, Song Q, Jia R, Li R, Sun J, Wang Z, Liu N, Feng Y, Sun X, Cai G, Feng Y, Cai J, Cao Y, Cai G, Wang Y, Li Q.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample nameNon-metastatic colorectal cancer patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
ELISA
EV-TRACK -

35
Experiment ID3309
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 32139701   
OrganismHomo sapiens
Experiment descriptionPrimary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
AuthorsJi Q, Zhou L, Sui H, Yang L, Wu X, Song Q, Jia R, Li R, Sun J, Wang Z, Liu N, Feng Y, Sun X, Cai G, Feng Y, Cai J, Cao Y, Cai G, Wang Y, Li Q.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample nameMetastatic colorectal cancer patients
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

36
Experiment ID3447
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 32341770   
OrganismMus musculus
Experiment descriptionDUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination
AuthorsWang CA, Chang IH, Hou PC, Tai YJ, Li WN, Hsu PL, Wu SR, Chiu WT, Li CF, Shan YS, Tsai SJ.
Journal name J Extracell Vesicles
Publication year2020
SamplePlasma
Sample nameWT mice
Isolation/purification methodsDifferential centrifugation
ExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

37
Experiment ID3448
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Western blotting
PubMed ID 32341770   
OrganismMus musculus
Experiment descriptionDUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination
AuthorsWang CA, Chang IH, Hou PC, Tai YJ, Li WN, Hsu PL, Wu SR, Chiu WT, Li CF, Shan YS, Tsai SJ.
Journal name J Extracell Vesicles
Publication year2020
SamplePlasma
Sample nameKras-active and Dusp2-null (KDC) mice
Isolation/purification methodsDifferential centrifugation
ExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
EV-TRACK -

38
Experiment ID3515
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameHealthy control
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

39
Experiment ID3516
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameLymphoma patients
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

40
Experiment ID3517
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameBreast cancer patients
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

41
Experiment ID3518
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameLiver cancer patients
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

42
Experiment ID3519
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameLung cancer patients
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

43
Experiment ID3520
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameOvarian cancer patients
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

44
Experiment ID3521
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameProstate cancer patients
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

45
Experiment ID3522
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameCancer patients - Stage I
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

46
Experiment ID3523
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameCancer patients - Stage II
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

47
Experiment ID3524
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameCancer patients - Stage III
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

48
Experiment ID3525
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameCancer patients - Stage IV
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

49
Experiment ID3526
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameProstate cancer patients - without treatment
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

50
Experiment ID3527
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameBenign disease
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

51
Experiment ID3528
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameProstate cancer patients - no recurrence
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

52
Experiment ID3529
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Thermophoretic aptasensor (TAS)
PubMed ID 30948809   
OrganismHomo sapiens
Experiment descriptionLow-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
AuthorsLiu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W.
Journal name Nat Biomed Eng
Publication year2019
SamplePlasma
Sample nameProstate cancer patients - recurrence
Isolation/purification methodsFiltration
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyThermophoretic aptasensor (TAS)
EV-TRACK -

53
Experiment ID1726
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
ELISA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 8
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
ELISA
EV-TRACK -

54
Experiment ID1727
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
ELISA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 9
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
ELISA
EV-TRACK -

55
Experiment ID1724
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 6
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

56
Experiment ID1725
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 7
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
ELISA
EV-TRACK -

57
Experiment ID1728
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 10
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

58
Experiment ID1729
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 11
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

59
Experiment ID1730
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 12
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

60
Experiment ID1731
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 13
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

61
Experiment ID1732
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 14
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

62
Experiment ID1733
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 15
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

63
Experiment ID1734
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 16
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

64
Experiment ID1735
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 17
Isolation/purification methodsCentrifugal filtration
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

65
Experiment ID1748
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 2
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.028 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

66
Experiment ID1749
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 3
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.045 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

67
Experiment ID1750
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 4
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.056 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

68
Experiment ID1751
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 5
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.065 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

69
Experiment ID1752
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 6
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.076 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

70
Experiment ID1753
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 7
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.097 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

71
Experiment ID1754
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 8
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.113 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

72
Experiment ID1755
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 9
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.138 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

73
Experiment ID1756
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 10
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.193 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

74
Experiment ID1757
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method SIMOA
PubMed ID 34092791   
OrganismHomo sapiens
Experiment descriptionL1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
AuthorsNorman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR.
Journal name Nat Methods
Publication year2021
SamplePlasma
Sample nameFraction 11
Isolation/purification methodsCentrifugal filtration
OptiPrep density gradient centrifugation
Flotation density1.219 g/mL
Molecules identified in the studyProtein
Methods used in the studySIMOA
EV-TRACK -

75
Experiment ID2831
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Microflow vesiclometry
PubMed ID 35058437   
OrganismHomo sapiens
Experiment descriptionCirculating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
AuthorsEl-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H.
Journal name Nat Commun
Publication year2022
SamplePlasma
Sample nameCOVID-19 patients - Convalescent phase
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMicroflow vesiclometry
EV-TRACK -

76
Experiment ID2379
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 15
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

77
Experiment ID2380
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 16
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

78
Experiment ID2381
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 17
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

79
Experiment ID2382
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 18
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

80
Experiment ID2383
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 19
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

81
Experiment ID2384
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 20
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

82
Experiment ID2385
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 21
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

83
Experiment ID2386
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Column 1 Fraction 14-15
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

84
Experiment ID2387
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction Column 1 16-17
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

85
Experiment ID2388
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction Column 1 18-19
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

86
Experiment ID2389
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Column 1 Fraction 20-21
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

87
Experiment ID2394
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Column 3 Fraction 14-15
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

88
Experiment ID2395
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction Column 3 16-17
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

89
Experiment ID2396
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction Column 3 18-19
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

90
Experiment ID2397
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Column 3 Fraction 20-21
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

91
Experiment ID2398
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 14-21
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

92
Experiment ID2431
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 29320704   
OrganismHomo sapiens
Experiment descriptionExtracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
AuthorsWhitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA.
Journal name Cell Metab
Publication year2018
SamplePlasma
Sample namePlasma - 20K pellet
Isolation/purification methodsCentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

93
Experiment ID2432
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 29320704   
OrganismHomo sapiens
Experiment descriptionExtracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
AuthorsWhitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA.
Journal name Cell Metab
Publication year2018
SamplePlasma
Sample namePlasma - 100K pellet
Isolation/purification methodsUltracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

94
Experiment ID2436
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 29320704   
OrganismHomo sapiens
Experiment descriptionExtracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
AuthorsWhitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA.
Journal name Cell Metab
Publication year2018
SamplePlasma
Sample namePlasma
Isolation/purification methodsCentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

95
Experiment ID2848
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 35058437   
OrganismHomo sapiens
Experiment descriptionCirculating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
AuthorsEl-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H.
Journal name Nat Commun
Publication year2022
SamplePlasma
Sample nameNWL-001 - Lung cancer patient
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Mass spectrometry
EV-TRACK -

96
Experiment ID2329
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Flow cytometry
PubMed ID 32487994   
OrganismHomo sapiens
Experiment descriptionPlasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
AuthorsToda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample nameHealthy donors
Isolation/purification methodsCentrifugation
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Mass spectrometry
Flow cytometry
EV-TRACK -

97
Experiment ID2330
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Flow cytometry
PubMed ID 32487994   
OrganismHomo sapiens
Experiment descriptionPlasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
AuthorsToda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample namePlasmodium vivax (Malaria) patients
Isolation/purification methodsCentrifugation
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Mass spectrometry
Flow cytometry
EV-TRACK -

98
Experiment ID2512
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - ExoQuick Ultra
Isolation/purification methodsExoQuick Kit
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
Mass spectometry
EV-TRACK -

99
Experiment ID2513
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - exoEasy
Isolation/purification methodsexoEasy Maxi Kit
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
Mass spectometry
EV-TRACK -

100
Experiment ID2514
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - iZON 35 nm column
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
Mass spectometry
EV-TRACK -

101
Experiment ID2516
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVLarge EVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - OptiPrep
Isolation/purification methodsOptiPrep density gradient centrifugation
Ultracentrifugation
Flotation density1.12–1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
Mass spectometry
EV-TRACK -

102
Experiment ID2517
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - iZON 35 nm column flow-through fraction
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
Mass spectometry
EV-TRACK -

103
Experiment ID2518
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - iZON 70 nm column flow-through fraction
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
Mass spectometry
EV-TRACK -

104
Experiment ID2520
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Flow cytometry
PubMed ID 34322205   
OrganismHomo sapiens
Experiment descriptionMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
AuthorsVeerman RE, Teeuwen L, Czarnewski P, Güclüler Akpinar G, Sandberg A, Cao X, Pernemalm M, Orre LM, Gabrielsson S, Eldh M.
Journal name J Extracell Vesicles
Publication year2021
SamplePlasma
Sample namePlasma - OptiPrep low density fraction
Isolation/purification methodsOptiPrep density gradient centrifugation
Ultracentrifugation
Flotation densityTwo closest fractions below 1.12 g/mL
Molecules identified in the studyProtein
Methods used in the studyFlow cytometry
EV-TRACK -

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